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Southern Illinois

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Southern Illinois Flights as Low as $158

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

Frontier Airlines
Fri, Mar 13 - Sun, Mar 22
TPA
Tampa Intl.
STL
Lambert-St. Louis Intl.
$158 Roundtrip, found 3 days ago
$158
Roundtrip
found 3 days ago
Select Frontier Airlines flight, departing Fri, Mar 13 from Tampa Intl. to Lambert-St. Louis Intl., returning Sun, Mar 22, priced at $158 found 3 days ago
Frontier Airlines
Wed, Mar 11 - Sun, Mar 22
TPA
Tampa Intl.
STL
Lambert-St. Louis Intl.
$159 Roundtrip, found 3 days ago
$159
Roundtrip
found 3 days ago
Select Frontier Airlines flight, departing Wed, Mar 11 from Tampa Intl. to Lambert-St. Louis Intl., returning Sun, Mar 22, priced at $159 found 3 days ago
Frontier Airlines
Fri, Mar 13 - Sun, Mar 15
TPA
Tampa Intl.
STL
Lambert-St. Louis Intl.
$162 Roundtrip, found 2 days ago
$162
Roundtrip
found 2 days ago
Select Frontier Airlines flight, departing Fri, Mar 13 from Tampa Intl. to Lambert-St. Louis Intl., returning Sun, Mar 15, priced at $162 found 2 days ago
Frontier Airlines
Thu, Mar 12 - Mon, Mar 23
TPA
Tampa Intl.
STL
Lambert-St. Louis Intl.
$174 Roundtrip, found 6 days ago
$174
Roundtrip
found 6 days ago
Select Frontier Airlines flight, departing Thu, Mar 12 from Tampa Intl. to Lambert-St. Louis Intl., returning Mon, Mar 23, priced at $174 found 6 days ago
Frontier Airlines
Sun, Mar 8 - Sun, Mar 22
TPA
Tampa Intl.
STL
Lambert-St. Louis Intl.
$174 Roundtrip, found 3 days ago
$174
Roundtrip
found 3 days ago
Select Frontier Airlines flight, departing Sun, Mar 8 from Tampa Intl. to Lambert-St. Louis Intl., returning Sun, Mar 22, priced at $174 found 3 days ago
Frontier Airlines
Tue, Mar 31 - Wed, Apr 15
TPA
Tampa Intl.
STL
Lambert-St. Louis Intl.
$175 Roundtrip, found 3 days ago
$175
Roundtrip
found 3 days ago
Select Frontier Airlines flight, departing Tue, Mar 31 from Tampa Intl. to Lambert-St. Louis Intl., returning Wed, Apr 15, priced at $175 found 3 days ago
Frontier Airlines
Mon, Mar 9 - Sun, Mar 22
TPA
Tampa Intl.
STL
Lambert-St. Louis Intl.
$177 Roundtrip, found 3 days ago
$177
Roundtrip
found 3 days ago
Select Frontier Airlines flight, departing Mon, Mar 9 from Tampa Intl. to Lambert-St. Louis Intl., returning Sun, Mar 22, priced at $177 found 3 days ago
Frontier Airlines
Sat, Mar 7 - Sun, Mar 22
TPA
Tampa Intl.
STL
Lambert-St. Louis Intl.
$178 Roundtrip, found 3 days ago
$178
Roundtrip
found 3 days ago
Select Frontier Airlines flight, departing Sat, Mar 7 from Tampa Intl. to Lambert-St. Louis Intl., returning Sun, Mar 22, priced at $178 found 3 days ago
Frontier Airlines
Fri, Mar 13 - Mon, Mar 23
TPA
Tampa Intl.
STL
Lambert-St. Louis Intl.
$180 Roundtrip, found 6 days ago
$180
Roundtrip
found 6 days ago
Select Frontier Airlines flight, departing Fri, Mar 13 from Tampa Intl. to Lambert-St. Louis Intl., returning Mon, Mar 23, priced at $180 found 6 days ago
Frontier Airlines
Sun, Mar 8 - Tue, Mar 24
TPA
Tampa Intl.
STL
Lambert-St. Louis Intl.
$190 Roundtrip, found 3 days ago
$190
Roundtrip
found 3 days ago
Select Frontier Airlines flight, departing Sun, Mar 8 from Tampa Intl. to Lambert-St. Louis Intl., returning Tue, Mar 24, priced at $190 found 3 days ago
Frontier Airlines
Mon, Mar 9 - Tue, Mar 24
TPA
Tampa Intl.
STL
Lambert-St. Louis Intl.
$193 Roundtrip, found 3 days ago
$193
Roundtrip
found 3 days ago
Select Frontier Airlines flight, departing Mon, Mar 9 from Tampa Intl. to Lambert-St. Louis Intl., returning Tue, Mar 24, priced at $193 found 3 days ago
Frontier Airlines
Sat, Mar 7 - Tue, Mar 24
TPA
Tampa Intl.
STL
Lambert-St. Louis Intl.
$195 Roundtrip, found 3 days ago
$195
Roundtrip
found 3 days ago
Select Frontier Airlines flight, departing Sat, Mar 7 from Tampa Intl. to Lambert-St. Louis Intl., returning Tue, Mar 24, priced at $195 found 3 days ago
American Airlines
Sat, Apr 18 - Wed, Apr 22
TPA
Tampa Intl.
EVV
Evansville Regional
$259 Roundtrip, found 4 days ago
$259
Roundtrip
found 4 days ago
Select American Airlines flight, departing Sat, Apr 18 from Tampa Intl. to Evansville Regional, returning Wed, Apr 22, priced at $259 found 4 days ago
Delta
Tue, Apr 14 - Tue, Apr 21
TPA
Tampa Intl.
EVV
Evansville Regional
$265 Roundtrip, found 3 days ago
$265
Roundtrip
found 3 days ago
Select Delta flight, departing Tue, Apr 14 from Tampa Intl. to Evansville Regional, returning Tue, Apr 21, priced at $265 found 3 days ago
Bargain Flight
Fri, Feb 20 - Mon, Feb 23
TPA
Tampa Intl.
STL
Lambert-St. Louis Intl.
$287 Roundtrip, found 3 days ago
$287
Roundtrip
found 3 days ago
Select Bargain Flight flight, departing Fri, Feb 20 from Tampa Intl. to Lambert-St. Louis Intl., returning Mon, Feb 23, priced at $287 found 3 days ago
American Airlines
Tue, May 5 - Sat, May 9
COS
Colorado Springs
EVV
Evansville Regional
$382 Roundtrip, found 1 day ago
$382
Roundtrip
found 1 day ago
Select American Airlines flight, departing Tue, May 5 from Colorado Springs to Evansville Regional, returning Sat, May 9, priced at $382 found 1 day ago

Cheap Flights to Southern Illinois

Fall in love at first flight with your vacation to Southern Illinois by saving a ton of cash on your last-minute cheap flight. There’s no more scouring the internet for a good deal—book your flight to Southern Illinois on Hotwire, and you’ll be up, up, and on a getaway in no time.

Because once the wheels are down in Southern Illinois, the good times start rolling. So buckle up, you’re in for a fun ride.

Frequently Asked Questions About flights to Southern Illinois

Don’t waste your time on endless searches for cheap airline tickets oneway or roundtrip. We’ll have you on your way to Southern Illinois with a tiny bag of pretzels in your hand before you can say “tray tables in the upright position”—and for a ticket price that works for your vacay budget.

So all you have to worry about is where you’re headed after the STL airport.

What is the cheapest month to fly to Southern Illinois?

Airline ticket prices fluctuate all the time, depending on the day of the week or the month of the year. The cheapest round trip flights to Southern Illinois are in March, but when you book your flight on Hotwire, savings are always in season.

How many airlines fly to Southern Illinois?

Variety is the spice of life, even when it comes to booking your next trip. Want options for airlines? You’ll find 15 to choose from for your flight to Southern Illinois.

What airport is best to fly into Southern Illinois?

When you’re planning your trip to Southern Illinois, convenience is the name of the game. Luckily, Southern Illinois Williamson County Regional Airport is nearby so you can deplane and get going on checking off everything on your Southern Illinois must-do list.

How much are flights to Southern Illinois?

Got very cheap flights on your vacation itinerary? When you book your airline tickets to Southern Illinois on Hotwire, you may just get what’s on your getaway wish list. With tickets as low as $158, you’ll have leftover cash for at least a magazine and a bottle of water at the airport book store.

How to get cheap flights to Southern Illinois?

The trick to saving a stack of cash on your flight to Southern Illinois? Snatch up that Hotwire flight deal when you see a killer rate because it could be gone in a flash. And with flights as low as $158 right now, why wait?

Southern Illinois Flight Information
Destination airport
Lambert-St. Louis Intl.
Destination airport IATA code
STL
Roundtrip price
$160

Last Minute Hotel Deals in Southern Illinois

Drury Plaza Hotel Mt. Vernon

Drury Plaza Hotel Mt. Vernon

3 out of 5
145 North 44th Street  Mount Vernon IL
Book a stay at this business-friendly hotel in Mount Vernon. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.6/10 Exceptional! (1,656 reviews)
The person greeting us at the front desk was very pleasant, efficient, and helpful.

Reviewed on Feb 17, 2026

Get rates
Drury Plaza Hotel Mt. Vernon
Drury Inn & Suites St. Louis Fairview Heights

Drury Inn & Suites St. Louis Fairview Heights

3 out of 5
12 Ludwig Dr Fairview Heights IL
Book a stay at this business-friendly hotel in Fairview Heights. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.2/10 Wonderful! (1,004 reviews)
Guest services, it was quiet and the food was great.

Reviewed on Feb 15, 2026

Get rates
Drury Inn & Suites St. Louis Fairview Heights
Drury Inn & Suites St. Louis O'Fallon, IL

Drury Inn & Suites St. Louis O'Fallon, IL

3 out of 5
1118 Central Park Drive O'Fallon IL
Book a stay at this business-friendly hotel in O'Fallon. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9.6/10 Exceptional! (1,001 reviews)
Cleanliness. Just wish a microwave was in room

Reviewed on Feb 16, 2026

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Drury Inn & Suites St. Louis O'Fallon, IL
Super 8 by Wyndham O'Fallon

Super 8 by Wyndham O'Fallon

2 out of 5
1100 Eastgate Dr O'Fallon IL
Book a stay at this business-friendly hotel in O'Fallon. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7/10 Good! (1,001 reviews)
Our room had some kind of Bugs biting us all nightlong we didn’t see any bed bugs but there were definitely bugs biting us we woke up in the morning and the bites were giant we took pictures of them. The whole experience was awful.

Reviewed on Feb 17, 2026

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Super 8 by Wyndham O'Fallon
Comfort Suites Mount Vernon

Comfort Suites Mount Vernon

2.5 out of 5
404 South 44th Street Mount Vernon IL
Book a stay at this business-friendly hotel in Mount Vernon. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9/10 Wonderful! (1,002 reviews)
Clean rooms and friendly staff

Reviewed on Feb 17, 2026

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Comfort Suites Mount Vernon
Quality Inn O'Fallon IL - St. Louis

Quality Inn O'Fallon IL - St. Louis

3 out of 5
1409 W US 50 O'Fallon IL
Book a stay at this business-friendly hotel in O'Fallon. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7.4/10 Good! (1,008 reviews)
Yes!

Reviewed on Feb 16, 2026

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Quality Inn O'Fallon IL - St. Louis
Drury Inn & Suites Marion

Drury Inn & Suites Marion

3 out of 5
2706 W DeYoung St Marion IL
Book a stay at this business-friendly hotel in Marion. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9.4/10 Exceptional! (1,002 reviews)
Absolutely awesome. Everything was clean, staff was great and the amenities were worth selecting it over any competition.

Reviewed on Feb 16, 2026

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Drury Inn & Suites Marion
Baymont by Wyndham Effingham

Baymont by Wyndham Effingham

2.5 out of 5
1811 W Fayette Avenue Effingham IL
Book a stay at this business-friendly hotel in Effingham. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8/10 Very Good! (1,000 reviews)
It was fine but it was too cold. Heat didn’t work too well. Only 65

Reviewed on Feb 11, 2026

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Baymont by Wyndham Effingham
See all 1,154 properties in Southern Illinois
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.