Search for Cheap Deals on
4 Star Hotels in Sant'Isidoro

Photo by Cesare Zuccaro

You choose what matters — star rating, location, amenities.

We pick the perfect hotel, packed with all your must-haves.

Your hotel is revealed right after booking!


Featured 4 Star Sant'Isidoro Hotels

Grand Hotel di Lecce
4 out of 5
Fully refundableReserve now, pay when you stay
  • 40 min drive from Spiaggia di Sant'Isidoro
The price is $101 per night from Jan 15 to Jan 16
$101
includes taxes & fees
Jan 15 - Jan 16
Stay at this 4-star hotel in Lecce. Enjoy free breakfast, free WiFi, and an outdoor pool. Popular attractions Railway Museum of Puglia and Sigismondo Castromediano ...
Grand Hotel di Lecce
8Piuhotel
4 out of 5
Fully refundableReserve now, pay when you stay
  • 41 min drive from Spiaggia di Sant'Isidoro
The price is $121 per night from Feb 1 to Feb 2
$121
includes taxes & fees
Feb 1 - Feb 2
Stay at this 4-star hotel in Lecce. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions ...
8Piuhotel
Grand Hotel Tiziano e dei Congressi
4 out of 5
  • 42 min drive from Spiaggia di Sant'Isidoro
Stay at this 4-star spa hotel in Lecce. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the property condition in our reviews. Popular attractions ...
Grand Hotel Tiziano e dei Congressi
Save an average of 15% on thousands of hotels when you're signed in
Mercure Hotel President Lecce
4 out of 5
Fully refundableReserve now, pay when you stay
  • 43 min drive from Spiaggia di Sant'Isidoro
The price is $92 per night from Jan 7 to Jan 8
$92
includes taxes & fees
Jan 7 - Jan 8
Stay at this 4-star business-friendly hotel in Lecce. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the property condition in our ...
Mercure Hotel President Lecce
Palazzo Sant'Anna Lecce
4 out of 5
  • 41 min drive from Spiaggia di Sant'Isidoro
The price is $268 per night from Jan 7 to Jan 8
$268
includes taxes & fees
Jan 7 - Jan 8
Stay at this 4-star spa hotel in Lecce. Enjoy free breakfast, free WiFi, and a full-service spa. Our guests praise the helpful staff in our reviews. Popular ...
Palazzo Sant'Anna Lecce
Hilton Garden Inn Lecce
4 out of 5
Fully refundableReserve now, pay when you stay
  • 44 min drive from Spiaggia di Sant'Isidoro
The price is $72 per night from Jan 12 to Jan 13
$72
includes taxes & fees
Jan 12 - Jan 13
Stay at this 4-star spa hotel in Lecce. Enjoy free WiFi, an outdoor pool, and a full-service spa. Popular attractions Franciscan Art Gallery and Chinese Missionary ...
Hilton Garden Inn Lecce
Suite Hotel Santa Chiara
4 out of 5
Fully refundableReserve now, pay when you stay
  • 41 min drive from Spiaggia di Sant'Isidoro
The price is $125 per night from Jan 7 to Jan 8
$125
includes taxes & fees
Jan 7 - Jan 8
Stay at this 4-star hotel in Lecce. Enjoy free WiFi, a rooftop terrace, and room service. Popular attractions Church of Santa Chiara and Roman Amphitheater are ...
Suite Hotel Santa Chiara
Victoria Palace Hotel & Zen Wellness
4 out of 5
Fully refundableReserve now, pay when you stay
  • 30 min drive from Spiaggia di Sant'Isidoro
The price is $125 per night from Jan 8 to Jan 9
$125
includes taxes & fees
Jan 8 - Jan 9
Stay at this 4-star beach hotel in Gallipoli. Enjoy free WiFi, an outdoor pool, and a full-service spa. Popular attractions Church of the Sacred Heart of Jesus ...
Victoria Palace Hotel & Zen Wellness
Le Club Boutique Hotel
4 out of 5
  • 41 min drive from Spiaggia di Sant'Isidoro
The price is $130 per night from Jan 11 to Jan 12
$130
includes taxes & fees
Jan 11 - Jan 12
Stay at this 4-star hotel in Lecce. Enjoy free WiFi, 24-hour room service, and an airport shuttle (surcharge). Popular attractions Church of Sant'Irene and Museo ...
Le Club Boutique Hotel
Pollicastro Boutique Hotel
4 out of 5
Fully refundableReserve now, pay when you stay
  • 41 min drive from Spiaggia di Sant'Isidoro
The price is $232 per night from Jan 11 to Jan 12
$232
includes taxes & fees
Jan 11 - Jan 12
Stay at this 4-star boutique hotel in Lecce. Enjoy free breakfast, free WiFi, and a rooftop terrace. Our guests praise the helpful staff in our reviews. Popular ...
Pollicastro Boutique Hotel
Torre del Parco
4 out of 5
Fully refundableReserve now, pay when you stay
  • 42 min drive from Spiaggia di Sant'Isidoro
The price is $148 per night from Jan 19 to Jan 20
$148
includes taxes & fees
Jan 19 - Jan 20
Stay at this 4-star hotel in Lecce. Enjoy free WiFi, breakfast (surcharge), and room service. Popular attractions Torre del Parco and Casa Museo Spada are located ...
Torre del Parco
Best Western Plus Leone di Messapia Hotel & Conference
4 out of 5
Fully refundableReserve now, pay when you stay
  • 41 min drive from Spiaggia di Sant'Isidoro
The price is $105 per night from Jan 11 to Jan 12
$105
includes taxes & fees
Jan 11 - Jan 12
Stay at this 4-star family-friendly hotel in Lecce. Enjoy free WiFi, free parking, and breakfast (surcharge). Popular attractions Torre del Parco and Casa Museo ...
Best Western Plus Leone di Messapia Hotel & Conference
Don't see what you're looking for?
See all available properties in Sant'Isidoro
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

4-star hotels in Sant'Isidoro

When you want to live it up, but not bust your bank account, then there’s nothing better than a 4-star hotel in Sant'Isidoro for your next trip. You’ll get all the amenities you can think of (and then some) at a rate within your means.

No fault in our stars

So what’s with the star rating anyway? Good question. The star rating has little to do with the price, and more to do with the amenities. 4-Star hotels in Sant'Isidoro as well as everywhere else, usually have all those thoughtful touches that make you go “Ooh,” “Ahh,” and ”YES!” Think amenities like luxury bedding, high-end electronics, concierge service, and restaurants that make eating in a gourmet experience.

Stars that shine

You know there are as many underground spots, inviting lounges, memory-making music venues as there are stars in the sky. But you’ll need the funds to check them all off. That’s why we give you the chance to take us up on the Hotwire Hot Rate. You can snag Sant'Isidoro 4-star hotels and still have plenty of leftover cash to paint the town whatever color you want. Filter hotels by:

  • Hotwire Hot Rate: We’ll snag you a crazy deal on a room by finding your hotel name after you book.
  • Price: You know that paying full price is for suckers? You can get a cheap 4-star hotel in Sant'Isidoro starting at $72 per night.
  • Amenities: What makes you flip for your trip? Full-service spa? Heated pool? 24-hour room service? Get a hotel that’ll send you over the moon.

Do you deserve a swanky hotel with a ton of amenities? Yes, yes you do. And you also deserve a sweet deal on it. Book with Hotwire today and get that star-studded Sant'Isidoro 4-star hotel and have plenty of cash left over to spend at that secret super star joint in the city.