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Southern Illinois

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Southern Illinois Flights as Low as $132

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

Frontier Airlines
Sat, Jun 14 - Sat, Jun 21
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$132 Roundtrip, found 10 hours ago
$132
Roundtrip
found 10 hours ago
Select Frontier Airlines flight, departing Sat, Jun 14 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Sat, Jun 21, priced at $132 found 10 hours ago
Frontier Airlines
Thu, Jun 19 - Sat, Jun 21
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$136 Roundtrip, found 2 days ago
$136
Roundtrip
found 2 days ago
Select Frontier Airlines flight, departing Thu, Jun 19 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Sat, Jun 21, priced at $136 found 2 days ago
Frontier Airlines
Sat, Jun 14 - Sat, Jun 21
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$149 Roundtrip, found 10 hours ago
$149
Roundtrip
found 10 hours ago
Select Frontier Airlines flight, departing Sat, Jun 14 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Sat, Jun 21, priced at $149 found 10 hours ago
American Airlines
Thu, Jun 19 - Sat, Jun 21
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$170 Roundtrip, found 2 days ago
$170
Roundtrip
found 2 days ago
Select American Airlines flight, departing Thu, Jun 19 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Sat, Jun 21, priced at $170 found 2 days ago
American Airlines
Sat, Jun 14 - Sat, Jun 21
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$176 Roundtrip, found 10 hours ago
$176
Roundtrip
found 10 hours ago
Select American Airlines flight, departing Sat, Jun 14 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Sat, Jun 21, priced at $176 found 10 hours ago
American Airlines
Mon, Jun 9 - Thu, Jun 12
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$179 Roundtrip, found 6 days ago
$179
Roundtrip
found 6 days ago
Select American Airlines flight, departing Mon, Jun 9 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Thu, Jun 12, priced at $179 found 6 days ago
Frontier Airlines
Mon, Jun 2 - Sat, Jun 14
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$183 Roundtrip, found 4 days ago
$183
Roundtrip
found 4 days ago
Select Frontier Airlines flight, departing Mon, Jun 2 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Sat, Jun 14, priced at $183 found 4 days ago
Frontier Airlines
Sat, Jun 14 - Sat, Jun 21
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$185 Roundtrip, found 10 hours ago
$185
Roundtrip
found 10 hours ago
Select Frontier Airlines flight, departing Sat, Jun 14 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Sat, Jun 21, priced at $185 found 10 hours ago
Frontier Airlines
Thu, Jun 19 - Sat, Jun 21
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$186 Roundtrip, found 2 days ago
$186
Roundtrip
found 2 days ago
Select Frontier Airlines flight, departing Thu, Jun 19 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Sat, Jun 21, priced at $186 found 2 days ago
Delta
Sat, Jun 14 - Sat, Jun 21
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$201 Roundtrip, found 10 hours ago
$201
Roundtrip
found 10 hours ago
Select Delta flight, departing Sat, Jun 14 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Sat, Jun 21, priced at $201 found 10 hours ago
Frontier Airlines
Mon, May 19 - Wed, May 21
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$204 Roundtrip, found 1 hour ago
$204
Roundtrip
found 1 hour ago
Select Frontier Airlines flight, departing Mon, May 19 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Wed, May 21, priced at $204 found 1 hour ago
United
Sat, Jun 14 - Sat, Jun 21
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$206 Roundtrip, found 10 hours ago
$206
Roundtrip
found 10 hours ago
Select United flight, departing Sat, Jun 14 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Sat, Jun 21, priced at $206 found 10 hours ago
Delta
Tue, Jun 24 - Sat, Jun 28
GSO
Piedmont Triad Intl.
STL
Lambert-St. Louis Intl.
$220 Roundtrip, found 5 hours ago
$220
Roundtrip
found 5 hours ago
Select Delta flight, departing Tue, Jun 24 from Piedmont Triad Intl. to Lambert-St. Louis Intl., returning Sat, Jun 28, priced at $220 found 5 hours ago
American Airlines
Sat, Jun 14 - Sat, Jun 21
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$220 Roundtrip, found 10 hours ago
$220
Roundtrip
found 10 hours ago
Select American Airlines flight, departing Sat, Jun 14 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Sat, Jun 21, priced at $220 found 10 hours ago
United
Mon, Sep 8 - Sun, Sep 14
GSO
Piedmont Triad Intl.
STL
Lambert-St. Louis Intl.
$254 Roundtrip, found 3 hours ago
$254
Roundtrip
found 3 hours ago
Select United flight, departing Mon, Sep 8 from Piedmont Triad Intl. to Lambert-St. Louis Intl., returning Sun, Sep 14, priced at $254 found 3 hours ago
Delta
Sat, Jul 5 - Mon, Jul 7
ATL
Hartsfield-Jackson Atlanta Intl.
EVV
Evansville Regional
$259 Roundtrip, found 1 day ago
$259
Roundtrip
found 1 day ago
Select Delta flight, departing Sat, Jul 5 from Hartsfield-Jackson Atlanta Intl. to Evansville Regional, returning Mon, Jul 7, priced at $259 found 1 day ago

Cheap Flights to Southern Illinois

Fall in love at first flight with your vacation to Southern Illinois by saving a ton of cash on your last-minute cheap flight. There’s no more scouring the internet for a good deal—book your flight to Southern Illinois on Hotwire, and you’ll be up, up, and on a getaway in no time.

Because once the wheels are down in Southern Illinois, the good times start rolling. So buckle up, you’re in for a fun ride.

Frequently Asked Questions About flights to Southern Illinois

Don’t waste your time on endless searches for cheap airline tickets oneway or roundtrip. We’ll have you on your way to Southern Illinois with a tiny bag of pretzels in your hand before you can say “tray tables in the upright position”—and for a ticket price that works for your vacay budget.

So all you have to worry about is where you’re headed after the STL airport.

What is the cheapest month to fly to Southern Illinois?

Airline ticket prices fluctuate all the time, depending on the day of the week or the month of the year. The cheapest round trip flights to Southern Illinois are in June, but when you book your flight on Hotwire, savings are always in season.

How many airlines fly to Southern Illinois?

Variety is the spice of life, even when it comes to booking your next trip. Want options for airlines? You’ll find 16 to choose from for your flight to Southern Illinois.

What airport is best to fly into Southern Illinois?

When you’re planning your trip to Southern Illinois, convenience is the name of the game. Luckily, Southern Illinois Williamson County Regional Airport is nearby so you can deplane and get going on checking off everything on your Southern Illinois must-do list.

How much are flights to Southern Illinois?

Got very cheap flights on your vacation itinerary? When you book your airline tickets to Southern Illinois on Hotwire, you may just get what’s on your getaway wish list. With tickets as low as $132, you’ll have leftover cash for at least a magazine and a bottle of water at the airport book store.

How to get cheap flights to Southern Illinois?

The trick to saving a stack of cash on your flight to Southern Illinois? Snatch up that Hotwire flight deal when you see a killer rate because it could be gone in a flash. And with flights as low as $132 right now, why wait?

Southern Illinois Flight Information
Destination airport
Lambert-St. Louis Intl.
Destination airport IATA code
STL
Roundtrip price
$132

Last Minute Hotel Deals in Southern Illinois

Drury Plaza Hotel Mt. Vernon
Drury Plaza Hotel Mt. Vernon
3 out of 5
145 North 44th Street , Mount Vernon, IL
The price is $142 per night from May 18 to May 19
$142
includes taxes & fees
May 18 - May 19
Stay at this 3-star business-friendly hotel in Mount Vernon. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.6/10 Exceptional! (1,304 reviews)
"Very nice!"

Reviewed on May 2, 2025

Drury Plaza Hotel Mt. Vernon
Super 8 by Wyndham O'Fallon
Super 8 by Wyndham O'Fallon
2 out of 5
1100 Eastgate Dr, O'Fallon, IL
The price is $61 per night from May 12 to May 13
$61
includes taxes & fees
May 12 - May 13
Book a stay at this business-friendly hotel in O'Fallon. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7.6/10 Good! (1,002 reviews)
"Not as horrible as expected"

Reviewed on Apr 19, 2025

Super 8 by Wyndham O'Fallon
Quality Inn & Suites near St. Louis and I-255
Quality Inn & Suites near St. Louis and I-255
2.5 out of 5
1607 Pontiac Dr, East St. Louis, IL
The price is $76 per night from May 12 to May 13
$76
includes taxes & fees
May 12 - May 13
Book a stay at this business-friendly hotel in East St. Louis. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the ...
7.4/10 Good! (1,003 reviews)
"By"

Reviewed on Apr 30, 2025

Quality Inn & Suites near St. Louis and I-255
Drury Inn & Suites St. Louis O'Fallon, IL
Drury Inn & Suites St. Louis O'Fallon, IL
3 out of 5
1118 Central Park Drive, O'Fallon, IL
The price is $123 per night from May 11 to May 12
$123
includes taxes & fees
May 11 - May 12
Stay at this 3-star business-friendly hotel in O'Fallon. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9.4/10 Exceptional! (1,007 reviews)
"Good place, we stay only one night"

Reviewed on May 4, 2025

Drury Inn & Suites St. Louis O'Fallon, IL
Red Lion Inn & Suites Pontoon Beach
Red Lion Inn & Suites Pontoon Beach
2.5 out of 5
1240 E Chain Of Rocks Rd, Granite City, IL
The price is $76 per night from May 7 to May 8
$76
includes taxes & fees
May 7 - May 8
Stay at this hotel in Granite City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions ...
7.8/10 Good! (331 reviews)
"Nice. Worked as a one nighter. You wouldnt want to vacation here. But ok overall."

Reviewed on Apr 27, 2025

Red Lion Inn & Suites Pontoon Beach
Comfort Suites Mount Vernon
Comfort Suites Mount Vernon
2.5 out of 5
404 South 44th Street, Mount Vernon, IL
The price is $123 per night from May 7 to May 8
$123
includes taxes & fees
May 7 - May 8
Book a stay at this business-friendly hotel in Mount Vernon. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
8.8/10 Excellent! (1,010 reviews)
"I liked that the pool was indoors but it was not heated."

Reviewed on May 4, 2025

Comfort Suites Mount Vernon
Drury Inn & Suites St. Louis Fairview Heights
Drury Inn & Suites St. Louis Fairview Heights
3 out of 5
12 Ludwig Dr, Fairview Heights, IL
The price is $127 per night from May 11 to May 12
$127
includes taxes & fees
May 11 - May 12
Book a stay at this business-friendly hotel in Fairview Heights. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9/10 Wonderful! (1,006 reviews)
"I love staying at this brewery Inn because it’s convenient when I have an appointment at Barns Hospital it’s not that far but it’s far enough out that it’s quiet and not directly in the city. I am having surgery in May and plan to stay there after surgery at least two days."

Reviewed on May 3, 2025

Drury Inn & Suites St. Louis Fairview Heights
Drury Inn & Suites Marion
Drury Inn & Suites Marion
3 out of 5
2706 W DeYoung St, Marion, IL
The price is $140 per night from May 11 to May 12
$140
includes taxes & fees
May 11 - May 12
Stay at this 3-star business-friendly hotel in Marion. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9.4/10 Exceptional! (1,002 reviews)
"Loved my stay. Very clean, great location."

Reviewed on May 1, 2025

Drury Inn & Suites Marion
See all 981 properties in Southern Illinois
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.