Search for Cheap Deals on
Hotels in Piketon

Choose from 194 Piketon Hotel Deals

Comfort Inn Piketon near Fairgrounds

Comfort Inn Piketon near Fairgrounds

2.5 out of 5
7525 US 23 Piketon OH
  • 9 min drive from Portsmouth Gaseous Diffusion Plant
Book a stay at this business-friendly hotel in Piketon. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
Comfort Inn Piketon near Fairgrounds
Christopher Inn and Suites

Christopher Inn and Suites

2.5 out of 5
30 North Plaza Boulevard Chillicothe OH
  • 56 min drive from Portsmouth Gaseous Diffusion Plant
Book a stay at this business-friendly hotel in Chillicothe. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the pool in ...
Christopher Inn and Suites
Super 8 by Wyndham Portsmouth

Super 8 by Wyndham Portsmouth

2 out of 5
4266 US Route 23 N Portsmouth OH
  • 38 min drive from Portsmouth Gaseous Diffusion Plant
Book a stay at this business-friendly motel in Portsmouth. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7/10 Good! (819 reviews)
"Everything was amazing"

Reviewed on Nov 8, 2026

Super 8 by Wyndham Portsmouth
Days Inn by Wyndham Jackson

Days Inn by Wyndham Jackson

2 out of 5
972 E Main St. Jackson OH
  • 16 min drive from Portsmouth Gaseous Diffusion Plant
Book a stay at this business-friendly hotel in Jackson. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7.4/10 Good! (471 reviews)
"Small rooms, even smaller bathroom. No coffee pot in room, stained sheets, no toilet paper holder. I could go on. But you got the point."

Reviewed on Nov 8, 2026

Days Inn by Wyndham Jackson
Jungle House Luxury Stays - Downtown Chillicothe

Jungle House Luxury Stays - Downtown Chillicothe

5 out of 5
241 West Water Street Chillicothe OH
  • 54 min drive from Portsmouth Gaseous Diffusion Plant
Book a stay at this luxury apartment in Chillicothe. Enjoy free WiFi, free parking, and a 24-hour business center. Popular attractions Yoctangee Park and Majestic ...
9.6/10 Exceptional! (15 reviews)
"The property was very clean and spacious. We enjoyed our stay. The host was great at communicating with us and anticipated any possible questions we might have."

Reviewed on Sep 20, 2026

Jungle House Luxury Stays - Downtown Chillicothe
Best Western Adena Inn

Best Western Adena Inn

2.5 out of 5
1250 N Bridge Street Chillicothe OH
  • 58 min drive from Portsmouth Gaseous Diffusion Plant
Book a stay at this business-friendly hotel in Chillicothe. Enjoy free breakfast, free parking, and an outdoor pool. Our guests praise the helpful staff and ...
7.8/10 Good! (859 reviews)
"Breakfast was amazing both days!!! I loved the coffee!"

Reviewed on Nov 9, 2026

Best Western Adena Inn
Executive Inn

Executive Inn

2.5 out of 5
24 North Bridge Street Chillicothe OH
  • 54 min drive from Portsmouth Gaseous Diffusion Plant
Stay at this hotel in Chillicothe. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff and the clean rooms in our reviews. ...
Executive Inn
Quality Inn Chillicothe

Quality Inn Chillicothe

2.5 out of 5
20 N Plaza Blvd Chillicothe OH
  • 56 min drive from Portsmouth Gaseous Diffusion Plant
Book a stay at this business-friendly hotel in Chillicothe. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Pump House Center for the ...
Quality Inn Chillicothe
Holiday Inn Portsmouth Downtown by IHG

Holiday Inn Portsmouth Downtown by IHG

3 out of 5
711 2nd St Portsmouth OH
  • 47 min drive from Portsmouth Gaseous Diffusion Plant
Book a stay at this business-friendly hotel in Portsmouth. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff in our ...
Holiday Inn Portsmouth Downtown by IHG
Red Roof Inn Jackson, OH

Red Roof Inn Jackson, OH

2 out of 5
1000 Acy Ave Jackson OH
  • 17 min drive from Portsmouth Gaseous Diffusion Plant
Stay at this hotel in Jackson. Enjoy free WiFi, a fitness center, and a 24-hour front desk. Our guests praise the helpful staff and the clean rooms in our reviews. ...
Red Roof Inn Jackson, OH
Quality Inn Jackson

Quality Inn Jackson

2.5 out of 5
605 E Main St Jackson OH
  • 16 min drive from Portsmouth Gaseous Diffusion Plant
Book a stay at this business-friendly hotel in Jackson. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
Quality Inn Jackson
Quality Inn & Suites Portsmouth

Quality Inn & Suites Portsmouth

2.5 out of 5
5100 Old Scioto Trail Portsmouth OH
  • 37 min drive from Portsmouth Gaseous Diffusion Plant
Book a stay at this business-friendly hotel in Portsmouth. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
6.8/10 (636 reviews)
"Room was @ 61 degrees when first entered. The room is located very close to Highway 23 which was very loud and noisy, including the train tracks a few feet away with a train coming through every two hours. The shower continued to drip all the time, as well as the toilet continued to cycle flushing ..."

Reviewed on Nov 6, 2026

Quality Inn & Suites Portsmouth
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find cheap hotels in Piketon

You’re not an average traveler—and Hotwire knows it. Your wanderlust takes you off the beaten path to discover unique adventures and every travel destination’s lesser-known tourist scenes. Hotwire has the hookup! Book your Piketon hotel with Hotwire to complete your one-of-a-kind travel checklist.

For you, intrepid voyager, Hotwire has a large selection of the best hotels in Piketon.

Choosing the right hotel in Ohio has everything to do with the way you want your trip to go. If you’ve scribbled a few obscure destinations on your itinerary, you probably already have a good sense of how your getaway is taking shape. Lean into that by booking one of Piketon’s 194 hotels. Choose the one that best catches your trip’s tourist drift.

If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $78. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get great Piketon hotel deals at the last minute.

While traveling, where you stay plays a major role in your overall vacation enjoyment. Choosing the right hotel is just as important as making sure you book the right flight and car rental. If you’re traveling with family or friends, you may need to book a hotel with connecting rooms. If you enjoy an elegant and relaxing hotel ambiance, opt for one of Hotwire’s luxury hotels in Piketon. No matter your reason for visiting Piketon, with Hotwire’s large selection of hotels in the area, you’re sure to book a hotel that meets all your accommodation needs.

Frequently Asked Questions About Piketon hotels

Where can I find the best last-minute travel deals?

If you’re traveling in the spirit of spontaneity, you’ll love the idea of leaving your exact hotel choice up to chance. With Hotwire Hot Rates, you can unlock great deals on your next flight, hotel, or car rental. Just plug in your general preferences and let Hotwire choose last-minute hotel deals in Piketon for as low as $78.

How many hotels are there in Piketon?

With over 194 hotels in Piketon, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $78.

How to find cheap car rentals in Piketon?

Finding a cheap car rental deal in Piketon is as easy as scoring cheap hotels in Piketon. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can unlock great car rental deals if you book a Hotwire Hot Rate at the last minute.