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Hotels in Charleston

Choose from 101 Charleston Hotel Deals

Super 8 by Wyndham Charleston/Sikeston East MO

Super 8 by Wyndham Charleston/Sikeston East MO

2 out of 5
310 S Story St Charleston MO
  • 7 hours drive from Mississippi River
Stay at this motel in Charleston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews.
6.6/10 (634 reviews)
"DON'T STAY HERE-- KEEP GOING SOMEWHERE ELSE, & couldn't get a refund--Property is older property being renovated. The workers stay on property. The men congregate outside their rooms drinking, smoking, & some smoking weed. To each his own, but my daughter & I are allergic to cigarette smoke & get ..."

Reviewed on May 16, 2026

Super 8 by Wyndham Charleston/Sikeston East MO
The Riverstone Hotel Charleston-Sikeston

The Riverstone Hotel Charleston-Sikeston

2.5 out of 5
102 Drake St Charleston MO
  • 7 hours drive from Mississippi River
Book a stay at this business-friendly hotel in Charleston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the property condition in our ...
6.8/10 (412 reviews)
"Coffee"

Reviewed on Apr 22, 2026

The Riverstone Hotel Charleston-Sikeston
Eagle Inn Charleston

Eagle Inn Charleston

2 out of 5
2811 East Marshall Street Charleston MO
  • 7 hours drive from Mississippi River
Stay at this motel in Charleston. Enjoy free WiFi, free parking, and a health club.
6.6/10 (106 reviews)
"Great"

Reviewed on Apr 14, 2026

Eagle Inn Charleston
Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center

3 out of 5
3351 Percy Drive Cape Girardeau MO
  • 6 hours drive from Mississippi River
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.6/10 Exceptional! (1,005 reviews)
"Always great to save money. Having a good breakfast and supper provided by the hotel was awesome."

Reviewed on May 16, 2026

Drury Plaza Hotel Cape Girardeau Conference Center
Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

3 out of 5
2608 East Malone Ave, Miner Sikeston MO
  • 7 hours drive from Mississippi River
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9.6/10 Exceptional! (1,003 reviews)
"Breakfast was good,pool hot tub excellent"

Reviewed on May 17, 2026

Drury Inn & Suites Sikeston, MO
The Riverview

The Riverview

4 out of 5
777 Main St Cape Girardeau MO
  • 6 hours drive from Mississippi River
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free WiFi, free parking, and 2 restaurants. Popular attractions Century Casino & Hotel Cape ...
9.4/10 Exceptional! (572 reviews)
"The room and view were amazing!"

Reviewed on May 15, 2026

The Riverview
Hampton Inn Sikeston

Hampton Inn Sikeston

2.5 out of 5
1240 Commerce Drive Sikeston MO
  • 7 hours drive from Mississippi River
Stay at this hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions Central ...
9/10 Wonderful! (562 reviews)
"Everything was good"

Reviewed on May 10, 2026

Hampton Inn Sikeston
Fairfield Inn & Suites by Marriott Cape Girardeau

Fairfield Inn & Suites by Marriott Cape Girardeau

3 out of 5
433 CAPE WEST CROSSINGS Cape Girardeau MO
  • 6 hours drive from Mississippi River
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Fort D Historic Site and ...
9.4/10 Exceptional! (184 reviews)
"The hotel room was very clean and the beds were comfortable, which made for a good night’s sleep. The staff was friendly and the overall stay was pleasant. The only downside was the breakfast. The food selection was limited and the quality was disappointing. Other than breakfast, the hotel experience ..."

Reviewed on May 11, 2026

Fairfield Inn & Suites by Marriott Cape Girardeau
Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West

2.5 out of 5
103 Cape West Pkwy Cape Girardeau MO
  • 6 hours drive from Mississippi River
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the ...
9/10 Wonderful! (1,003 reviews)
"Yes"

Reviewed on May 16, 2026

Pear Tree Inn Cape Girardeau West
Candlewood Suites Cape Girardeau by IHG

Candlewood Suites Cape Girardeau by IHG

2.5 out of 5
485 S Mount Auburn Rd Cape Girardeau MO
  • 6 hours drive from Mississippi River
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free WiFi, free parking, and a fitness center. Our guests praise the helpful staff and the ...
8/10 Very Good! (936 reviews)
"The staff was very friendly and helpful. Location is great and easy to navigate. We went for a soccer tournament. It is close to the fields."

Reviewed on May 18, 2026

Candlewood Suites Cape Girardeau by IHG
Courtyard by Marriott Cape Girardeau Downtown

Courtyard by Marriott Cape Girardeau Downtown

3 out of 5
400 Broadway St. Cape Girardeau MO
  • 6 hours drive from Mississippi River
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff ...
9.6/10 Exceptional! (507 reviews)
"Great stay!!"

Reviewed on May 17, 2026

Courtyard by Marriott Cape Girardeau Downtown
Best Western Plus Sikeston I-55

Best Western Plus Sikeston I-55

2.5 out of 5
120 S Interstate Drive Sikeston MO
  • 7 hours drive from Mississippi River
Stay at this hotel in Sikeston. Enjoy free breakfast, free parking, and a fitness center. Our guests praise the breakfast and the helpful staff in our reviews. ...
8.4/10 Very Good! (1,012 reviews)
"Best Best Western Plus that I have been to in a long time. The breakfast staff was exceptionally helpful and they had an above average breakfast, including hot water for tea and a single serving coffee maker to use my own coffee (yes, I bring it just in case). So very awesome. The room was comfortable ..."

Reviewed on May 17, 2026

Best Western Plus Sikeston I-55
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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