Search Deals on
Santo Domingo Vacation Packages

Build your package with 2 more options

Leaving from

Going to

Departing

Returning

Travelers

Room 1

Adults

ChildrenAges 2 to 17

InfantsYounger than 2

Add specific hotel dates

Santo Domingo
Los Santos
Panama
Mexico and Central America
Hotwire.com

Santo Domingo Flight + Hotel Packages

Price found within the past 48 hours. Click for updated prices.

Hotel Riu Plaza Panama

5 out of 5

Price was $795, price is now $562 per person

$562

per person

Nov 20 - Nov 24

found 1 day ago

Roundtrip flight included

Atlanta (ATL) to Panama City (PTY)

Stay at this 5-star luxury hotel in Panama City. Enjoy free breakfast, free WiFi, and 3 restaurants. Our guests praise the breakfast and the pool in our reviews. Popular attractions Albrook Shopping Mall and Via Espana are located nearby.

Central Hotel Bocas del Toro

3 out of 5

Save 100% on your flight

Price was $2,616, price is now $1,518 per person

$1,518

per person

Oct 8 - Oct 13

found 1 day ago

Roundtrip flight included

Miami (MIA) to Panama City (PTY)

Stay at this 3-star hotel in Bocas del Toro. Enjoy free breakfast, free WiFi, and a marina. Popular attractions Bolivar Park and Bocas del Toro Ferry Terminal are located nearby.

Villa Botero By Casa Mojito B&B

3 out of 5

Price was $1,086, price is now $699 per person

$699

per person

Oct 20 - Oct 26

found 6 hours ago

Roundtrip non-stop flight included

Atlanta (ATL) to Panama City (PTY)

Stay at this 3-star golf B&B in Rio Hato. Enjoy free WiFi, free parking, and breakfast (surcharge). Popular attractions Playa Blanca and Farallón Beach are located nearby.

Hotel Panamonte

3.5 out of 5

Price was $1,141, price is now $750 per person

$750

per person

Oct 20 - Oct 26

found 6 hours ago

Roundtrip non-stop flight included

Atlanta (ATL) to Panama City (PTY)

Stay at this 3.5-star hotel in Jaramillo. Enjoy free WiFi, free parking, and breakfast (surcharge). Popular attractions Boquete Community Players Theater and Events Center and Church of San Juan Bautista are located nearby.

Central Hotel Panama Casco Viejo

4 out of 5

Save 100% on your flight

Price was $1,304, price is now $897 per person

$897

per person

Nov 20 - Nov 24

found 1 day ago

Roundtrip flight included

Atlanta (ATL) to Panama City (PTY)

Stay at this 4-star spa hotel in Panama City. Enjoy free WiFi, a full-service spa, and 3 restaurants. Our guests praise the helpful staff and the clean rooms in our reviews. Popular attractions Albrook Shopping Mall and Cinta Costera are located nearby.

La Coralina Island House

3.5 out of 5

Price was $1,227, price is now $868 per person

$868

per person

Oct 21 - Oct 25

found 7 hours ago

Roundtrip flight included

Atlanta (ATL) to Panama City (PTY)

Stay at this 3.5-star beach hotel in Bocas del Toro. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions Paunch Beach and Tortuga Beach are located nearby.

Ciel y Miel

3 out of 5

Save 100% on your flight

Price was $1,394, price is now $999 per person

$999

per person

Oct 5 - Oct 9

found 1 day ago

Roundtrip flight included

Miami (MIA) to Panama City (PTY)

Stay at this 3-star beach hotel in Cacique. Enjoy free breakfast, free WiFi, and free valet parking. Popular attractions Isla Mamey and Portobelo National Park are located nearby.

The Sands by Wynwood House

2 out of 5

Save 100% on your flight

Price was $1,888, price is now $1,359 per person

$1,359

per person

Nov 14 - Nov 17

found 14 hours ago

Roundtrip flight included

Miami (MIA) to Panama City (PTY)

Stay at this apartment in Panama City. Enjoy free WiFi and an outdoor pool. Popular attractions Albrook Shopping Mall and Cinta Costera are located nearby.