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Santo Domingo Vacation Packages

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Santo Domingo
Los Santos
Panama
Mexico and Central America
Hotwire.com

Santo Domingo Flight + Hotel Packages

Price found within the past 48 hours. Click for updated prices.

Riande Aeropuerto Hotel & Casino

4 out of 5

Price was $1,063, price is now $812 per person

$812

per person

Nov 26 - Nov 29

found 1 day ago

Roundtrip non-stop flight included

Atlanta (ATL) to Panama City (PTY)

Book a stay at this family-friendly resort in Tocumen. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the pool in our reviews. Popular attractions Metromall Panama and Los Pueblos Commercial Center are located nearby.

Central Hotel Panama Casco Viejo

4 out of 5

Save 100% on your flight

Price was $2,499, price is now $1,379 per person

$1,379

per person

Nov 25 - Nov 30

found 1 day ago

Roundtrip flight included

Atlanta (ATL) to Panama City (PTY)

Book a stay at this spa hotel in Panama City. Enjoy free WiFi, a full-service spa, and 3 restaurants. Our guests praise the helpful staff and the clean rooms in our reviews. Popular attractions Albrook Shopping Mall and Cinta Costera are located nearby.

It was a wonderful experience!

Reviewed on Oct 11, 2026

Megapolis Hotel Panamá

4.5 out of 5

Price was $1,414, price is now $905 per person

$905

per person

Nov 26 - Nov 29

found 1 day ago

Roundtrip non-stop flight included

Atlanta (ATL) to Panama City (PTY)

Book a stay at this luxury hotel in Panama City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. Popular attractions Albrook Shopping Mall and Avenida Balboa are located nearby.

Great

Reviewed on Oct 12, 2026

Casa Mallet by Wynwood House

3.5 out of 5

Price was $1,893, price is now $1,343 per person

$1,343

per person

Nov 29 - Dec 6

found 1 day ago

Roundtrip flight included

Miami (MIA) to Panama City (PTY)

Stay at this apartment in Panama City. Enjoy free WiFi, parking (surcharge), and premium bedding. Popular attractions Albrook Shopping Mall and Cinta Costera are located nearby.

I would highly recommend, the service I received was impeccable and just a wonderful experience! I was a bit hesitant regarding the location but once I got there, it turned out to be perfect. The concierge staff was such a pleasure to work with especially ‘Jerry’, who provided recommendations and information. This was such a blessing to us. I would stay here again in a heart beat. It’s a must stay!

Reviewed on Sep 16, 2026

Casa Lefevre By Wynwood House

3 out of 5

Price was $1,603, price is now $1,182 per person

$1,182

per person

Nov 29 - Dec 6

found 1 day ago

Roundtrip flight included

Miami (MIA) to Panama City (PTY)

Stay at this apartment in Panama City. Enjoy free WiFi, cable TV channels, and premium bedding. Popular attractions Albrook Shopping Mall and Cinta Costera are located nearby.

Villa Caprichosa

2.5 out of 5

Price was $1,770, price is now $1,350 per person

$1,350

per person

Nov 12 - Nov 18

just found

Roundtrip flight included

Newark Liberty Intl. Airport (EWR) to Panama City (PTY)

Book a stay at this beach hotel in Taboga. Enjoy free breakfast, free WiFi, and a free ferry terminal shuttle. Popular attraction Taboga Beach is located nearby.

Surfside Beachfront Suites by Playa Caracol Resorts

3.5 out of 5

Price was $1,595, price is now $1,228 per person

$1,228

per person

Dec 26 - Dec 30

found 14 hours ago

Roundtrip flight included

Atlanta (ATL) to Panama City (PTY)

Stay at this apartment in Punta Chame. Enjoy free WiFi, free parking, and 2 outdoor pools.

Yoo by Wynwood House

4 out of 5

Price was $1,509, price is now $1,176 per person

$1,176

per person

Nov 29 - Dec 6

found 1 day ago

Roundtrip flight included

Miami (MIA) to Panama City (PTY)

Stay at this condo in Panama City. Enjoy free WiFi, a fitness center, and a 24-hour front desk. Popular attractions Albrook Shopping Mall and Cinta Costera are located nearby.

Unfortunately the name of the property was not Yoo by Wynwood. It is P. H. Yoo Panama & Arts Tower. This detail that was incorrect cost us time, money and stress at the beginning of our trip. We weren't able to get in touch with anyone at the property or at expedia and we ended up having to cross reference google photos to figure out the correct name and address of the location. This took us about an hour to do in a Country that we had never been to. We are very displeased with Expedia about this. We still have not been contacted by anyone.

Reviewed on Jul 26, 2025