Search for Cheap Deals onHotels in New Madrid
Choose from 55 New Madrid Hotel Deals
Holiday Inn Express & Suites Sikeston Southwest by IHG
"Only stayed one night. Slept great after a 16 hour trip!"
Reviewed on Aug 7, 2026
Hampton Inn Sikeston
"I was awoken around 6pm so they could change locks? I understand that 6pm might not be that late for some but as I had to get up at 2am to start my day of work I was not happy. That sounds like something that should be taken care of when the room is vacant."
Reviewed on Aug 7, 2026
Fairfield Inn & Suites by Marriott Sikeston
"Excellent stay. New hotel. We stayed there 2 times in a week. Great beds, Great staff. Good breakfast. Nice bar area. Great parking. We would definitely return."
Reviewed on Jul 26, 2026
New Orleans Inn Portageville
Reelfoot Lake Inn
"This is not a safe hotel. After talking to the locals, I found out that they rent rooms out by the week and that there is a correction center nearby. There were only 3 other people staying in the hotel and they put a creep in the room next to mine. I saw him outside and he told me not to worry because ..."
Reviewed on Jul 31, 2026
TownePlace Suites by Marriott Sikeston
"The need a better breakfast area. Poor hygiene at the breakfast area"
Reviewed on Jul 31, 2026
Super 8 By Wyndham Marston
Travel Inn Marston I-55 by Hotel O
Prime Fishing & Boating: Tiptonville Home
Find cheap hotels in New Madrid
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For you, intrepid voyager, Hotwire has a large selection of the best hotels in New Madrid.
Choosing the right hotel in Missouri has everything to do with the way you want your trip to go. If you’ve scribbled a few obscure destinations on your itinerary, you probably already have a good sense of how your getaway is taking shape. Lean into that by booking one of New Madrid’s 55 hotels. Choose the one that best catches your trip’s tourist drift.
If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $76. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get great New Madrid hotel deals at the last minute.
While traveling, where you stay plays a major role in your overall vacation enjoyment. Choosing the right hotel is just as important as making sure you book the right flight and car rental. If you’re traveling with family or friends, you may need to book a hotel with connecting rooms. If you enjoy an elegant and relaxing hotel ambiance, opt for one of Hotwire’s luxury hotels in New Madrid. No matter your reason for visiting New Madrid, with Hotwire’s large selection of hotels in the area, you’re sure to book a hotel that meets all your accommodation needs.
Frequently Asked Questions About New Madrid hotels
Where can I find the best last-minute travel deals?
If you’re traveling in the spirit of spontaneity, you’ll love the idea of leaving your exact hotel choice up to chance. With Hotwire Hot Rates, you can unlock great deals on your next flight, hotel, or car rental. Just plug in your general preferences and let Hotwire choose last-minute hotel deals in New Madrid for as low as $76.
How many hotels are there in New Madrid?
With over 55 hotels in New Madrid, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $76.
How to find cheap car rentals in New Madrid?
Finding a cheap car rental deal in New Madrid is as easy as scoring cheap hotels in New Madrid. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can unlock great car rental deals if you book a Hotwire Hot Rate at the last minute.
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