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Hotels in Santa Cruz

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Check Last Minute Santa Cruz Hotel Deals

Tonight Nov 23 - Nov 24Next weekend Nov 29 - Dec 1

Choose from 61 Santa Cruz Hotel Deals

Santa Cruz Plaza
Santa Cruz Plaza
4 out of 5
Plaza De Armas 286, Santa Cruz, O'Higgins
  • 15 min drive from Lapostolle Clos Apalta Winery
The price is $136 per night from Nov 24 to Nov 25
$136
includes taxes & fees
Nov 24 - Nov 25
Stay at this 4-star spa hotel in Santa Cruz. Enjoy free WiFi, free parking, and a full-service spa. Our guests praise the helpful staff in our reviews. Popular ...
8.6/10 Excellent! (287 reviews)
Beautiful property, incredible service
"Wow! We had a fantastic time at the Santa Cruz Plaza hotel. From the moment we arrived, the staff was extremely attentive and helpful. The property is beautiful, restaurant delicious, and it’s very conveniently located. Parking was easy and secure, too. A big thanks to the hotel staff for going above-and-beyond. ..."

Reviewed on Jun 17, 2024

Santa Cruz Plaza
Hotel Cava Colchagua
Hotel Cava Colchagua
4 out of 5
Barreales´s Way, 3km from Santa Cruz Square, Santa Cruz, O'Higgins
  • 14 min drive from Lapostolle Clos Apalta Winery
The price is $142 per night from Nov 24 to Nov 25
$142
includes taxes & fees
Nov 24 - Nov 25
Stay at this 4-star spa hotel in Santa Cruz. Enjoy free breakfast, a full-service spa, and an attached winery. Popular attractions Laura Hartwig Winery and Casino ...
8.8/10 Excellent! (132 reviews)
"OMG! This hotel was beyond my expectations. The grounds are beautiful, peaceful and relaxing. The rooms are perfect, I mean sleeping in an old wine barrel with a view of the vineyard - nothing tops that! The restaurant has a sumptuous breakfast and tasty lunch and dinner menu. Above all, their service ..."

Reviewed on Oct 29, 2024

Hotel Cava Colchagua
Hotel Vendimia Parador
Hotel Vendimia Parador
3 out of 5
Camino Los Boldos SN, Santa Cruz, O'Higgins
  • 16 min drive from Lapostolle Clos Apalta Winery
The price is $126 per night from Dec 24 to Dec 25
$126
includes taxes & fees
Dec 24 - Dec 25
Stay at this 3-star hotel in Santa Cruz. Enjoy free WiFi, free parking, and free grocery shopping service. Our guests praise the helpful staff in our reviews. ...
9.4/10 Exceptional! (65 reviews)
Nice stay in a Quirky hotel.
"An interesting stay in a characterful building with beautiful garden and relaxing space to sit outside and enjoy a nice wine, produced by the owner, Mauricio. Breakfast is clearly a thing set in a very well dressed room. It is a cold buffet with plenty of fresh ingredients."

Reviewed on Nov 13, 2024

Hotel Vendimia Parador
TerraViña
TerraViña
3 out of 5
Camino Los Boldos S/n, Santa Cruz, O'Higgins
  • 15 min drive from Lapostolle Clos Apalta Winery
The price is $180 per night from Nov 24 to Nov 25
$180
includes taxes & fees
Nov 24 - Nov 25
Stay at this 3-star business-friendly hotel in Santa Cruz. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Laura Hartwig Winery and Plaza ...
9.2/10 Wonderful! (185 reviews)
"Situated in the middle of wineries, away from the hustle bustle - TerraVina is a beautiful property with rooms with a balcony facing the Andes. There is a terrific winery just a 5 to 8 minute walk and three restaurants within 5 minutes, one located directly within the property."

Reviewed on Nov 18, 2024

TerraViña
Casa Calfu
Casa Calfu
3 out of 5
21 de Mayo 552, Santa Cruz, OHiggins
  • 16 min drive from Lapostolle Clos Apalta Winery
Stay at this 3-star B&B in Santa Cruz. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Plaza de Armas and Museo de Colchagua are located ...
9.8/10 Exceptional! (49 reviews)
"Lovely grounds, well appointed room, wonderful staff, lovely pool and abundant breakfast."

Reviewed on Feb 19, 2024

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Casa Calfu
La Perla Hotel
La Perla Hotel
3.5 out of 5
El Rosal, Parcela 4, Lote A, Capellanía, Santa Cruz, O'Higgins
  • 12 min drive from Lapostolle Clos Apalta Winery
The price is $98 per night from Nov 25 to Nov 26
$98
includes taxes & fees
Nov 25 - Nov 26
Stay at this 3.5-star business-friendly hotel in Santa Cruz. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Museo de Colchagua and Plaza ...
9.2/10 Wonderful! (82 reviews)
"Friendly staff, Quiet and Safe. Clean rooms. Hot tub and pool not available when we were there (spring time)."

Reviewed on Oct 24, 2024

La Perla Hotel
Hotel Boutique Vendimia Premium
Hotel Boutique Vendimia Premium
3.5 out of 5
Ismael Valdes 92, Santa Cruz, O'Higgins
  • 13 min drive from Lapostolle Clos Apalta Winery
The price is $122 per night from Dec 20 to Dec 21
$122
includes taxes & fees
Dec 20 - Dec 21
Stay at this 3.5-star business-friendly hotel in Santa Cruz. Enjoy free WiFi, free parking, and an outdoor pool. Popular attractions Museo de Colchagua and Plaza ...
9/10 Wonderful! (130 reviews)
Quirky but nice
"Good location. Antiques everywhere. Helpful staff. Nice to stay somewhere different."

Reviewed on Oct 5, 2024

Hotel Boutique Vendimia Premium
Hotel Boutique Solaz Bella Vista de Colchagua
Hotel Boutique Solaz Bella Vista de Colchagua
3 out of 5
San Pedro de Callihue Lote 5 J, Santa Cruz, O'Higgins
  • 29 min drive from Lapostolle Clos Apalta Winery
The price is $101 per night from Nov 25 to Nov 26
$101
includes taxes & fees
Nov 25 - Nov 26
Stay at this 3-star spa hotel in Santa Cruz. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Laura Hartwig Winery and Plaza de Armas are ...
9.2/10 Wonderful! (93 reviews)
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Reviewed on Feb 7, 2024

Hotel Boutique Solaz Bella Vista de Colchagua
Callihue de Colchagua Lodge
Callihue de Colchagua Lodge
3 out of 5
San Pedro de Callihue lote 15, Camino Lolol, Santa Cruz
  • 30 min drive from Lapostolle Clos Apalta Winery
Stay at this 3-star guesthouse in Santa Cruz. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Laura Hartwig Winery and Plaza de Armas ...
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Callihue de Colchagua Lodge
Hostal Vida 2000
Hostal Vida 2000
2.5 out of 5
Ismael Valdes 245, Santa Cruz
  • 13 min drive from Lapostolle Clos Apalta Winery
Book a stay at this spa B&B in Santa Cruz. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Museo de Colchagua and Plaza de Armas are located ...
5.4/10 (3 reviews)
"Simple clean place with wonderful hosts that were very accommodating. Breakfast was set up beautifully with plenty of food."

Reviewed on Aug 7, 2023

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Hostal Vida 2000
Hostal Gomero
Hostal Gomero
3 out of 5
Pasaje Sausal 327, Poblacion Endesa,, Santa Cruz, Santa Cruz
  • 14 min drive from Lapostolle Clos Apalta Winery
Stay at this 3-star hostal in Santa Cruz. Enjoy free breakfast, free WiFi, and a 24-hour front desk. Popular attractions Museo de Colchagua and Plaza de Armas ...
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Hostal Gomero
El Refugio de Santa Cruz
El Refugio de Santa Cruz
3 out of 5
La Pataguilla S/N, parcela 60, lote28, Santa Cruz, Colchagua
  • 18 min drive from Lapostolle Clos Apalta Winery
Stay at this 3-star B&B in Santa Cruz. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Plaza de Armas and Museo de Colchagua are located ...
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El Refugio de Santa Cruz
See all 61 properties in Santa Cruz
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find cheap hotels in Santa Cruz

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For you, intrepid voyager, Hotwire has a large selection of the best hotels in Santa Cruz.

Choosing the right hotel in O'Higgins Region has everything to do with the way you want your trip to go. If you’ve scribbled a few obscure destinations on your itinerary, you probably already have a good sense of how your getaway is taking shape. Lean into that by booking one of Santa Cruz’s 61 hotels. Choose the one that best catches your trip’s tourist drift.

If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $98. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get up to 60% Santa Cruz hotel deals at the last minute.

While traveling, where you stay plays a major role in your overall vacation enjoyment. Choosing the right hotel is just as important as making sure you book the right flight and car rental. If you’re traveling with family or friends, you may need to book a hotel with connecting rooms. If you enjoy an elegant and relaxing hotel ambiance, opt for one of Hotwire’s luxury hotels in Santa Cruz. No matter your reason for visiting Santa Cruz, with Hotwire’s large selection of hotels in the area, you’re sure to book a hotel that meets all your accommodation needs.

Frequently Asked Questions About Santa Cruz hotels

Where can I find the best last-minute travel deals?

If you’re traveling in the spirit of spontaneity, you’ll love the idea of leaving your exact hotel choice up to chance. With Hotwire Hot Rates, you can save up to 60% off your next flight, hotel, or car rental. Just plug in your general preferences and let Hotwire choose last-minute hotel deals in Santa Cruz for as low as $98.

How many hotels are there in Santa Cruz?

With over 61 hotels in Santa Cruz, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $98.

How to find cheap car rentals in Santa Cruz?

Finding a cheap car rental deal in Santa Cruz is as easy as scoring cheap hotels in Santa Cruz. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can even save up to 60% off a car rental deal if you book a Hotwire Hot Rate at the last minute.

Is it safe to travel to Santa Cruz now?

With recent COVID-19 closures and reopenings, many people are wondering, “Is it safe to travel to Santa Cruz right now?” When it’s time to book your getaway, be sure to check out the most up-to-date information on all safety measures, any restrictions, and guidance on traveling during the coronavirus pandemic.