Search for Cheap Deals onHotels in Southeast Missouri
Choose from 697 Southeast Missouri Hotel Deals
Drury Plaza Hotel Cape Girardeau Conference Center
Drury Inn & Suites Sikeston, MO
"Very friendly & professional staff. Trustworthy room attendants, with attention to details. Beds comfortable. Everyone enjoyed the morning breakfast, with a good menu. Cocktail hour widely attended. Would definitely stay here again!"
Reviewed on Oct 15, 2026
Pear Tree Inn Cape Girardeau West
"We have stayed at the Pear Tree several times and never disappointed!! Great staff, clean rooms, generous breakfast. A special thanks to Lydia who took extra care to make our last stay remarkable. Thank you."
Reviewed on Oct 15, 2026
Baymont Inn and Suites by Wyndham Farmington, MO
"The AC appeared to not be cooling the room. It was cycling off and on. Set the temp to 69 degrees and still did not cool the room. In the morning I figured out the problem. When the air was blowing the window drapes were bellowing out. They were capturing the cooled air and not allowing it to blow ..."
Reviewed on Oct 15, 2026
Hampton Inn Poplar Bluff
"Room smelled musty and there was only two luggage carts. Had to carry all of our luggage"
Reviewed on Oct 15, 2026
The Riverview
Days Inn and Suites by Wyndham Sikeston
"It was nice having a 2 room suite. Plenty of room. Fridge with freezer was a plus."
Reviewed on Oct 15, 2026
Comfort Inn Festus - St Louis South
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy
"The room was clean and the staff was very helpful. A great getaway for anyone who likes nature"
Reviewed on Oct 9, 2026
Hampton Inn Sikeston
Fairfield Inn & Suites by Marriott Cape Girardeau
Find cheap hotels in Southeast Missouri
You’re not an average traveler—and Hotwire knows it. Your wanderlust takes you off the beaten path to discover unique adventures and every travel destination’s lesser-known tourist scenes. Hotwire has the hookup! Book your Southeast Missouri hotel with Hotwire to complete your one-of-a-kind travel checklist.
For you, intrepid voyager, Hotwire has a large selection of the best hotels in Southeast Missouri.
Choosing the right hotel in Missouri has everything to do with the way you want your trip to go. If you’ve scribbled a few obscure destinations on your itinerary, you probably already have a good sense of how your getaway is taking shape. Lean into that by booking one of Southeast Missouri’s 697 hotels. Choose the one that best catches your trip’s tourist drift.
If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $62. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get great Southeast Missouri hotel deals at the last minute.
While traveling, where you stay plays a major role in your overall vacation enjoyment. Choosing the right hotel is just as important as making sure you book the right flight and car rental. If you’re traveling with family or friends, you may need to book a hotel with connecting rooms. If you enjoy an elegant and relaxing hotel ambiance, opt for one of Hotwire’s luxury hotels in Southeast Missouri. No matter your reason for visiting Southeast Missouri, with Hotwire’s large selection of hotels in the area, you’re sure to book a hotel that meets all your accommodation needs.
Frequently Asked Questions About Southeast Missouri hotels
Where can I find the best last-minute travel deals?
If you’re traveling in the spirit of spontaneity, you’ll love the idea of leaving your exact hotel choice up to chance. With Hotwire Hot Rates, you can unlock great deals on your next flight, hotel, or car rental. Just plug in your general preferences and let Hotwire choose last-minute hotel deals in Southeast Missouri for as low as $62.
How many hotels are there in Southeast Missouri?
With over 697 hotels in Southeast Missouri, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $62.
How to find cheap car rentals in Southeast Missouri?
Finding a cheap car rental deal in Southeast Missouri is as easy as scoring cheap hotels in Southeast Missouri. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can unlock great car rental deals if you book a Hotwire Hot Rate at the last minute.
- Hotel Brand
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- Near An Airport
- Areas Of Southeast Missouri
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- Other Cities Near Southeast Missouri
- Hotels near Echo Bluff State Park
- Hotels near Elephant Rocks State Park
- Hotels near Johnson's Shut-ins State Park
- Hotels near Century Casino & Hotel Cape Girardeau
- Hotels near Southeast Missouri State University
- Hotels near Ozark National Scenic Riverways
- Hotels near Century Casino Caruthersville
- Hotels near Taum Sauk Mountain State Park
- Hotels near Lake Wappapello
- Hotels near Big Spring
- Hotels near Alley Spring & Mill
- Hotels near Rocky Falls
- Hotels near Current River State Park
- Hotels near Akers Ferry
- Hotels near Hunter Valley Winery
- Hotels near Sainte Genevieve Winery
- Hotels near Hawn State Park
- Hotels near Fort Davidson State Historic Site
- Hotels near National Shrine of Our Lady of the Miraculous Medal
- Hotels near Black River Coliseum
- Hotels with Free Parking in Southeast Missouri
- Family Hotels in Southeast Missouri
- Pet-friendly Hotels in Southeast Missouri
- Hotels with a Pool in Southeast Missouri
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- Hotel Wedding Venues in Southeast Missouri
- Resorts & Hotels with Spas in Southeast Missouri
- Casinos in Southeast Missouri
- Luxury Hotels in Southeast Missouri
- Apartment Hotel in Southeast Missouri
- Historic Hotels in Southeast Missouri
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- Romantic Hotels in Southeast Missouri
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- Chesterfield Hotels
- Prairie du Rocher Hotels
- Cape Girardeau Hotels
- Carbondale Hotels
- Perryville Hotels
- Fenton Hotels
- Ozarks Hotels
- Farmington Hotels
- Sikeston Hotels
- Poplar Bluff Hotels
- Richmond Heights Hotels
- Town and Country Hotels
- Arnold Hotels
- Kirkwood Hotels
- Eureka Hotels
- East St. Louis Hotels
- Blytheville Hotels
- Eminence Hotels
- Festus Hotels
- West Plains Hotels
