Search Cheap Flights to
Middlesboro

Photo by Alexis Wyrick

Search 400 airlines and 321,000 hotels worldwide.

Stop Planning & Start Exploring

FREE 24 hour cancellation on most flights

Middlesboro Flights as Low as $109

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

Frontier Airlines
Sun, Jan 26 - Thu, Jan 30
DEN
Denver Intl.
TYS
McGhee Tyson
$109 Roundtrip, found 3 days ago
$109
Roundtrip
found 3 days ago
Select Frontier Airlines flight, departing Sun, Jan 26 from Denver Intl. to McGhee Tyson, returning Thu, Jan 30, priced at $109 found 3 days ago
Frontier Airlines
Sun, Jan 19 - Thu, Jan 23
DFW
Dallas-Fort Worth Intl.
TYS
McGhee Tyson
$150 Roundtrip, found 5 days ago
$150
Roundtrip
found 5 days ago
Select Frontier Airlines flight, departing Sun, Jan 19 from Dallas-Fort Worth Intl. to McGhee Tyson, returning Thu, Jan 23, priced at $150 found 5 days ago
Frontier Airlines
Thu, Feb 6 - Sun, Feb 9
ORD
O'Hare Intl.
TYS
McGhee Tyson
$150 Roundtrip, found 1 day ago
$150
Roundtrip
found 1 day ago
Select Frontier Airlines flight, departing Thu, Feb 6 from O'Hare Intl. to McGhee Tyson, returning Sun, Feb 9, priced at $150 found 1 day ago
American Airlines
Tue, Feb 11 - Sat, Feb 15
LGA
LaGuardia
TYS
McGhee Tyson
$179 Roundtrip, found 5 days ago
$179
Roundtrip
found 5 days ago
Select American Airlines flight, departing Tue, Feb 11 from LaGuardia to McGhee Tyson, returning Sat, Feb 15, priced at $179 found 5 days ago
Delta
Tue, Feb 11 - Sat, Feb 15
LGA
LaGuardia
TYS
McGhee Tyson
$181 Roundtrip, found 5 days ago
$181
Roundtrip
found 5 days ago
Select Delta flight, departing Tue, Feb 11 from LaGuardia to McGhee Tyson, returning Sat, Feb 15, priced at $181 found 5 days ago
United
Fri, Feb 7 - Mon, Feb 10
ORD
O'Hare Intl.
TYS
McGhee Tyson
$189 Roundtrip, found 1 day ago
$189
Roundtrip
found 1 day ago
Select United flight, departing Fri, Feb 7 from O'Hare Intl. to McGhee Tyson, returning Mon, Feb 10, priced at $189 found 1 day ago
Delta
Tue, Feb 18 - Wed, Feb 26
MIA
Miami Intl.
TYS
McGhee Tyson
$195 Roundtrip, found 5 days ago
$195
Roundtrip
found 5 days ago
Select Delta flight, departing Tue, Feb 18 from Miami Intl. to McGhee Tyson, returning Wed, Feb 26, priced at $195 found 5 days ago
Frontier Airlines
Sat, Jan 25 - Thu, Jan 30
LAS
Harry Reid Intl.
TYS
McGhee Tyson
$220 Roundtrip, found 1 day ago
$220
Roundtrip
found 1 day ago
Select Frontier Airlines flight, departing Sat, Jan 25 from Harry Reid Intl. to McGhee Tyson, returning Thu, Jan 30, priced at $220 found 1 day ago
Frontier Airlines
Sun, May 4 - Thu, May 8
AUS
Austin-Bergstrom Intl.
TYS
McGhee Tyson
$220 Roundtrip, found 5 days ago
$220
Roundtrip
found 5 days ago
Select Frontier Airlines flight, departing Sun, May 4 from Austin-Bergstrom Intl. to McGhee Tyson, returning Thu, May 8, priced at $220 found 5 days ago
Delta
Thu, Oct 9 - Sat, Oct 18
ILM
Wilmington Intl.
TYS
McGhee Tyson
$314 Roundtrip, found 22 hours ago
$314
Roundtrip
found 22 hours ago
Select Delta flight, departing Thu, Oct 9 from Wilmington Intl. to McGhee Tyson, returning Sat, Oct 18, priced at $314 found 22 hours ago
American Airlines
Wed, Feb 12 - Sat, Feb 15
BOS
Logan Intl.
TYS
McGhee Tyson
$347 Roundtrip, found 2 days ago
$347
Roundtrip
found 2 days ago
Select American Airlines flight, departing Wed, Feb 12 from Logan Intl. to McGhee Tyson, returning Sat, Feb 15, priced at $347 found 2 days ago
Delta
Tue, Jan 21 - Tue, Jan 28
DAL
Love Field
TYS
McGhee Tyson
$349 Roundtrip, found 5 days ago
$349
Roundtrip
found 5 days ago
Select Delta flight, departing Tue, Jan 21 from Love Field to McGhee Tyson, returning Tue, Jan 28, priced at $349 found 5 days ago
Delta
Tue, Mar 11 - Wed, Mar 19
SAV
Savannah - Hilton Head Intl.
TYS
McGhee Tyson
$379 Roundtrip, found 1 day ago
$379
Roundtrip
found 1 day ago
Select Delta flight, departing Tue, Mar 11 from Savannah - Hilton Head Intl. to McGhee Tyson, returning Wed, Mar 19, priced at $379 found 1 day ago
American Airlines
Wed, Jul 2 - Tue, Jul 8
JFK
John F. Kennedy Intl.
TYS
McGhee Tyson
$386 Roundtrip, found 23 hours ago
$386
Roundtrip
found 23 hours ago
Select American Airlines flight, departing Wed, Jul 2 from John F. Kennedy Intl. to McGhee Tyson, returning Tue, Jul 8, priced at $386 found 23 hours ago
United
Fri, Jan 24 - Sun, Jan 26
AVP
Scranton Intl.
TYS
McGhee Tyson
$389 Roundtrip, found 22 hours ago
$389
Roundtrip
found 22 hours ago
Select United flight, departing Fri, Jan 24 from Scranton Intl. to McGhee Tyson, returning Sun, Jan 26, priced at $389 found 22 hours ago
Alaska Airlines
Wed, Jan 22 - Sun, Jan 26
LAS
Harry Reid Intl.
TYS
McGhee Tyson
$645 Roundtrip, found 1 day ago
$645
Roundtrip
found 1 day ago
Select Alaska Airlines flight, departing Wed, Jan 22 from Harry Reid Intl. to McGhee Tyson, returning Sun, Jan 26, priced at $645 found 1 day ago

Cheap Flights to Middlesboro

Fall in love at first flight with your vacation to Middlesboro by saving a ton of cash on your last-minute cheap flight. There’s no more scouring the internet for a good deal—book your flight to Middlesboro on Hotwire, and you’ll be up, up, and on a getaway in no time.

Because once the wheels are down in Middlesboro, the good times start rolling. So buckle up, you’re in for a fun ride.

Frequently Asked Questions About flights to Middlesboro

Don’t waste your time on endless searches for cheap airline tickets oneway or roundtrip. We’ll have you on your way to Middlesboro with a tiny bag of pretzels in your hand before you can say “tray tables in the upright position”—and for a ticket price that works for your vacay budget.

So all you have to worry about is where you’re headed after the TYS airport.

What is the cheapest month to fly to Middlesboro?

Airline ticket prices fluctuate all the time, depending on the day of the week or the month of the year. The cheapest round trip flights to Middlesboro are in January, but when you book your flight on Hotwire, savings are always in season.

How many airlines fly to Middlesboro?

Variety is the spice of life, even when it comes to booking your next trip. Want options for airlines? You’ll find 16 to choose from for your flight to Middlesboro.

What airport is best to fly into Middlesboro?

When you’re planning your trip to Middlesboro, convenience is the name of the game. Luckily, Middlesboro McGhee Tyson Airport is nearby so you can deplane and get going on checking off everything on your Middlesboro must-do list.

How much are flights to Middlesboro?

Got very cheap flights on your vacation itinerary? When you book your airline tickets to Middlesboro on Hotwire, you may just get what’s on your getaway wish list. With tickets as low as $109, you’ll have leftover cash for at least a magazine and a bottle of water at the airport book store.

How to get cheap flights to Middlesboro?

The trick to saving a stack of cash on your flight to Middlesboro? Snatch up that Hotwire flight deal when you see a killer rate because it could be gone in a flash. And with flights as low as $109 right now, why wait?

Middlesboro Flight Information
Destination airport
McGhee Tyson
Destination airport IATA code
TYS
Roundtrip price
$108

Last Minute Hotel Deals in Middlesboro

Sleep Inn & Suites
Sleep Inn & Suites
2.5 out of 5
1260 N, 12th Street, Middlesboro, KY
The price is $99 per night from Jan 26 to Jan 27
$99
includes taxes & fees
Jan 26 - Jan 27
Book a stay at this business-friendly hotel in Middlesboro. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9/10 Wonderful! (671 reviews)
"."

Reviewed on Jan 7, 2025

Sleep Inn & Suites
Econo Lodge Middlesboro
Econo Lodge Middlesboro
2 out of 5
1623 Cumberland Avenue, Middlesboro, KY
The price is $93 per night from Jan 19 to Jan 20
$93
includes taxes & fees
Jan 19 - Jan 20
Stay at this motel in Middlesboro. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms in our reviews. ...
6.8/10 (357 reviews)
Good for the price
"Great cozy rooms..pillows suck"

Reviewed on Jan 5, 2025

Econo Lodge Middlesboro
Days Inn by Wyndham Jellico - Tennessee State Line
Days Inn by Wyndham Jellico - Tennessee State Line
2 out of 5
1417 5th Street, Jellico, TN
The price is $73 per night from Jan 20 to Jan 21
$73
includes taxes & fees
Jan 20 - Jan 21
Book a stay at this spa hotel in Jellico. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms in our reviews. ...
7.2/10 Good! (899 reviews)
"This is an older property with some nice 1960s charm. I promise, it has been renovated. It’s clean and set back from the highway, among a few other hotels. I could walk to a convenience store. The office is up front in a separate building. They honored my request for a first floor room. As a woman ..."

Reviewed on Jan 8, 2025

Days Inn by Wyndham Jellico - Tennessee State Line
Holiday Inn Express Williamsburg, an IHG Hotel
Holiday Inn Express Williamsburg, an IHG Hotel
2.5 out of 5
56 West Highway 92, Williamsburg, KY
The price is $105 per night from Jan 14 to Jan 15
$105
includes taxes & fees
Jan 14 - Jan 15
Stay at this hotel in Williamsburg. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. ...
9/10 Wonderful! (886 reviews)
"Great location. Short distance from interstate and easy to find. Easy check in and nice roomy accommodations. Nice hotel."

Reviewed on Jan 8, 2025

Holiday Inn Express Williamsburg, an IHG Hotel
Quality Inn
Quality Inn
2.5 out of 5
2608 South Highway 421, Harlan, KY
The price is $95 per night from Jan 14 to Jan 15
$95
includes taxes & fees
Jan 14 - Jan 15
Book a stay at this business-friendly hotel in Harlan. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
8.4/10 Very Good! (278 reviews)
"Did not like the fact the pool closes very early, I’ve never been to a hotel pool that closed before 9pm so that was disappointing"

Reviewed on Nov 26, 2024

Quality Inn
Best Western Wilderness Trail Inn
Best Western Wilderness Trail Inn
2.5 out of 5
1476 S US Highway 25E, Barbourville, KY
The price is $137 per night from Jan 12 to Jan 13
$137
includes taxes & fees
Jan 12 - Jan 13
Stay at this hotel in Barbourville. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Barbourville Water Park and Dr Thomas Walker State ...
8.2/10 Very Good! (234 reviews)
"The room was clean. Property was clean as well."

Reviewed on Dec 10, 2024

Best Western Wilderness Trail Inn
Pine Mountain State Resort Park
Pine Mountain State Resort Park
3 out of 5
1050 State Park Road, Pineville, KY
Stay at this 3-star golf hotel in Pineville. Enjoy free WiFi, free parking, and an outdoor pool. Our guests praise the helpful staff in our reviews. Popular ...
8.8/10 Excellent! (544 reviews)
"This property is in one of the most beautiful places I’ve ever seen. It was nice to convene with nature. My husband and I will definitely be back."

Reviewed on Dec 21, 2024

Get rates
Pine Mountain State Resort Park
Rodeway Inn
Rodeway Inn
2 out of 5
355 Skidmore Drive, Harlan, KY
The price is $61 per night from Jan 19 to Jan 20
$61
includes taxes & fees
Jan 19 - Jan 20
Stay at this motel in Harlan. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff in our reviews. Popular attractions ...
5.8/10 (194 reviews)
Good stay
"Good experience. Very staff was friendly"

Reviewed on Jan 2, 2025

Rodeway Inn
See all 317 properties in Middlesboro
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.