Search for Cheap Deals on
Hotels in Perryville

Check Last Minute Perryville Hotel Deals

Tonight May 3 - May 4Next weekend May 9 - May 11

Choose from 140 Perryville Hotel Deals

Holiday Inn Express & Suites Perryville by IHG
Holiday Inn Express & Suites Perryville by IHG
2.5 out of 5
2020 Jefferson St, Perryville, MO
  • 28 min walk from National Shrine of Our Lady of the Miraculous Medal
The price is $118 per night from May 11 to May 12
$118
includes taxes & fees
May 11 - May 12
Book a stay at this business-friendly hotel in Perryville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
9.2/10 Wonderful! (458 reviews)
"Great place to stay!"

Reviewed on Apr 25, 2025

Holiday Inn Express & Suites Perryville by IHG
Super 8 by Wyndham Perryville
Super 8 by Wyndham Perryville
2 out of 5
1119 Vincent Dr, Perryville, MO
  • 28 min walk from National Shrine of Our Lady of the Miraculous Medal
The price is $83 per night from May 11 to May 12
$83
includes taxes & fees
May 11 - May 12
Book a stay at this business-friendly motel in Perryville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8.4/10 Very Good! (850 reviews)
"I like the punctual opening of the breakfast room. I do wish that biscuits and gravy were available more often."

Reviewed on Apr 24, 2025

Super 8 by Wyndham Perryville
Days Inn by Wyndham Perryville
Days Inn by Wyndham Perryville
2 out of 5
1500 Liberty Street, Perryville, MO
  • 27 min walk from National Shrine of Our Lady of the Miraculous Medal
The price is $78 per night from May 11 to May 12
$78
includes taxes & fees
May 11 - May 12
Book a stay at this business-friendly hotel in Perryville. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Perryville Country Club and ...
6.8/10 (397 reviews)
"It was clean and quiet what more do you need"

Reviewed on Apr 26, 2025

Days Inn by Wyndham Perryville
Quality Inn Perryville I-55
Quality Inn Perryville I-55
2.5 out of 5
1517 S. Perryville Blvd., Perryville, MO
  • 28 min walk from National Shrine of Our Lady of the Miraculous Medal
The price is $92 per night from May 11 to May 12
$92
includes taxes & fees
May 11 - May 12
Stay at this hotel in Perryville. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Perryville Country Club and Saint Marys Lake are located ...
6.6/10 (104 reviews)
"ok"

Reviewed on Apr 12, 2025

Quality Inn Perryville I-55
Urban Lofts
Urban Lofts
3 out of 5
102 N Jackson St, Perryville, MO
  • 5 min drive from National Shrine of Our Lady of the Miraculous Medal
The price is $321 per night from May 4 to May 5
$321
includes taxes & fees
May 4 - May 5
Stay at this 3-star aparthotel in Perryville. Enjoy free WiFi, free parking, and dry cleaning or laundry services. Popular attractions Feltz Street Park and ...
9/10 Wonderful! (17 reviews)
"Great place to stay!"

Reviewed on Oct 21, 2024

Urban Lofts
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
2.5 out of 5
3003 SOUTH OLD ORCHARD ROAD, Jackson, MO
  • 1 hour drive from National Shrine of Our Lady of the Miraculous Medal
The price is $93 per night from Jun 1 to Jun 2
$93
includes taxes & fees
Jun 1 - Jun 2
Book a stay at this business-friendly hotel in Jackson. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8.8/10 Excellent! (543 reviews)
"The motel is very nice, clean, and recently renovated. The staff were all friendly and professional. We will definitely stay there again."

Reviewed on May 1, 2025

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
Holiday Inn Express & Suites Murphysboro - Carbondale by IHG
Holiday Inn Express & Suites Murphysboro - Carbondale by IHG
2.5 out of 5
120 MUDDY MONSTER ROAD, Murphysboro, IL
  • 2 hours drive from National Shrine of Our Lady of the Miraculous Medal
The price is $141 per night from May 11 to May 12
$141
includes taxes & fees
May 11 - May 12
Book a stay at this business-friendly hotel in Murphysboro. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.4/10 Exceptional! (428 reviews)
"The hotel is beautiful"

Reviewed on Apr 26, 2025

Holiday Inn Express & Suites Murphysboro - Carbondale by IHG
Drury Inn & Suites Jackson MO
Drury Inn & Suites Jackson MO
3 out of 5
225 Drury Lane, Jackson, MO
  • 1 hour drive from National Shrine of Our Lady of the Miraculous Medal
The price is $95 per night from May 7 to May 8
$95
includes taxes & fees
May 7 - May 8
Book a stay at this business-friendly hotel in Jackson. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
9.4/10 Exceptional! (1,001 reviews)
"Very convenient!"

Reviewed on May 1, 2025

Drury Inn & Suites Jackson MO
Tru By Hilton Cape Girardeau
Tru By Hilton Cape Girardeau
2.5 out of 5
2520 Veterans Memorial Dr, Cape Girardeau, MO
  • 1 hour drive from National Shrine of Our Lady of the Miraculous Medal
The price is $115 per night from May 11 to May 12
$115
includes taxes & fees
May 11 - May 12
Stay at this hotel in Cape Girardeau. Enjoy free breakfast, free parking, and a fitness center. Popular attractions Cape Girardeau Conservation Nature Center ...
9.6/10 Exceptional! (11 reviews)
"Staff was super. Very very clean"

Reviewed on Apr 30, 2025

Tru By Hilton Cape Girardeau
Comfort Suites Jackson-Cape Girardeau
Comfort Suites Jackson-Cape Girardeau
2.5 out of 5
2904 Old Orchard Rd, Jackson, MO
  • 1 hour drive from National Shrine of Our Lady of the Miraculous Medal
The price is $105 per night from May 4 to May 5
$105
includes taxes & fees
May 4 - May 5
Book a stay at this business-friendly hotel in Jackson. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Cape Girardeau Conservation Nature ...
8.2/10 Very Good! (703 reviews)
"I was only there for 5 hours to sleep. It was cozy and clean. I only wish I had more time to rest in my bed. I’m not sure what the surrounding area was like - probably not wonderful, but there was a police car stationed outside between our hotel and the next hotel. Everything outside was well lit, ..."

Reviewed on Apr 28, 2025

Comfort Suites Jackson-Cape Girardeau
Holiday Inn Express Hotel & Suites Sparta by IHG
Holiday Inn Express Hotel & Suites Sparta by IHG
2.5 out of 5
1301 N Market St, Sparta, IL
  • 1 hour drive from National Shrine of Our Lady of the Miraculous Medal
The price is $110 per night from May 18 to May 19
$110
includes taxes & fees
May 18 - May 19
Book a stay at this business-friendly hotel in Sparta. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
9.2/10 Wonderful! (322 reviews)
"Great hotel. Nice breakfast. Great beds."

Reviewed on Apr 27, 2025

Holiday Inn Express Hotel & Suites Sparta by IHG
Baymont by Wyndham Chester IL
Baymont by Wyndham Chester IL
2.5 out of 5
2150 State Street, Chester, IL
  • 35 min drive from National Shrine of Our Lady of the Miraculous Medal
The price is $102 per night from May 11 to May 12
$102
includes taxes & fees
May 11 - May 12
Book a stay at this business-friendly hotel in Chester. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the property ...
8.6/10 Excellent! (296 reviews)
"I stay here usually once a month. Its a nice place the staff is very friendly and the price is decent"

Reviewed on Apr 17, 2025

Baymont by Wyndham Chester IL
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find cheap hotels in Perryville

You’re not an average traveler—and Hotwire knows it. Your wanderlust takes you off the beaten path to discover unique adventures and every travel destination’s lesser-known tourist scenes. Hotwire has the hookup! Book your Perryville hotel with Hotwire to complete your one-of-a-kind travel checklist.

For you, intrepid voyager, Hotwire has a large selection of the best hotels in Perryville.

Choosing the right hotel in Missouri has everything to do with the way you want your trip to go. If you’ve scribbled a few obscure destinations on your itinerary, you probably already have a good sense of how your getaway is taking shape. Lean into that by booking one of Perryville’s 140 hotels. Choose the one that best catches your trip’s tourist drift.

If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $78. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get great Perryville hotel deals at the last minute.

While traveling, where you stay plays a major role in your overall vacation enjoyment. Choosing the right hotel is just as important as making sure you book the right flight and car rental. If you’re traveling with family or friends, you may need to book a hotel with connecting rooms. If you enjoy an elegant and relaxing hotel ambiance, opt for one of Hotwire’s luxury hotels in Perryville. No matter your reason for visiting Perryville, with Hotwire’s large selection of hotels in the area, you’re sure to book a hotel that meets all your accommodation needs.

Frequently Asked Questions About Perryville hotels

Where can I find the best last-minute travel deals?

If you’re traveling in the spirit of spontaneity, you’ll love the idea of leaving your exact hotel choice up to chance. With Hotwire Hot Rates, you can unlock great deals on your next flight, hotel, or car rental. Just plug in your general preferences and let Hotwire choose last-minute hotel deals in Perryville for as low as $78.

How many hotels are there in Perryville?

With over 140 hotels in Perryville, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $78.

How to find cheap car rentals in Perryville?

Finding a cheap car rental deal in Perryville is as easy as scoring cheap hotels in Perryville. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can unlock great car rental deals if you book a Hotwire Hot Rate at the last minute.