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Hotels in Eastern Panama

Choose from 177 Eastern Panama Hotel Deals

Hotel Cocotal

Hotel Cocotal

2.5 out of 5
La Guaira Isla Grande Provincia de Colón
  • 7 min drive from Isla Mamey
Stay at this hotel in Isla Grande. Enjoy free breakfast, free WiFi, and 20 restaurants. Popular attractions Isla Mamey and Portobelo National Park are located ...
Hotel Cocotal
Ordovician Beach Resort

Ordovician Beach Resort

4.5 out of 5
Isla Grande Isla Grande Colon
  • 7 min drive from Isla Mamey
Book a stay at this luxury resort in Isla Grande. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Isla Mamey and Portobelo National Park ...
10/10 Exceptional! (9 reviews)
The resort was outstanding. It exceeded expectations in every way. The service was the best we had in Panama. The cocktails were fun and the food was delicious and they have a vegan menu. We stayed in a king room and it was very private, pristine and well appointed.

Reviewed on Feb 21, 2026

Ordovician Beach Resort
HOTEL ISLA GRANDE

HOTEL ISLA GRANDE

3 out of 5
Final de paseo La Punta Isla Grande, 01 Isla Grande Colón Province
  • 7 min drive from Isla Mamey
Book a stay at this beach hotel in Isla Grande. Enjoy free breakfast, a beach locale, and onsite spa services. Popular attractions Isla Mamey and Portobelo National ...
4.6/10 (7 reviews)
This hotel is very run down, and should not be $150/night. Did not have access to running water in our room. Location and beach are its saving graces.

Reviewed on Feb 4, 2026

HOTEL ISLA GRANDE
Konsenda San Blas

Konsenda San Blas

2 out of 5
Llano Cartí Km 11 El Llano Panamá Province
  • 2 hours drive from Isla Mamey
Stay at this hotel in El Llano. Enjoy free breakfast, free parking, and a garden.
10/10 Exceptional! (2 reviews)
Great location for bird watching! The hosts were friendly and helpful. It is best to contact them directly using WhatsApp in addition to booking on Expedia.

Reviewed on Feb 13, 2026

Konsenda San Blas
 San Blas Paradise Private Cabins on Shipwreck Island - meals included

San Blas Paradise Private Cabins on Shipwreck Island - meals included

2 out of 5
Perro Island Ailigandi Guna Yala
  • 4 hours drive from Isla Mamey
Book a stay at this beach hotel in Ailigandí. Enjoy free breakfast, a beach locale, and an airport shuttle (surcharge).
San Blas Paradise Private Cabins on Shipwreck Island - meals included
Cocoloco - Catamaran Lagoon 52F SAN BLAS

Cocoloco - Catamaran Lagoon 52F SAN BLAS

3 out of 5
El Porvenir Narganá Guna Yala
  • 2 hours drive from Isla Mamey
Book a stay at this beach property in San Blas Islands. Enjoy free breakfast, free WiFi, and a beach locale. Popular attractions Porvenir Museum and Isla Chichime ...
Cocoloco - Catamaran Lagoon 52F SAN BLAS
San Blas Private Beach Cabin

San Blas Private Beach Cabin

2.5 out of 5
Nusatupo Narganá Guna Yala
  • 2 hours drive from Isla Mamey
Book a stay at this beach cabin in Narganá. Enjoy free breakfast, a beach locale, and an airport shuttle (surcharge). Popular attractions Museum of the Kuna ...
San Blas Private Beach Cabin
Discovery Gunayar

Discovery Gunayar

2 out of 5
Archipiélago de San Blas Narganá Guna Yala
  • 2 hours drive from Isla Mamey
Book a stay at this beach lodge in Narganá. Enjoy free breakfast, a beach locale, and an airport shuttle (surcharge). Popular attractions Isla Chichime and Isla ...
6/10 (1 review)
Please fix my Expedia mobile app. It hasn’t worked for several days. The error message says the problem is at Expedia’s end. I have reported this issue by phone but nothing is being done.

Reviewed on Jan 13, 2025

Discovery Gunayar
Private Bedroom on Paradise San Blas Island

Private Bedroom on Paradise San Blas Island

2.5 out of 5
Isla Yansailadup Narganá Guna Yala
  • 2 hours drive from Isla Mamey
Stay at this guesthouse in Narganá. Enjoy free breakfast, a beach locale, and an airport shuttle (surcharge). Popular attractions Isla Diablo and Museum of the ...
10/10 Exceptional! (1 review)
Paradise
Don’t go expecting a resort and you will thoroughly enjoy yourself. The Guna that run the island are all warm, friendly, helpful. Great snorkelling tours and beautiful clean water. The accommodations are very simple but comfortable. Shared bathroom that was kept very clean. A great place to get away ...

Reviewed on Jan 13, 2023

Private Bedroom on Paradise San Blas Island
Private Ocean-Front Cabin with private bathroom on San Blas Island

Private Ocean-Front Cabin with private bathroom on San Blas Island

2 out of 5
Diablo Island Narganá Guna Yala
  • 2 hours drive from Isla Mamey
Stay at this hotel in San Blas Islands. Enjoy free breakfast, an airport shuttle (surcharge), and a garden. Popular attractions Isla Diablo and Isla Chichime ...
Private Ocean-Front Cabin with private bathroom on San Blas Island
Ranchos de Chalia

Ranchos de Chalia

3 out of 5
Portobelo via Puerto Lindo, Unit 3 Puerto Lindo Colón
  • 29 min walk from Isla Mamey
Stay at this hotel in Puerto Lindo. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Isla Mamey and Portobelo National Park are located ...
9.8/10 Exceptional! (15 reviews)
Amazing location, beautiful vistas of mountains, forest and ocean. Very relaxing environment with infinity pool. Well maintained grounds. Wonderful breakfast and dinners. Jose and Anna were amazing hosts. Marijka and Garth

Reviewed on Feb 19, 2026

Ranchos de Chalia
Ciel y Miel

Ciel y Miel

3 out of 5
Caillle Principale Cacique Provincia de Colón
  • 25 min walk from Isla Mamey
Book a stay at this beach hotel in Cacique. Enjoy free breakfast, free WiFi, and free valet parking. Popular attractions Isla Mamey and Portobelo National Park ...
10/10 Exceptional! (10 reviews)
The views from this mountain-top boutique hotel are extraordinary.

Reviewed on Feb 1, 2026

Ciel y Miel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find cheap hotels in Eastern Panama

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