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21C Museum Hotel St Louis

4.5 star property

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Photo gallery for 21C Museum Hotel St Louis

Exterior
1 bedroom, in-room safe, desk, laptop workspace
Room, 1 King Bed, Corner | 1 bedroom, in-room safe, desk, laptop workspace
Indoor pool
Lobby

Reviews

9.0 out of 10
Wonderful

Popular amenities

  • Bar

Explore the area

Map
1528 Locust street, St. Louis, MO, 63103
  • St. Louis Union Station
    ‪6 min walk‬
  • City Museum
    ‪6 min walk‬
  • Busch Stadium
    ‪14 min walk‬
  • St. Louis, MO (STL-Lambert-St. Louis Intl.)
    ‪21 min drive‬

Room options

Loft, 2 Queen Beds

  • Sleeps 4
  • 2 Queen Beds

Luxury Suite, 1 King Bed

  • Sleeps 2
  • 1 King Bed

View all photos for Room (Bunk Bed)

Room (Bunk Bed) | 1 bedroom, in-room safe, desk, laptop workspace

Room (Bunk Bed)

8.0 out of 10
Very good
(6 reviews)
  • Sleeps 2
  • 1 Twin Bunk Bed

Deluxe Room, Accessible (Accessible)

  • Sleeps 2
  • 1 King Bed

Suite, 1 King Bed (Library)

  • Sleeps 2
  • 1 King Bed

Suite, 1 King Bed (21C)

  • Sleeps 2
  • 1 King Bed

Deluxe Room, 1 Double Bed, Accessible

  • Sleeps 4
  • 1 Double Bed

View all photos for Deluxe Room, 1 King Bed

Deluxe Room, 1 King Bed | 1 bedroom, in-room safe, desk, laptop workspace

Deluxe Room, 1 King Bed

9.2 out of 10
Wonderful
(60 reviews)
  • 309 sq ft
  • Sleeps 2
  • 1 King Bed

Deluxe Suite, 1 Double Bed, Accessible

  • Sleeps 2
  • 1 Double Bed

View all photos for Deluxe Double Room, 2 Queen Beds

1 bedroom, in-room safe, desk, laptop workspace

Deluxe Double Room, 2 Queen Beds

8.4 out of 10
Very good
(17 reviews)
  • 369 sq ft
  • Sleeps 4
  • 2 Queen Beds

Deluxe Room, 1 Double Bed, Accessible

  • Sleeps 4
  • 1 Double Bed

View all photos for Room, 1 King Bed, Corner

Room, 1 King Bed, Corner | 1 bedroom, in-room safe, desk, laptop workspace

Room, 1 King Bed, Corner

8.8 out of 10
Excellent
(22 reviews)
  • 326 sq ft
  • City view
  • Sleeps 2
  • 1 King Bed

View all photos for Suite, 1 King Bed

1 bedroom, in-room safe, desk, laptop workspace

Suite, 1 King Bed

  • Sleeps 2
  • 1 King Bed

View all photos for Deluxe Suite, 1 King Bed

1 bedroom, in-room safe, desk, laptop workspace

Deluxe Suite, 1 King Bed

9.2 out of 10
Wonderful
(5 reviews)
  • Sleeps 2
  • 1 King Bed

View all photos for Luxury Double Room, 2 Queen Beds

1 bedroom, in-room safe, desk, laptop workspace

Luxury Double Room, 2 Queen Beds

9.0 out of 10
Wonderful
(16 reviews)
  • 423 sq ft
  • Sleeps 4
  • 2 Queen Beds

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Miscellaneous

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  • Free WiFi
  • Restaurant
  • Air conditioning
4.2 out of 5, Very Good, (3825)
$176 nightly
The price is $176 total
includes taxes & fees
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About this property

21C Museum Hotel St Louis

4.5-star hotel in Downtown West
This smoke-free hotel features an indoor pool, a restaurant, and a fitness center. WiFi in public areas is free. Additionally, a bar/lounge, a steam room, and a coffee shop/cafe are onsite. Change of towels is available on request.
21C Museum Hotel St Louis offers 104 air-conditioned accommodations with espresso makers and safes. Flat-screen televisions come with premium cable channels. Bathrooms include bathrobes, complimentary toiletries, and hair dryers.

This St. Louis hotel provides complimentary wireless Internet access. Business-friendly amenities include desks, desk chairs, and phones. Additionally, rooms include complimentary bottled water and irons/ironing boards. Change of towels and change of bedsheets can be requested. Housekeeping is provided daily.

Recreational amenities at the hotel include an indoor pool, a steam room, and a fitness center.
Guests can pamper themselves by indulging in the onsite spa services. Services include massages.
In addition to an indoor pool, 21C Museum Hotel St Louis provides a steam room and a fitness center. Dining options at the hotel include a restaurant and a coffee shop/cafe. A bar/lounge is on site where guests can unwind with a drink. Public areas are equipped with complimentary wireless Internet access.

Business-related amenities at this 4.5-star property consist of a business center and meeting rooms. This luxury hotel also offers spa services, a vending machine, and concierge services. Parking is available onsite for a surcharge.

21C Museum Hotel St Louis is a smoke-free property.

Cooked-to-order breakfasts are available for a surcharge and are served each morning between 6:30 AM and 1:00 PM.
21C Museum Hotel St Louis has a restaurant on site.
Room service (during limited hours) is available.

Languages

English

Property amenities

Internet

  • Available in all rooms: Free WiFi
  • Available in some public areas: Free WiFi

Parking and transportation

  • Valet parking on site (USD 50 per day; includes in/out privileges)

Food and drink

  • Daily cooked-to-order breakfast available 6:30 AM to 1:00 PM for a fee: USD 10 to 25 per person
  • A bar/lounge
  • A coffee shop/cafe
  • A restaurant

Things to do

  • Billiards/pool table
  • Gym
  • Indoor pool
  • Steam room

Family friendly

  • Indoor pool
  • Soundproofed rooms

Conveniences

  • 24-hour front desk
  • ATM
  • Luggage storage
  • Vending machine

Guest services

  • Change of bedsheets (on request)
  • Change of towels on request
  • Concierge services
  • Dry cleaning/laundry service
  • Housekeeping (daily)

Business services

  • Business center
  • Meeting rooms

Spa

  • Massage
  • Spa services

Accessibility

  • If you have requests for specific accessibility needs, please contact the property using the information on the reservation confirmation received after booking.
  • Area rugs in room
  • Braille/raised signage
  • Elevator (42 inch wide door)
  • Grab bar in shower (35 inches high)
  • Handrails in stairways (36 inches high)
  • Lever door handles
  • Magnifying mirror
  • Pool hoist on site
  • Stair-free path to entrance
  • Thin carpet in room
  • Tile flooring in room
  • Visual fire alarm
  • Well-lit path to entrance
  • Wheelchair accessible (may have limitations)
  • Wheelchair-accessible gym
  • Wheelchair-accessible lounge
  • Wheelchair-accessible path of travel
  • Wheelchair-accessible pool
  • Wheelchair-accessible public washroom
  • Wheelchair-accessible registration desk (36 inches high)
  • Wheelchair-accessible restaurant
  • Wheelchair-accessible spa
  • Wheelchairs on site

More

  • Banquet hall
  • Biodegradable coffee stirrers available
  • Biodegradable drinking straws available
  • No plastic coffee stirrers
  • No plastic drinking straws
  • No plastic soft drink bottles
  • No plastic water bottles
  • Reusable cups
  • Reusable tableware
  • Smoking not allowed

Room amenities

Bedroom

  • Bedsheets provided
  • Blackout drapes

Bathroom

  • Bathrobes
  • Free toiletries
  • Hair dryer
  • Shampoo
  • Soap
  • Toilet paper
  • Toothbrush and toothpaste (on request)
  • Towels provided

Entertainment

  • Flat-screen TV with premium digital channels

Food and drink

  • Espresso maker
  • Free bottled water
  • Limited room service

More

  • Air conditioning
  • Desk
  • Desk chair
  • Heating
  • Iron/ironing board
  • Laptop workspace
  • Phone
  • Safe
  • Soundproofed rooms

Policies

Check-in

Check-in start time: 4:00 PM; Check-in end time: 11:00 AM
Late check-in subject to availability
Minimum check-in age: 21

Check-out

Check-out before 11:00 AM

Special check-in instructions

Front desk staff will greet guests on arrival at the property

Access methods

Staffed front desk

Pets

Pets allowed for an extra charge of USD 100 per accommodation, per stay
Service animals are welcome, and are exempt from fees
Welcoming dogs only

Children and extra beds

Children are welcome
Rollaway/extra beds are not available
Cribs (infant beds) are not available

Property payment types

Important information

Fees

You'll be asked to pay the following charges at the property. Fees may include applicable taxes:

  • Service fee: USD 5 per accommodation, per stay

We have included all charges provided to us by the property.

Optional extras

  • Fee for cooked-to-order breakfast: approximately USD 10 to 25 per person
  • Valet parking fee: USD 50 per day (in/out privileges)
  • Pet fee: USD 100 per accommodation, per stay
  • Service animals are exempt from fees

The above list may not be comprehensive. Fees and deposits may not include tax and are subject to change.

You need to know

Extra-person charges may apply and vary depending on property policy
Government-issued photo identification and a credit card, debit card, or cash deposit may be required at check-in for incidental charges
Special requests are subject to availability upon check-in and may incur additional charges; special requests cannot be guaranteed
This property accepts credit cards; cash is not accepted
Safety features at this property include a smoke detector and outdoor lighting

We should mention

Reservations are required for massage services; reservations can be made by contacting the property prior to arrival, using the contact information on the booking confirmation
This property welcomes guests of all sexual orientations and gender identities (LGBTQ+ friendly)

Property is also known as

21C Museum Hotel St Louis
21c Museum St Louis St Louis
21C Museum Hotel St Louis Hotel
21C Museum Hotel St Louis St. Louis
21C Museum Hotel St Louis Hotel St. Louis
21C Museum Hotel St Louis (Opening Spring 2023)

21C Museum Hotel St Louis Reviews

Reviews

9.0

Wonderful

Rating 10 - Excellent. 879 out of 1217 reviews
Rating 8 - Good. 185 out of 1217 reviews
Rating 6 - Okay. 68 out of 1217 reviews
Rating 4 - Poor. 38 out of 1217 reviews
Rating 2 - Terrible. 47 out of 1217 reviews

9.2/10

Cleanliness

9.2/10

Staff & service

9.2/10

Amenities

9.4/10

Property conditions & facilities

9.2/10

Eco-friendliness

Reviews

10/10 Excellent

David

Traveled with family
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Great staff and lobby bar
Stayed 4 nights in Mar 2025

8/10 Good

William

Stayed 2 nights in Mar 2025

10/10 Excellent

Robert

Traveled with family
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
You can tell that this staff is well managed. The property was wonderful. We felt safe
Stayed 1 night in Mar 2025

10/10 Excellent

Gavin

Stayed 1 night in Mar 2025

10/10 Excellent

Bradley

Stayed 3 nights in Mar 2025

8/10 Good

Cynthia

Traveled with partner
Liked: Staff & service, property conditions & facilities
Rooms are nice, museum is a good bonus. Restaurant inside of the restaurant was pretty good but the service lacked
Stayed 2 nights in Mar 2025

10/10 Excellent

Christine

Traveled with family and small children
Liked: Cleanliness, staff & service, property conditions & facilities
i wish there were more breakfast options at the hotel. we are breakfasty oeople Standing in line at a lunch counter for a pre packaged turkey roll up and an orange fanta doesn't hit the spot for my Howard Johnson childhood memories. iby the same token My 13 year old doesnt love a filthy martini extra olives which is more likely your demographic. WE LOVE 21C. we have stayed twice and will ABSOLUTELY stay again.
Stayed 3 nights in Mar 2025

10/10 Excellent

Holly

Liked: Cleanliness, staff & service, property conditions & facilities
Stayed 2 nights in Mar 2025

8/10 Good

mell

Traveled with partner
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
love the museum and how long it was open for access
Stayed 1 night in Mar 2025

10/10 Excellent

Alison

Stayed 1 night in Feb 2025

10/10 Excellent

Samuel

Traveled with family
Liked: Cleanliness, amenities
It’s eclectic and a calming atmosphere to be in. I brought my friend and she was very impressed with the experience. It’s one of my fav places to stay.
Stayed 1 night in Mar 2025

10/10 Excellent

Verified traveler

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Stayed 2 nights in Mar 2025

10/10 Excellent

Mark, Bloomington

Traveled with family
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
I have stayed at 21C hitels before, but never this one in St. Louis. The facility is beautiful! Our room was very clean, and the bathroom was huge! The amenities here are wonderful. The pool is beautiful, and the hot tub is huge. The check in process was smooth and quick, and we got a very early check in. The gentleman at the front desk was very accommodating and especially cordial. The only downfall was the neighborhood. That, however, is not a hotel problem, but a St. Louis issue. I always forget how dead the St. Louis downtown is unless there's a Cardinal baseball game scheduled. Walking through a pretty dark and desolate downtown to get back to the hotel late at night is concerning. I walk all over downtown Chicago at all hours and never feel unsafe, but I dont have the same confidence in downtown St. Louis.
Stayed 1 night in Mar 2025

6/10 Okay

Ashley

Traveled with family
Liked: Room comfort

Cool, but quite a few misses in my opinion

The hotel is in a good spot close to union station activities and everything else is 10min away which isn’t a bad drive. Loved that it was artsy and cute decor. Cute bar inside. Did not have enough time to experience restaurant but the menu sounded good. The fitness spa area is a nice accommodation and visiting the art free museum associated with hotel was nice to bum around. My stars were due to walking in not feeling like the staff was very accommodating and acted annoyed with me and eachother so that was different. Just weird attitudes kind of cool kids not really great concierges. But, Finding street parking was easy on a weekend so appreciated that. But, they are limited in carts and The elevators were all broken except one so that took forever. Room appeared semi clean. They left only a 1/4 used toilet paper roll and a few tissues back in tissue box. Just odd. So the staff didn’t even restock and there was food and drinks left in the fridge from previous people. So I felt like it was “fake” cleaned. There was a wad of hair on our bed and in the bathtub it had another wad of a dust bunny. The coffee machine would have been great but they didn’t stock any cups. Maybe they were trying to encourage you to go to their coffee shop. Which I did and it was good and the staff there were probably the most with the program. It was fine. I’d come back to try their Spanish restaurant but would probably stay elsewhere with my family next time. We did all like the decor in hotel
Stayed 2 nights in Mar 2025

10/10 Excellent

Jeremy

Traveled with partner
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
To start off the valet was amazing and the staff was great. The bartenders were on point and our waiter was very helpful too. The little coffee shop was great for a quick breakfast and the robes were like a hug from your loved one. Room were really cool with an older feel yet modern. The gallery was very unique and loved all the amenities. Only thing I would say I didn’t like was the pillows on the bed. But all in all would definitely stay again if ever in St Louis.
Stayed 2 nights in Mar 2025

8/10 Good

James

Stayed 1 night in Jan 2025

10/10 Excellent

Colleen

Traveled with partner
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Welcoming, kind staff. So enjoyed our stay.
Stayed 2 nights in Mar 2025

10/10 Excellent

Nyna

Traveled with partner
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
This hotel is fantastic. All in one entertainment with the museum combined. Very clean and nice staff.
Stayed 1 night in Mar 2025

8/10 Good

Nathalie

Liked: Cleanliness, staff & service, property conditions & facilities
Stayed 2 nights in Mar 2025

10/10 Excellent

Toni

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Stayed 1 night in Mar 2025

6/10 Okay

Arron

Business traveler
Liked: Staff & service, amenities
Disliked: Cleanliness, property conditions & facilities
I’ve been visiting St. Louis for over 12 years and used to try different hotels — until I stayed at 21c. Since that first visit, I haven’t stayed anywhere else. It had a fresh energy, a unique atmosphere, and the kind of people that made it feel exciting. The real standout has always been the staff, especially the bar and restaurant team — people like Carson, Cam, and JoJo. Their effort, warmth, and attention to detail make every stay feel like more than just a hotel visit. Over time, they’ve become familiar faces and genuine friends. But on my most recent stay, I was let down — not by them, but by housekeeping and management. My room simply wasn’t clean: mould in the shower, someone else’s hair, stains left untouched, and amenities not replaced. Once you see it, you start noticing more — and unfortunately, I did. I raised it with the team (not even their job to fix) and they went out of their way to make things right — offering a credit and even leaving a bottle of their own gin in my room. Lovely gestures, truly appreciated — but the mould was still there the next day. The issue wasn’t fixed. For a short stay, I’d still recommend it. But for anything longer, if you value cleanliness and comfort, I’d think twice. The team out front are brilliant — but they’re being let down by what’s happening behind the scenes.
Stayed 9 nights in Mar 2025

10/10 Excellent

Steve

Stayed 1 night in Mar 2025

8/10 Good

JANA

Traveled with group
Liked: Staff & service, amenities, property conditions & facilities
The property is very special, with a historic and totally renovated pool and spa, and a large art exhibit. The bar and lobby are loaded with art and beautifully designed surroundings. Only one of three elevators were working this week, so a lot of waiting and frankly feeling unsafe. The breakfast restaurant is good. There is no lunch option and the front desk has zero intel regarding outside options. The dinner menu is ridiculously expensive and not very enticing. Drinks are crazy expensive ($14 for 3 oz of sav blanc) The valet is $45/night in kind of a rundown, crummy neighborhood.
Stayed 2 nights in Mar 2025

10/10 Excellent

Veronica

Liked: Cleanliness, staff & service, property conditions & facilities
Beautiful hotel. Amazing indoor pool. My kids Loved the bunk beds.
Stayed 2 nights in Mar 2025

10/10 Excellent

Rebecca

Traveled with partner
Liked: Amenities
We stayed here for a night while we were in town to watch the Blues. It's close enough to walk to the stadium or take a quick uber. It was close to union station too. Wonderful hotel! We will be back.
Stayed 1 night in Mar 2025