Hotels Near
Lake Nona Medical City

Check Last Minute Lake Nona Medical City Hotel Deals

Tonight Mar 26 - Mar 27This weekend Mar 28 - Mar 30Next weekend Apr 4 - Apr 6

You choose what matters — star rating, location, amenities.

We pick the perfect hotel, packed with all your must-haves.

Your hotel is revealed right after booking!


Featured Lake Nona Medical City Hotels

Holiday Inn Resort Orlando Suites - Waterpark by IHG
Holiday Inn Resort Orlando Suites - Waterpark by IHG
3.5 out of 5
14500 Continental Gateway, Orlando, FL
Fully refundable
Stay at this 3.5-star family-friendly hotel in Orlando. Enjoy 2 outdoor pools, 5 restaurants, and 2 hot tubs. Our guests praise the clean rooms and the family ...
7/10 Good! (2,404 reviews)
"I liked the onsite water park and how close the room was to it"

Reviewed on Mar 25, 2025

Holiday Inn Resort Orlando Suites - Waterpark by IHG
DoubleTree by Hilton Hotel Orlando at SeaWorld
DoubleTree by Hilton Hotel Orlando at SeaWorld
4 out of 5
10100 International Drive, Orlando, FL
Stay at this 4-star family-friendly resort in Orlando. Enjoy free WiFi, 2 outdoor pools, and 2 restaurants. Our guests praise the breakfast and the pool in our ...
7.2/10 Good! (5,801 reviews)
"The outdoor pools and bar were great for our family. Everything was very clean and neat. The rooms in the tower were comfortable and had everything we needed, but are dated and in need of some TLC."

Reviewed on Mar 24, 2025

DoubleTree by Hilton Hotel Orlando at SeaWorld
DoubleTree by Hilton at the Entrance to Universal Orlando
DoubleTree by Hilton at the Entrance to Universal Orlando
4 out of 5
5780 Major Blvd, Orlando, FL
Fully refundableReserve now, pay when you stay
Stay at this 4-star family-friendly hotel in Orlando. Enjoy free WiFi, 2 restaurants, and 2 bars/lounges. Our guests praise the pool and the helpful staff in ...
8.2/10 Very Good! (6,298 reviews)
"Very accommodating and pleasant stay."

Reviewed on Mar 25, 2025

DoubleTree by Hilton at the Entrance to Universal Orlando
Universal's Cabana Bay Beach Resort
Universal's Cabana Bay Beach Resort
3.5 out of 5
6550 Adventure Way, Orlando, FL
Fully refundableReserve now, pay when you stay
Stay at this 3.5-star family-friendly hotel in Orlando. Enjoy free WiFi, 2 outdoor pools, and 2 restaurants. Our guests praise the pool and the helpful staff ...
8.8/10 Excellent! (5,117 reviews)
"It was very nice. A little short staffed so the check in took a bit and Starbucks was always a 40 min wait. But very nice and walkable to universal"

Reviewed on Mar 25, 2025

Universal's Cabana Bay Beach Resort
Westgate Lakes Resort & Spa Universal Studios Area
Westgate Lakes Resort & Spa Universal Studios Area
4 out of 5
9500 Turkey Lake Rd, Orlando, FL
Stay at this 4-star spa hotel in Orlando. Enjoy free parking, 7 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff in our ...
8/10 Very Good! (4,610 reviews)
"."

Reviewed on Mar 24, 2025

Westgate Lakes Resort & Spa Universal Studios Area
Hyatt Regency Orlando
Hyatt Regency Orlando
4.5 out of 5
9801 International Dr, Orlando, FL
Fully refundableReserve now, pay when you stay
Stay at this 4.5-star luxury hotel in Orlando. Enjoy free WiFi, 2 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff in ...
9/10 Wonderful! (1,633 reviews)
"Property nice. I've had better stays at the old Peabody Hotel."

Reviewed on Mar 22, 2025

Hyatt Regency Orlando
Vacation Village at Parkway
Vacation Village at Parkway
3 out of 5
2975 Arabian Nights Blvd, Kissimmee, FL
Stay at this 3-star family-friendly condo in Kissimmee. Enjoy free WiFi, 7 outdoor pools, and 7 hot tubs. Our guests praise the helpful staff and the clean rooms ...
8.4/10 Very Good! (1,824 reviews)
Check in
"Was very hectic and very time-consuming. Long lines."

Reviewed on Mar 24, 2025

Vacation Village at Parkway
Caribe Royale Orlando
Caribe Royale Orlando
4.5 out of 5
8101 World Center Dr, Orlando, FL
Fully refundableReserve now, pay when you stay
Book a stay at this luxury hotel in Orlando. Enjoy 3 outdoor pools, a full-service spa, and 4 restaurants. Our guests praise the pool and the restaurant in our ...
9/10 Wonderful! (3,868 reviews)
"Clean, quiet, a ton of food and drink options."

Reviewed on Mar 25, 2025

Caribe Royale Orlando
Sheraton Orlando Lake Buena Vista Resort
Sheraton Orlando Lake Buena Vista Resort
4 out of 5
12205 S Apopka Vineland Rd, Orlando, FL
Fully refundableReserve now, pay when you stay
Book a stay at this spa hotel in Orlando. Enjoy 2 outdoor pools, a full-service spa, and 2 hot tubs. Our guests praise the pool and the bar in our reviews. Popular ...
7.4/10 Good! (1,092 reviews)
"The shower handle should be updated really difficult to het shower going, all else was good."

Reviewed on Mar 23, 2025

Sheraton Orlando Lake Buena Vista Resort
Walt Disney World Dolphin
Walt Disney World Dolphin
4 out of 5
1500 Epcot Resort Blvd, Lake Buena Vista, FL
Fully refundableReserve now, pay when you stay
Stay at this 4-star beach hotel in Lake Buena Vista. Enjoy free WiFi, 3 outdoor pools, and a full-service spa. Our guests praise the pool and the restaurant ...
8.6/10 Excellent! (3,448 reviews)
"Excellent place to stay!"

Reviewed on Mar 25, 2025

Walt Disney World Dolphin
Universal's Endless Summer Resort - Dockside Inn and Suites
Universal's Endless Summer Resort - Dockside Inn and Suites
3 out of 5
7125 Universal Boulevard, Orlando, FL
Fully refundableReserve now, pay when you stay
Stay at this 3-star family-friendly hotel in Orlando. Enjoy free WiFi, 2 outdoor pools, and 3 bars/lounges. Our guests praise the pool and the restaurant in ...
9/10 Wonderful! (5,264 reviews)
"Nice property"

Reviewed on Mar 25, 2025

Universal's Endless Summer Resort - Dockside Inn and Suites
Rosen Inn International
Rosen Inn International
3 out of 5
7600 International Drive, Orlando, FL
Fully refundableReserve now, pay when you stay
Stay at this 3-star family-friendly hotel in Orlando. Enjoy free WiFi, free parking, and 2 outdoor pools. Our guests praise the breakfast and the pool in our ...
8.2/10 Very Good! (5,434 reviews)
"it is really good hotel for the price and quality. It is also convenient for accessing The Universal Studio."

Reviewed on Mar 24, 2025

Rosen Inn International
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels in Lake Nona Medical City

Orlando is a city that has a lot going on, but you have your sights set on Lake Nona Medical City. This part of town is perfect for what you want to be doing, and that is everything that is not on everyone’s radar. For all that Lake Nona Medical City has going on, you’ll still need a place to crash, eventually. But you don’t want any old shack, you need something that fits the trip. We have a slew of Lake Nona Medical City hotels that will do the trick.

A beautiful day in the neighborhood

As much as you like getting out there, it’s also good to know a part of Orlando so well you’ll be telling the tourists where to go. Make friends with the concierge or be bold and chat up a local. It’s your trip, so choose your own adventure. And when you get in at night, you’ll have a comfy room and plenty of amenities to help you settle in. Call a friend and spin tales from the Lake Nona Medical City underground. What’s a journey without a good story to go with it?

Beyond the block

We’re not talking about the Lake Nona Medical City city block. We’re talking about looking beyond that block of hotels you always focus on. We give you tons of ways to sort our stash of Lake Nona Medical City cheap hotels. And if you feel like living a little, but not killing your vacation vibes, choose the Hotwire Hot Rate deal. Filter by:

  • Hotwire Hot Rate: Snag some of the best hotels in Lake Nona Medical City at an almost too good to be true rate. After you book, we’ll reveal the name of the hotel. You can get a luxury hotel at a budget price.
  • Price: You have a price in mind, and we have solutions. Hotels start as low as $88
  • Amenities: Rooftop lounge, designer furniture, 24-7 room service, and everything else you look for to live it up large.

Find the Lake Nona Medical City hotel you want, book it, and never look back. Because your great escape is ahead of you.