See all properties

21C Museum Hotel St Louis

4.5 star property

Choose dates to view prices

Photo gallery for 21C Museum Hotel St Louis

Exterior
Bar (on property)
Indoor pool
Interior
Billiards

Reviews

9.0 out of 10
Wonderful

Popular amenities

  • Pool
  • Spa
  • Bar
  • Room service
  • 24/7 front desk
$193
includes taxes & fees
Oct 5 - Oct 6

Explore the area

View in a map
1528 Locust street, St. Louis, MO, 63103
  • St. Louis Union Station
    ‪6 min walk‬
  • Enterprise Center
    ‪6 min walk‬
  • Busch Stadium
    ‪14 min walk‬
  • St. Louis, MO (STL-Lambert-St. Louis Intl.)
    ‪21 min drive‬

Room options

Loft, 2 Queen Beds

  • 431 sq ft
  • Sleeps 4
  • 2 Queen Beds

Luxury Suite, 1 King Bed

  • 549 sq ft
  • Sleeps 2
  • 1 King Bed

View all photos for Room (Bunk Bed)

Room (Bunk Bed) | 1 bedroom, in-room safe, desk, laptop workspace

Room (Bunk Bed)

8.0 out of 10
Very good
(6 reviews)
  • 237 sq ft
  • 1 bedroom
  • Sleeps 2
  • 1 Twin Bunk Bed

Deluxe Room, Accessible (Accessible)

  • 269 sq ft
  • Sleeps 2
  • 1 King Bed

Suite, 1 King Bed (Library)

  • 732 sq ft
  • City view
  • Sleeps 2
  • 1 King Bed

Suite, 1 King Bed (21C)

  • 1119 sq ft
  • Sleeps 2
  • 1 King Bed

Deluxe Room, 1 Double Bed, Accessible

  • 388 sq ft
  • Sleeps 4
  • 1 Double Bed

View all photos for Deluxe Room, 1 King Bed

Deluxe Room, 1 King Bed | 1 bedroom, in-room safe, desk, laptop workspace

Deluxe Room, 1 King Bed

9.2 out of 10
Wonderful
(69 reviews)
  • 309 sq ft
  • Sleeps 2
  • 1 King Bed

Deluxe Suite, 1 Double Bed, Accessible

  • 517 sq ft
  • Sleeps 2
  • 1 Double Bed

View all photos for Deluxe Double Room, 2 Queen Beds

1 bedroom, in-room safe, desk, laptop workspace

Deluxe Double Room, 2 Queen Beds

8.6 out of 10
Excellent
(20 reviews)
  • 369 sq ft
  • Sleeps 4
  • 2 Queen Beds

Deluxe Room, 1 Double Bed, Accessible

  • 388 sq ft
  • Sleeps 4
  • 1 Double Bed

View all photos for Room, 1 King Bed, Corner

Room, 1 King Bed, Corner | 1 bedroom, in-room safe, desk, laptop workspace

Room, 1 King Bed, Corner

8.6 out of 10
Excellent
(24 reviews)
  • 326 sq ft
  • City view
  • Sleeps 2
  • 1 King Bed

View all photos for Suite, 1 King Bed

1 bedroom, in-room safe, desk, laptop workspace

Suite, 1 King Bed

  • 517 sq ft
  • Sleeps 2
  • 1 King Bed

View all photos for Deluxe Suite, 1 King Bed

1 bedroom, in-room safe, desk, laptop workspace

Deluxe Suite, 1 King Bed

9.2 out of 10
Wonderful
(5 reviews)
  • 517 sq ft
  • Sleeps 2
  • 1 King Bed

View all photos for Luxury Double Room, 2 Queen Beds

1 bedroom, in-room safe, desk, laptop workspace

Luxury Double Room, 2 Queen Beds

9.2 out of 10
Wonderful
(21 reviews)
  • 423 sq ft
  • Sleeps 4
  • 2 Queen Beds

Similar properties

Lobby

Hyatt Regency St. Louis at The Arch

  • Pet friendly
  • Free WiFi
  • Restaurant
  • Air conditioning
4.2 out of 5, Very Good, 3,981 reviews
Hyatt Regency St. Louis at The Arch

About this property

21C Museum Hotel St Louis

4.5-star hotel in Downtown West
This smoke-free hotel features an indoor pool, a restaurant, and a fitness center. WiFi in public areas is free. Additionally, a bar/lounge, a steam room, and a coffee shop/cafe are onsite. Change of towels is available on request.
21C Museum Hotel St Louis offers 104 air-conditioned accommodations with espresso makers and safes. Flat-screen televisions come with premium cable channels. Bathrooms include bathrobes, complimentary toiletries, and hair dryers.

This St. Louis hotel provides complimentary wireless Internet access. Business-friendly amenities include desks, desk chairs, and phones. Additionally, rooms include complimentary bottled water and irons/ironing boards. Change of towels and change of bedsheets can be requested. Housekeeping is provided daily.

Recreational amenities at the hotel include an indoor pool, a steam room, and a fitness center.
Guests can pamper themselves by indulging in the onsite spa services. Services include massages.
In addition to an indoor pool, 21C Museum Hotel St Louis provides a steam room and a fitness center. Dining options at the hotel include a restaurant and a coffee shop/cafe. A bar/lounge is on site where guests can unwind with a drink. Public areas are equipped with complimentary wireless Internet access.

Business-related amenities at this 4.5-star property consist of a business center and meeting rooms. This luxury hotel also offers spa services, a vending machine, and concierge services. Parking is available onsite for a surcharge.

21C Museum Hotel St Louis is a smoke-free property.

Cooked-to-order breakfasts are available for a surcharge and are served each morning between 6:30 AM and 1:00 PM.
21C Museum Hotel St Louis has a restaurant on site.
Room service (during limited hours) is available.

Property amenities

Internet

  • Available in all rooms: Free WiFi
  • Available in some public areas: Free WiFi

Parking and transportation

  • Valet parking on site (USD 50 per day; includes in/out privileges)

Food and drink

  • Daily cooked-to-order breakfast available 6:30 AM to 1:00 PM for a fee: USD 10 to 25 per person
  • A bar/lounge
  • A coffee shop/cafe
  • A restaurant

Things to do

  • Billiards/pool table
  • Gym
  • Indoor pool
  • Steam room

Family friendly

  • Indoor pool
  • Soundproofed rooms

Conveniences

  • 24-hour front desk
  • ATM
  • Luggage storage
  • Vending machine

Guest services

  • Change of bedsheets (on request)
  • Change of towels on request
  • Concierge services
  • Dry cleaning/laundry service
  • Housekeeping (daily)

Business services

  • Business center
  • Meeting rooms

Spa

  • Massage
  • Spa services

Accessibility

  • If you have requests for specific accessibility needs, please contact the property using the information on the reservation confirmation received after booking.
  • Area rugs in room
  • Braille/raised signage
  • Elevator (42 inch wide door)
  • Grab bar in shower (35 inches high)
  • Handrails in stairways (36 inches high)
  • Lever door handles
  • Magnifying mirror
  • Pool hoist on site
  • Stair-free path to entrance
  • Thin carpet in room
  • Tile flooring in room
  • Visual fire alarm
  • Well-lit path to entrance
  • Wheelchair accessible (may have limitations)
  • Wheelchair-accessible gym
  • Wheelchair-accessible lounge
  • Wheelchair-accessible path of travel
  • Wheelchair-accessible pool
  • Wheelchair-accessible public washroom
  • Wheelchair-accessible registration desk (36 inches high)
  • Wheelchair-accessible restaurant
  • Wheelchair-accessible spa
  • Wheelchairs on site

More

  • Banquet hall
  • Biodegradable coffee stirrers available
  • Biodegradable drinking straws available
  • No plastic coffee stirrers
  • No plastic drinking straws
  • No plastic soft drink bottles
  • No plastic water bottles
  • Reusable cups
  • Reusable tableware
  • Smoking not allowed

Room amenities

Bedroom

  • Bedsheets provided
  • Blackout drapes

Bathroom

  • Bathrobes
  • Free toiletries
  • Hair dryer
  • Shampoo
  • Soap
  • Toilet paper
  • Toothbrush and toothpaste (on request)
  • Towels provided

Entertainment

  • Flat-screen TV with premium digital channels

Food and drink

  • Espresso maker
  • Free bottled water
  • Limited room service

More

  • Air conditioning
  • Desk
  • Desk chair
  • Heating
  • Iron/ironing board
  • Laptop workspace
  • Phone
  • Safe
  • Soundproofed rooms

Policies

Check-in

Check-in start time: 4:00 PM; Check-in end time: 11:00 AM
Late check-in subject to availability
Minimum check-in age: 21

Check-out

Check-out before 11:00 AM

Special check-in instructions

Front desk staff will greet guests on arrival at the property

Access methods

Staffed front desk

Pets

Pets allowed for an extra charge of USD 100 per accommodation, per stay
Service animals are welcome, and are exempt from fees
Welcoming dogs only

Children and extra beds

Children are welcome
Rollaway/extra beds are not available
Cribs (infant beds) are not available

Property payment types

Important information

Fees

You'll be asked to pay the following charges at the property. Fees may include applicable taxes:

  • Service fee: USD 5 per accommodation, per stay

We have included all charges provided to us by the property.

Optional extras

  • Fee for cooked-to-order breakfast: approximately USD 10 to 25 per person
  • Valet parking fee: USD 50 per day (in/out privileges)
  • Pet fee: USD 100 per accommodation, per stay
  • Service animals are exempt from fees

The above list may not be comprehensive. Fees and deposits may not include tax and are subject to change.

You need to know

Extra-person charges may apply and vary depending on property policy
Government-issued photo identification and a credit card, debit card, or cash deposit may be required at check-in for incidental charges
Special requests are subject to availability upon check-in and may incur additional charges; special requests cannot be guaranteed
This property accepts credit cards; cash is not accepted
Safety features at this property include a smoke detector and outdoor lighting

We should mention

Reservations are required for massage services; reservations can be made by contacting the property prior to arrival, using the contact information on the booking confirmation
This property welcomes guests of all sexual orientations and gender identities (LGBTQ+ friendly)

Property is also known as

21C Museum Hotel St Louis
21c Museum St Louis St Louis
21C Museum Hotel St Louis Hotel
21C Museum Hotel St Louis St. Louis
21C Museum Hotel St Louis Hotel St. Louis
21C Museum Hotel St Louis (Opening Spring 2023)

21C Museum Hotel St Louis Reviews

Reviews

9.0

Wonderful

Rating 10 - Excellent. 972 out of 1346 reviews
Rating 8 - Good. 200 out of 1346 reviews
Rating 6 - Okay. 83 out of 1346 reviews
Rating 4 - Poor. 41 out of 1346 reviews
Rating 2 - Terrible. 50 out of 1346 reviews

9.2/10

Cleanliness

9.2/10

Staff & service

9.2/10

Amenities

9.4/10

Property conditions & facilities

9.2/10

Eco-friendliness

Reviews

10/10 Excellent

Maria

Stayed 1 night in Jun 2025

10/10 Excellent

Katixa

Business traveler
Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Absolutely love these properties and stay whenever I can.
Stayed 3 nights in May 2025

10/10 Excellent

Jamie

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort

So good

What a gem of a hotel! Great room, great service at the desk and by the valet Isabella. The pool/sauna/hot tub is excellent and rare to find at a modern downtown hotel. Cant wait to stay again!
Stayed 1 night in Jun 2025

10/10 Excellent

Jeffrey

Traveled with partner
Liked: Cleanliness, amenities, property conditions & facilities
The staff was amazing, room was awesome. Very close to the convention center
Stayed 5 nights in May 2025

10/10 Excellent

Axel, Champaign

Traveled with family and small children, Traveled with family
Liked: Cleanliness
Elevators are very slow!!!
Stayed 1 night in May 2025

10/10 Excellent

Jessica

Liked: Cleanliness, amenities, property conditions & facilities
Neat property in a good location. We easily walked to the Stifel Theater for a concert. Nice rooms. We opted to upgrade to a corner suite and it was worth it. Nice indoor pool and 2 gyms. The only negatives the trip were no washcloths in the bathroom and we called for ice (you have to get through room service) but it never came so we ended up getting from the bar in the lobby. Got a resort pass to yse the rooftop pool of another hotel since 21c pool is indoor and it was really nice outside. Othewise was wonderful!
View from corner suite 8th floor
Living area
Stayed 2 nights in May 2025

10/10 Excellent

Jamie

Business traveler
Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Great location near downtown. Amazing staff! Great restaurant and coffee shop on the property. For those that don't know they also have an amazing art museum on the 2nd floor. Love the 21C hotel chain Would love to see one of these in every city!
Stayed 1 night in May 2025

10/10 Excellent

Jason

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Stayed 1 night in May 2025

10/10 Excellent

Guochen

Stayed 1 night in May 2025

8/10 Good

Lakeith

Liked: Cleanliness, property conditions & facilities
Stayed 1 night in May 2025

10/10 Excellent

Robert

Traveled with family
Liked: Cleanliness, property conditions & facilities
Good hotel located within walking distance of the ballpark, arch, and numerous other parks.
Stayed 2 nights in May 2025

8/10 Good

Jason

Traveled with family
Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Stayed 1 night in May 2025

10/10 Excellent

Andrew

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Stayed 2 nights in May 2025

10/10 Excellent

Charlinda

Liked: Cleanliness, amenities, property conditions & facilities
Stayed 1 night in May 2025

8/10 Good

Patrick

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Stayed 1 night in Apr 2025

10/10 Excellent

William

Stayed 1 night in May 2025

10/10 Excellent

Denise

Business traveler
Liked: Cleanliness, amenities, property conditions & facilities
The art in house was cool! I also liked the restaurant. My room was comfortable and quiet.
Stayed 1 night in May 2025

10/10 Excellent

Lisa

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Stayed 6 nights in May 2025

2/10 Terrible

Suann

Liked: Cleanliness
Disliked: Property conditions & facilities

You need management ASAP

We stayed here for our anniversary. From the time we arrived until the time we left, there were issues. There was a fire alarm that went off after we were in bed and we had use an actual fire escape from the 9th floor only to find out it was someone who was smoking in the hallway but yet no one notified the hotel of an all clear as we stood outside in our pajamas after going down a fire escape. When I talked to the Room Director he told me it was the fire department’s job not his. Next, the elevators weren’t working and we had to walk up and down 9 flights of stairs. When I inquired, I was told some kids were jumping in the elevator and it caused a problem. Perhaps someone would be managing the property a bit better? We asked for cups for our coffee maker in our room. Never could get them. This was a terrible start. It was our first time here and it will be our last. When we stopped to talk to the front desk at check out, multiple people were complaining. Strong suggestion to get some alert and involved manager.
Stayed 3 nights in May 2025

10/10 Excellent

James

Liked: Cleanliness, amenities, property conditions & facilities
Stayed 1 night in May 2025

10/10 Excellent

Lori

Traveled with family
Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Stayed 3 nights in May 2025

10/10 Excellent

Joe

Traveled with family
Liked: Cleanliness, property conditions & facilities, room comfort

A clean, classy stay

Such a nice hotel that I thought I was in a classier city than Saint Louis. Very clean. Lively scene in the lobby area. Art art art. All looks very new and well thought out. I will recommend to family and friends when they visit.
Stayed 1 night in May 2025

8/10 Good

Melissa

Stayed 1 night in May 2025

10/10 Excellent

Alexis

Business traveler
Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Stayed 3 nights in May 2025

10/10 Excellent

Lori

Stay

Loved it … only issue with us was pillows were HARD
Stayed 1 night in May 2025