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Choose from 546 Southeast Missouri Hotel Deals

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Reviewed on Mar 9, 2025
Find cheap hotels in Southeast Missouri
You’re not an average traveler—and Hotwire knows it. Your wanderlust takes you off the beaten path to discover unique adventures and every travel destination’s lesser-known tourist scenes. Hotwire has the hookup! Book your Southeast Missouri hotel with Hotwire to complete your one-of-a-kind travel checklist.
For you, intrepid voyager, Hotwire has a large selection of the best hotels in Southeast Missouri.
Choosing the right hotel in Missouri has everything to do with the way you want your trip to go. If you’ve scribbled a few obscure destinations on your itinerary, you probably already have a good sense of how your getaway is taking shape. Lean into that by booking one of Southeast Missouri’s 546 hotels. Choose the one that best catches your trip’s tourist drift.
If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $61. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get great Southeast Missouri hotel deals at the last minute.
While traveling, where you stay plays a major role in your overall vacation enjoyment. Choosing the right hotel is just as important as making sure you book the right flight and car rental. If you’re traveling with family or friends, you may need to book a hotel with connecting rooms. If you enjoy an elegant and relaxing hotel ambiance, opt for one of Hotwire’s luxury hotels in Southeast Missouri. No matter your reason for visiting Southeast Missouri, with Hotwire’s large selection of hotels in the area, you’re sure to book a hotel that meets all your accommodation needs.
Frequently Asked Questions About Southeast Missouri hotels
Where can I find the best last-minute travel deals?
If you’re traveling in the spirit of spontaneity, you’ll love the idea of leaving your exact hotel choice up to chance. With Hotwire Hot Rates, you can unlock great deals on your next flight, hotel, or car rental. Just plug in your general preferences and let Hotwire choose last-minute hotel deals in Southeast Missouri for as low as $61.
How many hotels are there in Southeast Missouri?
With over 546 hotels in Southeast Missouri, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $61.
How to find cheap car rentals in Southeast Missouri?
Finding a cheap car rental deal in Southeast Missouri is as easy as scoring cheap hotels in Southeast Missouri. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can unlock great car rental deals if you book a Hotwire Hot Rate at the last minute.
Top Booked Hotels in Southeast Missouri
- Hotel Brand
- Hotel Class
- Near An Airport
- Areas Of Southeast Missouri
- Near An Attraction
- Hotel Theme
- Other Cities Near Southeast Missouri
- Hotels near Southeast Missouri State University
- Hotels near Elephant Rocks State Park
- Hotels near Johnson's Shut-ins State Park
- Hotels near Echo Bluff State Park
- Hotels near Lake Wappapello
- Hotels near Ozark National Scenic Riverways
- Hotels near Century Casino Caruthersville
- Hotels near Isle Casino Cape Girardeau
- Hotels near Big Spring
- Hotels near Bonne Terre Mine
- Hotels near Alley Spring & Mill
- Hotels near Sainte Genevieve Winery
- Hotels near Taum Sauk Mountain State Park
- Hotels near Rocky Falls
- Hotels near Current River State Park
- Hotels near Black River Coliseum
- Hotels near Trail of Tears State Park
- Hotels near Pickle Springs Natural Area
- Hotels near Crown Valley Winery
- Hotels near Riverfront Bridge Park
- Hotels with Free Parking in Southeast Missouri
- Family Hotels in Southeast Missouri
- Pet-friendly Hotels in Southeast Missouri
- Hotels with a Pool in Southeast Missouri
- Hotels with an Indoor Pool in Southeast Missouri
- Hotels with Hot Tubs in Southeast Missouri
- Hotel Wedding Venues in Southeast Missouri
- Resorts & Hotels with Spas in Southeast Missouri
- Casinos in Southeast Missouri
- Luxury Hotels in Southeast Missouri
- Apartment Hotel in Southeast Missouri
- Historic Hotels in Southeast Missouri
- Hotels with smoking rooms in Southeast Missouri
- Winery Hotels in Southeast Missouri
- Romantic Hotels in Southeast Missouri
- Adults Only Resorts & Hotels in Southeast Missouri
- Hotels with Waterslides in Southeast Missouri
- Chesterfield Hotels
- Cape Girardeau Hotels
- Carbondale Hotels
- Ste Genevieve Hotels
- Sikeston Hotels
- Ozarks Hotels
- Poplar Bluff Hotels
- Richmond Heights Hotels
- Fenton Hotels
- Eminence Hotels
- Farmington Hotels
- Kirkwood Hotels
- East St. Louis Hotels
- Southern Illinois Hotels
- Wildwood Hotels
- Arnold Hotels
- Brentwood Hotels
- West Plains Hotels
- Dyersburg Hotels
- Blytheville Hotels