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Main Street Hyannis Vacation Packages

Main Street Hyannis Flight + Hotel Packages

Price found within the past 48 hours. Click for updated prices.
The Earl of Sandwich Motel

The Earl of Sandwich Motel

2 out of 5
per person
Mar 5 - Mar 9
found 1 day ago
Roundtrip non-stop flight included
Chicago (ORD) to Boston (BOS)
Stay at this motel in East Sandwich. Enjoy free WiFi, free parking, and a garden. Our guests praise the clean rooms in our reviews. Popular attractions Cape Cod Massage Therapy and East Sandwich Beach are located nearby.
Courtyard Resort

Courtyard Resort

3 out of 5
Save 100% on your flight
per person
Mar 5 - Mar 9
found 1 day ago
Roundtrip non-stop flight included
Chicago (ORD) to Hyannis (HYA)
Stay at this 3-star condo in Hyannis. Enjoy free WiFi, free parking, and cable TV channels. Popular attractions Hyannis Harbor and Cape Cod Baseball Hall of Fame are located nearby.
Sea Mist Resort by VRI Americas

Sea Mist Resort by VRI Americas

3 out of 5
Save 100% on your flight
per person
Mar 5 - Mar 9
found 1 day ago
Roundtrip non-stop flight included
Chicago (ORD) to Boston (BOS)
Stay at this 3-star business-friendly aparthotel in Mashpee. Enjoy free WiFi, free parking, and a fitness center. Popular attractions Mashpee Commons and Cape Cod Children's Museum are located nearby.
Holly Tree Resort by VRI Americas

Holly Tree Resort by VRI Americas

3 out of 5
Save 100% on your flight
per person
Mar 5 - Mar 9
found 1 day ago
Roundtrip non-stop flight included
Chicago (ORD) to Boston (BOS)
Stay at this 3-star aparthotel in West Yarmouth. Enjoy free WiFi, free parking, and a fitness center. Popular attractions Cape Cod Inflatable Park and Englewood Beach are located nearby.
The Wylie Inn and Conference Center at Endicott College

The Wylie Inn and Conference Center at Endicott College

3.5 out of 5
per person
Mar 24 - Mar 28
found 1 day ago
Roundtrip flight included
Chicago (ORD) to Boston (BOS)
Stay at this 3.5-star beach hotel in Beverly. Enjoy free WiFi, free parking, and a 24-hour fitness center. Our guests praise the helpful staff and the clean rooms in our reviews. Popular attractions Salem Willows Beach and John Cabot House are located nearby.
Bayside Resort Hotel

Bayside Resort Hotel

3 out of 5
per person
Mar 5 - Mar 9
found 1 day ago
Roundtrip non-stop flight included
Chicago (ORD) to Boston (BOS)
Stay at this 3-star beach hotel in West Yarmouth. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the pool in our reviews. Popular attractions Hyannis Harbor and Putter's Paradise Miniature Golf are located nearby.
InnSeason Resorts Surfside

InnSeason Resorts Surfside

3 out of 5
per person
Mar 5 - Mar 9
found 1 day ago
Roundtrip non-stop flight included
Chicago (ORD) to Boston (BOS)
Stay at this 3-star beach hotel in East Falmouth. Enjoy free WiFi, free parking, and a beach locale. Our guests praise the helpful staff in our reviews. Popular attractions Menauhant Beach and Falmouth Heights Beach are located nearby.
Falmouth Tides

Falmouth Tides

2.5 out of 5
per person
Mar 5 - Mar 9
found 1 day ago
Roundtrip non-stop flight included
Chicago (ORD) to Boston (BOS)
Book a stay at this beach motel in Falmouth. Enjoy free WiFi, free parking, and a private beach. Our guests praise the helpful staff and the clean rooms in our reviews. Popular attractions Woods Hole Ferry Terminal and Island Queen Ferry are located nearby.
Inn on Main

Inn on Main

3.5 out of 5
Save 100% on your flight
per person
Mar 5 - Mar 9
found 1 day ago
Roundtrip non-stop flight included
Chicago (ORD) to Hyannis (HYA)
Stay at this 3.5-star B&B in Yarmouth Port. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Hyannis Harbor and Edward Gorey House are located nearby.
Bluegreen Vacations The Breakers, an Ascend Resort

Bluegreen Vacations The Breakers, an Ascend Resort

3.5 out of 5
per person
Mar 5 - Mar 9
found 1 day ago
Roundtrip non-stop flight included
Chicago (ORD) to Boston (BOS)
Stay at this 3.5-star beach hotel in Dennis Port. Enjoy free WiFi, free parking, and an outdoor pool. Popular attractions Sea Street Beach and Pleasant Road Beach are located nearby.
Beachside Village Resort by VRI Americas

Beachside Village Resort by VRI Americas

3 out of 5
per person
Mar 5 - Mar 9
found 1 day ago
Roundtrip non-stop flight included
Chicago (ORD) to Boston (BOS)
Stay at this 3-star beach apartment in Falmouth. Enjoy free WiFi, an outdoor pool, and daily housekeeping. Our guests praise the property condition in our reviews. Popular attractions Surf Drive Beach and Falmouth Beach are located nearby.
An English Garden Bed & Breakfast

An English Garden Bed & Breakfast

3 out of 5
per person
Mar 5 - Mar 9
found 1 day ago
Roundtrip non-stop flight included
Chicago (ORD) to Boston (BOS)
Stay at this 3-star beach B&B in Dennis Port. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Cliff Metcalf Memorial Beach and Cape Cod Theatre Company – Home of the Harwich Jr. Theatre are located nearby.

5-7 Night Vacations in Main Street Hyannis

Price found within the past 48 hours. Click for updated prices.
DoubleTree Suites by Hilton Hotel Boston - Cambridge

DoubleTree Suites by Hilton Hotel Boston - Cambridge

4 out of 5
Allston
Save 100% on your flight
per person
Mar 26 - Mar 31
found 1 day ago
Roundtrip flight included
Chicago (ORD) to Boston (BOS)
Fairmont Copley Plaza, Boston

Fairmont Copley Plaza, Boston

4.5 out of 5
Back Bay
Save 100% on your flight
per person
Mar 23 - Mar 28
found 1 day ago
Roundtrip flight included
Detroit (DTW) to Boston (BOS)
Encore Boston Harbor

Encore Boston Harbor

5 out of 5
Save 100% on your flight
per person
Mar 23 - Mar 28
found 1 day ago
Roundtrip flight included
Detroit (DTW) to Boston (BOS)
The Westin Boston Seaport District

The Westin Boston Seaport District

4 out of 5
Seaport District
Save 100% on your flight
per person
Mar 23 - Mar 28
found 1 day ago
Roundtrip flight included
Detroit (DTW) to Boston (BOS)

Main Street Hyannis Last Minute Hotel Deals

Fairfield Inn & Suites by Marriott Cape Cod Hyannis
Fairfield Inn & Suites by Marriott Cape Cod Hyannis
2.5 out of 5
867 Iyannough Road, Hyannis, MA
Book a stay at this business-friendly hotel in Hyannis. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the helpful staff in our reviews. ...
Fairfield Inn & Suites by Marriott Cape Cod Hyannis
Margaritaville Resort Cape Cod
Margaritaville Resort Cape Cod
3 out of 5
1225 Iyannough Rd, Hyannis, MA
Book a stay at this family-friendly resort in Hyannis. Enjoy free WiFi, free parking, and 2 restaurants. Our guests praise the clean rooms in our reviews. Popular ...
Margaritaville Resort Cape Cod
Comfort Inn Hyannis - Cape Cod
Comfort Inn Hyannis - Cape Cod
2.5 out of 5
259 Main Street, Hyannis, MA
Book a stay at this business-friendly hotel in Hyannis. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
Comfort Inn Hyannis - Cape Cod
Courtyard Resort
Courtyard Resort
3 out of 5
125 North St, Hyannis, MA
Stay at this 3-star condo in Hyannis. Enjoy free WiFi, free parking, and cable TV channels. Popular attractions Hyannis Harbor and Cape Cod Baseball Hall of ...
Courtyard Resort
Hyannis Travel Inn
Hyannis Travel Inn
2.5 out of 5
18 North St, Hyannis, MA
Stay at this hotel in Hyannis. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the pool in our reviews. Popular attractions ...
Hyannis Travel Inn
Anchor In Distinctive Waterfront Lodging
Anchor In Distinctive Waterfront Lodging
3 out of 5
1 South Street, Hyannis, MA
Stay at this 3-star hotel in Hyannis. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms in our reviews. ...
Anchor In Distinctive Waterfront Lodging
Cape Cod Inn
Cape Cod Inn
2 out of 5
447 Main St, Hyannis, MA
Stay at this motel in Hyannis. Enjoy free WiFi, free parking, and daily housekeeping. Our guests praise the helpful staff and the clean rooms in our reviews. ...
Cape Cod Inn
Hyannis Harbor Hotel
Hyannis Harbor Hotel
3.5 out of 5
213 Ocean St, Hyannis, MA
Stay at this 3.5-star business-friendly hotel in Hyannis. Enjoy free WiFi, an outdoor pool, and parking (surcharge). Our guests praise the helpful staff in our ...
Hyannis Harbor Hotel
See all 3,394 properties in Main Street Hyannis
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top Flight Deals

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

Spirit Airlines
Sat, Feb 15 - Wed, Feb 19
LAX
Los Angeles Intl.
BOS
Logan Intl.
$128 Roundtrip, found 20 hours ago
$128
Roundtrip
found 20 hours ago
Select Spirit Airlines flight, departing Sat, Feb 15 from Los Angeles Intl. to Logan Intl., returning Wed, Feb 19, priced at $128 found 20 hours ago
JetBlue Airways
Tue, Jun 3 - Wed, Jun 4
PDX
Portland Intl.
BOS
Logan Intl.
$197 Roundtrip, found 7 hours ago
$197
Roundtrip
found 7 hours ago
Select JetBlue Airways flight, departing Tue, Jun 3 from Portland Intl. to Logan Intl., returning Wed, Jun 4, priced at $197 found 7 hours ago
American Airlines
Thu, Aug 7 - Mon, Aug 11
LAX
Los Angeles Intl.
MVY
Martha's Vineyard
$515 Roundtrip, found 2 days ago
$515
Roundtrip
found 2 days ago
Select American Airlines flight, departing Thu, Aug 7 from Los Angeles Intl. to Martha's Vineyard, returning Mon, Aug 11, priced at $515 found 2 days ago
Cathay Pacific
Wed, May 14 - Wed, Oct 8
PEK
Capital Intl.
BOS
Logan Intl.
$1,395 Roundtrip, found 2 days ago
$1,395
Roundtrip
found 2 days ago
Select Cathay Pacific flight, departing Wed, May 14 from Capital Intl. to Logan Intl., returning Wed, Oct 8, priced at $1,395 found 2 days ago