Search for Cheap Deals onHotels in Southern Illinois
Choose from 840 Southern Illinois Hotel Deals

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Find cheap hotels in Southern Illinois
You’re not an average traveler—and Hotwire knows it. Your wanderlust takes you off the beaten path to discover unique adventures and every travel destination’s lesser-known tourist scenes. Hotwire has the hookup! Book your Southern Illinois hotel with Hotwire to complete your one-of-a-kind travel checklist.
For you, intrepid voyager, Hotwire has a large selection of the best hotels in Southern Illinois.
Choosing the right hotel in Illinois has everything to do with the way you want your trip to go. If you’ve scribbled a few obscure destinations on your itinerary, you probably already have a good sense of how your getaway is taking shape. Lean into that by booking one of Southern Illinois’s 840 hotels. Choose the one that best catches your trip’s tourist drift.
If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $52. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get up to 60% Southern Illinois hotel deals at the last minute.
While traveling, where you stay plays a major role in your overall vacation enjoyment. Choosing the right hotel is just as important as making sure you book the right flight and car rental. If you’re traveling with family or friends, you may need to book a hotel with connecting rooms. If you enjoy an elegant and relaxing hotel ambiance, opt for one of Hotwire’s luxury hotels in Southern Illinois. No matter your reason for visiting Southern Illinois, with Hotwire’s large selection of hotels in the area, you’re sure to book a hotel that meets all your accommodation needs.
Frequently Asked Questions About Southern Illinois hotels
Where can I find the best last-minute travel deals?
If you’re traveling in the spirit of spontaneity, you’ll love the idea of leaving your exact hotel choice up to chance. With Hotwire Hot Rates, you can save up to 60% off your next flight, hotel, or car rental. Just plug in your general preferences and let Hotwire choose last-minute hotel deals in Southern Illinois for as low as $52.
How many hotels are there in Southern Illinois?
With over 840 hotels in Southern Illinois, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $52.
How to find cheap car rentals in Southern Illinois?
Finding a cheap car rental deal in Southern Illinois is as easy as scoring cheap hotels in Southern Illinois. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can even save up to 60% off a car rental deal if you book a Hotwire Hot Rate at the last minute.
Is it safe to travel to Southern Illinois now?
With recent COVID-19 closures and reopenings, many people are wondering, “Is it safe to travel to Southern Illinois right now?” When it’s time to book your getaway, be sure to check out the most up-to-date information on all safety measures, any restrictions, and guidance on traveling during the coronavirus pandemic.
Top Booked Hotels in Southern Illinois
- Baymont by Wyndham Marion
- Ramada by Wyndham Effingham
- La Quinta Inn & Suites by Wyndham O'Fallon, IL - St. Louis
- Comfort Suites Mount Vernon
- La Quinta Inn & Suites by Wyndham Collinsville - St. Louis
- Best Western Troy Hotel
- La Quinta Inn & Suites by Wyndham Effingham
- Super 8 by Wyndham O'Fallon
- Quality Inn & Suites Caseyville - St. Louis
- Unique Suites Hotel
- Hotel Brand
- Hotel Class
- Near An Airport
- Areas Of Southern Illinois
- Near An Attraction
- Hotel Theme
- Other Cities Near Southern Illinois
- Hotels near Shawnee National Forest
- Hotels near Southern Illinois University
- Hotels near Garden of the Gods Recreation Area
- Hotels near Rend Lake
- Hotels near Harrah's Metropolis
- Hotels near Lake of Egypt
- Hotels near Giant City State Park
- Hotels near O'Fallon Family Sports Park
- Hotels near Gateway Conference Center
- Hotels near Scott Air Force Base
- Hotels near Carlyle Lake
- Hotels near World Wide Technology Raceway
- Hotels near Cahokia Mounds State Historic Site
- Hotels near The Gardens at SIUE
- Hotels near Cave in Rock State Park
- Hotels near St. Claire Square Mall
- Hotels near McKendree University
- Hotels near Lake Shelbyville Beach
- Hotels near I-57 Drag Strip
- Hotels near National Shrine of Our Lady of the Snows
- Hotels with Free Parking (190)
- Family Hotels (167)
- Pet-friendly Hotels (139)
- Hotels with a Pool (131)
- Hotels with an Indoor Pool (102)
- Hotels with Hot Tubs (61)
- Historic Hotels (56)
- Luxury Hotels (54)
- Resorts & Hotels with Spas (45)
- Hotel Wedding Venues (28)
- Winery Hotels (26)
- Hotels with smoking rooms (24)
- Romantic Hotels (21)
- Apartment Hotel (20)
- Casinos (13)
- Beach Hotels (8)
- Waterpark Hotels (2)
- Hotels with Early Check-in (1)
- St. Charles Hotels
- Evansville Hotels
- Paducah Hotels
- Terre Haute Hotels
- Maryland Heights Hotels
- Cape Girardeau Hotels
- Chesterfield Hotels
- Carbondale Hotels
- Effingham Hotels
- Decatur Hotels
- Marion Hotels
- Mount Vernon Hotels
- O'Fallon Hotels
- Collinsville Hotels
- Sikeston Hotels
- Alton Hotels
- Fairview Heights Hotels
- Edwardsville Hotels
- Grafton Hotels
- Metropolis Hotels