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Choose from 93 Charleston Hotel Deals

Super 8 by Wyndham Charleston/Sikeston East MO

Super 8 by Wyndham Charleston/Sikeston East MO

2 out of 5
310 S Story St Charleston MO
  • 7 hours drive from Mississippi River
Stay at this motel in Charleston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews.
6.6/10 (609 reviews)
Thank you

Reviewed on Nov 7, 2025

Super 8 by Wyndham Charleston/Sikeston East MO
Quality Inn Charleston - Sikeston

Quality Inn Charleston - Sikeston

2.5 out of 5
102 Drake St Charleston MO
  • 7 hours drive from Mississippi River
Book a stay at this business-friendly hotel in Charleston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the property condition in our ...
6.8/10 (406 reviews)
Ladydi
The only issue was the temperature display on the ac/heating unit went to E5 during the night and it was overly warm. I woke up because of this and was able to get the fan only running but it was still uncomfortable for me and I spent 5 hours tossing and turning with little sleep after that with ...

Reviewed on Oct 22, 2025

Quality Inn Charleston - Sikeston
Eagle Inn Charleston

Eagle Inn Charleston

2 out of 5
2811 East Marshall Street Charleston MO
  • 7 hours drive from Mississippi River
Stay at this motel in Charleston. Enjoy free WiFi, free parking, and a health club.
6.6/10 (103 reviews)
Convenient

Reviewed on Nov 26, 2025

Eagle Inn Charleston
Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center

3 out of 5
3351 Percy Drive Cape Girardeau MO
  • 6 hours drive from Mississippi River
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.4/10 Exceptional! (1,004 reviews)
We had a wonderful stay at this hotel. The room and common areas were spotless and the food was wonderful. Our children had a glorious time swimming in the indoor pool.

Reviewed on Nov 26, 2025

Drury Plaza Hotel Cape Girardeau Conference Center
The Riverview

The Riverview

4 out of 5
777 Main St Cape Girardeau MO
  • 6 hours drive from Mississippi River
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free WiFi, free parking, and 2 restaurants. Popular attractions Isle Casino Cape Girardeau ...
9.2/10 Wonderful! (457 reviews)
Great room, close to downtown, awesome food options in the venue as well. Really nice views of the river.

Reviewed on Nov 19, 2025

The Riverview
Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West

2.5 out of 5
103 Cape West Pkwy Cape Girardeau MO
  • 6 hours drive from Mississippi River
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the ...
9/10 Wonderful! (1,002 reviews)
Everything was great.

Reviewed on Nov 21, 2025

Pear Tree Inn Cape Girardeau West
Hampton Inn Sikeston

Hampton Inn Sikeston

2.5 out of 5
1240 Commerce Drive Sikeston MO
  • 7 hours drive from Mississippi River
Stay at this hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions Central ...
8.8/10 Excellent! (430 reviews)
From arrival to departure, our stay at Hampton-Sikeston was book like. The front desk attendant greeted us, like family. She was friendly and helpful, getting our stay off to a geat start. The pool was clear and inviting, forcing me to 'take a dip'. We woke up the next to a great breakfast. EVERYTHING ...

Reviewed on Nov 24, 2025

Hampton Inn Sikeston
Courtyard by Marriott Cape Girardeau Downtown

Courtyard by Marriott Cape Girardeau Downtown

3 out of 5
400 Broadway St. Cape Girardeau MO
  • 6 hours drive from Mississippi River
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff ...
9.4/10 Exceptional! (464 reviews)
Amazing. Nice staff. Good food. Great location.

Reviewed on Nov 23, 2025

Courtyard by Marriott Cape Girardeau Downtown
Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

3 out of 5
2608 East Malone Ave, Miner Sikeston MO
  • 7 hours drive from Mississippi River
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9.4/10 Exceptional! (1,003 reviews)
Wonderful place to stay! Kayla checked us in and was so friendly and helpful. The grounds and rooms are spotless and comfortable. We would definitely stay here again

Reviewed on Nov 23, 2025

Drury Inn & Suites Sikeston, MO
Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau

3 out of 5
3303 Campster Drive Cape Girardeau MO
  • 6 hours drive from Mississippi River
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the ...
9.4/10 Exceptional! (1,002 reviews)
Being able to eat supper and breakfast plus the free drinks and a great clean room (really nice shower) makes Drury the place we will lok for when we travel in the future.

Reviewed on Nov 22, 2025

Drury Inn & Suites Cape Girardeau
Pear Tree Inn Cape Girardeau Near the Medical Center

Pear Tree Inn Cape Girardeau Near the Medical Center

2.5 out of 5
3248 William St Cape Girardeau MO
  • 6 hours drive from Mississippi River
Stay at this hotel in Cape Girardeau. Enjoy free WiFi, a 24-hour front desk, and daily housekeeping. Our guests praise the helpful staff and the clean rooms ...
8.8/10 Excellent! (1,000 reviews)
good

Reviewed on Nov 12, 2025

Pear Tree Inn Cape Girardeau Near the Medical Center
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

2.5 out of 5
3253 William Street Cape Girardeau MO
  • 6 hours drive from Mississippi River
Book a stay at this spa hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in ...
9.4/10 Exceptional! (1,002 reviews)
Upon entering this luxurious property, it’s as if one has accidentally teleported and stumbled into the Lobby of an upscale Hotel in a metropolitan city! Very modern, beautiful and a clean line type of architecture. The bed was fabulously comfortable! Way to go to Staff and Manager!! You guys are ...

Reviewed on Nov 23, 2025

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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