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Serena

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Serena Flights as Low as $70

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

Frontier Airlines
Tue, Apr 21 - Wed, Apr 22
IAH
George Bush Intercontinental
ORD
O'Hare Intl.
$70 Roundtrip, found 2 hours ago
$70
Roundtrip
found 2 hours ago
Select Frontier Airlines flight, departing Tue, Apr 21 from George Bush Intercontinental to O'Hare Intl., returning Wed, Apr 22, priced at $70 found 2 hours ago
Frontier Airlines
Thu, Apr 30 - Mon, May 4
MCO
Orlando Intl.
MDW
Midway Intl.
$88 Roundtrip, found 1 hour ago
$88
Roundtrip
found 1 hour ago
Select Frontier Airlines flight, departing Thu, Apr 30 from Orlando Intl. to Midway Intl., returning Mon, May 4, priced at $88 found 1 hour ago
Spirit Airlines
Wed, Apr 15 - Sat, Apr 18
IAH
George Bush Intercontinental
ORD
O'Hare Intl.
$93 Roundtrip, found 2 hours ago
$93
Roundtrip
found 2 hours ago
Select Spirit Airlines flight, departing Wed, Apr 15 from George Bush Intercontinental to O'Hare Intl., returning Sat, Apr 18, priced at $93 found 2 hours ago
Spirit Airlines
Sun, May 10 - Mon, May 11
MCO
Orlando Intl.
ORD
O'Hare Intl.
$118 Roundtrip, found 14 hours ago
$118
Roundtrip
found 14 hours ago
Select Spirit Airlines flight, departing Sun, May 10 from Orlando Intl. to O'Hare Intl., returning Mon, May 11, priced at $118 found 14 hours ago
Frontier Airlines
Sat, Apr 25 - Tue, May 12
IAH
George Bush Intercontinental
MDW
Midway Intl.
$181 Roundtrip, found 2 hours ago
$181
Roundtrip
found 2 hours ago
Select Frontier Airlines flight, departing Sat, Apr 25 from George Bush Intercontinental to Midway Intl., returning Tue, May 12, priced at $181 found 2 hours ago
United
Tue, Apr 21 - Wed, Apr 22
IAH
George Bush Intercontinental
ORD
O'Hare Intl.
$187 Roundtrip, found 2 hours ago
$187
Roundtrip
found 2 hours ago
Select United flight, departing Tue, Apr 21 from George Bush Intercontinental to O'Hare Intl., returning Wed, Apr 22, priced at $187 found 2 hours ago
American Airlines
Tue, Apr 21 - Wed, Apr 22
IAH
George Bush Intercontinental
ORD
O'Hare Intl.
$187 Roundtrip, found 2 hours ago
$187
Roundtrip
found 2 hours ago
Select American Airlines flight, departing Tue, Apr 21 from George Bush Intercontinental to O'Hare Intl., returning Wed, Apr 22, priced at $187 found 2 hours ago
Delta
Wed, Apr 29 - Wed, May 20
IAH
George Bush Intercontinental
MDW
Midway Intl.
$199 Roundtrip, found 10 hours ago
$199
Roundtrip
found 10 hours ago
Select Delta flight, departing Wed, Apr 29 from George Bush Intercontinental to Midway Intl., returning Wed, May 20, priced at $199 found 10 hours ago
Delta
Tue, Apr 21 - Sat, May 2
IAH
George Bush Intercontinental
BMI
Central Illinois Regional
$291 Roundtrip, found 3 hours ago
$291
Roundtrip
found 3 hours ago
Select Delta flight, departing Tue, Apr 21 from George Bush Intercontinental to Central Illinois Regional, returning Sat, May 2, priced at $291 found 3 hours ago
American Airlines
Tue, Apr 14 - Sat, Apr 18
IAH
George Bush Intercontinental
PIA
Greater Peoria Regional
$303 Roundtrip, found 8 hours ago
$303
Roundtrip
found 8 hours ago
Select American Airlines flight, departing Tue, Apr 14 from George Bush Intercontinental to Greater Peoria Regional, returning Sat, Apr 18, priced at $303 found 8 hours ago
American Airlines
Tue, May 5 - Wed, May 6
EWN
Coastal Carolina Regional
ORD
O'Hare Intl.
$332 Roundtrip, found 2 days ago
$332
Roundtrip
found 2 days ago
Select American Airlines flight, departing Tue, May 5 from Coastal Carolina Regional to O'Hare Intl., returning Wed, May 6, priced at $332 found 2 days ago
United
Tue, Jun 9 - Wed, Jun 24
MCO
Orlando Intl.
PIA
Greater Peoria Regional
$339 Roundtrip, found 9 hours ago
$339
Roundtrip
found 9 hours ago
Select United flight, departing Tue, Jun 9 from Orlando Intl. to Greater Peoria Regional, returning Wed, Jun 24, priced at $339 found 9 hours ago
Delta
Tue, May 19 - Wed, May 27
MCO
Orlando Intl.
BMI
Central Illinois Regional
$353 Roundtrip, found 7 hours ago
$353
Roundtrip
found 7 hours ago
Select Delta flight, departing Tue, May 19 from Orlando Intl. to Central Illinois Regional, returning Wed, May 27, priced at $353 found 7 hours ago
JetBlue Airways
Wed, Apr 29 - Sat, May 2
MCO
Orlando Intl.
ORD
O'Hare Intl.
$353 Roundtrip, found 1 day ago
$353
Roundtrip
found 1 day ago
Select JetBlue Airways flight, departing Wed, Apr 29 from Orlando Intl. to O'Hare Intl., returning Sat, May 2, priced at $353 found 1 day ago
American Airlines
Sat, Mar 28 - Tue, Mar 31
EWN
Coastal Carolina Regional
BMI
Central Illinois Regional
$498 Roundtrip, found 2 days ago
$498
Roundtrip
found 2 days ago
Select American Airlines flight, departing Sat, Mar 28 from Coastal Carolina Regional to Central Illinois Regional, returning Tue, Mar 31, priced at $498 found 2 days ago
Alaska Airlines
Tue, May 12 - Tue, May 12
IAH
George Bush Intercontinental
ORD
O'Hare Intl.
$780 Roundtrip, found 19 hours ago
$780
Roundtrip
found 19 hours ago
Select Alaska Airlines flight, departing Tue, May 12 from George Bush Intercontinental to O'Hare Intl., returning Tue, May 12, priced at $780 found 19 hours ago

Cheap Flights to Serena

Fall in love at first flight with your vacation to Serena by saving a ton of cash on your last-minute cheap flight. There’s no more scouring the internet for a good deal—book your flight to Serena on Hotwire, and you’ll be up, up, and on a getaway in no time.

Because once the wheels are down in Serena, the good times start rolling. So buckle up, you’re in for a fun ride.

Frequently Asked Questions About flights to Serena

Don’t waste your time on endless searches for cheap airline tickets oneway or roundtrip. We’ll have you on your way to Serena with a tiny bag of pretzels in your hand before you can say “tray tables in the upright position”—and for a ticket price that works for your vacay budget.

So all you have to worry about is where you’re headed after the VYS airport.

What is the cheapest month to fly to Serena?

Airline ticket prices fluctuate all the time, depending on the day of the week or the month of the year. The cheapest round trip flights to Serena are in April, but when you book your flight on Hotwire, savings are always in season.

How many airlines fly to Serena?

Variety is the spice of life, even when it comes to booking your next trip. Want options for airlines? You’ll find 16 to choose from for your flight to Serena.

What airport is best to fly into Serena?

When you’re planning your trip to Serena, convenience is the name of the game. Luckily, Serena Dupage Airport is nearby so you can deplane and get going on checking off everything on your Serena must-do list.

How much are flights to Serena?

Got very cheap flights on your vacation itinerary? When you book your airline tickets to Serena on Hotwire, you may just get what’s on your getaway wish list. With tickets as low as $70, you’ll have leftover cash for at least a magazine and a bottle of water at the airport book store.

How to get cheap flights to Serena?

The trick to saving a stack of cash on your flight to Serena? Snatch up that Hotwire flight deal when you see a killer rate because it could be gone in a flash. And with flights as low as $70 right now, why wait?

Serena Flight Information
Destination airport
O'Hare Intl.
Destination airport IATA code
ORD
Roundtrip price
$62

Last Minute Hotel Deals in Serena

Grand Bear Resort at Starved Rock

Grand Bear Resort at Starved Rock

3 out of 5
2643 IL-178 Utica IL
Book a stay at this golf hotel in Utica. Enjoy free WiFi, free parking, and 2 bars/lounges. Our guests praise the helpful staff in our reviews. Popular attractions ...
7.4/10 Good! (1,000 reviews)
It was weird... Came with my 28 year old and my 11 year old. The location is great as it was only a 1.5 hour drive. Checked in at 4pm. Checkin process was not bad, a little slow, but not bad. Facility looked clean and inviting. Entered our room, there was a moldy smell. Lights worked. Microwave OLD, ...

Reviewed on Mar 23, 2026

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Grand Bear Resort at Starved Rock
Postcard Cabins Starved Rock, Outdoor Collection by Marriott Bonvoy

Postcard Cabins Starved Rock, Outdoor Collection by Marriott Bonvoy

2 out of 5
1879 N 2703rd Rd Ottawa IL
Stay at this cabin in Ottawa. Enjoy free parking, patios, and climate control. Popular attractions Tangled Roots Brewing Company - The Lone Buffalo and Washington ...
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Postcard Cabins Starved Rock, Outdoor Collection by Marriott Bonvoy
Holiday Inn Express & Suites Yorkville by IHG

Holiday Inn Express & Suites Yorkville by IHG

2.5 out of 5
577 E KENDALL DRIVE Yorkville IL
Book a stay at this spa hotel in Yorkville. Enjoy free breakfast, free parking, and a full-service spa. Our guests praise the helpful staff in our reviews. Popular ...
8.4/10 Very Good! (673 reviews)
Paid for the room through Expedia with affirm payments. Got charged the full price for the room on my debit card plus the $50 incidental. Talked to management. They said they would reverse the charge on my card for the room. Which they have. However, upon checkout, I got charged another $210 dollars ...

Reviewed on Mar 19, 2026

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Holiday Inn Express & Suites Yorkville by IHG
Days Inn by Wyndham Oglesby/ Starved Rock

Days Inn by Wyndham Oglesby/ Starved Rock

2 out of 5
120 N Lewis Ave Oglesby IL
Book a stay at this business-friendly hotel in Oglesby. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8.2/10 Very Good! (1,001 reviews)
The room had a minimal amenities but very clean. The stuff is extremely polite and helpful, especially the night attendant Jou.

Reviewed on Mar 23, 2026

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Days Inn by Wyndham Oglesby/ Starved Rock
Days Inn & Suites by Wyndham Morris/I-80

Days Inn & Suites by Wyndham Morris/I-80

2 out of 5
80 Hampton Road Morris IL
Book a stay at this business-friendly hotel in Morris. Enjoy free breakfast, free parking, and a 24-hour front desk. Our guests praise the helpful staff and ...
7/10 Good! (894 reviews)
The room was clean and on the 1st floor and I was able to park car in front of my room window. Bed was comfortable and sufficient comfy pillows. Loved the zero walk in shower with handicapped bars on 3 sides. Room was large and comfy with Refrigerator & ice maker close to the room. Breakfast was ...

Reviewed on Mar 10, 2026

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Days Inn & Suites by Wyndham Morris/I-80
Comfort Inn Morris I-80

Comfort Inn Morris I-80

2.5 out of 5
70 Gore Rd Morris IL
Book a stay at this business-friendly hotel in Morris. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
8.2/10 Very Good! (624 reviews)
Things were broken and dirty. Minimal options in the area so you’re somewhat a forced to use it as an option.

Reviewed on Mar 23, 2026

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Comfort Inn Morris I-80
Best Western Oglesby Inn

Best Western Oglesby Inn

2.5 out of 5
900 Holiday Street Oglesby IL
Book a stay at this business-friendly hotel in Oglesby. Enjoy free breakfast, free parking, and a 24-hour fitness center. Our guests praise the breakfast and ...
8.2/10 Very Good! (1,000 reviews)
Very clean. The staff were very friendly. The breakfast seating area could have been bigger but the food selection and temperatures were good. Pool was clean, well-lit and well stocked with towels. Stayed with kids. Very satisfied!

Reviewed on Mar 23, 2026

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Best Western Oglesby Inn
Hampton Inn Yorkville

Hampton Inn Yorkville

2.5 out of 5
310 East Countryside Parkway Yorkville IL
Book a stay at this business-friendly hotel in Yorkville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
9/10 Wonderful! (923 reviews)
The room was clean. The bed comfortable. The tub is not deep. The water pressure is a bit weak. The towels were nice. Breakfast was ok. Loved the omelet and the waffle! Boiled egg was old. Apple Juice tasted funny. Dog areas are great! TV was big and nice. Fridge was good. Parking was good. Overall ...

Reviewed on Mar 21, 2026

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Hampton Inn Yorkville
See all 270 properties in Serena
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.