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A dense forest with a mountain in the background partially covered by clouds.

Santa Fe
Veraguas
Panama
Mexico and Central America
Hotwire.com

Santa Fe Flight + Hotel Packages

Price found within the past 48 hours. Click for updated prices.

Riande Aeropuerto Hotel & Casino

4 out of 5

Price was $1,010, price is now $681 per person

$681

per person

Oct 22 - Oct 26

found 1 day ago

Roundtrip flight included

Atlanta (ATL) to Panama City (PTY)

Book a stay at this family-friendly resort in Tocumen. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the pool in our reviews. Popular attractions Metromall Panama and Los Pueblos Commercial Center are located nearby.

Muy limpio ,restaurant excelente ,personal amable y cordial ,el transporte al aeropuerto fue todo muy eficaz,gracias

Reviewed on Sep 7, 2026

Megapolis Hotel Panamá

4.5 out of 5

Price was $1,513, price is now $737 per person

$737

per person

Oct 22 - Oct 26

found 1 day ago

Roundtrip flight included

Atlanta (ATL) to Panama City (PTY)

Book a stay at this luxury hotel in Panama City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. Popular attractions Albrook Shopping Mall and Avenida Balboa are located nearby.

Todo bien

Reviewed on Sep 8, 2026

Central Hotel Panama Casco Viejo

4 out of 5

Save 100% on your flight

Price was $2,100, price is now $1,072 per person

$1,072

per person

Nov 11 - Nov 16

found 1 day ago

Roundtrip non-stop flight included

Atlanta (ATL) to Panama City (PTY)

Book a stay at this spa hotel in Panama City. Enjoy free WiFi, a full-service spa, and 3 restaurants. Our guests praise the helpful staff and the clean rooms in our reviews. Popular attractions Albrook Shopping Mall and Cinta Costera are located nearby.

Wonderful stay! Will return!

Reviewed on Sep 8, 2026

Best Western Plus Panama Zen Hotel

4 out of 5

Price was $1,064, price is now $699 per person

$699

per person

Oct 19 - Oct 23

found 1 day ago

Roundtrip flight included

Miami (MIA) to Panama City (PTY)

Book a stay at this business-friendly hotel in Panama City. Enjoy free breakfast, free WiFi, and a rooftop terrace. Our guests praise the helpful staff in our reviews. Popular attractions Albrook Shopping Mall and Multiplaza Pacific Mall are located nearby.

Hotel Riu Plaza Panama

5 out of 5

Price was $1,240, price is now $828 per person

$828

per person

Oct 11 - Oct 17

found 1 day ago

Roundtrip flight included

Atlanta (ATL) to Panama City (PTY)

Book a stay at this luxury hotel in Panama City. Enjoy free breakfast, free WiFi, and 3 restaurants. Our guests praise the breakfast and the pool in our reviews. Popular attractions Albrook Shopping Mall and Avenida Balboa are located nearby.

Great hotel

Reviewed on Sep 8, 2026

Decapolis Hotel Panama City

4 out of 5

Price was $994, price is now $687 per person

$687

per person

Oct 22 - Oct 26

found 1 day ago

Roundtrip flight included

Atlanta (ATL) to Panama City (PTY)

Book a stay at this spa hotel in Panama City. Enjoy free breakfast, free WiFi, and free valet parking. Our guests praise the breakfast and the helpful staff in our reviews. Popular attractions Albrook Shopping Mall and Avenida Balboa are located nearby.

El lugar está céntrico pero fue difícil conseguir hielo paras habitaciones que están más arriba del piso 14 hay que ir al restaurante la piscina es pequeña

Reviewed on Sep 8, 2026

w Upscale 1BR w AC in Vibrant Obarrio

2 out of 5

Price was $1,070, price is now $745 per person

$745

per person

Oct 19 - Oct 23

found 1 day ago

Roundtrip flight included

Miami (MIA) to Panama City (PTY)

Stay at this apartment in Panama City. Popular attractions Albrook Shopping Mall and Multiplaza Pacific Mall are located nearby.

Villa Marina Hotel

3.5 out of 5

Price was $1,084, price is now $758 per person

$758

per person

Nov 4 - Nov 8

found 1 day ago

Roundtrip flight included

Miami (MIA) to Panama City (PTY)

Book a stay at this family-friendly hotel in Las Escobas del Venado. Enjoy free WiFi, free parking, and 2 bars/lounges. Our guests praise the helpful staff in our reviews. Popular attraction Venao Beach is located nearby.