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Southern Illinois

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Southern Illinois Flights as Low as $130

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

Frontier Airlines
Sat, Jul 26 - Sat, Aug 2
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$130 Roundtrip, found 2 days ago
$130
Roundtrip
found 2 days ago
Select Frontier Airlines flight, departing Sat, Jul 26 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Sat, Aug 2, priced at $130 found 2 days ago
Frontier Airlines
Sat, Jul 19 - Sun, Jul 20
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$140 Roundtrip, found 2 days ago
$140
Roundtrip
found 2 days ago
Select Frontier Airlines flight, departing Sat, Jul 19 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Sun, Jul 20, priced at $140 found 2 days ago
Spirit Airlines
Thu, Jun 12 - Sat, Jun 14
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$161 Roundtrip, found 2 days ago
$161
Roundtrip
found 2 days ago
Select Spirit Airlines flight, departing Thu, Jun 12 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Sat, Jun 14, priced at $161 found 2 days ago
Delta
Sat, Jul 26 - Sat, Aug 2
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$164 Roundtrip, found 2 days ago
$164
Roundtrip
found 2 days ago
Select Delta flight, departing Sat, Jul 26 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Sat, Aug 2, priced at $164 found 2 days ago
Spirit Airlines
Wed, May 14 - Sat, May 17
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$170 Roundtrip, found 14 hours ago
$170
Roundtrip
found 14 hours ago
Select Spirit Airlines flight, departing Wed, May 14 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Sat, May 17, priced at $170 found 14 hours ago
American Airlines
Sat, Jul 26 - Sat, Aug 2
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$174 Roundtrip, found 2 days ago
$174
Roundtrip
found 2 days ago
Select American Airlines flight, departing Sat, Jul 26 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Sat, Aug 2, priced at $174 found 2 days ago
Delta
Sat, May 24 - Sun, May 25
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$180 Roundtrip, found 6 days ago
$180
Roundtrip
found 6 days ago
Select Delta flight, departing Sat, May 24 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Sun, May 25, priced at $180 found 6 days ago
American Airlines
Sat, Jul 19 - Sun, Jul 20
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$184 Roundtrip, found 2 days ago
$184
Roundtrip
found 2 days ago
Select American Airlines flight, departing Sat, Jul 19 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Sun, Jul 20, priced at $184 found 2 days ago
Spirit Airlines
Wed, May 14 - Sat, May 24
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$191 Roundtrip, found 14 hours ago
$191
Roundtrip
found 14 hours ago
Select Spirit Airlines flight, departing Wed, May 14 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Sat, May 24, priced at $191 found 14 hours ago
Delta
Sat, Jul 26 - Sat, Aug 2
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$197 Roundtrip, found 2 days ago
$197
Roundtrip
found 2 days ago
Select Delta flight, departing Sat, Jul 26 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Sat, Aug 2, priced at $197 found 2 days ago
Delta
Sat, Jul 26 - Sat, Aug 2
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$199 Roundtrip, found 2 days ago
$199
Roundtrip
found 2 days ago
Select Delta flight, departing Sat, Jul 26 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Sat, Aug 2, priced at $199 found 2 days ago
Spirit Airlines
Sat, Jul 26 - Sat, Aug 2
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$201 Roundtrip, found 2 days ago
$201
Roundtrip
found 2 days ago
Select Spirit Airlines flight, departing Sat, Jul 26 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Sat, Aug 2, priced at $201 found 2 days ago
Delta
Wed, May 21 - Sat, May 24
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$203 Roundtrip, found 6 days ago
$203
Roundtrip
found 6 days ago
Select Delta flight, departing Wed, May 21 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Sat, May 24, priced at $203 found 6 days ago
American Airlines
Sat, Jul 26 - Sat, Aug 2
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$217 Roundtrip, found 2 days ago
$217
Roundtrip
found 2 days ago
Select American Airlines flight, departing Sat, Jul 26 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Sat, Aug 2, priced at $217 found 2 days ago
United
Wed, May 21 - Tue, May 27
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$247 Roundtrip, found 6 days ago
$247
Roundtrip
found 6 days ago
Select United flight, departing Wed, May 21 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Tue, May 27, priced at $247 found 6 days ago
American Airlines
Tue, Jun 17 - Wed, Jul 16
PBI
Palm Beach Intl.
STL
Lambert-St. Louis Intl.
$316 Roundtrip, found 21 hours ago
$316
Roundtrip
found 21 hours ago
Select American Airlines flight, departing Tue, Jun 17 from Palm Beach Intl. to Lambert-St. Louis Intl., returning Wed, Jul 16, priced at $316 found 21 hours ago

Cheap Flights to Southern Illinois

Fall in love at first flight with your vacation to Southern Illinois by saving a ton of cash on your last-minute cheap flight. There’s no more scouring the internet for a good deal—book your flight to Southern Illinois on Hotwire, and you’ll be up, up, and on a getaway in no time.

Because once the wheels are down in Southern Illinois, the good times start rolling. So buckle up, you’re in for a fun ride.

Frequently Asked Questions About flights to Southern Illinois

Don’t waste your time on endless searches for cheap airline tickets oneway or roundtrip. We’ll have you on your way to Southern Illinois with a tiny bag of pretzels in your hand before you can say “tray tables in the upright position”—and for a ticket price that works for your vacay budget.

So all you have to worry about is where you’re headed after the STL airport.

What is the cheapest month to fly to Southern Illinois?

Airline ticket prices fluctuate all the time, depending on the day of the week or the month of the year. The cheapest round trip flights to Southern Illinois are in July, but when you book your flight on Hotwire, savings are always in season.

How many airlines fly to Southern Illinois?

Variety is the spice of life, even when it comes to booking your next trip. Want options for airlines? You’ll find 16 to choose from for your flight to Southern Illinois.

What airport is best to fly into Southern Illinois?

When you’re planning your trip to Southern Illinois, convenience is the name of the game. Luckily, Southern Illinois Williamson County Regional Airport is nearby so you can deplane and get going on checking off everything on your Southern Illinois must-do list.

How much are flights to Southern Illinois?

Got very cheap flights on your vacation itinerary? When you book your airline tickets to Southern Illinois on Hotwire, you may just get what’s on your getaway wish list. With tickets as low as $130, you’ll have leftover cash for at least a magazine and a bottle of water at the airport book store.

How to get cheap flights to Southern Illinois?

The trick to saving a stack of cash on your flight to Southern Illinois? Snatch up that Hotwire flight deal when you see a killer rate because it could be gone in a flash. And with flights as low as $130 right now, why wait?

Southern Illinois Flight Information
Destination airport
Lambert-St. Louis Intl.
Destination airport IATA code
STL
Roundtrip price
$130

Last Minute Hotel Deals in Southern Illinois

Drury Plaza Hotel Mt. Vernon
Drury Plaza Hotel Mt. Vernon
3 out of 5
145 North 44th Street , Mount Vernon, IL
The price is $112 per night from Apr 20 to Apr 21
$112
includes taxes & fees
Apr 20 - Apr 21
Stay at this 3-star business-friendly hotel in Mount Vernon. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.6/10 Exceptional! (1,291 reviews)
"Very clean, friendly and helpful staff, amenities as described"

Reviewed on Apr 13, 2025

Drury Plaza Hotel Mt. Vernon
Super 8 by Wyndham O'Fallon
Super 8 by Wyndham O'Fallon
2 out of 5
1100 Eastgate Dr, O'Fallon, IL
The price is $62 per night from Apr 23 to Apr 24
$62
includes taxes & fees
Apr 23 - Apr 24
Book a stay at this business-friendly hotel in O'Fallon. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7.6/10 Good! (1,011 reviews)
"service was very friendly. easy location very dated but was clean reasonable place to stay out the storms as we were traveling"

Reviewed on Apr 12, 2025

Super 8 by Wyndham O'Fallon
Quality Inn & Suites near St. Louis and I-255
Quality Inn & Suites near St. Louis and I-255
2.5 out of 5
1607 Pontiac Dr, East St. Louis, IL
The price is $75 per night from Apr 16 to Apr 17
$75
includes taxes & fees
Apr 16 - Apr 17
Book a stay at this business-friendly hotel in East St. Louis. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the ...
7.4/10 Good! (1,001 reviews)
Perfect for visiting someone at Barnes
"I had a great experience here while visiting my father at Barnes hospital. It’s a 15-20 minute easy drive to Barnes. The room was clean, bed and linens were comfortable. There is a grocery store close and several fast food places close. The price was great and was close enough to the city for easy ..."

Reviewed on Apr 11, 2025

Quality Inn & Suites near St. Louis and I-255
Best Western St. Louis Fairview Heights
Best Western St. Louis Fairview Heights
2.5 out of 5
150 Ludwig Dr, Fairview Heights, IL
The price is $73 per night from Apr 27 to Apr 28
$73
includes taxes & fees
Apr 27 - Apr 28
Book a stay at this business-friendly hotel in Fairview Heights. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our ...
5.6/10 (45 reviews)
"It was good"

Reviewed on Apr 10, 2025

Best Western St. Louis Fairview Heights
Drury Inn & Suites St. Louis O'Fallon, IL
Drury Inn & Suites St. Louis O'Fallon, IL
3 out of 5
1118 Central Park Drive, O'Fallon, IL
The price is $118 per night from Apr 20 to Apr 21
$118
includes taxes & fees
Apr 20 - Apr 21
Stay at this 3-star business-friendly hotel in O'Fallon. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9.4/10 Exceptional! (1,001 reviews)
"It was very clean. The breakfast was good with several hot food options. Lots of stores and restaurants in the area."

Reviewed on Apr 9, 2025

Drury Inn & Suites St. Louis O'Fallon, IL
Drury Inn & Suites Marion
Drury Inn & Suites Marion
3 out of 5
2706 W DeYoung St, Marion, IL
The price is $130 per night from Apr 20 to Apr 21
$130
includes taxes & fees
Apr 20 - Apr 21
Stay at this 3-star business-friendly hotel in Marion. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9.4/10 Exceptional! (1,007 reviews)
"Liked it was clean, and the 5:30 pm kick back (dinner) Is great because I don’t like leaving the hotel when traveling all day."

Reviewed on Apr 14, 2025

Drury Inn & Suites Marion
Red Lion Inn & Suites Pontoon Beach
Red Lion Inn & Suites Pontoon Beach
2.5 out of 5
1240 E Chain Of Rocks Rd, Granite City, IL
The price is $79 per night from Apr 20 to Apr 21
$79
includes taxes & fees
Apr 20 - Apr 21
Stay at this hotel in Granite City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions ...
7.8/10 Good! (314 reviews)
"Room was clean, staff was nice."

Reviewed on Mar 31, 2025

Red Lion Inn & Suites Pontoon Beach
Comfort Suites Mount Vernon
Comfort Suites Mount Vernon
2.5 out of 5
404 South 44th Street, Mount Vernon, IL
The price is $123 per night from Apr 16 to Apr 17
$123
includes taxes & fees
Apr 16 - Apr 17
Book a stay at this business-friendly hotel in Mount Vernon. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
8.8/10 Excellent! (1,005 reviews)
"The staff was friendly. The room was clean. The breakfast was also good."

Reviewed on Apr 11, 2025

Comfort Suites Mount Vernon
See all 978 properties in Southern Illinois
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.