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Hotels in Southeast Missouri

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Choose from 657 Southeast Missouri Hotel Deals

Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center

3 out of 5
3351 Percy Drive Cape Girardeau MO
  • 5 hours drive from Mark Twain National Forest
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.6/10 Exceptional! (1,004 reviews)
Always great to save money. Having a good breakfast and supper provided by the hotel was awesome.

Reviewed on May 16, 2026

Drury Plaza Hotel Cape Girardeau Conference Center
Baymont Inn and Suites by Wyndham Farmington, MO

Baymont Inn and Suites by Wyndham Farmington, MO

2.5 out of 5
1625 W Columbia St Farmington MO
  • 2 hours drive from Mark Twain National Forest
Book a stay at this business-friendly hotel in Farmington. Enjoy free breakfast, free parking, and an outdoor pool. Our guests praise the helpful staff and the ...
8/10 Very Good! (1,002 reviews)
Husband noted breakfast wasn’t very good. I did not have any, so I can’t really express an opinion on that. Hotel room was clean is everything I needed to get a good nights sleep

Reviewed on May 16, 2026

Baymont Inn and Suites by Wyndham Farmington, MO
Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

3 out of 5
2608 East Malone Ave, Miner Sikeston MO
  • 4 hours drive from Mark Twain National Forest
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9.6/10 Exceptional! (1,001 reviews)
Very nice and clean place with courteous staff.

Reviewed on May 13, 2026

Drury Inn & Suites Sikeston, MO
The Riverview

The Riverview

4 out of 5
777 Main St Cape Girardeau MO
  • 5 hours drive from Mark Twain National Forest
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free WiFi, free parking, and 2 restaurants. Popular attractions Century Casino & Hotel Cape ...
9.4/10 Exceptional! (572 reviews)
The room and view were amazing!

Reviewed on May 15, 2026

The Riverview
Hampton Inn Sikeston

Hampton Inn Sikeston

2.5 out of 5
1240 Commerce Drive Sikeston MO
  • 4 hours drive from Mark Twain National Forest
Stay at this hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions Central ...
9/10 Wonderful! (560 reviews)
Everything was good

Reviewed on May 10, 2026

Hampton Inn Sikeston
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

3 out of 5
3003 SOUTH OLD ORCHARD ROAD Jackson MO
  • 5 hours drive from Mark Twain National Forest
Book a stay at this business-friendly hotel in Jackson. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
9/10 Wonderful! (765 reviews)
Great location, felt safe, clean room, good staff.

Reviewed on May 15, 2026

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
Fairfield Inn & Suites by Marriott Cape Girardeau

Fairfield Inn & Suites by Marriott Cape Girardeau

3 out of 5
433 CAPE WEST CROSSINGS Cape Girardeau MO
  • 5 hours drive from Mark Twain National Forest
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Fort D Historic Site and ...
9.4/10 Exceptional! (184 reviews)
The hotel room was very clean and the beds were comfortable, which made for a good night’s sleep. The staff was friendly and the overall stay was pleasant. The only downside was the breakfast. The food selection was limited and the quality was disappointing. Other than breakfast, the hotel experience ...

Reviewed on May 11, 2026

Fairfield Inn & Suites by Marriott Cape Girardeau
Drury Inn & Suites Jackson MO

Drury Inn & Suites Jackson MO

3 out of 5
225 Drury Lane Jackson MO
  • 4 hours drive from Mark Twain National Forest
Book a stay at this business-friendly hotel in Jackson. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
9.6/10 Exceptional! (1,004 reviews)
Great

Reviewed on May 16, 2026

Drury Inn & Suites Jackson MO
Drury Inn & Suites Hayti Caruthersville

Drury Inn & Suites Hayti Caruthersville

3 out of 5
1317 E Highway 84 Hayti MO
  • 4 hours drive from Mark Twain National Forest
Book a stay at this business-friendly hotel in Hayti. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9.4/10 Exceptional! (1,001 reviews)
The best stay at a hotel we’ve had in years! I couldn’t give them enough praise. Every staff member we encountered was absolutely precious and so attentive. The breakfast is delicious and so many different options. The pool and hot tub were lovely. The nightly “kickback” was such a nice surprise! ...

Reviewed on May 12, 2026

Drury Inn & Suites Hayti Caruthersville
Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West

2.5 out of 5
103 Cape West Pkwy Cape Girardeau MO
  • 5 hours drive from Mark Twain National Forest
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the ...
9/10 Wonderful! (1,001 reviews)
Yes

Reviewed on May 16, 2026

Pear Tree Inn Cape Girardeau West
Candlewood Suites Cape Girardeau by IHG

Candlewood Suites Cape Girardeau by IHG

2.5 out of 5
485 S Mount Auburn Rd Cape Girardeau MO
  • 5 hours drive from Mark Twain National Forest
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free WiFi, free parking, and a fitness center. Our guests praise the helpful staff and the ...
8/10 Very Good! (934 reviews)
Sorry to say but the garbage in bathroom had not been picked up before we got there. And the coffee provided was stale dated and stale when I made it. That was a bummer first thing in the morning! The room was comfy and clean to the max besides!

Reviewed on May 13, 2026

Candlewood Suites Cape Girardeau by IHG
Courtyard by Marriott Cape Girardeau Downtown

Courtyard by Marriott Cape Girardeau Downtown

3 out of 5
400 Broadway St. Cape Girardeau MO
  • 5 hours drive from Mark Twain National Forest
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff ...
9.6/10 Exceptional! (506 reviews)
Wow! Zero complaints. Perfect stay. Great value.

Reviewed on May 7, 2026

Courtyard by Marriott Cape Girardeau Downtown
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find cheap hotels in Southeast Missouri

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Frequently Asked Questions About Southeast Missouri hotels

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How many hotels are there in Southeast Missouri?

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