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Hotels in New Madrid

Choose from 52 New Madrid Hotel Deals

New Orleans Inn Portageville
New Orleans Inn Portageville
2.5 out of 5
600 US-61, Portageville, MO
  • 29 min drive from New Madrid Historical Museum
The price is $63 per night from Mar 31 to Apr 1
$63
per night
Mar 31 - Apr 1
Stay at this motel in Portageville. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff and the clean rooms in our reviews. ...
8/10 Very Good! (383 reviews)
"Not as nice as pic"

Reviewed on Mar 25, 2024

New Orleans Inn Portageville
Holiday Inn Express & Suites Sikeston Southwest, an IHG Hotel
Holiday Inn Express & Suites Sikeston Southwest, an IHG Hotel
2.5 out of 5
115 Hospitality Dr, Sikeston, MO
  • 45 min drive from New Madrid Historical Museum
The price is $116 per night from Apr 28 to Apr 29
$116
per night
Apr 28 - Apr 29
Stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
8.6/10 Excellent! (335 reviews)
Highly Recommend
"Very clean and friendly staff, bed was a little too hard for me but over all I would highly recommend staying here."

Reviewed on Mar 15, 2024

Holiday Inn Express & Suites Sikeston Southwest, an IHG Hotel
Hampton Inn Sikeston
Hampton Inn Sikeston
2.5 out of 5
1240 Commerce Drive, Sikeston, MO
  • 45 min drive from New Madrid Historical Museum
The price is $110 per night from Apr 28 to Apr 29
$110
per night
Apr 28 - Apr 29
Stay at this hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions Central ...
8.8/10 Excellent! (263 reviews)
"I enjoyed my stay. The beds are really comfortable. They have slide doors for the bathroom which I'm really not crazy about, but other than that everything was great. Front desk staff was really nice. Convenient right off the highway. I would definitely stay here again."

Reviewed on Mar 8, 2024

Hampton Inn Sikeston
Reelfoot Lake Inn
Reelfoot Lake Inn
2 out of 5
1520 State Route 21 East, Tiptonville, TN
  • 36 min drive from New Madrid Historical Museum
The price is $70 per night from Mar 29 to Mar 30
$70
per night
Mar 29 - Mar 30
Stay at this motel in Tiptonville. Enjoy free WiFi, a 24-hour front desk, and daily housekeeping. Our guests praise the helpful staff and the clean rooms in ...
7.2/10 Good! (403 reviews)
Would recommend
"I’ve stayed here several times over the last year. The staff is friendly and helpful!"

Reviewed on Feb 18, 2024

Reelfoot Lake Inn
Red Roof Inn Sikeston - Marston
Red Roof Inn Sikeston - Marston
2 out of 5
501 SE Outer Rd, Marston, MO
  • 13 min drive from New Madrid Historical Museum
The price is $79 per night from Mar 31 to Apr 1
$79
per night
Mar 31 - Apr 1
Stay at this motel in Marston. Enjoy free breakfast, free WiFi, and free parking. Popular attraction Marston Community Center is located nearby. Discover genuine ...
7.2/10 Good! (53 reviews)
"Really worried about some of the other reviews that I read but I’m here to say that the hotel was great for an overnight stop. Comfy bed and pillows. Clean room. Good breakfast. Some cosmetic signs of age in the room. Otherwise a great stay!! Would stay again!!"

Reviewed on Nov 29, 2023

Red Roof Inn Sikeston - Marston
Travel Inn
Travel Inn
2.5 out of 5
301 Route Ad, Marston, MO
  • 13 min drive from New Madrid Historical Museum
Stay at this hotel in Marston. Enjoy free breakfast, free WiFi, and free parking. Popular attraction Marston Community Center is located nearby. Discover genuine ...
5.2/10 (82 reviews)
"Was disappointed to find out that the restaurant was not open. Rooms need a little TLC, but everything is clean and comfortable."

Reviewed on Oct 27, 2023

Travel Inn
Mainstay Suites
Mainstay Suites
2.5 out of 5
1111 Blue Heron Lane, Portageville, MO
  • 28 min drive from New Madrid Historical Museum
Stay at this hotel in Portageville. Enjoy a fitness center, dry cleaning or laundry services, and barbecue grills. Discover genuine guest reviews for Mainstay ...
Mainstay Suites
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

HOTW-Hotel-Deals-726-959@2x.jpg (1918×258)*Savings based on Hot Rate® hotel bookings as compared with the lowest published rates found on leading retail travel sites. Hot Rates are different from retail rates. With Hot Rates you enter the date, location and star rating. Hotel revealed only after booking. All bookings final.

Find cheap hotels in New Madrid

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For you, intrepid voyager, Hotwire has a large selection of the best hotels in New Madrid.

Choosing the right hotel in Missouri has everything to do with the way you want your trip to go. If you’ve scribbled a few obscure destinations on your itinerary, you probably already have a good sense of how your getaway is taking shape. Lean into that by booking one of New Madrid’s 52 hotels. Choose the one that best catches your trip’s tourist drift.

If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $63. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get up to 60% New Madrid hotel deals at the last minute.

While traveling, where you stay plays a major role in your overall vacation enjoyment. Choosing the right hotel is just as important as making sure you book the right flight and car rental. If you’re traveling with family or friends, you may need to book a hotel with connecting rooms. If you enjoy an elegant and relaxing hotel ambiance, opt for one of Hotwire’s luxury hotels in New Madrid. No matter your reason for visiting New Madrid, with Hotwire’s large selection of hotels in the area, you’re sure to book a hotel that meets all your accommodation needs.

Frequently Asked Questions About New Madrid hotels

Where can I find the best last-minute travel deals?

If you’re traveling in the spirit of spontaneity, you’ll love the idea of leaving your exact hotel choice up to chance. With Hotwire Hot Rates, you can save up to 60% off your next flight, hotel, or car rental. Just plug in your general preferences and let Hotwire choose last-minute hotel deals in New Madrid for as low as $63.

How many hotels are there in New Madrid?

With over 52 hotels in New Madrid, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $63.

How to find cheap car rentals in New Madrid?

Finding a cheap car rental deal in New Madrid is as easy as scoring cheap hotels in New Madrid. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can even save up to 60% off a car rental deal if you book a Hotwire Hot Rate at the last minute.

Is it safe to travel to New Madrid now?

With recent COVID-19 closures and reopenings, many people are wondering, “Is it safe to travel to New Madrid right now?” When it’s time to book your getaway, be sure to check out the most up-to-date information on all safety measures, any restrictions, and guidance on traveling during the coronavirus pandemic.