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Santiago Island Vacation Packages

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One of the highlights of my trip to the Galapagos was snorkeling with Galapagos penguins off of Bartolome Island. Galapagos Penguins are the only penguin bread found north of the equator. #lifeatexpedia

Photo by Sarah Mack

Santiago Island
Galápagos
Ecuador
South America
Hotwire.com

Santiago Island Flight + Hotel Packages

Price found within the past 48 hours. Click for updated prices.

Hotel el descanso del Guia

3.5 out of 5

Price was $811, price is now $558 per person

$558

per person

Dec 22 - Dec 26

found 1 day ago

Roundtrip non-stop flight included

Quito (UIO) to Isla Baltra (GPS)

Stay at this 3.5-star family-friendly hotel in Puerto Ayora. Enjoy free breakfast, free WiFi, and a rooftop terrace. Our guests praise the helpful staff in our reviews. Popular attractions Las Ninfas Lagoon and Fishing Piers are located nearby.

Twin Hotel Galapagos

3 out of 5

Price was $866, price is now $617 per person

$617

per person

Dec 22 - Dec 26

found 1 day ago

Roundtrip non-stop flight included

Quito (UIO) to Isla Baltra (GPS)

Stay at this 3-star family-friendly hotel in Bella Vista. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Charles Darwin Research Station and Fishing Piers are located nearby.

Natura Gardens Galápagos Hotel

3 out of 5

Price was $801, price is now $580 per person

$580

per person

Dec 22 - Dec 26

found 1 day ago

Roundtrip non-stop flight included

Quito (UIO) to Isla Baltra (GPS)

Stay at this 3-star hotel in Bella Vista. Enjoy free breakfast, onsite spa services, and daily housekeeping. Popular attractions Charles Darwin Research Station and Fishing Piers are located nearby.

BAY VIEW HOUSE

3.5 out of 5

Price was $775, price is now $567 per person

$567

per person

Nov 12 - Nov 15

found 1 day ago

Roundtrip flight included

Guayaquil (GYE) to Isla Baltra (GPS)

Stay at this 3.5-star spa guesthouse in Puerto Ayora. Enjoy free WiFi, a full-service spa, and daily housekeeping. Popular attractions Gus Angermeyer Ferry Terminal and Malecon are located nearby.

Angermeyer Waterfront Inn

3.5 out of 5

Price was $924, price is now $702 per person

$702

per person

Nov 12 - Nov 15

found 1 day ago

Roundtrip flight included

Guayaquil (GYE) to Isla Baltra (GPS)

Stay at this 3.5-star hotel in Puerto Ayora. Enjoy free breakfast, free WiFi, and a marina. Our guests praise the helpful staff in our reviews. Popular attractions Playa de los Alemanes and Malecon are located nearby.

Blu Galapagos Sustainable Waterfront Lodge

4 out of 5

Price was $1,676, price is now $1,328 per person

$1,328

per person

Dec 22 - Dec 26

found 1 day ago

Roundtrip non-stop flight included

Quito (UIO) to Isla Baltra (GPS)

Stay at this 4-star business-friendly hotel in Puerto Ayora. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the helpful staff in our reviews. Popular attractions Fishing Piers and Charles Darwin Research Station are located nearby.

Galapagos Sea Star

2 out of 5

Save 100% on your flight

Price was $3,865, price is now $3,084 per person

$3,084

per person

Dec 22 - Dec 26

found 1 day ago

Roundtrip non-stop flight included

Quito (UIO) to Isla Baltra (GPS)

Stay at this cruise ship in Puerto Ayora. Enjoy free breakfast, WiFi (surcharge), and daily housekeeping. Popular attractions Fishing Piers and Gus Angermeyer Ferry Terminal are located nearby.

Hotel Villa Escalesia Galapagos

2.5 out of 5

Save 100% on your flight

Price was $9,923, price is now $7,928 per person

$7,928

per person

Dec 22 - Dec 26

found 1 day ago

Roundtrip non-stop flight included

Quito (UIO) to Isla Baltra (GPS)

Stay at this hotel in Puerto Ayora. Enjoy free breakfast, free WiFi, and an airport shuttle (surcharge). Popular attractions Fishing Piers and Gus Angermeyer Ferry Terminal are located nearby.