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Hotels in Southeast Missouri

Choose from 546 Southeast Missouri Hotel Deals

The Riverview
The Riverview
3.5 out of 5
777 Main St, Cape Girardeau, MO
  • 5 hours drive from Mark Twain National Forest
The price is $106 per night from Mar 16 to Mar 17
$106
includes taxes & fees
Mar 16 - Mar 17
Stay at this 3.5-star hotel in Cape Girardeau. Enjoy free WiFi, free parking, and 2 restaurants. Popular attractions Isle Casino Cape Girardeau and Riverfront ...
9.2/10 Wonderful! (174 reviews)
"It is great"

Reviewed on Mar 9, 2025

The Riverview
Drury Plaza Hotel Cape Girardeau Conference Center
Drury Plaza Hotel Cape Girardeau Conference Center
3 out of 5
3351 Percy Drive, Cape Girardeau, MO
  • 5 hours drive from Mark Twain National Forest
The price is $107 per night from Mar 30 to Mar 31
$107
includes taxes & fees
Mar 30 - Mar 31
Stay at this 3-star business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.4/10 Exceptional! (1,001 reviews)
Great stay
"Great stay. Love the atmosphere and food. Our stay was for basketball tournament. Enjoyed every bit of the stay."

Reviewed on Mar 9, 2025

Drury Plaza Hotel Cape Girardeau Conference Center
Motel 6 Poplar Bluff, MO
Motel 6 Poplar Bluff, MO
2 out of 5
4101 Highway 67 N, Poplar Bluff, MO
  • 3 hours drive from Mark Twain National Forest
The price is $71 per night from Mar 15 to Mar 16
$71
includes taxes & fees
Mar 15 - Mar 16
Stay at this motel in Poplar Bluff. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff and the clean rooms in our reviews. ...
7.8/10 Good! (1,001 reviews)
"Good service"

Reviewed on Mar 11, 2025

Motel 6 Poplar Bluff, MO
Days Inn and Suites by Wyndham Sikeston
Days Inn and Suites by Wyndham Sikeston
2 out of 5
220 S Interstate Dr, Sikeston, MO
  • 4 hours drive from Mark Twain National Forest
The price is $87 per night from Mar 16 to Mar 17
$87
includes taxes & fees
Mar 16 - Mar 17
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7.2/10 Good! (1,012 reviews)
"It was a nice building"

Reviewed on Mar 2, 2025

Days Inn and Suites by Wyndham Sikeston
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
2.5 out of 5
3253 William Street, Cape Girardeau, MO
  • 5 hours drive from Mark Twain National Forest
The price is $112 per night from Mar 23 to Mar 24
$112
includes taxes & fees
Mar 23 - Mar 24
Book a stay at this spa hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in ...
9.4/10 Exceptional! (1,000 reviews)
"Love everything"

Reviewed on Mar 10, 2025

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Baymont Inn and Suites by Wyndham Farmington, MO
Baymont Inn and Suites by Wyndham Farmington, MO
2.5 out of 5
1625 W Columbia St, Farmington, MO
  • 2 hours drive from Mark Twain National Forest
The price is $61 per night from Mar 23 to Mar 24
$61
includes taxes & fees
Mar 23 - Mar 24
Book a stay at this business-friendly hotel in Farmington. Enjoy free breakfast, free parking, and an outdoor pool. Our guests praise the breakfast and the helpful ...
8/10 Very Good! (870 reviews)
"Pleasantly surprised by how great everything was! Will definitely stay here again when in the area."

Reviewed on Mar 4, 2025

Baymont Inn and Suites by Wyndham Farmington, MO
Fairfield Inn & Suites by Marriott Poplar Bluff
Fairfield Inn & Suites by Marriott Poplar Bluff
2.5 out of 5
3109 Oak Grove, Poplar Bluff, MO
  • 3 hours drive from Mark Twain National Forest
The price is $114 per night from Mar 16 to Mar 17
$114
includes taxes & fees
Mar 16 - Mar 17
Book a stay at this business-friendly hotel in Poplar Bluff. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
9.4/10 Exceptional! (701 reviews)
"I loved that it was very clean compared to other places we've stayed at. I mean it looked fenominal in there only thing I say needs work is making the beds they were sloppy"

Reviewed on Mar 9, 2025

Fairfield Inn & Suites by Marriott Poplar Bluff
Pear Tree Inn Cape Girardeau West
Pear Tree Inn Cape Girardeau West
2.5 out of 5
103 Cape West Pkwy, Cape Girardeau, MO
  • 5 hours drive from Mark Twain National Forest
The price is $76 per night from Mar 24 to Mar 25
$76
includes taxes & fees
Mar 24 - Mar 25
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the ...
9/10 Wonderful! (1,006 reviews)
"Nice place and affordable. The breakfast is pretty simple."

Reviewed on Mar 10, 2025

Pear Tree Inn Cape Girardeau West
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
2.5 out of 5
3003 SOUTH OLD ORCHARD ROAD, Jackson, MO
  • 5 hours drive from Mark Twain National Forest
The price is $88 per night from Mar 16 to Mar 17
$88
includes taxes & fees
Mar 16 - Mar 17
Book a stay at this business-friendly hotel in Jackson. Enjoy free WiFi, free parking, and room service. Our guests praise the helpful staff and the clean rooms ...
8.8/10 Excellent! (513 reviews)
Book it!
"Check in was very simple. The room was nice and clean very quiet. The price was very reasonable. Very safe."

Reviewed on Mar 10, 2025

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
Candlewood Suites Cape Girardeau by IHG
Candlewood Suites Cape Girardeau by IHG
2.5 out of 5
485 S Mount Auburn Rd, Cape Girardeau, MO
  • 5 hours drive from Mark Twain National Forest
The price is $94 per night from Mar 30 to Mar 31
$94
includes taxes & fees
Mar 30 - Mar 31
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free WiFi, free parking, and a fitness center. Our guests praise the helpful staff and the ...
8/10 Very Good! (741 reviews)
"Every thing was handled quickly. The room was awesome. The shower was great. I would say the only drawback was the refrigerator and freezer were not on and I did not realize that. I was on at my previous stay earlier in the week and some ice cream I put in the freezer melted."

Reviewed on Mar 1, 2025

Candlewood Suites Cape Girardeau by IHG
The Farmstead Hotel
The Farmstead Hotel
2.5 out of 5
778 E 3rd St, Caruthersville, MO
  • 4 hours drive from Mark Twain National Forest
The price is $107 per night from Mar 16 to Mar 17
$107
includes taxes & fees
Mar 16 - Mar 17
Stay at this hotel in Caruthersville. Enjoy free WiFi, free parking, and a casino. Our guests praise the helpful staff and the clean rooms in our reviews. Popular ...
8.8/10 Excellent! (297 reviews)
"Nice and quiet. Plenty of coffee in room however shower stream wasnt very strong."

Reviewed on Mar 8, 2025

The Farmstead Hotel
Pear Tree Inn Sikeston
Pear Tree Inn Sikeston
2.5 out of 5
2602 E Malone Avenue, Sikeston, MO
  • 4 hours drive from Mark Twain National Forest
The price is $88 per night from Mar 23 to Mar 24
$88
includes taxes & fees
Mar 23 - Mar 24
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the helpful ...
9.2/10 Wonderful! (1,007 reviews)
"Great"

Reviewed on Mar 9, 2025

Pear Tree Inn Sikeston
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find cheap hotels in Southeast Missouri

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Choosing the right hotel in Missouri has everything to do with the way you want your trip to go. If you’ve scribbled a few obscure destinations on your itinerary, you probably already have a good sense of how your getaway is taking shape. Lean into that by booking one of Southeast Missouri’s 546 hotels. Choose the one that best catches your trip’s tourist drift.

If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $61. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get great Southeast Missouri hotel deals at the last minute.

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Frequently Asked Questions About Southeast Missouri hotels

Where can I find the best last-minute travel deals?

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How many hotels are there in Southeast Missouri?

With over 546 hotels in Southeast Missouri, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $61.

How to find cheap car rentals in Southeast Missouri?

Finding a cheap car rental deal in Southeast Missouri is as easy as scoring cheap hotels in Southeast Missouri. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can unlock great car rental deals if you book a Hotwire Hot Rate at the last minute.