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Río Sereno Vacation Packages

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Río Sereno Flight + Hotel Packages

Price found within the past 48 hours. Click for updated prices.
Hotel Casa Panamá

Hotel Casa Panamá

4 out of 5
Price was $1,301, price is now $981 per person
$981
per person
Dec 26 - Dec 31
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to Panama City (PTY)
Stay at this hotel in Panama City. Enjoy free WiFi, 2 restaurants, and a nightclub. Our guests praise the helpful staff in our reviews. Popular attractions Albrook Shopping Mall and Cinta Costera are located nearby.
Casa Panama Hotel has an excellent location in Casco Viejo, and the staff kindly held our luggage. However, the rooms are small, and the hotel shares an elevator with the restaurant upstairs. Overall, it was an okay stay for one night, with the location being the main highlight. The pool is on the roof in the middle of the restaurant. Wi-fi was very spotty.

Reviewed on Oct 29, 2026

Megapolis Hotel Panamá

Megapolis Hotel Panamá

4.5 out of 5
Price was $2,836, price is now $1,365 per person
$1,365
per person
Dec 26 - Dec 31
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to Panama City (PTY)
Book a stay at this luxury hotel in Panama City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. Popular attractions Albrook Shopping Mall and Avenida Balboa are located nearby.

Central Hotel Panama Casco Viejo

Central Hotel Panama Casco Viejo

4 out of 5
Price was $3,634, price is now $2,337 per person
$2,337
per person
Dec 26 - Dec 31
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to Panama City (PTY)
Book a stay at this spa hotel in Panama City. Enjoy free WiFi, a full-service spa, and 3 restaurants. Our guests praise the helpful staff and the clean rooms in our reviews. Popular attractions Albrook Shopping Mall and Cinta Costera are located nearby.

Hotel San Pedro de Taboga

Hotel San Pedro de Taboga

3 out of 5
Price was $1,460, price is now $1,014 per person
$1,014
per person
Jan 4 - Jan 11
found 8 hours ago
Roundtrip non-stop flight included
Phoenix (PHX) to Panama City (PTY)
Stay at this hotel in Taboga. Enjoy free breakfast, free WiFi, and daily housekeeping. Popular attraction Taboga Beach is located nearby.
Peronal muy amable y dispuestos ayudar en todo momento.

Reviewed on Sep 21, 2026

Casa Mallet by Wynwood House

Casa Mallet by Wynwood House

3.5 out of 5
Price was $4,470, price is now $3,152 per person
$3,152
per person
Dec 27 - Dec 31
found 6 hours ago
Roundtrip non-stop flight included
Charlotte (CLT) to Panama City (PTY)
Stay at this apartment in Panama City. Enjoy free WiFi, parking (surcharge), and premium bedding. Popular attractions Albrook Shopping Mall and Cinta Costera are located nearby.
I would highly recommend, the service I received was impeccable and just a wonderful experience! I was a bit hesitant regarding the location but once I got there, it turned out to be perfect. The concierge staff was such a pleasure to work with especially ‘Jerry’, who provided recommendations and information. This was such a blessing to us. I would stay here again in a heart beat. It’s a must stay!

Reviewed on Sep 16, 2026

Riande Aeropuerto Hotel & Casino

Riande Aeropuerto Hotel & Casino

4 out of 5
Price was $1,447, price is now $1,023 per person
$1,023
per person
Dec 26 - Dec 31
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to Panama City (PTY)
Book a stay at this family-friendly resort in Tocumen. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the pool in our reviews. Popular attractions Metromall Panama and Los Pueblos Commercial Center are located nearby.

Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

5 out of 5
Price was $1,507, price is now $1,123 per person
$1,123
per person
Dec 26 - Dec 31
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to Panama City (PTY)
Book a stay at this luxury hotel in Panama City. Enjoy free breakfast, free WiFi, and 3 restaurants. Our guests praise the breakfast and the pool in our reviews. Popular attractions Albrook Shopping Mall and Via Espana are located nearby.

Villa Caprichosa

Villa Caprichosa

2.5 out of 5
Price was $1,875, price is now $1,415 per person
$1,415
per person
Jan 4 - Jan 11
found 8 hours ago
Roundtrip non-stop flight included
Phoenix (PHX) to Panama City (PTY)
Book a stay at this beach hotel in Taboga. Enjoy free breakfast, free WiFi, and a free ferry terminal shuttle. Popular attraction Taboga Beach is located nearby.
Wonderful stay!

Reviewed on Oct 27, 2026

Río Sereno Vacation Packages 3-4 Night Stays

Price found within the past 48 hours. Click for updated prices.
Riande Aeropuerto Hotel & Casino

Riande Aeropuerto Hotel & Casino

4 out of 5
Tocumen Airport
Price was $1,383, price is now $928 per person
$928
per person
Dec 10 - Dec 14
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to Panama City (PTY)
Megapolis Hotel Panamá

Megapolis Hotel Panamá

4.5 out of 5
San Francisco
Price was $2,370, price is now $1,075 per person
$1,075
per person
Dec 10 - Dec 14
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to Panama City (PTY)
Central Hotel Panama Casco Viejo

Central Hotel Panama Casco Viejo

4 out of 5
Casco Viejo
Price was $1,915, price is now $1,227 per person
$1,227
per person
Dec 3 - Dec 6
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to Panama City (PTY)
Hyatt Regency Panama City

Hyatt Regency Panama City

5 out of 5
Bella Vista
Price was $1,581, price is now $1,112 per person
$1,112
per person
Dec 10 - Dec 14
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to Panama City (PTY)

Río Sereno Vacation Packages 5-7 Night Stays

Price found within the past 48 hours. Click for updated prices.
Hotel San Pedro de Taboga

Hotel San Pedro de Taboga

3 out of 5
Price was $1,460, price is now $1,014 per person
$1,014
per person
Jan 4 - Jan 11
found 8 hours ago
Roundtrip non-stop flight included
Phoenix (PHX) to Panama City (PTY)
Megapolis Hotel Panamá

Megapolis Hotel Panamá

4.5 out of 5
San Francisco
Price was $2,836, price is now $1,365 per person
$1,365
per person
Dec 26 - Dec 31
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to Panama City (PTY)
Central Hotel Panama Casco Viejo

Central Hotel Panama Casco Viejo

4 out of 5
Casco Viejo
Price was $3,634, price is now $2,337 per person
$2,337
per person
Dec 26 - Dec 31
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to Panama City (PTY)
La Concordia Boutique Hotel

La Concordia Boutique Hotel

4 out of 5
Casco Viejo
Price was $2,752, price is now $1,902 per person
$1,902
per person
Jan 4 - Jan 11
found 8 hours ago
Roundtrip non-stop flight included
Phoenix (PHX) to Panama City (PTY)

Top Flight Deals

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

Copa
Sat, Nov 21 - Wed, Nov 25
PTY
Tocumen Intl.
DAV
Enrique Malek Intl.
$91 Roundtrip, found 23 hours ago
$91
Roundtrip
found 23 hours ago
Select Copa flight, departing Sat, Nov 21 from Tocumen Intl. to Enrique Malek Intl., returning Wed, Nov 25, priced at $91 found 23 hours ago
Copa
Fri, Apr 2 - Fri, Apr 16
MIA
Miami Intl.
DAV
Enrique Malek Intl.
$492 Roundtrip, found 1 hour ago
$492
Roundtrip
found 1 hour ago
Select Copa flight, departing Fri, Apr 2 from Miami Intl. to Enrique Malek Intl., returning Fri, Apr 16, priced at $492 found 1 hour ago
Copa
Mon, Dec 14 - Thu, Jan 7
FLL
Fort Lauderdale - Hollywood Intl.
DAV
Enrique Malek Intl.
$568 Roundtrip, found 3 hours ago
$568
Roundtrip
found 3 hours ago
Select Copa flight, departing Mon, Dec 14 from Fort Lauderdale - Hollywood Intl. to Enrique Malek Intl., returning Thu, Jan 7, priced at $568 found 3 hours ago
Copa
Tue, Feb 16 - Mon, Feb 22
JFK
John F. Kennedy Intl.
DAV
Enrique Malek Intl.
$592 Roundtrip, found 2 hours ago
$592
Roundtrip
found 2 hours ago
Select Copa flight, departing Tue, Feb 16 from John F. Kennedy Intl. to Enrique Malek Intl., returning Mon, Feb 22, priced at $592 found 2 hours ago