Search for Cheap Deals on
4 Star Hotels in Mesopotamia

You choose what matters — star rating, location, amenities.

We pick the perfect hotel, packed with all your must-haves.

Your hotel is revealed right after booking!


Featured 4 Star Mesopotamia Hotels

Esplendor by Wyndham Savoy Rosario
4 out of 5
Fully refundableReserve now, pay when you stay
  • 6 hours drive from Termas de Federacion
The price is $95 per night from Dec 24 to Dec 25
$95
includes taxes & fees
Dec 24 - Dec 25
Stay at this 4-star business-friendly hotel in Rosario. Enjoy free breakfast, free WiFi, and an outdoor pool. Popular attractions Centro de Expresiones Contemporaneas ...
Esplendor by Wyndham Savoy Rosario
InterTower Hotel
4 out of 5
Fully refundableReserve now, pay when you stay
  • 7 hours drive from Termas de Federacion
The price is $105 per night from Dec 24 to Dec 25
$105
includes taxes & fees
Dec 24 - Dec 25
Stay at this 4-star spa hotel in Santa Fe. Enjoy free breakfast, free WiFi, and a full-service spa. Popular attractions Museo Del Colegio De Medicos and Centro ...
InterTower Hotel
Dazzler by Wyndham Rosario
4 out of 5
Fully refundableReserve now, pay when you stay
  • 6 hours drive from Termas de Federacion
The price is $99 per night from Dec 24 to Dec 25
$99
includes taxes & fees
Dec 24 - Dec 25
Stay at this 4-star hotel in Rosario. Enjoy free breakfast, free WiFi, and room service. Our guests praise the property condition in our reviews. Popular attractions ...
Dazzler by Wyndham Rosario
Save an average of 15% on thousands of hotels when you're signed in
Agustín 1 Apart
4 out of 5
Fully refundableReserve now, pay when you stay
  • 7 hours drive from Termas de Federacion
The price is $41 per night from Dec 26 to Dec 27
$41
includes taxes & fees
Dec 26 - Dec 27
Stay at this 4-star aparthotel in Parana. Enjoy free WiFi, parking (surcharge), and onsite spa services. Popular attractions Parana Cathedral and Plaza de Mayo ...
Agustín 1 Apart
Puerto Norte Design Hotel
4 out of 5
Fully refundableReserve now, pay when you stay
  • 6 hours drive from Termas de Federacion
The price is $120 per night from Dec 25 to Dec 26
$120
includes taxes & fees
Dec 25 - Dec 26
Stay at this 4-star spa hotel in Rosario. Enjoy free breakfast, free WiFi, and a full-service spa. Popular attractions Alto Rosario Shopping Mall and Parque ...
Puerto Norte Design Hotel
Ros Tower Hotel
4 out of 5
  • 6 hours drive from Termas de Federacion
The price is $99 per night from Jan 1 to Jan 2
$99
includes taxes & fees
Jan 1 - Jan 2, 2025
Stay at this 4-star spa hotel in Rosario. Enjoy a full-service spa, 24-hour room service, and a steam room. Popular attractions Parque España Cultural Centre ...
Ros Tower Hotel
Pullman Rosario City Center Hotel
4 out of 5
Fully refundableReserve now, pay when you stay
  • 6 hours drive from Termas de Federacion
The price is $194 per night from Jan 1 to Jan 2
$194
includes taxes & fees
Jan 1 - Jan 2, 2025
Stay at this 4-star spa hotel in Rosario. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Casa De La Cultura and Museo Castagnino are ...
Pullman Rosario City Center Hotel
La Alondra Casa De Huéspedes
4 out of 5
  • 10 hours drive from Termas de Federacion
Stay at this 4-star boutique guesthouse in Corrientes. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Museo Historico De Vias Navegables ...
La Alondra Casa De Huéspedes
Hotel Parque
4 out of 5
  • 2 hours drive from Termas de Federacion
Stay at this 4-star aparthotel in Federal. Enjoy free WiFi, free parking, and a rooftop terrace.
Hotel Parque
HOTEL TERMAS VICTORIA Wellness Spa
4 out of 5
  • 6 hours drive from Termas de Federacion
Stay at this 4-star business-friendly hotel in Victoria. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Victoria del Agua Water Park ...
HOTEL TERMAS VICTORIA Wellness Spa
Hotel Solans Presidente
4 out of 5
Fully refundableReserve now, pay when you stay
  • 6 hours drive from Termas de Federacion
The price is $105 per night from Dec 24 to Dec 25
$105
includes taxes & fees
Dec 24 - Dec 25
Stay at this 4-star business-friendly hotel in Rosario. Enjoy free breakfast, free WiFi, and an outdoor pool. Popular attractions Pedestrian Cordoba Street and ...
Hotel Solans Presidente
Apart Club San Pedro
4.5 out of 5
  • 6 hours drive from Termas de Federacion
Stay at this 4.5-star luxury aparthotel in San Pedro. Enjoy free WiFi, a private beach, and a marina. Popular attractions ARA Irigoyen Vessel Museum and Belgrano ...
Apart Club San Pedro
Don't see what you're looking for?
See all available properties in Mesopotamia
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

4-star hotels in Mesopotamia

When you want to live it up, but not bust your bank account, then there’s nothing better than a 4-star hotel in Mesopotamia for your next trip. You’ll get all the amenities you can think of (and then some) at a rate within your means.

No fault in our stars

So what’s with the star rating anyway? Good question. The star rating has little to do with the price, and more to do with the amenities. 4-Star hotels in Mesopotamia as well as everywhere else, usually have all those thoughtful touches that make you go “Ooh,” “Ahh,” and ”YES!” Think amenities like luxury bedding, high-end electronics, concierge service, and restaurants that make eating in a gourmet experience.

Stars that shine

You know there are as many underground spots, inviting lounges, memory-making music venues as there are stars in the sky. But you’ll need the funds to check them all off. That’s why we give you the chance to take us up on the Hotwire Hot Rate. You can snag Mesopotamia 4-star hotels and still have plenty of leftover cash to paint the town whatever color you want. Filter hotels by:

  • Hotwire Hot Rate: We’ll snag you a crazy deal on a room by finding your hotel name after you book.
  • Price: You know that paying full price is for suckers? You can get a cheap 4-star hotel in Mesopotamia starting at $41 per night.
  • Amenities: What makes you flip for your trip? Full-service spa? Heated pool? 24-hour room service? Get a hotel that’ll send you over the moon.

Do you deserve a swanky hotel with a ton of amenities? Yes, yes you do. And you also deserve a sweet deal on it. Book with Hotwire today and get that star-studded Mesopotamia 4-star hotel and have plenty of cash left over to spend at that secret super star joint in the city.