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Río Sereno Vacation Packages

Build your package with 2 more options

Río Sereno Flight + Hotel Packages

Price found within the past 48 hours. Click for updated prices.
Las Clementinas

Las Clementinas

3.5 out of 5
Price was $1,219, price is now $915 per person
$915
per person
Jan 4 - Jan 7
found 1 day ago
Roundtrip flight included
Miami (MIA) to Panama City (PTY)
Stay at this aparthotel in Panama City. Enjoy free WiFi, parking (surcharge), and an airport shuttle (surcharge). Popular attractions Albrook Shopping Mall and Cinta Costera are located nearby.

Megapolis Hotel Panamá

Megapolis Hotel Panamá

4.5 out of 5
Price was $3,443, price is now $1,645 per person
$1,645
per person
Dec 18 - Dec 24
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to Panama City (PTY)
Book a stay at this luxury hotel in Panama City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. Popular attractions Albrook Shopping Mall and Avenida Balboa are located nearby.
Thanks

Reviewed on Nov 3, 2026

Central Hotel Panama Casco Viejo

Central Hotel Panama Casco Viejo

4 out of 5
Price was $3,721, price is now $1,836 per person
$1,836
per person
Dec 18 - Dec 24
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to Panama City (PTY)
Book a stay at this spa hotel in Panama City. Enjoy free WiFi, a full-service spa, and 3 restaurants. Our guests praise the helpful staff and the clean rooms in our reviews. Popular attractions Albrook Shopping Mall and Cinta Costera are located nearby.
Ac worked great.

Reviewed on Nov 2, 2026

Casa Lefevre By Wynwood House

Casa Lefevre By Wynwood House

3 out of 5
Price was $1,754, price is now $1,174 per person
$1,174
per person
Dec 26 - Dec 30
found 1 day ago
Roundtrip flight included
Miami (MIA) to Panama City (PTY)
Stay at this apartment in Panama City. Enjoy free WiFi, cable TV channels, and premium bedding. Popular attractions Albrook Shopping Mall and Cinta Costera are located nearby.

Riande Aeropuerto Hotel & Casino

Riande Aeropuerto Hotel & Casino

4 out of 5
Price was $1,925, price is now $1,297 per person
$1,297
per person
Dec 18 - Dec 24
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to Panama City (PTY)
Book a stay at this family-friendly resort in Tocumen. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the pool in our reviews. Popular attractions Metromall Panama and Los Pueblos Commercial Center are located nearby.
Le personnel très gentil - mais pas d'eau chaude

Reviewed on Nov 2, 2026

Hyatt Regency Panama City

Hyatt Regency Panama City

5 out of 5
Price was $2,268, price is now $1,624 per person
$1,624
per person
Dec 18 - Dec 24
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to Panama City (PTY)
Book a stay at this luxury hotel in Panama City. Enjoy free WiFi, free valet parking, and 2 restaurants. Popular attractions Albrook Shopping Mall and Via Espana are located nearby.

Casa Mallet by Wynwood House

Casa Mallet by Wynwood House

3.5 out of 5
Price was $2,386, price is now $1,737 per person
$1,737
per person
Dec 24 - Dec 29
just found
Roundtrip flight included
Atlanta (ATL) to Panama City (PTY)
Stay at this apartment in Panama City. Enjoy free WiFi, parking (surcharge), and premium bedding. Popular attractions Albrook Shopping Mall and Cinta Costera are located nearby.
I would highly recommend, the service I received was impeccable and just a wonderful experience! I was a bit hesitant regarding the location but once I got there, it turned out to be perfect. The concierge staff was such a pleasure to work with especially ‘Jerry’, who provided recommendations and information. This was such a blessing to us. I would stay here again in a heart beat. It’s a must stay!

Reviewed on Sep 16, 2026

Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

5 out of 5
Price was $1,887, price is now $1,376 per person
$1,376
per person
Dec 18 - Dec 24
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to Panama City (PTY)
Book a stay at this luxury hotel in Panama City. Enjoy free breakfast, free WiFi, and 3 restaurants. Our guests praise the breakfast and the pool in our reviews. Popular attractions Albrook Shopping Mall and Via Espana are located nearby.
Breakfast is the best in the entire country! The gym is quite nice for a hotel. Beds are extremely comfortable. And the location is perfect: it is blocks away from Santuario Nacional de Panama which offers daily Mass and Adoration every day of the week. What more could one ask for???

Reviewed on Nov 3, 2026

Río Sereno Vacation Packages 3-4 Night Stays

Price found within the past 48 hours. Click for updated prices.
Casa Lefevre By Wynwood House

Casa Lefevre By Wynwood House

3 out of 5
Casco Viejo
Price was $1,754, price is now $1,174 per person
$1,174
per person
Dec 26 - Dec 30
found 1 day ago
Roundtrip flight included
Miami (MIA) to Panama City (PTY)
Central Hotel Panama Casco Viejo

Central Hotel Panama Casco Viejo

4 out of 5
Casco Viejo
Price was $2,764, price is now $1,515 per person
$1,515
per person
Dec 20 - Dec 24
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to Panama City (PTY)
Megapolis Hotel Panamá

Megapolis Hotel Panamá

4.5 out of 5
San Francisco
Price was $2,206, price is now $1,340 per person
$1,340
per person
Dec 20 - Dec 24
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to Panama City (PTY)
Casa Mallet by Wynwood House

Casa Mallet by Wynwood House

3.5 out of 5
Casco Viejo
Price was $3,918, price is now $2,538 per person
$2,538
per person
Dec 26 - Dec 30
found 1 day ago
Roundtrip flight included
Miami (MIA) to Panama City (PTY)

Río Sereno Vacation Packages 5-7 Night Stays

Price found within the past 48 hours. Click for updated prices.
Hotel Casa Panamá

Hotel Casa Panamá

4 out of 5
Casco Viejo
Price was $1,040, price is now $735 per person
$735
per person
Jan 17 - Jan 23
found 1 day ago
Roundtrip non-stop flight included
Miami (MIA) to Panama City (PTY)
Megapolis Hotel Panamá

Megapolis Hotel Panamá

4.5 out of 5
San Francisco
Price was $3,443, price is now $1,645 per person
$1,645
per person
Dec 18 - Dec 24
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to Panama City (PTY)
Central Hotel Panama Casco Viejo

Central Hotel Panama Casco Viejo

4 out of 5
Casco Viejo
Price was $3,721, price is now $1,836 per person
$1,836
per person
Dec 18 - Dec 24
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to Panama City (PTY)
Riande Aeropuerto Hotel & Casino

Riande Aeropuerto Hotel & Casino

4 out of 5
Tocumen Airport
Price was $1,925, price is now $1,297 per person
$1,297
per person
Dec 18 - Dec 24
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to Panama City (PTY)

Top Flight Deals

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

Copa
Sat, Nov 21 - Wed, Nov 25
PTY
Tocumen Intl.
DAV
Enrique Malek Intl.
$91 Roundtrip, found 2 days ago
$91
Roundtrip
found 2 days ago
Select Copa flight, departing Sat, Nov 21 from Tocumen Intl. to Enrique Malek Intl., returning Wed, Nov 25, priced at $91 found 2 days ago
Copa
Thu, Dec 10 - Thu, Jan 7
FLL
Fort Lauderdale - Hollywood Intl.
DAV
Enrique Malek Intl.
$568 Roundtrip, found 18 hours ago
$568
Roundtrip
found 18 hours ago
Select Copa flight, departing Thu, Dec 10 from Fort Lauderdale - Hollywood Intl. to Enrique Malek Intl., returning Thu, Jan 7, priced at $568 found 18 hours ago
Copa
Sun, Jan 3 - Thu, Jan 14
MIA
Miami Intl.
DAV
Enrique Malek Intl.
$580 Roundtrip, found 17 hours ago
$580
Roundtrip
found 17 hours ago
Select Copa flight, departing Sun, Jan 3 from Miami Intl. to Enrique Malek Intl., returning Thu, Jan 14, priced at $580 found 17 hours ago
Copa
Tue, Feb 16 - Mon, Feb 22
JFK
John F. Kennedy Intl.
DAV
Enrique Malek Intl.
$632 Roundtrip, found 2 hours ago
$632
Roundtrip
found 2 hours ago
Select Copa flight, departing Tue, Feb 16 from John F. Kennedy Intl. to Enrique Malek Intl., returning Mon, Feb 22, priced at $632 found 2 hours ago