21C Museum Hotel St Louis
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1528 Locust street, St. Louis, MO, 63103
- St. Louis Union Station6 min walk
- City Museum6 min walk
- Busch Stadium14 min walk
- St. Louis, MO (STL-Lambert-St. Louis Intl.)21 min drive
Room options
Loft, 2 Queen Beds
Luxury Suite, 1 King Bed
View all photos for Room (Bunk Bed)

Room (Bunk Bed)
8.0 out of 10
Very good
(6 reviews)
Deluxe Room, Accessible (Accessible)
Suite, 1 King Bed (Library)
Suite, 1 King Bed (21C)
Deluxe Room, 1 Double Bed, Accessible
View all photos for Deluxe Room, 1 King Bed

Deluxe Room, 1 King Bed
9.4 out of 10
Exceptional
(64 reviews)
Deluxe Suite, 1 Double Bed, Accessible
View all photos for Deluxe Double Room, 2 Queen Beds

Deluxe Double Room, 2 Queen Beds
8.4 out of 10
Very good
(18 reviews)
Deluxe Room, 1 Double Bed, Accessible
View all photos for Room, 1 King Bed, Corner

Room, 1 King Bed, Corner
8.8 out of 10
Excellent
(23 reviews)
View all photos for Suite, 1 King Bed

Suite, 1 King Bed
View all photos for Deluxe Suite, 1 King Bed

Deluxe Suite, 1 King Bed
9.2 out of 10
Wonderful
(5 reviews)
View all photos for Luxury Double Room, 2 Queen Beds

Luxury Double Room, 2 Queen Beds
9.0 out of 10
Wonderful
(17 reviews)
Similar properties

Hyatt Regency St. Louis at The Arch
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- Pet friendly
- Free WiFi
- Restaurant
- Air conditioning
4.2 out of 5, Very Good, (3885)
$184 nightly
The price was $204
The price is $184 total
includes taxes & fees
About this property
Property amenities
Room amenities
Policies
Important information
21C Museum Hotel St Louis Reviews
Reviews
9.0
Wonderful
9.2/10
Cleanliness
9.2/10
Staff & service
9.2/10
Amenities
9.4/10
Property conditions & facilities
9.2/10
Eco-friendliness
Reviews
Traveled with partner
Apr 25, 2025
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Stayed 2 nights in Apr 2025
10/10 Excellent
Michelle
Traveled with family
Apr 25, 2025
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Michelle
Stayed 2 nights in Apr 2025
10/10 Excellent
Emily
Traveled with family
Apr 25, 2025
Liked: Staff & service, property conditions & facilities, room comfort
Emily
Stayed 2 nights in Apr 2025
10/10 Excellent
Jennifer
Traveled with group, Traveled with family
Apr 22, 2025
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Jennifer
Stayed 1 night in Apr 2025
6/10 Okay
Sandra
Apr 21, 2025
Sandra
Stayed 4 nights in Apr 2025
8/10 Good
Katherine L
Traveled with family
Apr 21, 2025
Liked: Cleanliness, room comfort
Disliked: Property conditions & facilities
Beautiful hotel, disappointing service
Katherine L
Stayed 2 nights in Apr 2025
10/10 Excellent
KARI
Apr 21, 2025
Liked: Cleanliness, staff & service, property conditions & facilities
KARI
Stayed 2 nights in Apr 2025
10/10 Excellent
Anthony
Traveled with group, Business traveler, Traveled with family
Apr 19, 2025
Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Anthony
Stayed 2 nights in Apr 2025
10/10 Excellent
John
Business traveler
Apr 18, 2025
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
John
Stayed 2 nights in Apr 2025
10/10 Excellent
Roberta
Apr 18, 2025
Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Roberta
Stayed 1 night in Apr 2025
10/10 Excellent
Kaley
Apr 17, 2025
Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Kaley
Stayed 1 night in Apr 2025
6/10 Okay
Michael
Apr 17, 2025
Michael
Stayed 3 nights in Apr 2025
10/10 Excellent
stacey
Apr 16, 2025
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
stacey
Stayed 1 night in Apr 2025
10/10 Excellent
Claudia
Apr 15, 2025
Liked: Cleanliness, staff & service, property conditions & facilities
Claudia
Stayed 4 nights in Apr 2025
2/10 Terrible
Aaron
Traveled with group, Traveled with family
Apr 15, 2025
Liked: Cleanliness, amenities, property conditions & facilities
Disliked: Staff & service
Aaron
Stayed 4 nights in Apr 2025
6/10 Okay
Dena
Apr 15, 2025
Dena
Stayed 3 nights in Apr 2025
10/10 Excellent
Paula
Apr 15, 2025
Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Paula
Stayed 2 nights in Apr 2025
10/10 Excellent
Kathy
Apr 14, 2025
Liked: Cleanliness, staff & service, property conditions & facilities
Kathy
Stayed 1 night in Apr 2025
10/10 Excellent
James Bryce
Apr 14, 2025
Liked: Cleanliness, staff & service, property conditions & facilities
James Bryce
Stayed 1 night in Apr 2025
10/10 Excellent
Mariah
Apr 14, 2025
Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Mariah
Stayed 1 night in Mar 2025
10/10 Excellent
Stephanie
Traveled with family
Apr 14, 2025
Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Wonderful Hotel
Stephanie
Stayed 4 nights in Apr 2025
10/10 Excellent
Payton
Traveled with partner
Apr 14, 2025
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Payton
Stayed 1 night in Apr 2025
10/10 Excellent
David Michael
Traveled with family
Apr 13, 2025
Liked: Cleanliness, amenities, property conditions & facilities
David Michael
Stayed 4 nights in Apr 2025
8/10 Good
David, Rockville
Apr 13, 2025
Liked: Cleanliness, staff & service
David
Stayed 3 nights in Apr 2025
10/10 Excellent
Kimberly, SPRINGFIELD
Traveled with group
Apr 13, 2025
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Kimberly
Stayed 1 night in Apr 2025