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Hotels in Charleston

Choose from 102 Charleston Hotel Deals

Super 8 by Wyndham Charleston/Sikeston East MO

Super 8 by Wyndham Charleston/Sikeston East MO

2 out of 5
310 S Story St Charleston MO
  • 7 hours drive from Mississippi River
Stay at this motel in Charleston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews.
6.6/10 (644 reviews)
"Breakfast was pitiful, good coffee. I already wrote a review about the check in."

Reviewed on Jun 29, 2026

Super 8 by Wyndham Charleston/Sikeston East MO
The Riverstone Hotel Charleston-Sikeston

The Riverstone Hotel Charleston-Sikeston

2.5 out of 5
102 Drake St Charleston MO
  • 7 hours drive from Mississippi River
Book a stay at this business-friendly hotel in Charleston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the property condition in our ...
6.8/10 (418 reviews)
"We didn’t stay that hotel because they didn't see my reservation that I paid $65.11"

Reviewed on Jun 21, 2026

The Riverstone Hotel Charleston-Sikeston
Eagle Inn Charleston

Eagle Inn Charleston

2 out of 5
2811 East Marshall Street Charleston MO
  • 7 hours drive from Mississippi River
Stay at this motel in Charleston. Enjoy free WiFi, free parking, and a health club.
6.6/10 (106 reviews)
"Great"

Reviewed on Apr 14, 2026

Eagle Inn Charleston
Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center

3 out of 5
3351 Percy Drive Cape Girardeau MO
  • 6 hours drive from Mississippi River
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.6/10 Exceptional! (1,002 reviews)
"Just a wonderful relaxing place to stay! Terrace on the 8th floor is a nice place to relax in the evening or with coffee in the morning!"

Reviewed on Jul 1, 2026

Drury Plaza Hotel Cape Girardeau Conference Center
Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

3 out of 5
2608 East Malone Ave, Miner Sikeston MO
  • 7 hours drive from Mississippi River
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9.6/10 Exceptional! (1,000 reviews)
"Very clean"

Reviewed on Jul 1, 2026

Drury Inn & Suites Sikeston, MO
The Riverview

The Riverview

4 out of 5
777 Main St Cape Girardeau MO
  • 6 hours drive from Mississippi River
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free WiFi, free parking, and 2 restaurants. Popular attractions Century Casino & Hotel Cape ...
9.4/10 Exceptional! (615 reviews)
"Great experience!! Beautiful!"

Reviewed on Jul 2, 2026

The Riverview
Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston

2 out of 5
220 S Interstate Dr Sikeston MO
  • 7 hours drive from Mississippi River
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7.2/10 Good! (1,000 reviews)
"The air conditioning was good! But not very clean room. Hair everywhere. Strange fluids on bed and couch. Very spacious. You get what you pay for."

Reviewed on Jun 29, 2026

Days Inn and Suites by Wyndham Sikeston
Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West

2.5 out of 5
103 Cape West Pkwy Cape Girardeau MO
  • 6 hours drive from Mississippi River
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the ...
9/10 Wonderful! (1,002 reviews)
"Great service"

Reviewed on Jul 2, 2026

Pear Tree Inn Cape Girardeau West
Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau

3 out of 5
3303 Campster Drive Cape Girardeau MO
  • 6 hours drive from Mississippi River
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the ...
9.4/10 Exceptional! (1,000 reviews)
"We had a very good experience at this hotel. The rooms are spacious & very clean. The staff were wonderful, helpful and friendly. The breakfast was outstanding. Would definitely stay here again."

Reviewed on Jun 30, 2026

Drury Inn & Suites Cape Girardeau
Candlewood Suites Cape Girardeau by IHG

Candlewood Suites Cape Girardeau by IHG

2.5 out of 5
485 S Mount Auburn Rd Cape Girardeau MO
  • 6 hours drive from Mississippi River
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free WiFi, free parking, and a fitness center. Our guests praise the helpful staff and the ...
8/10 Very Good! (969 reviews)
"Great place to stay very nice staff."

Reviewed on Jun 26, 2026

Candlewood Suites Cape Girardeau by IHG
Best Western Plus Sikeston I-55

Best Western Plus Sikeston I-55

2.5 out of 5
120 S Interstate Drive Sikeston MO
  • 7 hours drive from Mississippi River
Stay at this hotel in Sikeston. Enjoy free breakfast, free parking, and a fitness center. Our guests praise the breakfast and the helpful staff in our reviews. ...
8.4/10 Very Good! (1,008 reviews)
"Would not stay here again."

Reviewed on Jul 1, 2026

Best Western Plus Sikeston I-55
Fairfield Inn & Suites by Marriott Cape Girardeau

Fairfield Inn & Suites by Marriott Cape Girardeau

3 out of 5
433 CAPE WEST CROSSINGS Cape Girardeau MO
  • 6 hours drive from Mississippi River
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Fort D Historic Site and ...
9.4/10 Exceptional! (204 reviews)
"staff was very friendly and accommodating, would stay here again. rooms were comfortable and clean."

Reviewed on Jun 17, 2026

Fairfield Inn & Suites by Marriott Cape Girardeau
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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