Search for Cheap Deals onHotels in Southern Illinois
Check Last Minute Southern Illinois Hotel Deals
Choose from 1035 Southern Illinois Hotel Deals

Drury Plaza Hotel Mt. Vernon
Reviewed on Jul 14, 2025

Best Western Plus Pontoon Beach
Reviewed on Jul 13, 2025

Super 8 by Wyndham O'Fallon
Reviewed on Jul 14, 2025

Drury Inn & Suites St. Louis Fairview Heights
Reviewed on Jul 14, 2025

Drury Inn & Suites Marion
Reviewed on Jul 8, 2025

Days Inn & Suites by Wyndham Caseyville
Reviewed on Jun 30, 2025

Red Lion Inn & Suites Pontoon Beach
Reviewed on Jul 15, 2025

La Quinta Inn & Suites by Wyndham O'Fallon, IL - St. Louis
Reviewed on Jun 30, 2025

Country Inn & Suites by Radisson, Effingham, IL
Reviewed on Jul 16, 2025

Best Western Troy Hotel
Reviewed on Jul 13, 2025

Comfort Suites Fairview Heights
Reviewed on Jul 14, 2025

Baymont by Wyndham Marion
Reviewed on Jul 14, 2025
Find cheap hotels in Southern Illinois
You’re not an average traveler—and Hotwire knows it. Your wanderlust takes you off the beaten path to discover unique adventures and every travel destination’s lesser-known tourist scenes. Hotwire has the hookup! Book your Southern Illinois hotel with Hotwire to complete your one-of-a-kind travel checklist.
For you, intrepid voyager, Hotwire has a large selection of the best hotels in Southern Illinois.
Choosing the right hotel in Illinois has everything to do with the way you want your trip to go. If you’ve scribbled a few obscure destinations on your itinerary, you probably already have a good sense of how your getaway is taking shape. Lean into that by booking one of Southern Illinois’s 1,035 hotels. Choose the one that best catches your trip’s tourist drift.
If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $60. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get great Southern Illinois hotel deals at the last minute.
While traveling, where you stay plays a major role in your overall vacation enjoyment. Choosing the right hotel is just as important as making sure you book the right flight and car rental. If you’re traveling with family or friends, you may need to book a hotel with connecting rooms. If you enjoy an elegant and relaxing hotel ambiance, opt for one of Hotwire’s luxury hotels in Southern Illinois. No matter your reason for visiting Southern Illinois, with Hotwire’s large selection of hotels in the area, you’re sure to book a hotel that meets all your accommodation needs.
Frequently Asked Questions About Southern Illinois hotels
Where can I find the best last-minute travel deals?
If you’re traveling in the spirit of spontaneity, you’ll love the idea of leaving your exact hotel choice up to chance. With Hotwire Hot Rates, you can unlock great deals on your next flight, hotel, or car rental. Just plug in your general preferences and let Hotwire choose last-minute hotel deals in Southern Illinois for as low as $60.
How many hotels are there in Southern Illinois?
With over 1,035 hotels in Southern Illinois, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $60.
How to find cheap car rentals in Southern Illinois?
Finding a cheap car rental deal in Southern Illinois is as easy as scoring cheap hotels in Southern Illinois. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can unlock great car rental deals if you book a Hotwire Hot Rate at the last minute.
Top Booked Hotels in Southern Illinois
- Best Western Plus Pontoon Beach
- Super 8 by Wyndham O'Fallon
- Days Inn & Suites by Wyndham Caseyville
- Red Lion Inn & Suites Pontoon Beach
- La Quinta Inn & Suites by Wyndham O'Fallon, IL - St. Louis
- Country Inn & Suites by Radisson, Effingham, IL
- Best Western Troy Hotel
- Comfort Suites Fairview Heights
- Baymont by Wyndham Marion
- Hilton Garden Inn St. Louis Shiloh/O'Fallon IL
- Super 8 by Wyndham Pontoon Beach IL/St. Louis MO Area
- Comfort Suites Mount Vernon
- Hotel Brand
- Hotel Class
- Near An Airport
- Areas Of Southern Illinois
- Near An Attraction
- Hotel Theme
- Other Cities Near Southern Illinois
- Hotels near Shawnee National Forest
- Hotels near Southern Illinois University
- Hotels near Harrah's Metropolis
- Hotels near Garden of the Gods Recreation Area
- Hotels near Lake of Egypt
- Hotels near World Wide Technology Raceway
- Hotels near Rend Lake
- Hotels near Giant City State Park
- Hotels near Scott Air Force Base
- Hotels near Carlyle Lake
- Hotels near Superman Statue
- Hotels near St. Claire Square Mall
- Hotels near The Edge
- Hotels near Cahokia Mounds State Historic Site
- Hotels near DuQuoin State Fairgrounds
- Hotels near O'Fallon Family Sports Park
- Hotels near Marion Cultural and Civic Center
- Hotels near Lake Sara
- Hotels near Cave in Rock State Park
- Hotels near I-57 Drag Strip
- Hotels with Free Parking in Southern Illinois
- Family Hotels in Southern Illinois
- Pet-friendly Hotels in Southern Illinois
- Hotels with a Pool in Southern Illinois
- Hotels with an Indoor Pool in Southern Illinois
- Hotels with Hot Tubs in Southern Illinois
- Historic Hotels in Southern Illinois
- Luxury Hotels in Southern Illinois
- Resorts & Hotels with Spas in Southern Illinois
- Hotel Wedding Venues in Southern Illinois
- Winery Hotels in Southern Illinois
- Hotels with smoking rooms in Southern Illinois
- Romantic Hotels in Southern Illinois
- Apartment Hotel in Southern Illinois
- Casinos in Southern Illinois
- Beach Hotels in Southern Illinois
- Waterpark Hotels in Southern Illinois
- Adults Only Resorts & Hotels in Southern Illinois
- Hotels with Early Check-in in Southern Illinois
- Scuba Diving in Southern Illinois
- St. Charles Hotels
- Evansville Hotels
- Paducah Hotels
- Maryland Heights Hotels
- Chesterfield Hotels
- Terre Haute Hotels
- Cape Girardeau Hotels
- O'Fallon Hotels
- Marion Hotels
- Effingham Hotels
- Mount Vernon Hotels
- Carbondale Hotels
- Hazelwood Hotels
- Decatur Hotels
- Fairview Heights Hotels
- Collinsville Hotels
- Gilbertsville Hotels
- Grafton Hotels
- Fenton Hotels
- Alton Hotels