Search for Cheap Deals on
Spa Resort Hotels in Lower Keys

You choose what matters — star rating, location, amenities.

We pick the perfect hotel, packed with all your must-haves.

Your hotel is revealed right after booking!


Featured Lower Keys Resorts & Hotels with Spas

Little Palm Island Resort & Spa - A Noble House Resort
Little Palm Island Resort & Spa - A Noble House Resort
5 out of 5
28500 Overseas Hwy, Summerland Key, FL
Stay at this 5-star luxury resort in Summerland Key. Enjoy free WiFi, free parking, and a full-service spa. Popular attractions Big Pine Key Flea Market and ...
Little Palm Island Resort & Spa - A Noble House Resort
Deer Run Bed & Breakfast
Deer Run Bed & Breakfast
2.5 out of 5
1997 Long Beach Road, Big Pine Key, FL
Book a stay at this beach B&B in Big Pine Key. Enjoy free WiFi, free parking, and a beach locale. Popular attractions Coupon Bight Aquatic Preserve and Cook ...
Deer Run Bed & Breakfast
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.