Search for Cheap Deals onHotels in Southeast Missouri
Choose from 672 Southeast Missouri Hotel Deals
Drury Plaza Hotel Cape Girardeau Conference Center
"Property was very nice and clean, staff was great, breakfast all good. Only complaint is the noise, constant hall noise, constant noise above us like furniture moving all night, didnt get any sleep and the hotel i have been to that didn't have any form of fan noise, usually we can use a bathroom ..."
Reviewed on Jun 27, 2026
Baymont Inn and Suites by Wyndham Farmington, MO
"Clean room. Friendly front desk"
Reviewed on Jun 28, 2026
Drury Inn & Suites Sikeston, MO
"Quick check-in. Room was very clean and nice. Staff was helpful. Would definitely stay here again."
Reviewed on Jun 28, 2026
Days Inn and Suites by Wyndham Sikeston
"Rooms are nice and clean although fixtures could be updated. There is no central air and heat, room is cooled by a wall unit. Room was extremely hot when I first entered."
Reviewed on Jun 24, 2026
The Riverview
"It was clean and quiet. It wasn’t walkable though. It would have been nice if there was a way to enjoy the river like a balcony either from the room or from a restaurant or lounge."
Reviewed on Jun 27, 2026
La Quinta Inn & Suites by Wyndham Festus - St. Louis South
"The elevator broke and we were on the 3rd floor, the bathrooms were dirty and poorly kept, the rooms smelled moldy, when asked if they had any soda for sale the guest service lady said if there ’s any in the machine that all we have. The holiday Inn Express is right across the bridge and we stayed ..."
Reviewed on Jun 27, 2026
Lake Wappapello
"I had a reservation for 4 nights, also received a confermation and itinerary number from hotes.com, but upon arrival I found that hotels.cim never made the reservation with the place I was staying. The place i was supposed to stay at were as accommodating as they could be, tried to find me a place ..."
Reviewed on Jun 19, 2026
Pear Tree Inn Cape Girardeau West
"The staff was extremely friendly. The charger in my room didn't work and the front desk worker allowed me to borrow one. She was extremely helpful. Breakfast was really good and my room was very clean. Bed was comfy and I had everything I needed. Would definitely stay again."
Reviewed on Jun 21, 2026
Drury Inn & Suites Hayti Caruthersville
"NA"
Reviewed on Jun 24, 2026
Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy
"All in all just great and exciting"
Reviewed on Jun 26, 2026
Hampton Inn Poplar Bluff
"Great service, room and breakfast! Only issue was one elevator was out of service which made the other elevator slow."
Reviewed on Jun 26, 2026
Fairfield Inn & Suites by Marriott Poplar Bluff
"Great place, clean, friendly staff, breakfast was great!"
Reviewed on Jun 23, 2026
Find cheap hotels in Southeast Missouri
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Choosing the right hotel in Missouri has everything to do with the way you want your trip to go. If you’ve scribbled a few obscure destinations on your itinerary, you probably already have a good sense of how your getaway is taking shape. Lean into that by booking one of Southeast Missouri’s 672 hotels. Choose the one that best catches your trip’s tourist drift.
If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $64. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get great Southeast Missouri hotel deals at the last minute.
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Frequently Asked Questions About Southeast Missouri hotels
Where can I find the best last-minute travel deals?
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How many hotels are there in Southeast Missouri?
With over 672 hotels in Southeast Missouri, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $64.
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- Hotel Brand
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- Near An Airport
- Areas Of Southeast Missouri
- Near An Attraction
- Hotel Theme
- Other Cities Near Southeast Missouri
- Hotels near Johnson's Shut-ins State Park
- Hotels near Elephant Rocks State Park
- Hotels near Echo Bluff State Park
- Hotels near Century Casino & Hotel Cape Girardeau
- Hotels near Ozark National Scenic Riverways
- Hotels near Century Casino Caruthersville
- Hotels near Alley Spring & Mill
- Hotels near Current River State Park
- Hotels near Taum Sauk Mountain State Park
- Hotels near Rocky Falls
- Hotels near Southeast Missouri State University
- Hotels near Black River Coliseum
- Hotels near K Bridge Recreation Area
- Hotels near Akers Ferry
- Hotels near Sainte Genevieve Winery
- Hotels near Lake Wappapello
- Hotels near St. Joe State Park
- Hotels near Hawn State Park
- Hotels near Big Spring
- Hotels near Round Spring Cave
- Hotels with Free Parking in Southeast Missouri
- Family Hotels in Southeast Missouri
- Pet-friendly Hotels in Southeast Missouri
- Hotels with a Pool in Southeast Missouri
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- Hotels with Hot Tubs in Southeast Missouri
- Hotel Wedding Venues in Southeast Missouri
- Resorts & Hotels with Spas in Southeast Missouri
- Casinos in Southeast Missouri
- Luxury Hotels in Southeast Missouri
- Apartment Hotel in Southeast Missouri
- Historic Hotels in Southeast Missouri
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- Winery Hotels in Southeast Missouri
- Romantic Hotels in Southeast Missouri
- Adults Only Resorts & Hotels in Southeast Missouri
- Hotels with Waterslides in Southeast Missouri
- Chesterfield Hotels
- Wappapello Hotels
- Cape Girardeau Hotels
- Fenton Hotels
- Eminence Hotels
- Carbondale Hotels
- Eureka Hotels
- Richmond Heights Hotels
- Ozarks Hotels
- Poplar Bluff Hotels
- Kirkwood Hotels
- Van Buren Hotels
- Farmington Hotels
- Sikeston Hotels
- Arnold Hotels
- East St. Louis Hotels
- Brentwood Hotels
- Hardy Hotels
- West Plains Hotels
- Valley Park Hotels
