Search Deals on
Río Sereno Vacation Packages

Build your package with 2 more options

Leaving from

Going to

Departing

Returning

Travelers

Room 1

Adults

ChildrenAges 2 to 17

InfantsYounger than 2

Add specific hotel dates

Río Sereno
Chiriquí Province
Panama
Mexico and Central America
Hotwire.com

Río Sereno Flight + Hotel Packages

Price found within the past 48 hours. Click for updated prices.

Hotel Riu Plaza Panama

5 out of 5

Price was $704, price is now $529 per person

$529

per person

Nov 8 - Nov 11

found 1 day ago

Roundtrip flight included

Atlanta (ATL) to Panama City (PTY)

Stay at this 5-star luxury hotel in Panama City. Enjoy free breakfast, free WiFi, and 3 restaurants. Our guests praise the breakfast and the pool in our reviews. Popular attractions Albrook Shopping Mall and Via Espana are located nearby.

Villa Marina Lodge & Condos

3.5 out of 5

Save 100% on your flight

Price was $1,120, price is now $641 per person

$641

per person

Dec 13 - Dec 21

found 1 day ago

Roundtrip flight included

Miami (MIA) to Panama City (PTY)

Stay at this 3.5-star beach inn in Las Escobas del Venado. Enjoy free WiFi, free parking, and a beach locale. Our guests praise the helpful staff in our reviews. Popular attraction Venao Beach is located nearby.

Central Hotel Panama Casco Viejo

4 out of 5

Save 100% on your flight

Price was $1,140, price is now $719 per person

$719

per person

Nov 8 - Nov 11

found 1 day ago

Roundtrip flight included

Atlanta (ATL) to Panama City (PTY)

Stay at this 4-star spa hotel in Panama City. Enjoy free WiFi, a full-service spa, and 3 restaurants. Our guests praise the helpful staff and the clean rooms in our reviews. Popular attractions Albrook Shopping Mall and Cinta Costera are located nearby.

Villa Botero By Casa Mojito B&B

3 out of 5

Price was $1,056, price is now $761 per person

$761

per person

Nov 6 - Nov 10

found 1 day ago

Roundtrip flight included

Atlanta (ATL) to Panama City (PTY)

Stay at this 3-star golf B&B in Rio Hato. Enjoy free WiFi, free parking, and breakfast (surcharge). Popular attractions Playa Blanca and Farallón Beach are located nearby.

Casa Mallet by Wynwood House

4 out of 5

Save 100% on your flight

Price was $1,360, price is now $985 per person

$985

per person

Dec 10 - Dec 14

found 1 day ago

Roundtrip flight included

Miami (MIA) to Panama City (PTY)

Stay at this 4-star apartment in Panama City. Enjoy free WiFi, parking (surcharge), and premium bedding. Popular attractions Albrook Shopping Mall and Cinta Costera are located nearby.

Pocri Country Resort

3 out of 5

Price was $935, price is now $700 per person

$700

per person

Dec 13 - Dec 21

found 1 day ago

Roundtrip flight included

Miami (MIA) to Panama City (PTY)

Stay at this 3-star hotel in Pocrí. Enjoy free breakfast, free WiFi, and free parking. Popular attraction Isla de Cañas is located nearby.

Summit Rainforest & Golf Resort

4 out of 5

Price was $990, price is now $761 per person

$761

per person

Dec 25 - Dec 30

found 1 day ago

Roundtrip flight included

Atlanta (ATL) to Panama City (PTY)

Stay at this 4-star golf hotel in Panama City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. Popular attractions Centenario Bridge and Summit Botanical Gardens & Zoo are located nearby.

Ciel y Miel

3 out of 5

Price was $2,566, price is now $1,991 per person

$1,991

per person

Dec 14 - Dec 21

found 19 hours ago

Roundtrip non-stop flight included

Atlanta (ATL) to Panama City (PTY)

Stay at this 3-star beach hotel in Cacique. Enjoy free breakfast, free WiFi, and free valet parking. Popular attractions Isla Mamey and Portobelo National Park are located nearby.