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Choose from 186 Perryville Hotel Deals

Days Inn by Wyndham Perryville

Holiday Inn Express & Suites Perryville by IHG

Super 8 by Wyndham Perryville

Quality Inn Perryville I-55
"Clean Room"
Reviewed on Oct 26, 2026

Urban Lofts
"Beautiful, clean property in the heart of city center. Many options for food and shopping within short walking distance."
Reviewed on Jun 11, 2026

Perryville RV Resort

The Atrium - A Boutique Hotel

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

Drury Inn & Suites Jackson MO
"The AC went out the last night there."
Reviewed on Nov 3, 2026

Holiday Inn Express & Suites Murphysboro - Carbondale by IHG
"Cleanest hotel I’ve ever been in. Hotel breakfast was clean, hot, and so good compared to other hotels. The lady at the front desk (blond hair) was SO NICE!"
Reviewed on Nov 1, 2026

Baymont by Wyndham Chester IL

Tru By Hilton Cape Girardeau
Find cheap hotels in Perryville
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For you, intrepid voyager, Hotwire has a large selection of the best hotels in Perryville.
Choosing the right hotel in Missouri has everything to do with the way you want your trip to go. If you’ve scribbled a few obscure destinations on your itinerary, you probably already have a good sense of how your getaway is taking shape. Lean into that by booking one of Perryville’s 186 hotels. Choose the one that best catches your trip’s tourist drift.
If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $73. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get great Perryville hotel deals at the last minute.
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Frequently Asked Questions About Perryville hotels
Where can I find the best last-minute travel deals?
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How many hotels are there in Perryville?
With over 186 hotels in Perryville, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $73.
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Finding a cheap car rental deal in Perryville is as easy as scoring cheap hotels in Perryville. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can unlock great car rental deals if you book a Hotwire Hot Rate at the last minute.
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