Search for Cheap Deals on
Hotels in Mesopotamia

Choose from 513 Mesopotamia Hotel Deals

O2 Hotel Gualeguaychú

O2 Hotel Gualeguaychú

2.5 out of 5
115 3 de Febrero Gualeguaychú Entre Ríos
  • 6 hours drive from Termas de Federacion
Stay at this hotel in Gualeguaychú. Enjoy free WiFi, a 24-hour front desk, and a business center. Popular attractions Gualeguaychú Cathedral and San Martin Square ...
7.8/10 Good! (77 reviews)
Si un huesped pregunta si se olvida algo en la habitacion tener la deliquicadesa de contestar por eso la calificaccion no me volveria a quedar

Reviewed on Dec 23, 2025

O2 Hotel Gualeguaychú
Marriott Corrientes Hotel

Marriott Corrientes Hotel

4.5 out of 5
Av Costanera Juan Pablo II y Lavalle Corrientes
  • 10 hours drive from Termas de Federacion
Book a stay at this luxury hotel in Corrientes. Enjoy a steam room. Popular attractions Costanera de Corrientes and Cumba Cua Park are located nearby.
10/10 Exceptional! (22 reviews)
Fantastic stay. Room was immaculate and hotel staff were very friendly and helpful. Great pool and beds were super comfortable.

Reviewed on Feb 6, 2026

Marriott Corrientes Hotel
Hathor Concordia

Hathor Concordia

3 out of 5
Ruta Nacional 14-km 264.5 Concordia Entre Rios
  • 1 hour drive from Termas de Federacion
Book a stay at this business-friendly hotel in Concordia. Enjoy free breakfast, free WiFi, and room service. Popular attractions Concordia Golf Course and Castillo ...
8.6/10 Excellent! (369 reviews)
AC did not work well, food was OK. Staff friendly. Good hotel for a stay on the road.

Reviewed on Dec 22, 2025

Hathor Concordia
Turismo Hotel Casino

Turismo Hotel Casino

2.5 out of 5
650 Entre Ríos Corrientes Corrientes
  • 10 hours drive from Termas de Federacion
Stay at this hotel in Corrientes. Enjoy free breakfast, free WiFi, and 2 restaurants. Popular attractions Cumba Cua Park and Casinos del Litoral are located ...
8/10 Very Good! (4 reviews)
Boa infraestrutura, e localização!

Reviewed on Feb 4, 2026

Turismo Hotel Casino
Complejo La Loma

Complejo La Loma

3 out of 5
Santa Catalina entre Calle 40 y Tonello Federacion Entre Ríos
  • 8 min walk from Termas de Federacion
Stay at this aparthotel in Federacion. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Termas Federacion Water Park and Termas de Federacion ...
8/10 Very Good! (5 reviews)
Great self-contained suite!
Had a very good experience here. Hosts do not speak English, but were very patient with me as I used Google Translate to communicate. Woman at the desk was very kind. I had arrived late and was able to check in without issue. The suite is great - there is a full bathroom, bedroom and kitchen / dining ...

Reviewed on Sep 9, 2023

Complejo La Loma
Casa del Árbol Hostel

Casa del Árbol Hostel

3 out of 5
1096 8 de Junio Concepción del Uruguay Entre Ríos
  • 4 hours drive from Termas de Federacion
Stay at this guesthouse in Concepción del Uruguay. Enjoy free WiFi, a 24-hour front desk, and a garden. Popular attractions Termas Concepcion Entrerios and Sala ...
7.6/10 Good! (9 reviews)
La plataforma por.donde contrate te reserva aunque no haya lugar en el hostel Un desastre todo. No tienen verguenza. Poco serio

Reviewed on Feb 23, 2026

Casa del Árbol Hostel
Mayim Hotel Termal & SPA

Mayim Hotel Termal & SPA

3 out of 5
Av. Monseñor Ricardo Rösch Concordia Entre Ríos
  • 59 min drive from Termas de Federacion
Stay at this hotel in Concordia. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Concordia Speedway and Concordia Golf Course are located ...
9.2/10 Wonderful! (7 reviews)
Muy lindo hotel , lástima q se rompió el aire acondicionado y no hay secador de pelo an la habitación

Reviewed on Oct 3, 2025

Mayim Hotel Termal & SPA
Urban Hotel

Urban Hotel

3 out of 5
Vuelta de Obligado 556 Federacion Entre Ríos
  • 5 min walk from Termas de Federacion
Stay at this hotel in Federacion. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Termas de Federacion and Termas Federacion Water Park ...
6/10 (2 reviews)
La habitación muy bien y el personal excelente

Reviewed on Jan 25, 2026

Urban Hotel
La Regina Lodge

La Regina Lodge

4 out of 5
RN12 Municipo de Itati Corrientes
  • 10 hours drive from Termas de Federacion
Stay at this lodge in Municipo de Itatí. Enjoy free WiFi, free parking, and 3 outdoor pools.
10/10 Exceptional! (1 review)
Excelente pousada, piscina fantástica com visual do rio

Reviewed on Mar 4, 2026

La Regina Lodge
Club Valle Termal Resort

Club Valle Termal Resort

3 out of 5
Ñandubay S/N, Corner Coronel Salas Federacion Entre Rios
  • 10 min walk from Termas de Federacion
Book a stay at this family-friendly hotel in Federacion. Enjoy free breakfast, free WiFi, and room service. Popular attractions Termas de Federacion and Termas ...
9.2/10 Wonderful! (94 reviews)
La habitación estaba impecable, la limpieza de todo el complejo fue excelente, pero quiero destacar la atención de todo su personal, la disponibilidad constante para atender todas nuestras necesidades. Lo recomiendo y espero poder volver pronto.

Reviewed on Nov 18, 2025

Club Valle Termal Resort
Totoras Apart Federacion

Totoras Apart Federacion

2.5 out of 5
Ñandubay (ex Hermanas Betancourt) 2610 Federacion Entre Rios
  • 11 min walk from Termas de Federacion
Stay at this aparthotel in Federacion. Enjoy free WiFi, free parking, and room service. Popular attractions Termas de Federacion and Termas Federacion Water ...
Totoras Apart Federacion
Costarenas Hotel & Spa

Costarenas Hotel & Spa

3.5 out of 5
12 de Abril y Quiros Colon Entre Rios
  • 3 hours drive from Termas de Federacion
Book a stay at this spa hotel in Colon. Enjoy free breakfast, free WiFi, and an outdoor pool. Popular attractions Dr. Herminio J. Quiros Park and Termas De Colón ...
8.6/10 Excellent! (60 reviews)
Motel masquerading as a SPA Hotel
Short Version See pictures for detailed information) - Rooms and bathrooms are small, shower already tight spaced with doors that don’t close properly. - By day 3, construction noise and chemicals smells from remodeling work became a big issue. - Receptionist did not offer solutions and lied about ...

Reviewed on Sep 12, 2025

Costarenas Hotel & Spa
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find cheap hotels in Mesopotamia

You’re not an average traveler—and Hotwire knows it. Your wanderlust takes you off the beaten path to discover unique adventures and every travel destination’s lesser-known tourist scenes. Hotwire has the hookup! Book your Mesopotamia hotel with Hotwire to complete your one-of-a-kind travel checklist.

For you, intrepid voyager, Hotwire has a large selection of the best hotels in Mesopotamia.

Choosing the right hotel in has everything to do with the way you want your trip to go. If you’ve scribbled a few obscure destinations on your itinerary, you probably already have a good sense of how your getaway is taking shape. Lean into that by booking one of Mesopotamia’s 513 hotels. Choose the one that best catches your trip’s tourist drift.

If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $39. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get great Mesopotamia hotel deals at the last minute.

While traveling, where you stay plays a major role in your overall vacation enjoyment. Choosing the right hotel is just as important as making sure you book the right flight and car rental. If you’re traveling with family or friends, you may need to book a hotel with connecting rooms. If you enjoy an elegant and relaxing hotel ambiance, opt for one of Hotwire’s luxury hotels in Mesopotamia. No matter your reason for visiting Mesopotamia, with Hotwire’s large selection of hotels in the area, you’re sure to book a hotel that meets all your accommodation needs.

Frequently Asked Questions About Mesopotamia hotels

Where can I find the best last-minute travel deals?

If you’re traveling in the spirit of spontaneity, you’ll love the idea of leaving your exact hotel choice up to chance. With Hotwire Hot Rates, you can unlock great deals on your next flight, hotel, or car rental. Just plug in your general preferences and let Hotwire choose last-minute hotel deals in Mesopotamia for as low as $39.

How many hotels are there in Mesopotamia?

With over 513 hotels in Mesopotamia, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $39.

How to find cheap car rentals in Mesopotamia?

Finding a cheap car rental deal in Mesopotamia is as easy as scoring cheap hotels in Mesopotamia. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can unlock great car rental deals if you book a Hotwire Hot Rate at the last minute.