Search for Cheap Deals on
Hotels in Santa Cruz

Photo by Vivian Rennó

Check Last Minute Santa Cruz Hotel Deals

Tonight Sep 28 - Sep 29Next weekend Oct 4 - Oct 6

Choose from 60 Santa Cruz Hotel Deals

Santa Cruz Plaza
Santa Cruz Plaza
4 out of 5
Plaza De Armas 286, Santa Cruz, O'Higgins
  • 15 min drive from Lapostolle Clos Apalta Winery
The price is $120 per night from Sep 29 to Sep 30
$120
includes taxes & fees
Sep 29 - Sep 30
Stay at this 4-star spa hotel in Santa Cruz. Enjoy free WiFi, free parking, and a full-service spa. Our guests praise the helpful staff in our reviews. Popular ...
8.6/10 Excellent! (281 reviews)
Beautiful property, incredible service
"Wow! We had a fantastic time at the Santa Cruz Plaza hotel. From the moment we arrived, the staff was extremely attentive and helpful. The property is beautiful, restaurant delicious, and it’s very conveniently located. Parking was easy and secure, too. A big thanks to the hotel staff for going above-and-beyond. ..."

Reviewed on Jun 17, 2024

Santa Cruz Plaza
Hotel Cava Colchagua
Hotel Cava Colchagua
2.5 out of 5
Barreales´s Way, 3km from Santa Cruz Square, Santa Cruz, O'Higgins
  • 14 min drive from Lapostolle Clos Apalta Winery
The price is $164 per night from Oct 1 to Oct 2
$164
includes taxes & fees
Oct 1 - Oct 2
Book a stay at this spa hotel in Santa Cruz. Enjoy free breakfast, a full-service spa, and an attached winery. Popular attractions Laura Hartwig Winery and Casino ...
8.8/10 Excellent! (125 reviews)
"Interesting and beautiful place to stay. Barrel rooms are comfortable. Staff are very pleasant and accomodating. Food at the restaurant was fantastic. Shower was not the best."

Reviewed on Sep 19, 2024

Hotel Cava Colchagua
La Perla Hotel
La Perla Hotel
3.5 out of 5
El Rosal, Parcela 4, Lote A, Capellanía, Santa Cruz, O'Higgins
  • 12 min drive from Lapostolle Clos Apalta Winery
The price is $109 per night from Sep 30 to Oct 1
$109
includes taxes & fees
Sep 30 - Oct 1
Stay at this 3.5-star business-friendly hotel in Santa Cruz. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Museo de Colchagua and Plaza ...
9.2/10 Wonderful! (79 reviews)
"The staff here is all exceptionally friendly and keep the hotel very clean. The breakfast offerings are delicious and plentiful. The beds are comfortable and there is a variety of pillows from which to choose. I highly recommend, and if you go, please say hello to the owners, Lorena and Piero."

Reviewed on Mar 25, 2024

La Perla Hotel
TerraViña
TerraViña
3 out of 5
Camino Los Boldos S/n, Santa Cruz, O'Higgins
  • 15 min drive from Lapostolle Clos Apalta Winery
The price is $160 per night from Oct 16 to Oct 17
$160
includes taxes & fees
Oct 16 - Oct 17
Stay at this 3-star business-friendly hotel in Santa Cruz. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Laura Hartwig Winery and Plaza ...
9.2/10 Wonderful! (181 reviews)
"Pretty"

Reviewed on Jun 19, 2024

TerraViña
Hotel Boutique Vendimia Premium
Hotel Boutique Vendimia Premium
3.5 out of 5
Ismael Valdes 92, Santa Cruz, O'Higgins
  • 13 min drive from Lapostolle Clos Apalta Winery
The price is $92 per night from Sep 29 to Sep 30
$92
includes taxes & fees
Sep 29 - Sep 30
Stay at this 3.5-star business-friendly hotel in Santa Cruz. Enjoy free WiFi, free parking, and an outdoor pool. Popular attractions Museo de Colchagua and Plaza ...
9/10 Wonderful! (127 reviews)
"Very nice boutique hotel beautiful antiques, a little ways from main square but good location"

Reviewed on Mar 24, 2024

Hotel Boutique Vendimia Premium
Hotel Vendimia Parador
Hotel Vendimia Parador
3 out of 5
Camino Los Boldos SN, Santa Cruz, O'Higgins
  • 16 min drive from Lapostolle Clos Apalta Winery
The price is $90 per night from Sep 29 to Sep 30
$90
includes taxes & fees
Sep 29 - Sep 30
Stay at this 3-star hotel in Santa Cruz. Enjoy free WiFi, free parking, and free grocery shopping service. Our guests praise the helpful staff in our reviews. ...
9.4/10 Exceptional! (60 reviews)
"Excellent stay. Bed and breakfast feel. Manager Mauricio are wonderful!"

Reviewed on May 2, 2024

Hotel Vendimia Parador
Hotel Boutique Solaz Bella Vista de Colchagua
Hotel Boutique Solaz Bella Vista de Colchagua
3 out of 5
San Pedro de Callihue Lote 5 J, Santa Cruz, O'Higgins
  • 29 min drive from Lapostolle Clos Apalta Winery
The price is $98 per night from Sep 29 to Sep 30
$98
includes taxes & fees
Sep 29 - Sep 30
Stay at this 3-star spa hotel in Santa Cruz. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Laura Hartwig Winery and Plaza de Armas are ...
9.2/10 Wonderful! (92 reviews)
"."

Reviewed on Feb 7, 2024

Hotel Boutique Solaz Bella Vista de Colchagua
Casa Calfu
Casa Calfu
3 out of 5
21 de Mayo 552, Santa Cruz, OHiggins
  • 16 min drive from Lapostolle Clos Apalta Winery
The price is $83 per night from Sep 29 to Sep 30
$83
includes taxes & fees
Sep 29 - Sep 30
Stay at this 3-star B&B in Santa Cruz. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Plaza de Armas and Museo de Colchagua are located ...
9.8/10 Exceptional! (49 reviews)
"Lovely grounds, well appointed room, wonderful staff, lovely pool and abundant breakfast."

Reviewed on Feb 19, 2024

Casa Calfu
El Refugio de Santa Cruz
El Refugio de Santa Cruz
3 out of 5
La Pataguilla S/N, parcela 60, lote28, Santa Cruz, Colchagua
  • 18 min drive from Lapostolle Clos Apalta Winery
The price is $55 per night from Sep 29 to Sep 30
$55
includes taxes & fees
Sep 29 - Sep 30
Stay at this 3-star B&B in Santa Cruz. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Plaza de Armas and Museo de Colchagua are located ...
El Refugio de Santa Cruz
Callihue de Colchagua Lodge
Callihue de Colchagua Lodge
3 out of 5
San Pedro de Callihue lote 15, Camino Lolol, Santa Cruz
  • 30 min drive from Lapostolle Clos Apalta Winery
Stay at this 3-star guesthouse in Santa Cruz. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Laura Hartwig Winery and Plaza de Armas ...
Callihue de Colchagua Lodge
Hostal Vida 2000
Hostal Vida 2000
2.5 out of 5
Ismael Valdes 245, Santa Cruz
  • 13 min drive from Lapostolle Clos Apalta Winery
Book a stay at this spa B&B in Santa Cruz. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Museo de Colchagua and Plaza de Armas are located ...
5.4/10 (3 reviews)
"Simple clean place with wonderful hosts that were very accommodating. Breakfast was set up beautifully with plenty of food."

Reviewed on Aug 7, 2023

Hostal Vida 2000
Hostal Gomero
Hostal Gomero
3 out of 5
Pasaje Sausal 327, Poblacion Endesa,, Santa Cruz, Santa Cruz
  • 14 min drive from Lapostolle Clos Apalta Winery
The price is $90 per night from Sep 29 to Sep 30
$90
includes taxes & fees
Sep 29 - Sep 30
Stay at this 3-star hostal in Santa Cruz. Enjoy free breakfast, free WiFi, and a 24-hour front desk. Popular attractions Museo de Colchagua and Plaza de Armas ...
Hostal Gomero
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

HOTW-Hotel-Deals-726-959@2x.jpg (1918×258)*Savings based on Hot Rate® hotel bookings as compared with the lowest published rates found on leading retail travel sites. Hot Rates are different from retail rates. With Hot Rates you enter the date, location and star rating. Hotel revealed only after booking. All bookings final.

Find cheap hotels in Santa Cruz

You’re not an average traveler—and Hotwire knows it. Your wanderlust takes you off the beaten path to discover unique adventures and every travel destination’s lesser-known tourist scenes. Hotwire has the hookup! Book your Santa Cruz hotel with Hotwire to complete your one-of-a-kind travel checklist.

For you, intrepid voyager, Hotwire has a large selection of the best hotels in Santa Cruz.

Choosing the right hotel in O'Higgins Region has everything to do with the way you want your trip to go. If you’ve scribbled a few obscure destinations on your itinerary, you probably already have a good sense of how your getaway is taking shape. Lean into that by booking one of Santa Cruz’s 60 hotels. Choose the one that best catches your trip’s tourist drift.

If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $55. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get up to 60% Santa Cruz hotel deals at the last minute.

While traveling, where you stay plays a major role in your overall vacation enjoyment. Choosing the right hotel is just as important as making sure you book the right flight and car rental. If you’re traveling with family or friends, you may need to book a hotel with connecting rooms. If you enjoy an elegant and relaxing hotel ambiance, opt for one of Hotwire’s luxury hotels in Santa Cruz. No matter your reason for visiting Santa Cruz, with Hotwire’s large selection of hotels in the area, you’re sure to book a hotel that meets all your accommodation needs.

Frequently Asked Questions About Santa Cruz hotels

Where can I find the best last-minute travel deals?

If you’re traveling in the spirit of spontaneity, you’ll love the idea of leaving your exact hotel choice up to chance. With Hotwire Hot Rates, you can save up to 60% off your next flight, hotel, or car rental. Just plug in your general preferences and let Hotwire choose last-minute hotel deals in Santa Cruz for as low as $55.

How many hotels are there in Santa Cruz?

With over 60 hotels in Santa Cruz, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $55.

How to find cheap car rentals in Santa Cruz?

Finding a cheap car rental deal in Santa Cruz is as easy as scoring cheap hotels in Santa Cruz. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can even save up to 60% off a car rental deal if you book a Hotwire Hot Rate at the last minute.

Is it safe to travel to Santa Cruz now?

With recent COVID-19 closures and reopenings, many people are wondering, “Is it safe to travel to Santa Cruz right now?” When it’s time to book your getaway, be sure to check out the most up-to-date information on all safety measures, any restrictions, and guidance on traveling during the coronavirus pandemic.