Search for Cheap Deals onHotels in Charleston
Choose from 107 Charleston Hotel Deals
Super 8 by Wyndham Charleston/Sikeston East MO
The Riverstone Hotel Charleston-Sikeston
"This way by far the dirtiest motel I have ever stayed in first room was flooded by toilet and was moved to another room that was worse"
Reviewed on Aug 29, 2026
Eagle Inn Charleston
"Don’t go here if you’re a single woman traveling alone. I did not feel save even with my dog."
Reviewed on Aug 27, 2026
Drury Plaza Hotel Cape Girardeau Conference Center
"Everything was awesome! Breakfast was delicious, rooms spacious and clean."
Reviewed on Sep 4, 2026
The Riverview
Pear Tree Inn Cape Girardeau West
"Clean room friendly staff"
Reviewed on Sep 3, 2026
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
"This location is a must stay any time I am traveling in the area. The staff are helpful. There are lots of dinning options near by. I can always count on a peaceful night sleep at this location."
Reviewed on Sep 2, 2026
Drury Inn & Suites Sikeston, MO
"Very nice and clean property."
Reviewed on Sep 3, 2026
Drury Inn & Suites Cape Girardeau
Candlewood Suites Cape Girardeau by IHG
"Beautiful nice clean place. Beds are so comfortable too! Just wished they offered breakfast"
Reviewed on Aug 31, 2026
Best Western Plus Sikeston I-55
"We were greeted with a warm smile from a really nice gentleman that checked us in. He chatted with us the entire time we checked in. He gave us ideas where to eat and Lamberts won. The hotel and room was very clean. Breakfast was great. They serve something hot everyday like biscuits and gravy, eggs, ..."
Reviewed on Sep 3, 2026
Courtyard by Marriott Cape Girardeau Downtown
Find cheap hotels in Charleston
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For you, intrepid voyager, Hotwire has a large selection of the best hotels in Charleston.
Choosing the right hotel in Missouri has everything to do with the way you want your trip to go. If you’ve scribbled a few obscure destinations on your itinerary, you probably already have a good sense of how your getaway is taking shape. Lean into that by booking one of Charleston’s 107 hotels. Choose the one that best catches your trip’s tourist drift.
If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $66. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get great Charleston hotel deals at the last minute.
While traveling, where you stay plays a major role in your overall vacation enjoyment. Choosing the right hotel is just as important as making sure you book the right flight and car rental. If you’re traveling with family or friends, you may need to book a hotel with connecting rooms. If you enjoy an elegant and relaxing hotel ambiance, opt for one of Hotwire’s luxury hotels in Charleston. No matter your reason for visiting Charleston, with Hotwire’s large selection of hotels in the area, you’re sure to book a hotel that meets all your accommodation needs.
Frequently Asked Questions About Charleston hotels
Where can I find the best last-minute travel deals?
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How many hotels are there in Charleston?
With over 107 hotels in Charleston, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $66.
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