Search Cheap Flights to
Middlesboro

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Middlesboro Flights as Low as $179

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

American Airlines
Wed, Jul 23 - Tue, Jul 29
LGA
LaGuardia
TYS
McGhee Tyson
$179 Roundtrip, found 1 day ago
$179
Roundtrip
found 1 day ago
Select American Airlines flight, departing Wed, Jul 23 from LaGuardia to McGhee Tyson, returning Tue, Jul 29, priced at $179 found 1 day ago
Delta
Wed, Jun 11 - Mon, Jun 16
MIA
Miami Intl.
TYS
McGhee Tyson
$181 Roundtrip, found 6 hours ago
$181
Roundtrip
found 6 hours ago
Select Delta flight, departing Wed, Jun 11 from Miami Intl. to McGhee Tyson, returning Mon, Jun 16, priced at $181 found 6 hours ago
Delta
Wed, May 28 - Fri, May 30
STL
Lambert-St. Louis Intl.
TYS
McGhee Tyson
$202 Roundtrip, found 1 day ago
$202
Roundtrip
found 1 day ago
Select Delta flight, departing Wed, May 28 from Lambert-St. Louis Intl. to McGhee Tyson, returning Fri, May 30, priced at $202 found 1 day ago
Bargain Flight
Sat, Aug 23 - Sat, Aug 30
ROC
Greater Rochester Intl.
TYS
McGhee Tyson
$209 Roundtrip, found 22 hours ago
$209
Roundtrip
found 22 hours ago
Select Bargain Flight flight, departing Sat, Aug 23 from Greater Rochester Intl. to McGhee Tyson, returning Sat, Aug 30, priced at $209 found 22 hours ago
Bargain Flight
Wed, Jul 9 - Tue, Jul 22
DSM
Des Moines Intl.
TYS
McGhee Tyson
$214 Roundtrip, found 11 hours ago
$214
Roundtrip
found 11 hours ago
Select Bargain Flight flight, departing Wed, Jul 9 from Des Moines Intl. to McGhee Tyson, returning Tue, Jul 22, priced at $214 found 11 hours ago
Delta
Wed, Jul 2 - Fri, Jul 4
CID
Eastern Iowa
TYS
McGhee Tyson
$217 Roundtrip, found 13 hours ago
$217
Roundtrip
found 13 hours ago
Select Delta flight, departing Wed, Jul 2 from Eastern Iowa to McGhee Tyson, returning Fri, Jul 4, priced at $217 found 13 hours ago
United
Tue, May 13 - Tue, May 20
IAH
George Bush Intercontinental
TYS
McGhee Tyson
$222 Roundtrip, found 6 days ago
$222
Roundtrip
found 6 days ago
Select United flight, departing Tue, May 13 from George Bush Intercontinental to McGhee Tyson, returning Tue, May 20, priced at $222 found 6 days ago
Bargain Flight
Sat, Aug 9 - Sat, Aug 16
MSP
Minneapolis - St. Paul Intl.
TYS
McGhee Tyson
$226 Roundtrip, found 3 days ago
$226
Roundtrip
found 3 days ago
Select Bargain Flight flight, departing Sat, Aug 9 from Minneapolis - St. Paul Intl. to McGhee Tyson, returning Sat, Aug 16, priced at $226 found 3 days ago
Delta
Sat, Nov 8 - Tue, Nov 11
MEM
Memphis Intl.
TYS
McGhee Tyson
$229 Roundtrip, found 7 hours ago
$229
Roundtrip
found 7 hours ago
Select Delta flight, departing Sat, Nov 8 from Memphis Intl. to McGhee Tyson, returning Tue, Nov 11, priced at $229 found 7 hours ago
Bargain Flight
Fri, May 9 - Sun, May 11
CLE
Hopkins Intl.
TYS
McGhee Tyson
$231 Roundtrip, found 19 hours ago
$231
Roundtrip
found 19 hours ago
Select Bargain Flight flight, departing Fri, May 9 from Hopkins Intl. to McGhee Tyson, returning Sun, May 11, priced at $231 found 19 hours ago
Bargain Flight
Fri, Jul 4 - Fri, Jul 11
MCO
Orlando Intl.
TYS
McGhee Tyson
$242 Roundtrip, found 3 days ago
$242
Roundtrip
found 3 days ago
Select Bargain Flight flight, departing Fri, Jul 4 from Orlando Intl. to McGhee Tyson, returning Fri, Jul 11, priced at $242 found 3 days ago
American Airlines
Thu, May 8 - Sat, May 10
HOU
William P. Hobby
TYS
McGhee Tyson
$242 Roundtrip, found 3 days ago
$242
Roundtrip
found 3 days ago
Select American Airlines flight, departing Thu, May 8 from William P. Hobby to McGhee Tyson, returning Sat, May 10, priced at $242 found 3 days ago
American Airlines
Wed, Aug 6 - Sat, Aug 9
SJC
Norman Y. Mineta San Jose Intl.
TYS
McGhee Tyson
$251 Roundtrip, found 11 hours ago
$251
Roundtrip
found 11 hours ago
Select American Airlines flight, departing Wed, Aug 6 from Norman Y. Mineta San Jose Intl. to McGhee Tyson, returning Sat, Aug 9, priced at $251 found 11 hours ago
American Airlines
Wed, Jun 11 - Sun, Jun 15
FLL
Fort Lauderdale - Hollywood Intl.
TYS
McGhee Tyson
$253 Roundtrip, found 6 hours ago
$253
Roundtrip
found 6 hours ago
Select American Airlines flight, departing Wed, Jun 11 from Fort Lauderdale - Hollywood Intl. to McGhee Tyson, returning Sun, Jun 15, priced at $253 found 6 hours ago
American Airlines
Wed, May 21 - Sun, May 25
SGF
Springfield-Branson National
TYS
McGhee Tyson
$253 Roundtrip, found 5 days ago
$253
Roundtrip
found 5 days ago
Select American Airlines flight, departing Wed, May 21 from Springfield-Branson National to McGhee Tyson, returning Sun, May 25, priced at $253 found 5 days ago
American Airlines
Sat, Jul 5 - Sat, Jul 12
AMA
Rick Husband Amarillo Intl.
TYS
McGhee Tyson
$259 Roundtrip, found 1 day ago
$259
Roundtrip
found 1 day ago
Select American Airlines flight, departing Sat, Jul 5 from Rick Husband Amarillo Intl. to McGhee Tyson, returning Sat, Jul 12, priced at $259 found 1 day ago

Cheap Flights to Middlesboro

Fall in love at first flight with your vacation to Middlesboro by saving a ton of cash on your last-minute cheap flight. There’s no more scouring the internet for a good deal—book your flight to Middlesboro on Hotwire, and you’ll be up, up, and on a getaway in no time.

Because once the wheels are down in Middlesboro, the good times start rolling. So buckle up, you’re in for a fun ride.

Frequently Asked Questions About flights to Middlesboro

Don’t waste your time on endless searches for cheap airline tickets oneway or roundtrip. We’ll have you on your way to Middlesboro with a tiny bag of pretzels in your hand before you can say “tray tables in the upright position”—and for a ticket price that works for your vacay budget.

So all you have to worry about is where you’re headed after the TYS airport.

What is the cheapest month to fly to Middlesboro?

Airline ticket prices fluctuate all the time, depending on the day of the week or the month of the year. The cheapest round trip flights to Middlesboro are in July, but when you book your flight on Hotwire, savings are always in season.

How many airlines fly to Middlesboro?

Variety is the spice of life, even when it comes to booking your next trip. Want options for airlines? You’ll find 11 to choose from for your flight to Middlesboro.

What airport is best to fly into Middlesboro?

When you’re planning your trip to Middlesboro, convenience is the name of the game. Luckily, Middlesboro McGhee Tyson Airport is nearby so you can deplane and get going on checking off everything on your Middlesboro must-do list.

How much are flights to Middlesboro?

Got very cheap flights on your vacation itinerary? When you book your airline tickets to Middlesboro on Hotwire, you may just get what’s on your getaway wish list. With tickets as low as $179, you’ll have leftover cash for at least a magazine and a bottle of water at the airport book store.

How to get cheap flights to Middlesboro?

The trick to saving a stack of cash on your flight to Middlesboro? Snatch up that Hotwire flight deal when you see a killer rate because it could be gone in a flash. And with flights as low as $179 right now, why wait?

Middlesboro Flight Information
Destination airport
McGhee Tyson
Destination airport IATA code
TYS
Roundtrip price
$179

Last Minute Hotel Deals in Middlesboro

Sleep Inn & Suites
Sleep Inn & Suites
2.5 out of 5
1260 N, 12th Street, Middlesboro, KY
The price is $110 per night from May 11 to May 12
$110
includes taxes & fees
May 11 - May 12
Book a stay at this business-friendly hotel in Middlesboro. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9/10 Wonderful! (712 reviews)
"Nice site removed from heavy traffic on the street."

Reviewed on May 2, 2025

Sleep Inn & Suites
Econo Lodge Middlesboro
Econo Lodge Middlesboro
2 out of 5
1623 Cumberland Avenue, Middlesboro, KY
The price is $102 per night from May 18 to May 19
$102
includes taxes & fees
May 18 - May 19
Stay at this motel in Middlesboro. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms in our reviews. ...
7/10 Good! (376 reviews)
"Was not really in a prominent area, seemed kind of drab and not a lot to do, or places to dine or shop."

Reviewed on May 2, 2025

Econo Lodge Middlesboro
Holiday Inn Express Middlesboro by IHG
Holiday Inn Express Middlesboro by IHG
2.5 out of 5
1252 N 12th St, Middlesboro, KY
The price is $122 per night from May 11 to May 12
$122
includes taxes & fees
May 11 - May 12
Book a stay at this business-friendly hotel in Middlesboro. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.4/10 Exceptional! (649 reviews)
"Our room was clean and ready when we arrived. The staff were pleasant and very helpful!"

Reviewed on Apr 23, 2025

Holiday Inn Express Middlesboro by IHG
Boone Trail Inn
Boone Trail Inn
2 out of 5
2105 US HIGHWAY 25 E, Middlesboro, KY
The price is $91 per night from May 8 to May 9
$91
includes taxes & fees
May 8 - May 9
Stay at this motel in Middlesboro. Enjoy free WiFi, free parking, and an outdoor pool. Our guests praise the helpful staff in our reviews. Popular attractions ...
7/10 Good! (90 reviews)
"Very Clean and Extremely Friendly Staff. Thanks for a Great Stay."

Reviewed on Apr 30, 2025

Boone Trail Inn
Holiday Inn Express Williamsburg by IHG
Holiday Inn Express Williamsburg by IHG
2.5 out of 5
56 West Highway 92, Williamsburg, KY
The price is $141 per night from May 26 to May 27
$141
includes taxes & fees
May 26 - May 27
Stay at this hotel in Williamsburg. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. ...
9/10 Wonderful! (945 reviews)
"Good clean accommodations. Comfortable beds."

Reviewed on Apr 29, 2025

Holiday Inn Express Williamsburg by IHG
Days Inn by Wyndham Jellico - Tennessee State Line
Days Inn by Wyndham Jellico - Tennessee State Line
2 out of 5
1417 5th Street, Jellico, TN
The price is $75 per night from May 8 to May 9
$75
includes taxes & fees
May 8 - May 9
Book a stay at this spa hotel in Jellico. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms in our reviews. ...
7.2/10 Good! (940 reviews)
Good for the price
"Doing lots of upgrades, so there was construction mess, but otherwise it was all good."

Reviewed on Apr 30, 2025

Days Inn by Wyndham Jellico - Tennessee State Line
Pine Mountain State Resort Park
Pine Mountain State Resort Park
3 out of 5
1050 State Park Road, Pineville, KY
The price is $144 per night from May 7 to May 8
$144
includes taxes & fees
May 7 - May 8
Stay at this 3-star golf hotel in Pineville. Enjoy free WiFi, free parking, and an outdoor pool. Our guests praise the helpful staff in our reviews. Popular ...
8.8/10 Excellent! (557 reviews)
"The restaurant at the lodge has absolutely amazing food Canins are clean and has everything like home. Thank you for everything"

Reviewed on May 1, 2025

Pine Mountain State Resort Park
Cumberland Gap Inn
Cumberland Gap Inn
2.5 out of 5
630 Brooklyn Street, Cumberland Gap, TN
The price is $111 per night from May 7 to May 8
$111
includes taxes & fees
May 7 - May 8
Stay at this motel in Cumberland Gap. Enjoy free WiFi, free parking, and balconies or patios. Popular attractions Cumberland Gap National Historical Park and ...
7.8/10 Good! (568 reviews)
"Dillon was friendly and helpful. Nice town, nice folks"

Reviewed on May 1, 2025

Cumberland Gap Inn
See all 322 properties in Middlesboro
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.