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Charleston

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Charleston Flights as Low as $176

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

Southern Airways Express
Thu, Apr 24 - Mon, Apr 28
ORD
O'Hare Intl.
STL
Lambert-St. Louis Intl.
$176 Roundtrip, found 6 days ago
$176
Roundtrip
found 6 days ago
Select Southern Airways Express flight, departing Thu, Apr 24 from O'Hare Intl. to Lambert-St. Louis Intl., returning Mon, Apr 28, priced at $176 found 6 days ago
Frontier Airlines
Thu, Apr 24 - Mon, Apr 28
ORD
O'Hare Intl.
STL
Lambert-St. Louis Intl.
$188 Roundtrip, found 6 days ago
$188
Roundtrip
found 6 days ago
Select Frontier Airlines flight, departing Thu, Apr 24 from O'Hare Intl. to Lambert-St. Louis Intl., returning Mon, Apr 28, priced at $188 found 6 days ago
Southern Airways Express
Tue, Apr 22 - Fri, May 2
ORD
O'Hare Intl.
STL
Lambert-St. Louis Intl.
$189 Roundtrip, found 1 day ago
$189
Roundtrip
found 1 day ago
Select Southern Airways Express flight, departing Tue, Apr 22 from O'Hare Intl. to Lambert-St. Louis Intl., returning Fri, May 2, priced at $189 found 1 day ago
Frontier Airlines
Wed, Apr 16 - Wed, Apr 23
ONT
Los Angeles - Ontario Intl.
STL
Lambert-St. Louis Intl.
$190 Roundtrip, found 7 hours ago
$190
Roundtrip
found 7 hours ago
Select Frontier Airlines flight, departing Wed, Apr 16 from Los Angeles - Ontario Intl. to Lambert-St. Louis Intl., returning Wed, Apr 23, priced at $190 found 7 hours ago
Frontier Airlines
Sat, May 3 - Sat, May 10
ONT
Los Angeles - Ontario Intl.
STL
Lambert-St. Louis Intl.
$191 Roundtrip, found 12 hours ago
$191
Roundtrip
found 12 hours ago
Select Frontier Airlines flight, departing Sat, May 3 from Los Angeles - Ontario Intl. to Lambert-St. Louis Intl., returning Sat, May 10, priced at $191 found 12 hours ago
Southern Airways Express
Mon, Apr 21 - Sat, Apr 26
ORD
O'Hare Intl.
STL
Lambert-St. Louis Intl.
$195 Roundtrip, found 1 day ago
$195
Roundtrip
found 1 day ago
Select Southern Airways Express flight, departing Mon, Apr 21 from O'Hare Intl. to Lambert-St. Louis Intl., returning Sat, Apr 26, priced at $195 found 1 day ago
Southern Airways Express
Thu, Apr 24 - Mon, Apr 28
ORD
O'Hare Intl.
STL
Lambert-St. Louis Intl.
$196 Roundtrip, found 6 days ago
$196
Roundtrip
found 6 days ago
Select Southern Airways Express flight, departing Thu, Apr 24 from O'Hare Intl. to Lambert-St. Louis Intl., returning Mon, Apr 28, priced at $196 found 6 days ago
Frontier Airlines
Thu, May 1 - Sat, May 10
ONT
Los Angeles - Ontario Intl.
STL
Lambert-St. Louis Intl.
$198 Roundtrip, found 12 hours ago
$198
Roundtrip
found 12 hours ago
Select Frontier Airlines flight, departing Thu, May 1 from Los Angeles - Ontario Intl. to Lambert-St. Louis Intl., returning Sat, May 10, priced at $198 found 12 hours ago
Frontier Airlines
Thu, May 1 - Wed, May 7
LAX
Los Angeles Intl.
STL
Lambert-St. Louis Intl.
$198 Roundtrip, found 7 hours ago
$198
Roundtrip
found 7 hours ago
Select Frontier Airlines flight, departing Thu, May 1 from Los Angeles Intl. to Lambert-St. Louis Intl., returning Wed, May 7, priced at $198 found 7 hours ago
United
Thu, Apr 24 - Mon, Apr 28
ORD
O'Hare Intl.
STL
Lambert-St. Louis Intl.
$302 Roundtrip, found 6 days ago
$302
Roundtrip
found 6 days ago
Select United flight, departing Thu, Apr 24 from O'Hare Intl. to Lambert-St. Louis Intl., returning Mon, Apr 28, priced at $302 found 6 days ago
American Airlines
Thu, Apr 24 - Mon, Apr 28
ORD
O'Hare Intl.
STL
Lambert-St. Louis Intl.
$302 Roundtrip, found 6 days ago
$302
Roundtrip
found 6 days ago
Select American Airlines flight, departing Thu, Apr 24 from O'Hare Intl. to Lambert-St. Louis Intl., returning Mon, Apr 28, priced at $302 found 6 days ago
Delta
Tue, May 13 - Wed, May 14
ONT
Los Angeles - Ontario Intl.
STL
Lambert-St. Louis Intl.
$307 Roundtrip, found 3 days ago
$307
Roundtrip
found 3 days ago
Select Delta flight, departing Tue, May 13 from Los Angeles - Ontario Intl. to Lambert-St. Louis Intl., returning Wed, May 14, priced at $307 found 3 days ago
American Airlines
Sat, May 17 - Sun, May 18
FLO
Florence Regional
STL
Lambert-St. Louis Intl.
$379 Roundtrip, found 7 hours ago
$379
Roundtrip
found 7 hours ago
Select American Airlines flight, departing Sat, May 17 from Florence Regional to Lambert-St. Louis Intl., returning Sun, May 18, priced at $379 found 7 hours ago
Alaska Airlines
Wed, May 14 - Mon, May 19
ONT
Los Angeles - Ontario Intl.
STL
Lambert-St. Louis Intl.
$401 Roundtrip, found 3 days ago
$401
Roundtrip
found 3 days ago
Select Alaska Airlines flight, departing Wed, May 14 from Los Angeles - Ontario Intl. to Lambert-St. Louis Intl., returning Mon, May 19, priced at $401 found 3 days ago
American Airlines
Tue, Jun 3 - Tue, Jun 10
FLO
Florence Regional
CGI
Cape Girardeau Municipal
$406 Roundtrip, found 5 days ago
$406
Roundtrip
found 5 days ago
Select American Airlines flight, departing Tue, Jun 3 from Florence Regional to Cape Girardeau Municipal, returning Tue, Jun 10, priced at $406 found 5 days ago
Hawaiian Airlines
Tue, Apr 15 - Sat, Apr 26
LAX
Los Angeles Intl.
STL
Lambert-St. Louis Intl.
$643 Roundtrip, found 3 days ago
$643
Roundtrip
found 3 days ago
Select Hawaiian Airlines flight, departing Tue, Apr 15 from Los Angeles Intl. to Lambert-St. Louis Intl., returning Sat, Apr 26, priced at $643 found 3 days ago

Cheap Flights to Charleston

Fall in love at first flight with your vacation to Charleston by saving a ton of cash on your last-minute cheap flight. There’s no more scouring the internet for a good deal—book your flight to Charleston on Hotwire, and you’ll be up, up, and on a getaway in no time.

Because once the wheels are down in Charleston, the good times start rolling. So buckle up, you’re in for a fun ride.

Frequently Asked Questions About flights to Charleston

Don’t waste your time on endless searches for cheap airline tickets oneway or roundtrip. We’ll have you on your way to Charleston with a tiny bag of pretzels in your hand before you can say “tray tables in the upright position”—and for a ticket price that works for your vacay budget.

So all you have to worry about is where you’re headed after the STL airport.

What is the cheapest month to fly to Charleston?

Airline ticket prices fluctuate all the time, depending on the day of the week or the month of the year. The cheapest round trip flights to Charleston are in April, but when you book your flight on Hotwire, savings are always in season.

How many airlines fly to Charleston?

Variety is the spice of life, even when it comes to booking your next trip. Want options for airlines? You’ll find 16 to choose from for your flight to Charleston.

What airport is best to fly into Charleston?

When you’re planning your trip to Charleston, convenience is the name of the game. Luckily, Charleston Cairo Regional Airport is nearby so you can deplane and get going on checking off everything on your Charleston must-do list.

How much are flights to Charleston?

Got very cheap flights on your vacation itinerary? When you book your airline tickets to Charleston on Hotwire, you may just get what’s on your getaway wish list. With tickets as low as $176, you’ll have leftover cash for at least a magazine and a bottle of water at the airport book store.

How to get cheap flights to Charleston?

The trick to saving a stack of cash on your flight to Charleston? Snatch up that Hotwire flight deal when you see a killer rate because it could be gone in a flash. And with flights as low as $176 right now, why wait?

Charleston Flight Information
Destination airport
Lambert-St. Louis Intl.
Destination airport IATA code
STL
Roundtrip price
$176

Last Minute Hotel Deals in Charleston

Super 8 by Wyndham Charleston/Sikeston East MO
Super 8 by Wyndham Charleston/Sikeston East MO
2 out of 5
310 S Story St, Charleston, MO
The price is $73 per night from Apr 27 to Apr 28
$73
includes taxes & fees
Apr 27 - Apr 28
Stay at this motel in Charleston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews.
6.6/10 (547 reviews)
"The carpet in the room needs to be vacuumed."

Reviewed on Mar 24, 2025

Super 8 by Wyndham Charleston/Sikeston East MO
Quality Inn Charleston - Sikeston
Quality Inn Charleston - Sikeston
2.5 out of 5
102 Drake St, I-57 Exit 10, Charleston, MO
The price is $80 per night from May 4 to May 5
$80
includes taxes & fees
May 4 - May 5
Book a stay at this business-friendly hotel in Charleston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the property condition in our ...
6.6/10 (375 reviews)
"Staff were very friendly. Room was spacious and well designed."

Reviewed on Mar 17, 2025

Quality Inn Charleston - Sikeston
Eagle Inn Charleston
Eagle Inn Charleston
2 out of 5
2811 East Marshall Street, Charleston, MO
The price is $71 per night from Apr 14 to Apr 15
$71
includes taxes & fees
Apr 14 - Apr 15
Stay at this motel in Charleston. Enjoy free WiFi, free parking, and a health club.
6.6/10 (95 reviews)
"Comfortable bed, easy access to room"

Reviewed on Oct 8, 2024

Eagle Inn Charleston
The Riverview
The Riverview
3.5 out of 5
777 Main St, Cape Girardeau, MO
The price is $109 per night from Apr 14 to Apr 15
$109
includes taxes & fees
Apr 14 - Apr 15
Stay at this 3.5-star hotel in Cape Girardeau. Enjoy free WiFi, free parking, and 2 restaurants. Popular attractions Isle Casino Cape Girardeau and Riverfront ...
9.2/10 Wonderful! (222 reviews)
"Very nice place"

Reviewed on Apr 8, 2025

The Riverview
Drury Plaza Hotel Cape Girardeau Conference Center
Drury Plaza Hotel Cape Girardeau Conference Center
3 out of 5
3351 Percy Drive, Cape Girardeau, MO
The price is $107 per night from Apr 17 to Apr 18
$107
includes taxes & fees
Apr 17 - Apr 18
Stay at this 3-star business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.4/10 Exceptional! (1,005 reviews)
"This was our first time at a Drury hotel so it came as quite a surprise that they provide supper as well as breakfast. Clean, well-kept motel; friendly, helpful staff."

Reviewed on Apr 11, 2025

Drury Plaza Hotel Cape Girardeau Conference Center
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
2.5 out of 5
3253 William Street, Cape Girardeau, MO
The price is $116 per night from May 4 to May 5
$116
includes taxes & fees
May 4 - May 5
Book a stay at this spa hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in ...
9.4/10 Exceptional! (1,002 reviews)
"Will definitely stay there again!!"

Reviewed on Apr 9, 2025

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Pear Tree Inn Sikeston
Pear Tree Inn Sikeston
2.5 out of 5
2602 E Malone Avenue, Sikeston, MO
The price is $98 per night from Apr 17 to Apr 18
$98
includes taxes & fees
Apr 17 - Apr 18
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the helpful ...
9.2/10 Wonderful! (1,003 reviews)
"This hotel is very comfortable clean and staff goes out of their way to be friendly!!!! I love staying at this hotel!"

Reviewed on Apr 10, 2025

Pear Tree Inn Sikeston
Pear Tree Inn Cape Girardeau Near the Medical Center
Pear Tree Inn Cape Girardeau Near the Medical Center
2.5 out of 5
3248 William St, Cape Girardeau, MO
The price is $76 per night from Apr 17 to Apr 18
$76
includes taxes & fees
Apr 17 - Apr 18
Stay at this hotel in Cape Girardeau. Enjoy free WiFi, an outdoor pool, and a 24-hour front desk. Our guests praise the helpful staff and the clean rooms in ...
8.8/10 Excellent! (1,003 reviews)
"It was small room but was okay"

Reviewed on Mar 21, 2025

Pear Tree Inn Cape Girardeau Near the Medical Center
See all 91 properties in Charleston
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.