250 Main Hotel offers 26 air-conditioned accommodations with tablet computers and iPod docking stations. Each accommodation is individually furnished and decorated. Pillowtop beds feature Egyptian cotton sheets and premium bedding. Flat-screen televisions come with premium cable channels. Bathrooms include showers with rainfall showerheads, bathrobes, designer toiletries, and complimentary toiletries.
Guests can surf the web using the complimentary wireless Internet access (speed: 250+ Mbps (good for 3–5 people or up to 10 devices)). Business-friendly amenities include desks and phones. Additionally, rooms include MP3 docking stations and hair dryers.