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21C Museum Hotel St Louis

4.5 star property

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Photo gallery for 21C Museum Hotel St Louis

Interior
Exterior
Dining
Loft, 2 Queen Beds | 1 bedroom, in-room safe, desk, laptop workspace
Billiards

Reviews

9.0 out of 10
Wonderful

Popular amenities

  • Bar
$183
includes taxes & fees
Nov 21 - Nov 22

Explore the area

View in a map
1528 Locust street, St. Louis, MO, 63103
  • Place, St. Louis Union Station
    ‪6 min walk‬
  • Place, Enterprise Center
    ‪6 min walk‬
  • Place, City Museum
    ‪6 min walk‬
  • Airport, St. Louis, MO (STL-Lambert-St. Louis Intl.)
    ‪19 min drive‬

Room options

View all photos for Deluxe Room, 1 King Bed

1 bedroom, in-room safe, desk, laptop workspace

Deluxe Room, 1 King Bed

9.2 out of 10
Wonderful
(76 reviews)
  • 309 sq ft
  • Sleeps 2
  • 1 King Bed

View all photos for Luxury Double Room, 2 Queen Beds

Luxury Double Room, 2 Queen Beds | 1 bedroom, in-room safe, desk, laptop workspace

Luxury Double Room, 2 Queen Beds

9.2 out of 10
Wonderful
(23 reviews)
  • 423 sq ft
  • Sleeps 4
  • 2 Queen Beds

View all photos for Room (Bunk Bed)

1 bedroom, in-room safe, desk, laptop workspace

Room (Bunk Bed)

8.0 out of 10
Very good
(6 reviews)
  • 237 sq ft
  • 1 bedroom
  • Sleeps 2
  • 1 Twin Bunk Bed

View all photos for Loft, 2 Queen Beds

1 bedroom, in-room safe, desk, laptop workspace

Loft, 2 Queen Beds

  • 431 sq ft
  • Sleeps 4
  • 2 Queen Beds

View all photos for Deluxe Room, Accessible (Accessible)

1 bedroom, in-room safe, desk, laptop workspace

Deluxe Room, Accessible (Accessible)

  • 269 sq ft
  • Sleeps 2
  • 1 King Bed

View all photos for Suite, 1 King Bed (21C)

Suite, 1 King Bed (21C) | 1 bedroom, in-room safe, desk, laptop workspace

Suite, 1 King Bed (21C)

  • 1119 sq ft
  • Sleeps 2
  • 1 King Bed

View all photos for Suite, 1 King Bed (Library)

Suite, 1 King Bed (Library) | 1 bedroom, in-room safe, desk, laptop workspace

Suite, 1 King Bed (Library)

  • 732 sq ft
  • City view
  • Sleeps 2
  • 1 King Bed

View all photos for Luxury Suite, 1 King Bed

Luxury Suite, 1 King Bed | 1 bedroom, in-room safe, desk, laptop workspace

Luxury Suite, 1 King Bed

10.0 out of 10
Exceptional
(1 review)
  • 549 sq ft
  • Sleeps 2
  • 1 King Bed

View all photos for Deluxe Room, 1 Double Bed, Accessible

Deluxe Room, 1 Double Bed, Accessible | 1 bedroom, in-room safe, desk, laptop workspace

Deluxe Room, 1 Double Bed, Accessible

  • 388 sq ft
  • Sleeps 4
  • 1 Double Bed

View all photos for Deluxe Suite, 1 Double Bed, Accessible

1 bedroom, in-room safe, desk, laptop workspace

Deluxe Suite, 1 Double Bed, Accessible

  • 517 sq ft
  • Sleeps 2
  • 1 Double Bed

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About this property

21C Museum Hotel St Louis

4.5-star hotel in Downtown West
This smoke-free hotel features an indoor pool, a restaurant, and a fitness center. WiFi in public areas is free. Additionally, a bar/lounge, a steam room, and a coffee shop/cafe are onsite. Change of towels is available on request.
21C Museum Hotel St Louis offers 104 air-conditioned accommodations with espresso makers and safes. Flat-screen televisions come with premium cable channels. Bathrooms include bathrobes, complimentary toiletries, and hair dryers.

This St. Louis hotel provides complimentary wireless Internet access. Business-friendly amenities include desks, desk chairs, and phones. Additionally, rooms include complimentary bottled water and irons/ironing boards. Change of towels and change of bedsheets can be requested. Housekeeping is provided daily.

Recreational amenities at the hotel include an indoor pool, a steam room, and a fitness center.
Guests can pamper themselves by indulging in the onsite spa services. Services include massages.
In addition to an indoor pool, 21C Museum Hotel St Louis provides a steam room and a fitness center. Dining options at the hotel include a restaurant and a coffee shop/cafe. A bar/lounge is on site where guests can unwind with a drink. Public areas are equipped with complimentary wireless Internet access.

Business-related amenities at this 4.5-star property consist of a business center and meeting rooms. This luxury hotel also offers spa services, a vending machine, and concierge services. Parking is available onsite for a surcharge.

21C Museum Hotel St Louis is a smoke-free property.

Cooked-to-order breakfasts are available for a surcharge and are served each morning between 6:30 AM and 1:00 PM.
21C Museum Hotel St Louis has a restaurant on site.
Room service (during limited hours) is available.

Property amenities

Internet

  • Available in all rooms: Free WiFi
  • Available in some public areas: Free WiFi

Parking and transportation

  • Valet parking on site (USD 50 per day; includes in/out privileges)

Food and drink

  • Daily cooked-to-order breakfast available 6:30 AM to 1:00 PM for a fee: USD 10 to 25 per person
  • A bar/lounge
  • A coffee shop/cafe
  • A restaurant

Things to do

  • Billiards/pool table
  • Gym
  • Indoor pool
  • Steam room

Family friendly

  • Indoor pool
  • Soundproofed rooms

Conveniences

  • 24-hour front desk
  • ATM
  • Luggage storage
  • Vending machine

Guest services

  • Change of bedsheets (on request)
  • Change of towels on request
  • Concierge services
  • Dry cleaning/laundry service
  • Housekeeping (daily)

Business services

  • Business center
  • Meeting rooms

Spa

  • Massage
  • Spa services

Accessibility

  • If you have requests for specific accessibility needs, please contact the property using the information on the reservation confirmation received after booking.
  • Area rugs in room
  • Braille/raised signage
  • Elevator (42 inch wide door)
  • Grab bar in shower (35 inches high)
  • Handrails in stairways (36 inches high)
  • Lever door handles
  • Magnifying mirror
  • Pool hoist on site
  • Stair-free path to entrance
  • Thin carpet in room
  • Tile flooring in room
  • Visual fire alarm
  • Well-lit path to entrance
  • Wheelchair accessible (may have limitations)
  • Wheelchair-accessible gym
  • Wheelchair-accessible lounge
  • Wheelchair-accessible path of travel
  • Wheelchair-accessible pool
  • Wheelchair-accessible public washroom
  • Wheelchair-accessible registration desk (36 inches high)
  • Wheelchair-accessible restaurant
  • Wheelchair-accessible spa
  • Wheelchairs on site

More

  • Banquet hall
  • Biodegradable coffee stirrers available
  • Biodegradable drinking straws available
  • No plastic coffee stirrers
  • No plastic drinking straws
  • No plastic soft drink bottles
  • No plastic water bottles
  • Reusable cups
  • Reusable tableware
  • Smoking not allowed

Room amenities

Bedroom

  • Bedsheets provided
  • Blackout drapes

Bathroom

  • Bathrobes
  • Free toiletries
  • Hair dryer
  • Shampoo
  • Soap
  • Toilet paper
  • Toothbrush and toothpaste (on request)
  • Towels provided

Entertainment

  • Flat-screen TV with premium digital channels

Food and drink

  • Espresso maker
  • Free bottled water
  • Limited room service

More

  • Air conditioning
  • Desk
  • Desk chair
  • Heating
  • Iron/ironing board
  • Laptop workspace
  • Phone
  • Safe
  • Soundproofed rooms

Policies

Check-in

Check-in start time: 4:00 PM; Check-in end time: 11:00 AM
Late check-in subject to availability
Minimum check-in age: 21

Check-out

Check-out before 11:00 AM

Special check-in instructions

Front desk staff will greet guests on arrival at the property

Access methods

Staffed front desk

Pets

Pets allowed for an extra charge of USD 100 per accommodation, per stay
Service animals are welcome, and are exempt from fees
Welcoming dogs only

Children and extra beds

Children are welcome
Rollaway/extra beds are not available
Cribs (infant beds) are not available

Property payment types

Important information

Fees

You'll be asked to pay the following charges at the property. Fees may include applicable taxes:

  • Service fee: USD 5 per accommodation, per stay

We have included all charges provided to us by the property.

Optional extras

  • Fee for cooked-to-order breakfast: approximately USD 10 to 25 per person
  • Valet parking fee: USD 50 per day (in/out privileges)
  • Pet fee: USD 100 per accommodation, per stay
  • Service animals are exempt from fees

The above list may not be comprehensive. Fees and deposits may not include tax and are subject to change.

You need to know

Extra-person charges may apply and vary depending on property policy
Government-issued photo identification and a credit card, debit card, or cash deposit may be required at check-in for incidental charges
Special requests are subject to availability upon check-in and may incur additional charges; special requests cannot be guaranteed
This property accepts credit cards; cash is not accepted
Safety features at this property include a smoke detector and outdoor lighting

We should mention

Reservations are required for massage services; reservations can be made by contacting the property prior to arrival, using the contact information on the booking confirmation
This property welcomes guests of all sexual orientations and gender identities (LGBTQ+ friendly)

Property is also known as

21C Museum Hotel St Louis
21c Museum St Louis St Louis
21C Museum Hotel St Louis Hotel
21C Museum Hotel St Louis St. Louis
21C Museum Hotel St Louis Hotel St. Louis
21C Museum Hotel St Louis (Opening Spring 2023)

21C Museum Hotel St Louis Reviews

Reviews

9.0

Wonderful

Rating 10 - Excellent. 1053 out of 1459 reviews
Rating 8 - Good. 213 out of 1459 reviews
Rating 6 - Okay. 95 out of 1459 reviews
Rating 4 - Poor. 44 out of 1459 reviews
Rating 2 - Terrible. 54 out of 1459 reviews

9.2/10

Cleanliness

9.2/10

Staff & service

9.2/10

Amenities

9.4/10

Property conditions & facilities

9.2/10

Eco-friendliness

Reviews

10/10 Excellent

Amanda

Traveled with family
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Beautiful hotel and great food options. Gym and pool were great also.
Stayed 1 night in Aug 2025

10/10 Excellent

Keri

Traveled with family
Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Stayed 1 night in Aug 2025

10/10 Excellent

Patricia, Saint Charles

Liked: Cleanliness, staff & service, property conditions & facilities
Fun place to stay. Museum on the 2nd floor was so much fun.
Stayed 1 night in Aug 2025

10/10 Excellent

Jannie

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Stayed 1 night in Aug 2025

10/10 Excellent

Jennifer L

Traveled with family
Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
We enjoyed our stay! Close to Busch Stadium which was our destination. Staff was friendly and extremely helpful. Valet parking was worth it.
Stayed 2 nights in Aug 2025

10/10 Excellent

Amy

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Stayed 1 night in Aug 2025

10/10 Excellent

Amy

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort

Nice stay at 21c St. Louis

The valet and front desk staff were great! Everyone was friendly and helpful, really created a welcoming environment. The overnight parking is a little pricey, but they took good care of our car and offered a speedy retrieval when needed. Parking in the area is limited, and while there is some street parking, wasn’t sure it was secure enough for an overnight. The hotel amenities were wonderful. The indoor pool and hot tub were great, along with a really nice gym. All facilities were really clean. Be sure to check out the art galleries on the second floor. The gallery space was some of the best we’ve seen at a 21c Hotel. Free bottled water with easy refill stations was a plus. Our one critique was that our room carpet and bathroom floor could’ve used a better cleaning, and the rooms are showing some wear and tear. Not horrible, but we stayed here about two years ago for the first time, and the room was extremely clean and well cared for. Hopefully, they’ll pay better attention to this because it’s a nice hotel in a cool building and it would be a shame to let it fall into disrepair.
Stayed 1 night in Aug 2025

10/10 Excellent

Cicely

Liked: Property conditions & facilities
Stayed 1 night in Aug 2025

10/10 Excellent

Brian

Liked: Cleanliness, staff & service, property conditions & facilities
Stayed 2 nights in Jul 2025

10/10 Excellent

Andrea

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Stayed 1 night in Jul 2025

10/10 Excellent

Bethany

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Stayed 1 night in Aug 2025

10/10 Excellent

Laila

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Stayed 1 night in May 2025

6/10 Okay

Veronica

Liked: Staff & service, property conditions & facilities
Nice hotel but the bathroom was dirty and the area was a little shady.
Stayed 1 night in Aug 2025

10/10 Excellent

Leslie

So different and classy
Stayed 1 night in Aug 2025

10/10 Excellent

Edward

Liked: Cleanliness, staff & service, property conditions & facilities
Stayed 3 nights in Aug 2025

10/10 Excellent

Matthew

Traveled with family
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Always enjoy staying at this hotel. Staff is always willing to lend a hand. Love the pool, art, and other amenities.
Stayed 2 nights in Jun 2025

6/10 Okay

Anjelica

Traveled with family and small children, Traveled with family
Liked: Staff & service
Disliked: Cleanliness
I loved the hotel it was super pretty but it was so dirty. Our room was so dirty. They had the air off so it was super hot when we got there. Coffee machine was broken and they said they’d fix it and no one ever did. The location is not safe. There are tons of homeless in the area and we couldn’t even walk the town because of it. I like to but wouldn’t stay again.
Stayed 2 nights in Jul 2025

8/10 Good

Sylvia

Stayed 1 night in Jul 2025

10/10 Excellent

Denise

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Stayed 4 nights in Jul 2025

10/10 Excellent

Kim

Liked: Cleanliness, staff & service, property conditions & facilities
Stayed 2 nights in Jul 2025

8/10 Good

Darrell

Stayed 2 nights in Jul 2025

10/10 Excellent

Franny

Liked: Cleanliness, staff & service, property conditions & facilities
Stayed 1 night in Aug 2025

4/10 Poor

Cydney, Pilot Grove

Traveled with partner
Liked: Staff & service
Disliked: Cleanliness
One word captures the rooms. DRITY. Or maybe filthy. For the price of the hotel the rooms should at least be dusted. Not only was the room in need of a serious cleaning but I located a random pill on the floor and after checking it on drugs.com determined it was a 60 mg Adderall pill. Door entrances to the room were dusty and filthy again the space was just very unclean. The room was so dusty that both myself, and my significant other have been coughing and hacking and our allergies are in over drive. On the positive side, the hotel does have a very nice gallery space on the second floor and in the basement the fitness center and the pool were absolutely amazing.
Dust on window ledge.
Random pill just sitting on the floor.
Dust next to sofa.
Condition of the room doors.
Stayed 1 night in Aug 2025

10/10 Excellent

Jamie

Traveled with family
Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Stayed 3 nights in Jul 2025

10/10 Excellent

Frank

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Great gym and pool.
Stayed 3 nights in Apr 2025