Search for Cheap Deals on
Hotels in Eastern Panama

Choose from 162 Eastern Panama Hotel Deals

Ordovician Beach Resort
Ordovician Beach Resort
4.5 out of 5
Isla Grande, Isla Grande, Colon
  • 7 min drive from Isla Mamey
Stay at this 4.5-star luxury resort in Isla Grande. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Isla Mamey and Portobelo National ...
Superou as expectativas
"Excelente para casais"

Reviewed on May 5, 2025

Ordovician Beach Resort
 San Blas Paradise Private Cabins on Shipwreck Island - meals included
San Blas Paradise Private Cabins on Shipwreck Island - meals included
2 out of 5
Perro Island, Narganá, Guna Yala
  • 2 hours drive from Isla Mamey
Book a stay at this beach hotel in San Blas Islands. Enjoy free breakfast, a beach locale, and an airport shuttle (surcharge). Popular attraction Museum of the ...
San Blas Paradise Private Cabins on Shipwreck Island - meals included
Private Over the Water Cabin on San Blas Island
Private Over the Water Cabin on San Blas Island
2 out of 5
9.542876, -78.899058, Narganá, San Blas
  • 2 hours drive from Isla Mamey
Book a stay at this beach cabin in San Blas Islands. Enjoy free breakfast, a beach locale, and an airport shuttle (surcharge). Popular attractions Museum of ...
"Communication was good and highly organized. We felt safe and didn’t need to lock up our bags or valuables at all times. Weather was rough (not their fault) so the stay was a challenge with super high winds and rain. The island was covered in trash nearly all the way around. Our cabin doors were ..."

Reviewed on Feb 16, 2022

Private Over the Water Cabin on San Blas Island
Private Ocean-Front Cabin with private bathroom on San Blas Island
Private Ocean-Front Cabin with private bathroom on San Blas Island
2 out of 5
Diablo Island, Narganá, Guna Yala
  • 2 hours drive from Isla Mamey
Stay at this hotel in San Blas Islands. Enjoy free breakfast, an airport shuttle (surcharge), and a garden. Popular attraction Museum of the Kuna Nation is located ...
Private Ocean-Front Cabin with private bathroom on San Blas Island
Ranchos de Chalia
Ranchos de Chalia
3 out of 5
Portobelo via Puerto Lindo, Unit 3, Puerto Lindo, Colón
  • 29 min walk from Isla Mamey
Stay at this 3-star hotel in Puerto Lindo. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Isla Mamey and Portobelo National Park are ...
9.6/10 Exceptional! (4 reviews)
"Such a beautiful place! Lovely view and very close to access to the beach. 5 min small boats ride. Relaxing environment mixing mountain feeling and beach view. Very cozy for family of 2 kids. The people in charge there are exceptional!"

Reviewed on Apr 19, 2025

Ranchos de Chalia
Ciel y Miel
Ciel y Miel
3 out of 5
Caillle Principale, Cacique, Provincia de Colón
  • 25 min walk from Isla Mamey
Stay at this 3-star beach hotel in Cacique. Enjoy free breakfast, free WiFi, and free valet parking. Popular attractions Isla Mamey and Portobelo National Park ...
10/10 Exceptional! (6 reviews)
"Muy comodo todo"

Reviewed on May 11, 2025

Ciel y Miel
Discovery Gunayar
Discovery Gunayar
2 out of 5
Archipiélago de San Blas, Narganá, Guna Yala
  • 2 hours drive from Isla Mamey
Book a stay at this beach lodge in Narganá. Enjoy free breakfast, a beach locale, and an airport shuttle (surcharge). Popular attraction Museum of the Kuna Nation ...
"Please fix my Expedia mobile app. It hasn’t worked for several days. The error message says the problem is at Expedia’s end. I have reported this issue by phone but nothing is being done."

Reviewed on Jan 13, 2025

Discovery Gunayar
Cabins in Asserya Island - San Blas paradise - meals included
Cabins in Asserya Island - San Blas paradise - meals included
2 out of 5
Aroma Island (Isla Anzuelo), Narganá, Guna Yala
  • 2 hours drive from Isla Mamey
Stay at this hotel in San Blas Islands. Enjoy free breakfast, a marina, and an airport shuttle (surcharge). Popular attractions Museum and Porvenir Museum are ...
Cabins in Asserya Island - San Blas paradise - meals included
San Blas Tour Aridub
San Blas Tour Aridub
2 out of 5
Urgandi, Guna Yala, Panamá, Narganá, Guna Yala
  • 2 hours drive from Isla Mamey
Book a stay at this beach cabin in Narganá. Enjoy beach cabanas (surcharge), a beach shuttle (surcharge), and daily housekeeping.
San Blas Tour Aridub
 Paradise Over the Water Cabins in San Blas
Paradise Over the Water Cabins in San Blas
2.5 out of 5
G4V2 48, Narganá, Guna Yala
  • 2 hours drive from Isla Mamey
Book a stay at this beach cabin in San Blas Islands. Enjoy free breakfast, a beach locale, and an airport shuttle (surcharge). Popular attractions Porvenir Museum ...
"29/22 i stay with my family for three nights and 4 days the beds are not comfortable and the fan doesn't work the bathroom need cleaning, the worst part is the sandflyies we got bitten all over our bodies, the owners can do better with proper new nets and fan and maybe spray the place, after the ..."

Reviewed on Sep 4, 2022

Paradise Over the Water Cabins in San Blas
Private bedroom on paradise San Blas Island - Meals Included
Private bedroom on paradise San Blas Island - Meals Included
2.5 out of 5
Isla Yansailadup, Narganá, Guna Yala
  • 2 hours drive from Isla Mamey
Stay at this guesthouse in Narganá. Enjoy free breakfast, a beach locale, and an airport shuttle (surcharge). Popular attractions Museum of the Kuna Nation and ...
Paradise
"Don’t go expecting a resort and you will thoroughly enjoy yourself. The Guna that run the island are all warm, friendly, helpful. Great snorkelling tours and beautiful clean water. The accommodations are very simple but comfortable. Shared bathroom that was kept very clean. A great place to get away ..."

Reviewed on Jan 13, 2023

Private bedroom on paradise San Blas Island - Meals Included
Cocoloco - Catamaran Lagoon 52F SAN BLAS
Cocoloco - Catamaran Lagoon 52F SAN BLAS
3 out of 5
El Porvenir, Narganá, Guna Yala
  • 2 hours drive from Isla Mamey
Stay at this 3-star property in San Blas Islands. Enjoy free breakfast, free WiFi, and a 24-hour front desk. Popular attractions Porvenir Museum and Museum are ...
Cocoloco - Catamaran Lagoon 52F SAN BLAS
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find cheap hotels in Eastern Panama

You’re not an average traveler—and Hotwire knows it. Your wanderlust takes you off the beaten path to discover unique adventures and every travel destination’s lesser-known tourist scenes. Hotwire has the hookup! Book your Eastern Panama hotel with Hotwire to complete your one-of-a-kind travel checklist.

For you, intrepid voyager, Hotwire has a large selection of the best hotels in Eastern Panama.

Choosing the right hotel in has everything to do with the way you want your trip to go. If you’ve scribbled a few obscure destinations on your itinerary, you probably already have a good sense of how your getaway is taking shape. Lean into that by booking one of Eastern Panama’s 162 hotels. Choose the one that best catches your trip’s tourist drift.

If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as . In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get great Eastern Panama hotel deals at the last minute.

While traveling, where you stay plays a major role in your overall vacation enjoyment. Choosing the right hotel is just as important as making sure you book the right flight and car rental. If you’re traveling with family or friends, you may need to book a hotel with connecting rooms. If you enjoy an elegant and relaxing hotel ambiance, opt for one of Hotwire’s luxury hotels in Eastern Panama. No matter your reason for visiting Eastern Panama, with Hotwire’s large selection of hotels in the area, you’re sure to book a hotel that meets all your accommodation needs.

Frequently Asked Questions About Eastern Panama hotels

Where can I find the best last-minute travel deals?

If you’re traveling in the spirit of spontaneity, you’ll love the idea of leaving your exact hotel choice up to chance. With Hotwire Hot Rates, you can unlock great deals on your next flight, hotel, or car rental. Just plug in your general preferences and let Hotwire choose last-minute hotel deals in Eastern Panama for as low as .

How many hotels are there in Eastern Panama?

With over 162 hotels in Eastern Panama, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as .

How to find cheap car rentals in Eastern Panama?

Finding a cheap car rental deal in Eastern Panama is as easy as scoring cheap hotels in Eastern Panama. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can unlock great car rental deals if you book a Hotwire Hot Rate at the last minute.