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Southern Illinois

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Southern Illinois Flights as Low as $78

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

Frontier Airlines
Wed, Jul 8 - Sun, Jul 26
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$78 Roundtrip, found 1 hour ago
$78
Roundtrip
found 1 hour ago
Select Frontier Airlines flight, departing Wed, Jul 8 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Sun, Jul 26, priced at $78 found 1 hour ago
Frontier Airlines
Wed, Aug 12 - Thu, Aug 20
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$82 Roundtrip, found 4 days ago
$82
Roundtrip
found 4 days ago
Select Frontier Airlines flight, departing Wed, Aug 12 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Thu, Aug 20, priced at $82 found 4 days ago
Frontier Airlines
Fri, Jul 31 - Wed, Aug 12
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$85 Roundtrip, found 2 days ago
$85
Roundtrip
found 2 days ago
Select Frontier Airlines flight, departing Fri, Jul 31 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Wed, Aug 12, priced at $85 found 2 days ago
Frontier Airlines
Fri, Aug 14 - Sat, Aug 22
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$86 Roundtrip, found 1 day ago
$86
Roundtrip
found 1 day ago
Select Frontier Airlines flight, departing Fri, Aug 14 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Sat, Aug 22, priced at $86 found 1 day ago
Frontier Airlines
Sat, Aug 8 - Sun, Aug 23
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$87 Roundtrip, found 6 days ago
$87
Roundtrip
found 6 days ago
Select Frontier Airlines flight, departing Sat, Aug 8 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Sun, Aug 23, priced at $87 found 6 days ago
Frontier Airlines
Mon, Aug 10 - Sat, Aug 22
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$88 Roundtrip, found 1 day ago
$88
Roundtrip
found 1 day ago
Select Frontier Airlines flight, departing Mon, Aug 10 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Sat, Aug 22, priced at $88 found 1 day ago
Frontier Airlines
Mon, Jun 29 - Sat, Jul 11
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$89 Roundtrip, found 6 days ago
$89
Roundtrip
found 6 days ago
Select Frontier Airlines flight, departing Mon, Jun 29 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Sat, Jul 11, priced at $89 found 6 days ago
Frontier Airlines
Wed, Jun 24 - Wed, Jul 1
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$95 Roundtrip, found 5 days ago
$95
Roundtrip
found 5 days ago
Select Frontier Airlines flight, departing Wed, Jun 24 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Wed, Jul 1, priced at $95 found 5 days ago
Frontier Airlines
Mon, Aug 10 - Sun, Aug 23
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$98 Roundtrip, found 6 days ago
$98
Roundtrip
found 6 days ago
Select Frontier Airlines flight, departing Mon, Aug 10 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Sun, Aug 23, priced at $98 found 6 days ago
Delta
Wed, Jul 8 - Sun, Jul 26
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$99 Roundtrip, found 1 hour ago
$99
Roundtrip
found 1 hour ago
Select Delta flight, departing Wed, Jul 8 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Sun, Jul 26, priced at $99 found 1 hour ago
Delta
Tue, Jul 14 - Tue, Jul 14
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$114 Roundtrip, found 2 days ago
$114
Roundtrip
found 2 days ago
Select Delta flight, departing Tue, Jul 14 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Tue, Jul 14, priced at $114 found 2 days ago
American Airlines
Wed, Aug 12 - Tue, Aug 25
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$201 Roundtrip, found 19 hours ago
$201
Roundtrip
found 19 hours ago
Select American Airlines flight, departing Wed, Aug 12 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Tue, Aug 25, priced at $201 found 19 hours ago
Frontier Airlines
Tue, Aug 11 - Tue, Aug 18
TPA
Tampa Intl.
STL
Lambert-St. Louis Intl.
$215 Roundtrip, found 14 hours ago
$215
Roundtrip
found 14 hours ago
Select Frontier Airlines flight, departing Tue, Aug 11 from Tampa Intl. to Lambert-St. Louis Intl., returning Tue, Aug 18, priced at $215 found 14 hours ago
Bargain Flight
Sat, Jun 20 - Wed, Jul 1
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$237 Roundtrip, found 14 hours ago
$237
Roundtrip
found 14 hours ago
Select Bargain Flight flight, departing Sat, Jun 20 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Wed, Jul 1, priced at $237 found 14 hours ago
American Airlines
Tue, Jul 7 - Wed, Jul 15
TPA
Tampa Intl.
CGI
Cape Girardeau Municipal
$518 Roundtrip, found 4 days ago
$518
Roundtrip
found 4 days ago
Select American Airlines flight, departing Tue, Jul 7 from Tampa Intl. to Cape Girardeau Municipal, returning Wed, Jul 15, priced at $518 found 4 days ago
United
Mon, Jun 15 - Sat, Jun 20
ATL
Hartsfield-Jackson Atlanta Intl.
PAH
Barkley Regional
$832 Roundtrip, found 5 days ago
$832
Roundtrip
found 5 days ago
Select United flight, departing Mon, Jun 15 from Hartsfield-Jackson Atlanta Intl. to Barkley Regional, returning Sat, Jun 20, priced at $832 found 5 days ago

Cheap Flights to Southern Illinois

Fall in love at first flight with your vacation to Southern Illinois by saving a ton of cash on your last-minute cheap flight. There’s no more scouring the internet for a good deal—book your flight to Southern Illinois on Hotwire, and you’ll be up, up, and on a getaway in no time.

Because once the wheels are down in Southern Illinois, the good times start rolling. So buckle up, you’re in for a fun ride.

Frequently Asked Questions About flights to Southern Illinois

Don’t waste your time on endless searches for cheap airline tickets oneway or roundtrip. We’ll have you on your way to Southern Illinois with a tiny bag of pretzels in your hand before you can say “tray tables in the upright position”—and for a ticket price that works for your vacay budget.

So all you have to worry about is where you’re headed after the STL airport.

What is the cheapest month to fly to Southern Illinois?

Airline ticket prices fluctuate all the time, depending on the day of the week or the month of the year. The cheapest round trip flights to Southern Illinois are in July, but when you book your flight on Hotwire, savings are always in season.

How many airlines fly to Southern Illinois?

Variety is the spice of life, even when it comes to booking your next trip. Want options for airlines? You’ll find 15 to choose from for your flight to Southern Illinois.

What airport is best to fly into Southern Illinois?

When you’re planning your trip to Southern Illinois, convenience is the name of the game. Luckily, Southern Illinois Veterans Airport of Southern Illinois Airport is nearby so you can deplane and get going on checking off everything on your Southern Illinois must-do list.

How much are flights to Southern Illinois?

Got very cheap flights on your vacation itinerary? When you book your airline tickets to Southern Illinois on Hotwire, you may just get what’s on your getaway wish list. With tickets as low as $78, you’ll have leftover cash for at least a magazine and a bottle of water at the airport book store.

How to get cheap flights to Southern Illinois?

The trick to saving a stack of cash on your flight to Southern Illinois? Snatch up that Hotwire flight deal when you see a killer rate because it could be gone in a flash. And with flights as low as $78 right now, why wait?

Southern Illinois Flight Information
Destination airport
Lambert-St. Louis Intl.
Destination airport IATA code
STL
Roundtrip price
$78

Last Minute Hotel Deals in Southern Illinois

Drury Plaza Hotel Mt. Vernon

Drury Plaza Hotel Mt. Vernon

3.5 out of 5
145 North 44th Street  Mount Vernon IL
Book a stay at this business-friendly hotel in Mount Vernon. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.6/10 Exceptional! (1,731 reviews)
"Awesome stay! Well done!!"

Reviewed on Jun 14, 2026

Get rates
Drury Plaza Hotel Mt. Vernon
Drury Inn & Suites St. Louis Fairview Heights

Drury Inn & Suites St. Louis Fairview Heights

3 out of 5
12 Ludwig Dr Fairview Heights IL
Book a stay at this business-friendly hotel in Fairview Heights. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.2/10 Wonderful! (1,020 reviews)
"Room was clean ,staff helpful, breakfast good"

Reviewed on Jun 14, 2026

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Drury Inn & Suites St. Louis Fairview Heights
Baymont by Wyndham Effingham

Baymont by Wyndham Effingham

2.5 out of 5
1811 W Fayette Avenue Effingham IL
Book a stay at this business-friendly hotel in Effingham. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8.2/10 Very Good! (1,004 reviews)
"The room was surprisingly spacious! The breakfast was hot and delicious and the staff was constantly refilling items. It is an older hotel, and it shows in places, but it was clean and the price was right for a quick overnight stay. The only downfall - no elevator! We had kids and a cooler and it ..."

Reviewed on Jun 14, 2026

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Baymont by Wyndham Effingham
Ramada by Wyndham Effingham

Ramada by Wyndham Effingham

3 out of 5
1606 W Fayette Avenue Effingham IL
Book a stay at this business-friendly hotel in Effingham. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7.4/10 Good! (1,013 reviews)
"Friendly staff but there isn’t hotel-wide AC (only AC units in each room) and the unit never fully cooled the room down"

Reviewed on Jun 13, 2026

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Ramada by Wyndham Effingham
Super 8 by Wyndham O'Fallon

Super 8 by Wyndham O'Fallon

2 out of 5
1100 Eastgate Dr O'Fallon IL
Book a stay at this business-friendly hotel in O'Fallon. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
6.8/10 (1,011 reviews)
"Need new carpet in hallway, towels threads were thinning, toilet seat broken...... they change towels every 3 days? Was not happy."

Reviewed on Jun 14, 2026

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Super 8 by Wyndham O'Fallon
Drury Inn & Suites St. Louis O'Fallon, IL

Drury Inn & Suites St. Louis O'Fallon, IL

3 out of 5
1118 Central Park Drive O'Fallon IL
Book a stay at this business-friendly hotel in O'Fallon. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9.6/10 Exceptional! (1,005 reviews)
"A clean room but most impressive was the kind and courteous staff. Breakfast was plentiful and area kept clean. Dinner was impressive considering one usually doesn’t get an evening snack/ dinner with drinks served and included with room. Great for families and events. The hotel was busy and full ..."

Reviewed on Jun 13, 2026

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Drury Inn & Suites St. Louis O'Fallon, IL
Drury Inn & Suites Marion

Drury Inn & Suites Marion

3 out of 5
2706 W DeYoung St Marion IL
Book a stay at this business-friendly hotel in Marion. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9.4/10 Exceptional! (1,018 reviews)
"The manager and all the staff were so helpful The food was good. We did use the pool and jacuzzi and everything was clean Definitely will recommend"

Reviewed on Jun 14, 2026

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Drury Inn & Suites Marion
Welcome Suites

Welcome Suites

2 out of 5
148 Regency Park O'Fallon IL
Book a stay at this business-friendly hotel in O'Fallon. Enjoy free WiFi, free parking, and a fitness center. Popular attractions O'Fallon Family Sports Park ...
5.8/10 (275 reviews)
"1. I always do the book now and pay later so I know what I’m paying for when I get to the hotel 2. I called the hotel to make sure me arriving early the next morning was ok and they said yes and for some reason they checked me in and charged my card. 3. I wasn’t made aware of that til I went to cancel ..."

Reviewed on Jun 8, 2026

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Welcome Suites
See all 1,155 properties in Southern Illinois
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.