Search for Cheap Deals on
Hotels in Southern Illinois

Check Last Minute Southern Illinois Hotel Deals

Tonight Mar 13 - Mar 14This weekend Mar 13 - Mar 15

Choose from 1158 Southern Illinois Hotel Deals

Drury Inn & Suites St. Louis Fairview Heights

Drury Inn & Suites St. Louis Fairview Heights

3 out of 5
12 Ludwig Dr Fairview Heights IL
  • 4 hours drive from Shawnee National Forest
Book a stay at this business-friendly hotel in Fairview Heights. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.2/10 Wonderful! (1,001 reviews)
Clean room and a great breakfast!

Reviewed on Mar 12, 2026

Drury Inn & Suites St. Louis Fairview Heights
Best Western Delta Inn

Best Western Delta Inn

2.5 out of 5
1509 Hampton Dr Effingham IL
  • 4 hours drive from Shawnee National Forest
Book a stay at this business-friendly hotel in Effingham. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
9.2/10 Wonderful! (1,004 reviews)
Low toilet seat caused access problems high bed caused difficulty getting into the bed

Reviewed on Mar 12, 2026

Best Western Delta Inn
Drury Inn & Suites St. Louis O'Fallon, IL

Drury Inn & Suites St. Louis O'Fallon, IL

3 out of 5
1118 Central Park Drive O'Fallon IL
  • 4 hours drive from Shawnee National Forest
Book a stay at this business-friendly hotel in O'Fallon. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9.6/10 Exceptional! (1,001 reviews)
The room was comfortable, and clean. The beds had plenty of pillows and a comfortable bed. The check in process was quick. The room had a clean bathroom and shower, with plenty of towels for us. The only issue I would bring up is that there was only 1 operational elevator which meant a delay in getting ...

Reviewed on Mar 9, 2026

Drury Inn & Suites St. Louis O'Fallon, IL
Drury Plaza Hotel Mt. Vernon

Drury Plaza Hotel Mt. Vernon

3 out of 5
145 North 44th Street  Mount Vernon IL
  • 2 hours drive from Shawnee National Forest
Book a stay at this business-friendly hotel in Mount Vernon. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.6/10 Exceptional! (1,652 reviews)
Did not swim

Reviewed on Mar 11, 2026

Drury Plaza Hotel Mt. Vernon
Comfort Suites Mount Vernon

Comfort Suites Mount Vernon

2.5 out of 5
404 South 44th Street Mount Vernon IL
  • 2 hours drive from Shawnee National Forest
Book a stay at this business-friendly hotel in Mount Vernon. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9/10 Wonderful! (1,003 reviews)
yes

Reviewed on Mar 10, 2026

Comfort Suites Mount Vernon
Super 8 by Wyndham O'Fallon

Super 8 by Wyndham O'Fallon

2 out of 5
1100 Eastgate Dr O'Fallon IL
  • 4 hours drive from Shawnee National Forest
Book a stay at this business-friendly hotel in O'Fallon. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7/10 Good! (1,001 reviews)
It was very affordable but unfortunately the room we stayed in was not cleaned at all. Very bad odor in the room, bed and pillows were not cleaned still have hairs and stains on sheets and pillows. Went to front desk and told them but they just look like nothing they can do, it’s like oh well. Floors ...

Reviewed on Mar 12, 2026

Super 8 by Wyndham O'Fallon
Baymont by Wyndham Effingham

Baymont by Wyndham Effingham

2.5 out of 5
1811 W Fayette Avenue Effingham IL
  • 4 hours drive from Shawnee National Forest
Book a stay at this business-friendly hotel in Effingham. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8/10 Very Good! (1,000 reviews)
Staff was extremely friendly

Reviewed on Mar 9, 2026

Baymont by Wyndham Effingham
Comfort Suites Fairview Heights - St. Louis

Comfort Suites Fairview Heights - St. Louis

2.5 out of 5
137 Ludwig Dr Fairview Heights IL
  • 4 hours drive from Shawnee National Forest
Book a stay at this business-friendly hotel in Fairview Heights. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our ...
6.6/10 (1,000 reviews)
Room was so bad i did not complete my stay. Booked room to avoid having drive back home in a storm but ENDED UP DRIVING HOME IN THE STORM.. Tub was flithy splats of food or something was on the dresser. Got bitten by a bug sitting on the bed..went to either get a clean accommodating room waited several ...

Reviewed on Mar 10, 2026

Comfort Suites Fairview Heights - St. Louis
Drury Inn & Suites Marion

Drury Inn & Suites Marion

3 out of 5
2706 W DeYoung St Marion IL
  • 1 hour drive from Shawnee National Forest
Book a stay at this business-friendly hotel in Marion. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9.4/10 Exceptional! (1,001 reviews)
Lovely hotel with exceptionally nice staff and clean and great room!

Reviewed on Mar 13, 2026

Drury Inn & Suites Marion
Red Lion Inn & Suites Pontoon Beach

Red Lion Inn & Suites Pontoon Beach

2.5 out of 5
1240 E Chain Of Rocks Rd Granite City IL
  • 4 hours drive from Shawnee National Forest
Stay at this hotel in Granite City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions ...
8/10 Very Good! (630 reviews)
The room wasn’t clean, the pillows had hair all over, the chair in the room had tape over a holes it had, and the toilet was dirty. The microwave and mini fridge were dirty, had possibly mold or rust on the fridge. It was super noisy the whole time, paper thin walls and door. At 4am there were people ...

Reviewed on Mar 11, 2026

Red Lion Inn & Suites Pontoon Beach
Quality Inn O'Fallon IL - St. Louis

Quality Inn O'Fallon IL - St. Louis

3 out of 5
1409 W US 50 O'Fallon IL
  • 4 hours drive from Shawnee National Forest
Book a stay at this business-friendly hotel in O'Fallon. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7.4/10 Good! (1,001 reviews)
Toilet did not work. It’s been a week since our stay and still have not recieved our deposit back. Was told 3-5 business days and nothing.

Reviewed on Mar 13, 2026

Quality Inn O'Fallon IL - St. Louis
Best Western Marion Hotel

Best Western Marion Hotel

2.5 out of 5
400 Comfort Dr Marion IL
  • 1 hour drive from Shawnee National Forest
Book a stay at this business-friendly hotel in Marion. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
8.2/10 Very Good! (1,007 reviews)
It was a nice hotel, we both felt safe and everyone was so nice.

Reviewed on Mar 11, 2026

Best Western Marion Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find cheap hotels in Southern Illinois

You’re not an average traveler—and Hotwire knows it. Your wanderlust takes you off the beaten path to discover unique adventures and every travel destination’s lesser-known tourist scenes. Hotwire has the hookup! Book your Southern Illinois hotel with Hotwire to complete your one-of-a-kind travel checklist.

For you, intrepid voyager, Hotwire has a large selection of the best hotels in Southern Illinois.

Choosing the right hotel in Illinois has everything to do with the way you want your trip to go. If you’ve scribbled a few obscure destinations on your itinerary, you probably already have a good sense of how your getaway is taking shape. Lean into that by booking one of Southern Illinois’s 1,158 hotels. Choose the one that best catches your trip’s tourist drift.

If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $58. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get great Southern Illinois hotel deals at the last minute.

While traveling, where you stay plays a major role in your overall vacation enjoyment. Choosing the right hotel is just as important as making sure you book the right flight and car rental. If you’re traveling with family or friends, you may need to book a hotel with connecting rooms. If you enjoy an elegant and relaxing hotel ambiance, opt for one of Hotwire’s luxury hotels in Southern Illinois. No matter your reason for visiting Southern Illinois, with Hotwire’s large selection of hotels in the area, you’re sure to book a hotel that meets all your accommodation needs.

Frequently Asked Questions About Southern Illinois hotels

Where can I find the best last-minute travel deals?

If you’re traveling in the spirit of spontaneity, you’ll love the idea of leaving your exact hotel choice up to chance. With Hotwire Hot Rates, you can unlock great deals on your next flight, hotel, or car rental. Just plug in your general preferences and let Hotwire choose last-minute hotel deals in Southern Illinois for as low as $58.

How many hotels are there in Southern Illinois?

With over 1,158 hotels in Southern Illinois, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $58.

How to find cheap car rentals in Southern Illinois?

Finding a cheap car rental deal in Southern Illinois is as easy as scoring cheap hotels in Southern Illinois. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can unlock great car rental deals if you book a Hotwire Hot Rate at the last minute.