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Hotels in Perryville

Choose from 175 Perryville Hotel Deals

Days Inn by Wyndham Perryville

Days Inn by Wyndham Perryville

2 out of 5
1500 Liberty Street Perryville MO
  • 27 min walk from National Shrine of Our Lady of the Miraculous Medal
Book a stay at this business-friendly hotel in Perryville. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Perryville Country Club and ...
6.8/10 (439 reviews)
"The first room we were given had not been cleaned; dirty towels on the floor, unmade bed. The 2nd room we were given had dirty sheets. The front desk gave us new sheets which when we went to put them on the bed were stained and when removing the dirty sheets, the mattress topper had blood on it. ..."

Reviewed on Jun 1, 2026

Days Inn by Wyndham Perryville
Holiday Inn Express & Suites Perryville by IHG

Holiday Inn Express & Suites Perryville by IHG

2.5 out of 5
2020 Jefferson St Perryville MO
  • 28 min walk from National Shrine of Our Lady of the Miraculous Medal
Book a stay at this business-friendly hotel in Perryville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
9.2/10 Wonderful! (593 reviews)
"Beautiful new hotel didn’t disappoint! Rey comfortable beds. Great breakfast and attentive staff keeping things filed for the best guest experience. I would definitely stop there again on my next trip through Perryville!"

Reviewed on Jun 7, 2026

Holiday Inn Express & Suites Perryville by IHG
Super 8 by Wyndham Perryville

Super 8 by Wyndham Perryville

2 out of 5
1119 Vincent Dr Perryville MO
  • 28 min walk from National Shrine of Our Lady of the Miraculous Medal
Book a stay at this business-friendly motel in Perryville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8.4/10 Very Good! (1,001 reviews)
"The room was ok but the bed was very hard & uncomfortable."

Reviewed on May 26, 2026

Super 8 by Wyndham Perryville
The Atrium - A Boutique Hotel

The Atrium - A Boutique Hotel

2 out of 5
112 W Ste Maries St Perryville MO
  • 4 min drive from National Shrine of Our Lady of the Miraculous Medal
Stay at this aparthotel in Perryville. Enjoy free WiFi, free parking, and bathrobes. Popular attractions Feltz Street Park and Perryville Country Club are located ...
9.4/10 Exceptional! (3 reviews)
"Very nice clean room with comfortable bed and nice shower. Kitchenette was good with microwave and mini fridge, basic dishes. The owner was very easy to communicate with. Good location with Mary Jane’s restaurant bar next door had excellent food and nice atmosphere. My only small suggestion would ..."

Reviewed on May 3, 2026

The Atrium - A Boutique Hotel
Quality Inn Perryville I-55

Quality Inn Perryville I-55

2.5 out of 5
1517 S. Perryville Blvd. Perryville MO
  • 28 min walk from National Shrine of Our Lady of the Miraculous Medal
Stay at this hotel in Perryville. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Perryville Country Club and Saint Marys Lake are located ...
6.8/10 (133 reviews)
"Got in late and left early. Felt safe and clean. I appreciated the breakfast being open early on a Saturday morning."

Reviewed on May 21, 2026

Quality Inn Perryville I-55
Urban Lofts

Urban Lofts

3 out of 5
102 N Jackson St Perryville MO
  • 5 min drive from National Shrine of Our Lady of the Miraculous Medal
Stay at this aparthotel in Perryville. Enjoy free WiFi, free parking, and dry cleaning or laundry services. Popular attractions Feltz Street Park and Perryville ...
9.2/10 Wonderful! (20 reviews)
"Beautiful accommodations, close to restaurants, shopping. In the heart of city center."

Reviewed on May 29, 2026

Urban Lofts
Drury Inn & Suites Jackson MO

Drury Inn & Suites Jackson MO

3 out of 5
225 Drury Lane Jackson MO
  • 1 hour drive from National Shrine of Our Lady of the Miraculous Medal
Book a stay at this business-friendly hotel in Jackson. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
9.6/10 Exceptional! (1,016 reviews)
"Well kept and very clean. Very friendly staff. Worth the price !! Would stay again!"

Reviewed on Jun 8, 2026

Drury Inn & Suites Jackson MO
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

3 out of 5
3003 SOUTH OLD ORCHARD ROAD Jackson MO
  • 1 hour drive from National Shrine of Our Lady of the Miraculous Medal
Book a stay at this business-friendly hotel in Jackson. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
9/10 Wonderful! (779 reviews)
"Air didn’t work in our room and they didn’t have another room for us and would not give us a refund"

Reviewed on Jun 7, 2026

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
Holiday Inn Express & Suites Murphysboro - Carbondale by IHG

Holiday Inn Express & Suites Murphysboro - Carbondale by IHG

2.5 out of 5
120 MUDDY MONSTER ROAD Murphysboro IL
  • 2 hours drive from National Shrine of Our Lady of the Miraculous Medal
Book a stay at this business-friendly hotel in Murphysboro. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.4/10 Exceptional! (546 reviews)
"Very nice. Seems quite new. Great location, super modern rooms and common areas."

Reviewed on Jun 8, 2026

Holiday Inn Express & Suites Murphysboro - Carbondale by IHG
Tru By Hilton Cape Girardeau

Tru By Hilton Cape Girardeau

2.5 out of 5
2520 Veterans Memorial Dr Cape Girardeau MO
  • 1 hour drive from National Shrine of Our Lady of the Miraculous Medal
Stay at this hotel in Cape Girardeau. Enjoy free breakfast, free parking, and a fitness center. Popular attractions Cape Girardeau Conservation Nature Center ...
9.6/10 Exceptional! (133 reviews)
"I would like to say that the staff are some of the nicest people I’ve encountered while traveling. Expedia messed up with the payment and it was a 2 hour process to undo it. But the hotel staff were amazing and did everything in their power to resolve the issue."

Reviewed on May 28, 2026

Tru By Hilton Cape Girardeau
Baymont by Wyndham Chester IL

Baymont by Wyndham Chester IL

2.5 out of 5
2150 State Street Chester IL
  • 35 min drive from National Shrine of Our Lady of the Miraculous Medal
Book a stay at this business-friendly hotel in Chester. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
8.6/10 Excellent! (396 reviews)
"No pool for kids"

Reviewed on Jun 1, 2026

Baymont by Wyndham Chester IL
Microtel Inn & Suites by Wyndham Sainte Genevieve

Microtel Inn & Suites by Wyndham Sainte Genevieve

2.5 out of 5
21958 Hwy 32 Ste Genevieve MO
  • 49 min drive from National Shrine of Our Lady of the Miraculous Medal
Book a stay at this business-friendly hotel in Ste Genevieve. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the ...
8.8/10 Excellent! (637 reviews)
"No wifi"

Reviewed on Jun 1, 2026

Microtel Inn & Suites by Wyndham Sainte Genevieve
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find cheap hotels in Perryville

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How many hotels are there in Perryville?

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