Search Deals on
Santo Domingo Vacation Packages

Build your package with 2 more options

Leaving from

Going to

Departing

Returning

Travelers

Room 1

Adults

ChildrenAges 2 to 17

InfantsYounger than 2

Add specific hotel dates

Santo Domingo
Los Santos
Panama
Mexico and Central America
Hotwire.com

Santo Domingo Flight + Hotel Packages

Price found within the past 48 hours. Click for updated prices.

Mahogany Suites

2 out of 5

Price was $782, price is now $552 per person

$552

per person

Dec 11 - Dec 15

found 1 day ago

Roundtrip non-stop flight included

Atlanta (ATL) to Panama City (PTY)

Stay at this hotel in Arraijan. Enjoy free WiFi and an outdoor pool. Popular attractions Albrook Shopping Mall and Amador Causeway are located nearby.

Central Hotel Bocas del Toro

3 out of 5

Save 100% on your flight

Price was $3,119, price is now $1,780 per person

$1,780

per person

Dec 23 - Dec 28

found 1 day ago

Roundtrip flight included

New York (JFK) to Panama City (PTY)

Stay at this 3-star hotel in Bocas del Toro. Enjoy free breakfast, free WiFi, and a marina. Popular attractions Bolivar Park and Bocas del Toro Ferry Terminal are located nearby.

Central Hotel Panama Casco Viejo

4 out of 5

Save 100% on your flight

Price was $1,997, price is now $1,202 per person

$1,202

per person

Dec 24 - Dec 29

found 1 day ago

Roundtrip non-stop flight included

Atlanta (ATL) to Panama City (PTY)

Stay at this 4-star spa hotel in Panama City. Enjoy free WiFi, a full-service spa, and 3 restaurants. Our guests praise the helpful staff and the clean rooms in our reviews. Popular attractions Albrook Shopping Mall and Cinta Costera are located nearby.

Villa Marina Lodge & Condos

3.5 out of 5

Save 100% on your flight

Price was $1,062, price is now $689 per person

$689

per person

Dec 13 - Dec 21

found 1 day ago

Roundtrip flight included

Miami (MIA) to Panama City (PTY)

Stay at this 3.5-star beach inn in Las Escobas del Venado. Enjoy free WiFi, free parking, and a beach locale. Our guests praise the helpful staff in our reviews. Popular attraction Venao Beach is located nearby.

Punta Caracol Acqua Lodge

3.5 out of 5

Save 100% on your flight

Price was $960, price is now $641 per person

$641

per person

Dec 13 - Dec 21

found 1 day ago

Roundtrip flight included

Miami (MIA) to Panama City (PTY)

Stay at this 3.5-star beach lodge in Bocas del Toro. Enjoy free WiFi, breakfast (surcharge), and room service. Popular attractions La Gruta Cave and Institute for Tropical Ecology & Conservation - Bocas del Toro Biological Station are located nearby.

Hotel Riu Plaza Panama

5 out of 5

Price was $910, price is now $635 per person

$635

per person

Nov 20 - Nov 25

found 1 day ago

Roundtrip flight included

Atlanta (ATL) to Panama City (PTY)

Stay at this 5-star luxury hotel in Panama City. Enjoy free breakfast, free WiFi, and 3 restaurants. Our guests praise the breakfast and the pool in our reviews. Popular attractions Albrook Shopping Mall and Via Espana are located nearby.

Casa Mallet by Wynwood House

4 out of 5

Save 100% on your flight

Price was $2,350, price is now $1,639 per person

$1,639

per person

Dec 24 - Dec 29

found 1 day ago

Roundtrip non-stop flight included

Atlanta (ATL) to Panama City (PTY)

Stay at this 4-star apartment in Panama City. Enjoy free WiFi, parking (surcharge), and premium bedding. Popular attractions Albrook Shopping Mall and Cinta Costera are located nearby.

MARINN PLACE Financial District

3.5 out of 5

Price was $939, price is now $675 per person

$675

per person

Nov 20 - Nov 25

found 1 day ago

Roundtrip flight included

Atlanta (ATL) to Panama City (PTY)

Stay at this 3.5-star business-friendly hotel in Panama City. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Albrook Shopping Mall and Via Espana are located nearby.