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Hotels in Southeast Missouri

Choose from 624 Southeast Missouri Hotel Deals

Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center

3 out of 5
3351 Percy Drive Cape Girardeau MO
  • 5 hours drive from Mark Twain National Forest
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.6/10 Exceptional! (1,001 reviews)
Everything was great with this hotel!

Reviewed on Mar 11, 2026

Drury Plaza Hotel Cape Girardeau Conference Center
The Riverview

The Riverview

4 out of 5
777 Main St Cape Girardeau MO
  • 5 hours drive from Mark Twain National Forest
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free WiFi, free parking, and 2 restaurants. Popular attractions Isle Casino Cape Girardeau ...
9.4/10 Exceptional! (525 reviews)
Lovely property. I don’t gamble, but if you do, it’s clearly convenient to the casino. Comfortable bed, very clean room, lovely staff

Reviewed on Mar 8, 2026

The Riverview
Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau

3 out of 5
3303 Campster Drive Cape Girardeau MO
  • 5 hours drive from Mark Twain National Forest
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the ...
9.4/10 Exceptional! (1,009 reviews)
Easy parking. Very clean room. Accommodating. Nice and helpful staff.

Reviewed on Mar 11, 2026

Drury Inn & Suites Cape Girardeau
Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

3 out of 5
2608 East Malone Ave, Miner Sikeston MO
  • 4 hours drive from Mark Twain National Forest
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9.4/10 Exceptional! (1,000 reviews)
Everything and everyone were wonderful at this Drury Inn! Very clean rooms and common areas, helpful, positive staff, fun indoor/outdoor pool area with towels, and breakfast and evening snacks and drinks all included in a great price! What a deal!

Reviewed on Mar 10, 2026

Drury Inn & Suites Sikeston, MO
Baymont Inn and Suites by Wyndham Farmington, MO

Baymont Inn and Suites by Wyndham Farmington, MO

2.5 out of 5
1625 W Columbia St Farmington MO
  • 2 hours drive from Mark Twain National Forest
Book a stay at this business-friendly hotel in Farmington. Enjoy free breakfast, free parking, and an outdoor pool. Our guests praise the helpful staff and the ...
8/10 Very Good! (1,001 reviews)
Rooms are run down. Blanket had stains in it. Was given the wrong room at check in and got argued with on what i booked. Had to have my key reactivated on the 2nd night since they didnt put both nights in the syatem. Better to stay at another midgrade hotel.

Reviewed on Mar 7, 2026

Baymont Inn and Suites by Wyndham Farmington, MO
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

3 out of 5
3003 SOUTH OLD ORCHARD ROAD Jackson MO
  • 5 hours drive from Mark Twain National Forest
Book a stay at this business-friendly hotel in Jackson. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
9/10 Wonderful! (720 reviews)
Clean rooms good staff.

Reviewed on Mar 9, 2026

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
Drury Inn & Suites Jackson MO

Drury Inn & Suites Jackson MO

3 out of 5
225 Drury Lane Jackson MO
  • 4 hours drive from Mark Twain National Forest
Book a stay at this business-friendly hotel in Jackson. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
9.6/10 Exceptional! (1,009 reviews)
This was our first stay at a Drury hotel

Reviewed on Mar 5, 2026

Drury Inn & Suites Jackson MO
Hampton Inn Sikeston

Hampton Inn Sikeston

2.5 out of 5
1240 Commerce Drive Sikeston MO
  • 4 hours drive from Mark Twain National Forest
Stay at this hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions Central ...
9/10 Wonderful! (498 reviews)
East, friendly check in. Beautiful, large room.

Reviewed on Mar 9, 2026

Hampton Inn Sikeston
Motel 6 Poplar Bluff, MO

Motel 6 Poplar Bluff, MO

2 out of 5
4101 Highway 67 N Poplar Bluff MO
  • 3 hours drive from Mark Twain National Forest
Stay at this motel in Poplar Bluff. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff and the clean rooms in our reviews. ...
8/10 Very Good! (1,000 reviews)
This was our third stay at this Motel 6. It’s a great hotel with friendly staff, clean rooms and good location. Pets stay free!

Reviewed on Mar 9, 2026

Motel 6 Poplar Bluff, MO
The Farmstead Hotel

The Farmstead Hotel

2.5 out of 5
778 E 3rd St Caruthersville MO
  • 4 hours drive from Mark Twain National Forest
Stay at this hotel in Caruthersville. Enjoy free WiFi, free parking, and a casino. Our guests praise the helpful staff and the clean rooms in our reviews. Popular ...
8.6/10 Excellent! (508 reviews)
Can hear every noise in the hotel from your room, very thin walls. Door to the room wouldn't latch properly. When I reported it to the front desk, she just told me that it's fine if you lift the door in place when shutting. As a single woman alone in a hotel I did not like wondering if my door was ...

Reviewed on Mar 9, 2026

The Farmstead Hotel
Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

2 out of 5
7555 State Hwy Y French Village MO
  • 3 hours drive from Mark Twain National Forest
Stay at this cabin in French Village. Enjoy free parking, patios, and climate control.
9.8/10 Exceptional! (56 reviews)
Absolutely amazing time as always. Staff is beyond great. Always ready to help and never in the way

Reviewed on Mar 2, 2026

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy
Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West

2.5 out of 5
103 Cape West Pkwy Cape Girardeau MO
  • 5 hours drive from Mark Twain National Forest
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the ...
9/10 Wonderful! (1,000 reviews)
Yes

Reviewed on Mar 10, 2026

Pear Tree Inn Cape Girardeau West
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find cheap hotels in Southeast Missouri

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Frequently Asked Questions About Southeast Missouri hotels

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How many hotels are there in Southeast Missouri?

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