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Eastern Panama Vacation Packages

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A calm sea with a small boat and a row of palm trees on the shore.

Eastern Panama
Panama
Mexico and Central America
Hotwire.com

Eastern Panama Flight + Hotel Packages

Price found within the past 48 hours. Click for updated prices.

Decapolis Hotel Panama City

4 out of 5

Price was $1,058, price is now $779 per person

$779

per person

Sep 3 - Sep 7

found 2 days ago

Roundtrip flight included

Atlanta (ATL) to Panama City (PTY)

Book a stay at this spa hotel in Panama City. Enjoy free breakfast, free WiFi, and free valet parking. Our guests praise the breakfast and the helpful staff in our reviews. Popular attractions Albrook Shopping Mall and Avenida Balboa are located nearby.

Todo bien

Reviewed on Jul 16, 2026

Central Hotel Panama Casco Viejo

4 out of 5

Save 100% on your flight

Price was $1,851, price is now $937 per person

$937

per person

Oct 8 - Oct 13

found 1 day ago

Roundtrip flight included

Atlanta (ATL) to Panama City (PTY)

Book a stay at this spa hotel in Panama City. Enjoy free WiFi, a full-service spa, and 3 restaurants. Our guests praise the helpful staff and the clean rooms in our reviews. Popular attractions Albrook Shopping Mall and Cinta Costera are located nearby.

I really enjoyed my stay at Casco Viejo. I recommend purchasing the breakfast plan. The food was great. I enjoyed the area for walking. Not too far from Panama City.

Reviewed on Jul 13, 2026

Megapolis Hotel Panamá

4.5 out of 5

Price was $1,482, price is now $879 per person

$879

per person

Sep 30 - Oct 5

found 1 day ago

Roundtrip flight included

Atlanta (ATL) to Panama City (PTY)

Book a stay at this luxury hotel in Panama City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. Popular attractions Albrook Shopping Mall and Avenida Balboa are located nearby.

Muy bueno el menú de buffet y muy amable el personal del hotel. Pero, no me parece justo 5 dólares por una mini pasta dental y un cepillo de dientes de palos de mala calidad.

Reviewed on Jul 18, 2026

Riande Aeropuerto Hotel & Casino

4 out of 5

Price was $1,269, price is now $851 per person

$851

per person

Sep 30 - Oct 5

found 1 day ago

Roundtrip flight included

Atlanta (ATL) to Panama City (PTY)

Book a stay at this family-friendly resort in Tocumen. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the pool in our reviews. Popular attractions Metromall Panama and Los Pueblos Commercial Center are located nearby.

si tienes que hacer escala en panama. este lugar es perfecto. super cerca. te da transporte de aeropuerto hotel y viceversa. Y me toco comer ahi y todo rico. Dormi bien y volveria para ir de compras a panama

Reviewed on Jul 19, 2026

Hotel Riu Plaza Panama

5 out of 5

Price was $1,231, price is now $891 per person

$891

per person

Sep 30 - Oct 5

found 1 day ago

Roundtrip flight included

Atlanta (ATL) to Panama City (PTY)

Book a stay at this luxury hotel in Panama City. Enjoy free breakfast, free WiFi, and 3 restaurants. Our guests praise the breakfast and the pool in our reviews. Popular attractions Albrook Shopping Mall and Via Espana are located nearby.

The service from Krystel and Melissa on the Crown Lounge and business center is outstanding very professional from both of them

Reviewed on Jul 19, 2026

80m² Luxury Ocean View Apartment PH The Sands, Next to Hilton

2 out of 5

Price was $1,743, price is now $1,299 per person

$1,299

per person

Aug 19 - Aug 25

found 11 hours ago

Roundtrip flight included

Fort Lauderdale (FLL) to Panama City (PTY)

Stay at this apartment in Panama City. Enjoy a fitness center, parking (surcharge), and an outdoor pool. Popular attractions Albrook Shopping Mall and Cinta Costera are located nearby.

Casa Lefevre By Wynwood House

3.5 out of 5

Price was $1,343, price is now $1,020 per person

$1,020

per person

Aug 19 - Aug 25

found 11 hours ago

Roundtrip flight included

Fort Lauderdale (FLL) to Panama City (PTY)

Stay at this apartment in Panama City. Enjoy free WiFi, cable TV channels, and premium bedding. Popular attractions Albrook Shopping Mall and Cinta Costera are located nearby.

Casa Mallet by Wynwood House

4 out of 5

Price was $1,561, price is now $1,195 per person

$1,195

per person

Oct 8 - Oct 13

found 1 day ago

Roundtrip flight included

Atlanta (ATL) to Panama City (PTY)

Stay at this apartment in Panama City. Enjoy free WiFi, parking (surcharge), and premium bedding. Popular attractions Albrook Shopping Mall and Cinta Costera are located nearby.

In the middle of the old town, lovely rooftop. Beautiful apartment. Easy check in. WhatsApp line is available if anything was needed or if we had questions.

Reviewed on Mar 12, 2026