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Hotels in Perryville

Choose from 161 Perryville Hotel Deals

Days Inn by Wyndham Perryville

Days Inn by Wyndham Perryville

2 out of 5
1500 Liberty Street Perryville MO
  • 27 min walk from National Shrine of Our Lady of the Miraculous Medal
Book a stay at this business-friendly hotel in Perryville. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Perryville Country Club and ...
6.8/10 (420 reviews)
Great people there

Reviewed on Jan 29, 2026

Days Inn by Wyndham Perryville
Holiday Inn Express & Suites Perryville by IHG

Holiday Inn Express & Suites Perryville by IHG

2.5 out of 5
2020 Jefferson St Perryville MO
  • 28 min walk from National Shrine of Our Lady of the Miraculous Medal
Book a stay at this business-friendly hotel in Perryville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
9.2/10 Wonderful! (557 reviews)
Very nice and clean hotel, and I slept very well. The room was comfortable and quiet. The only area for improvement would be the staff interaction. They didn’t greet me when I came in or out and seemed a bit annoyed, which made the experience feel less welcoming. Breakfast was also disappointing. ...

Reviewed on Jan 19, 2026

Holiday Inn Express & Suites Perryville by IHG
Super 8 by Wyndham Perryville

Super 8 by Wyndham Perryville

2 out of 5
1119 Vincent Dr Perryville MO
  • 28 min walk from National Shrine of Our Lady of the Miraculous Medal
Book a stay at this business-friendly motel in Perryville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8.4/10 Very Good! (949 reviews)
Clean, well kept room. I would stay there again.

Reviewed on Jan 31, 2026

Super 8 by Wyndham Perryville
Quality Inn Perryville I-55

Quality Inn Perryville I-55

2.5 out of 5
1517 S. Perryville Blvd. Perryville MO
  • 28 min walk from National Shrine of Our Lady of the Miraculous Medal
Stay at this hotel in Perryville. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Perryville Country Club and Saint Marys Lake are located ...
6.6/10 (124 reviews)
This was an overnight trip…Our bathroom was dirty and there weren’t any extra towels or toilet paper in the room. Also the fire alarm went off at 6am without an explanation..They offered yogurt but didn’t have the key to the cabinet.

Reviewed on Aug 11, 2025

Quality Inn Perryville I-55
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

3 out of 5
3003 SOUTH OLD ORCHARD ROAD Jackson MO
  • 1 hour drive from National Shrine of Our Lady of the Miraculous Medal
Book a stay at this business-friendly hotel in Jackson. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8.8/10 Excellent! (694 reviews)
Staff was courteous; facility clean.

Reviewed on Jan 28, 2026

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
Drury Inn & Suites Jackson MO

Drury Inn & Suites Jackson MO

3 out of 5
225 Drury Lane Jackson MO
  • 1 hour drive from National Shrine of Our Lady of the Miraculous Medal
Book a stay at this business-friendly hotel in Jackson. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
9.6/10 Exceptional! (1,000 reviews)
Clean room with friendly staff.

Reviewed on Jan 22, 2026

Drury Inn & Suites Jackson MO
Baymont by Wyndham Chester IL

Baymont by Wyndham Chester IL

2.5 out of 5
2150 State Street Chester IL
  • 35 min drive from National Shrine of Our Lady of the Miraculous Medal
Book a stay at this business-friendly hotel in Chester. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
8.4/10 Very Good! (357 reviews)
Very clean hotel and the beds were comfortable. Will definitely stay there again. Very economical!

Reviewed on Jan 20, 2026

Baymont by Wyndham Chester IL
Holiday Inn Express Hotel & Suites Sparta by IHG

Holiday Inn Express Hotel & Suites Sparta by IHG

2.5 out of 5
1301 N Market St Sparta IL
  • 1 hour drive from National Shrine of Our Lady of the Miraculous Medal
Book a stay at this business-friendly hotel in Sparta. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
9/10 Wonderful! (382 reviews)
It was nice with friendly staff

Reviewed on Dec 29, 2025

Holiday Inn Express Hotel & Suites Sparta by IHG
Holiday Inn Express & Suites Murphysboro - Carbondale by IHG

Holiday Inn Express & Suites Murphysboro - Carbondale by IHG

2.5 out of 5
120 MUDDY MONSTER ROAD Murphysboro IL
  • 2 hours drive from National Shrine of Our Lady of the Miraculous Medal
Book a stay at this business-friendly hotel in Murphysboro. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.4/10 Exceptional! (519 reviews)
Yes, very clean and service was great.

Reviewed on Jan 27, 2026

Holiday Inn Express & Suites Murphysboro - Carbondale by IHG
Tru By Hilton Cape Girardeau

Tru By Hilton Cape Girardeau

2.5 out of 5
2520 Veterans Memorial Dr Cape Girardeau MO
  • 1 hour drive from National Shrine of Our Lady of the Miraculous Medal
Stay at this hotel in Cape Girardeau. Enjoy free breakfast, free parking, and a fitness center. Popular attractions Cape Girardeau Conservation Nature Center ...
9.4/10 Exceptional! (108 reviews)
Very nice room!

Reviewed on Jan 23, 2026

Tru By Hilton Cape Girardeau
Microtel Inn & Suites by Wyndham Sainte Genevieve

Microtel Inn & Suites by Wyndham Sainte Genevieve

2.5 out of 5
21958 Hwy 32 Ste Genevieve MO
  • 49 min drive from National Shrine of Our Lady of the Miraculous Medal
Book a stay at this business-friendly hotel in Ste Genevieve. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the ...
8.6/10 Excellent! (616 reviews)
Staff was accommodating

Reviewed on Jan 28, 2026

Microtel Inn & Suites by Wyndham Sainte Genevieve
Town House Inn

Town House Inn

2.5 out of 5
517 E Jackson Blvd Jackson MO
  • 1 hour drive from National Shrine of Our Lady of the Miraculous Medal
Stay at this motel in Jackson. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff in our reviews. Popular attractions ...
7.6/10 Good! (432 reviews)
Yes

Reviewed on Jan 24, 2026

Town House Inn
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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