Search for Cheap Deals onHotels in Southeast Missouri
Choose from 663 Southeast Missouri Hotel Deals
Drury Plaza Hotel Cape Girardeau Conference Center
"Very clean, helpful staff"
Reviewed on Jun 2, 2026
Drury Inn & Suites Sikeston, MO
"Clean rooms and was ready when we arrived. We did not use the pool but other guests were enjoying it. Breakfast and Kick back were both great meals."
Reviewed on Jun 4, 2026
Baymont Inn and Suites by Wyndham Farmington, MO
"Staff was courteous. However in hallway was a pungent odor. The room had same odor and we had to get some air freshener and turn on AC unit to circulate air."
Reviewed on Jun 1, 2026
Candlewood Suites Cape Girardeau by IHG
"on check-in, staff did not tell us there was not breakfast provided. Room clean, well-organized. Had plenty of towels without having to ask for any extra. Had we known no kitchen we might have brought in food for breakfast. the bag of popcorn provided was tasty and welcome. Main negative was the ..."
Reviewed on Jun 6, 2026
The Riverview
"Out room wasn't ready (we arrived a little after 3, check-in time). We had to wait for the room to be cleaned. Other than that, it was clean and comfortable. I wish they had a better breakfast option and an earlier time."
Reviewed on Jun 1, 2026
Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy
"The best accomodation I have had for years. The staff is easy to answer any request as long the request is reasonable. I also highly recommend the place for its superb cleanliness and cozy."
Reviewed on May 31, 2026
Drury Inn & Suites Hayti Caruthersville
"Clean & quiet are it priorities. All the other perks offered here were very pleasant extras"
Reviewed on Jun 6, 2026
Hampton Inn Poplar Bluff
"This was the best check in experience we've had. Rooms were ready and keys made when we checked in. Took 3 min. They also had all the rooms side by side we had 6 total. Will be using g Hilton owned from here on out."
Reviewed on Jun 6, 2026
Drury Inn & Suites Jackson MO
"Relaxing"
Reviewed on Jun 6, 2026
La Quinta Inn & Suites by Wyndham Festus - St. Louis South
"Nice place. Would stay there again"
Reviewed on Jun 2, 2026
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
"Beautiful hotel at a very good price."
Reviewed on Jun 5, 2026
Motel 6 Poplar Bluff, MO
"We check in late, the room was clean and we slept got early and got back on road home."
Reviewed on Jun 5, 2026
Find cheap hotels in Southeast Missouri
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For you, intrepid voyager, Hotwire has a large selection of the best hotels in Southeast Missouri.
Choosing the right hotel in Missouri has everything to do with the way you want your trip to go. If you’ve scribbled a few obscure destinations on your itinerary, you probably already have a good sense of how your getaway is taking shape. Lean into that by booking one of Southeast Missouri’s 663 hotels. Choose the one that best catches your trip’s tourist drift.
If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $63. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get great Southeast Missouri hotel deals at the last minute.
While traveling, where you stay plays a major role in your overall vacation enjoyment. Choosing the right hotel is just as important as making sure you book the right flight and car rental. If you’re traveling with family or friends, you may need to book a hotel with connecting rooms. If you enjoy an elegant and relaxing hotel ambiance, opt for one of Hotwire’s luxury hotels in Southeast Missouri. No matter your reason for visiting Southeast Missouri, with Hotwire’s large selection of hotels in the area, you’re sure to book a hotel that meets all your accommodation needs.
Frequently Asked Questions About Southeast Missouri hotels
Where can I find the best last-minute travel deals?
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How many hotels are there in Southeast Missouri?
With over 663 hotels in Southeast Missouri, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $63.
How to find cheap car rentals in Southeast Missouri?
Finding a cheap car rental deal in Southeast Missouri is as easy as scoring cheap hotels in Southeast Missouri. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can unlock great car rental deals if you book a Hotwire Hot Rate at the last minute.
- Hotel Brand
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- Near An Airport
- Areas Of Southeast Missouri
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- Other Cities Near Southeast Missouri
- Hotels near Johnson's Shut-ins State Park
- Hotels near Ozark National Scenic Riverways
- Hotels near Century Casino & Hotel Cape Girardeau
- Hotels near Elephant Rocks State Park
- Hotels near Century Casino Caruthersville
- Hotels near Southeast Missouri State University
- Hotels near Current River State Park
- Hotels near Echo Bluff State Park
- Hotels near Alley Spring & Mill
- Hotels near Rocky Falls
- Hotels near Hawn State Park
- Hotels near Akers Ferry
- Hotels near Lake Wappapello
- Hotels near Sainte Genevieve Winery
- Hotels near Taum Sauk Mountain State Park
- Hotels near Pickle Springs Natural Area
- Hotels near Big Spring
- Hotels near K Bridge Recreation Area
- Hotels near St. Francois State Park
- Hotels near Round Spring Cave
- Hotels with Free Parking in Southeast Missouri
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- Pet-friendly Hotels in Southeast Missouri
- Hotels with a Pool in Southeast Missouri
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- Resorts & Hotels with Spas in Southeast Missouri
- Casinos in Southeast Missouri
- Luxury Hotels in Southeast Missouri
- Apartment Hotel in Southeast Missouri
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- Chesterfield Hotels
- Cape Girardeau Hotels
- Fenton Hotels
- Carbondale Hotels
- Eminence Hotels
- Poplar Bluff Hotels
- Wappapello Hotels
- Eureka Hotels
- Kirkwood Hotels
- Sikeston Hotels
- Ozarks Hotels
- Farmington Hotels
- Richmond Heights Hotels
- Arnold Hotels
- Valley Park Hotels
- Town and Country Hotels
- East St. Louis Hotels
- Van Buren Hotels
- Brentwood Hotels
- West Plains Hotels
