Hotels Near
Santo Spirito

You choose what matters — star rating, location, amenities.

We pick the perfect hotel, packed with all your must-haves.

Your hotel is revealed right after booking!


Featured Santo Spirito Hotels

Hotel Horto Convento

Hotel Horto Convento

4 out of 5
Viale Ariosto, 13 Florence FI
Fully refundableReserve now, pay when you stay
Stay at this hotel in Florence. Enjoy free breakfast, free WiFi, and room service. Our guests praise the breakfast and the helpful staff in our reviews. Popular ...
9.6/10 Exceptional! (604 reviews)
A lovely property in a convenient location. You can walk to any attraction in Florence, and at the end of the day, the hotel is hidden away in a walled courtyard.

Reviewed on Jan 4, 2026

Hotel Horto Convento
Palazzo Mannaioni Suites

Palazzo Mannaioni Suites

4 out of 5
Via Maffia 9 - 17r Florence FI
Fully refundableReserve now, pay when you stay
Stay at this residence in Florence. Enjoy free WiFi, concierge services, and satellite TV channels. Our guests praise the helpful staff in our reviews. Popular ...
9.2/10 Wonderful! (1,062 reviews)
Beautiful, clean and staff were respectful & helpful! I love the place!

Reviewed on Dec 30, 2025

Palazzo Mannaioni Suites
UNA Hotels Vittoria Firenze

UNA Hotels Vittoria Firenze

4 out of 5
Via Pisana 59 Florence FI
Fully refundableReserve now, pay when you stay
Book a stay at this boutique hotel in Florence. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the helpful staff in our reviews. ...
8.4/10 Very Good! (988 reviews)
Perfect stay! Not only was the check-in smooth, but everything else was also satisfying. The breakfast was delicious, the staff were friendly, and the location was ideal. There wasn't a single thing I didn't like. I’ll definitely be back!

Reviewed on Jan 1, 2026

UNA Hotels Vittoria Firenze
La Torre Del Cestello

La Torre Del Cestello

Via Borgo San Frediano, 8 Florence FI
Fully refundableReserve now, pay when you stay
Stay at this residence in Florence. Enjoy free WiFi, valet parking (surcharge), and daily housekeeping. Popular attractions Pitti Palace and Ponte Vecchio are ...
9/10 Wonderful! (230 reviews)
Beautiful place to stay. Just outside of the bustle but walking within distance. Warmly welcomed and staff were lovely.

Reviewed on Dec 25, 2025

La Torre Del Cestello
Oltrarno Splendid

Oltrarno Splendid

Via dei Serragli 7 Florence FI
Fully refundableReserve now, pay when you stay
Stay at this B&B in Florence. Enjoy free breakfast, free WiFi, and daily housekeeping. Our guests praise the helpful staff in our reviews. Popular attractions ...
9.8/10 Exceptional! (98 reviews)
It was a great stay. The renovation style is very tasteful.

Reviewed on Dec 29, 2025

Oltrarno Splendid
Casa Santo Nome di Gesù

Casa Santo Nome di Gesù

Piazza del Carmine, 21 Florence FI
Stay at this guesthouse in Florence. Enjoy free breakfast, free WiFi, and parking (surcharge). Our guests praise the helpful staff in our reviews. Popular attractions ...
8.8/10 Excellent! (341 reviews)
Really a nice place, like the room style and good for family stay!

Reviewed on Jan 1, 2026

Casa Santo Nome di Gesù
La Fonderia Firenze

La Fonderia Firenze

Via della Fonderia 65/A Florence FI
Fully refundableReserve now, pay when you stay
Stay at this B&B in Florence. Enjoy free breakfast, free WiFi, and a garden. Our guests praise the breakfast and the helpful staff in our reviews. Popular attractions ...
9.4/10 Exceptional! (172 reviews)
The single room is in the attic upstairs, small but clean and sufficient. The bathroom is private for the guest, located just outside the room, and is clean and spacious. The staff is very friendly. The location is a bit far from the city center, but not excessively. Highly recommended.

Reviewed on Oct 17, 2025

La Fonderia Firenze
Ottantotto Firenze

Ottantotto Firenze

Via dei Serragli 88 Florence FI
Fully refundableReserve now, pay when you stay
Stay at this guesthouse in Florence. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the helpful staff in our reviews. Popular attractions ...
9.6/10 Exceptional! (169 reviews)
The young gentleman who welcomed us upon arrival, kindly provided us with a breakfast bag later that same night knowing we'd be leaving prior to the breakfast service the following morning. The boutique hotel was beautiful and very well kept.

Reviewed on Oct 23, 2025

Ottantotto Firenze
1900 Artevita

1900 Artevita

Viale Raffaello Sanzio 2 Florence FI
Fully refundableReserve now, pay when you stay
Stay at this B&B in Florence. Enjoy free WiFi, breakfast (surcharge), and housekeeping. Popular attractions Pitti Palace and Ponte Vecchio are located ...
8.6/10 Excellent! (176 reviews)
Our stay here was wonderful! The host was so pleasant and the view from the terrace was beautiful. The location was in a great spot for enjoying the Florentine neighborhoods, and close to many of the restaurants recommended to us. We would stay here again in a heartbeat.

Reviewed on Oct 16, 2025

1900 Artevita
B&B Mia Palace

B&B Mia Palace

Via della Fonderia 8 Florence FI
Fully refundableReserve now, pay when you stay
Stay at this affittacamere in Florence. Enjoy free WiFi, a 24-hour front desk, and daily housekeeping. Popular attractions Pitti Palace and Ponte Vecchio are ...
8.2/10 Very Good! (111 reviews)
Extremely helpful and friendly staff.

Reviewed on Oct 11, 2025

B&B Mia Palace
Palazzo Oliveto

Palazzo Oliveto

Via Monte Oliveto Florence FI
Fully refundableReserve now, pay when you stay
Stay at this guesthouse in Florence. Enjoy free breakfast, free WiFi, and a garden. Popular attractions Pitti Palace and Ponte Vecchio are located nearby.
7.4/10 Good! (90 reviews)
Great service easy check in Clean safe quiet

Reviewed on Oct 12, 2025

Palazzo Oliveto
Palazzo Guicciardini

Palazzo Guicciardini

via Santo Spirito 14 Florence FI
Book a stay at this luxury guesthouse in Florence. Enjoy free WiFi, in-room massages, and a 24-hour front desk. Popular attractions Pitti Palace and Ponte Vecchio ...
9.2/10 Wonderful! (148 reviews)
The hotel was difficult to find. Located in a side alley space. To enter, you had to buzz to get in, then enter a dark, metal gated area, then walk a dimly lit area to locate an unmarked door which was a lift. There was a young woman who checked us in. We didn’t see anyone at the desk till days later ...

Reviewed on May 31, 2025

Palazzo Guicciardini
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels in Santo Spirito

Florence is a city that has a lot going on, but you have your sights set on Santo Spirito. This part of town is perfect for what you want to be doing, and that is everything that is not on everyone’s radar. For all that Santo Spirito has going on, you’ll still need a place to crash, eventually. But you don’t want any old shack, you need something that fits the trip. We have a slew of Santo Spirito hotels that will do the trick.

A beautiful day in the neighborhood

As much as you like getting out there, it’s also good to know a part of Florence so well you’ll be telling the tourists where to go. Make friends with the concierge or be bold and chat up a local. It’s your trip, so choose your own adventure. And when you get in at night, you’ll have a comfy room and plenty of amenities to help you settle in. Call a friend and spin tales from the Santo Spirito underground. What’s a journey without a good story to go with it?

Beyond the block

We’re not talking about the Santo Spirito city block. We’re talking about looking beyond that block of hotels you always focus on. We give you tons of ways to sort our stash of Santo Spirito cheap hotels. And if you feel like living a little, but not killing your vacation vibes, choose the Hotwire Hot Rate deal. Filter by:

  • Hotwire Hot Rate: Snag some of the best hotels in Santo Spirito at an almost too good to be true rate. After you book, we’ll reveal the name of the hotel. You can get a luxury hotel at a budget price.
  • Price: You have a price in mind, and we have solutions. Hotels start as low as $89
  • Amenities: Rooftop lounge, designer furniture, 24-7 room service, and everything else you look for to live it up large.

Find the Santo Spirito hotel you want, book it, and never look back. Because your great escape is ahead of you.