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Southern Illinois

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Southern Illinois Flights as Low as $110

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

Frontier Airlines
Tue, Mar 4 - Wed, Mar 5
IAH
George Bush Intercontinental
STL
Lambert-St. Louis Intl.
$110 Roundtrip, found 4 days ago
$110
Roundtrip
found 4 days ago
Select Frontier Airlines flight, departing Tue, Mar 4 from George Bush Intercontinental to Lambert-St. Louis Intl., returning Wed, Mar 5, priced at $110 found 4 days ago
Frontier Airlines
Tue, Mar 4 - Mon, Mar 10
IAH
George Bush Intercontinental
STL
Lambert-St. Louis Intl.
$115 Roundtrip, found 4 days ago
$115
Roundtrip
found 4 days ago
Select Frontier Airlines flight, departing Tue, Mar 4 from George Bush Intercontinental to Lambert-St. Louis Intl., returning Mon, Mar 10, priced at $115 found 4 days ago
Frontier Airlines
Tue, Mar 4 - Tue, Mar 11
IAH
George Bush Intercontinental
STL
Lambert-St. Louis Intl.
$134 Roundtrip, found 4 days ago
$134
Roundtrip
found 4 days ago
Select Frontier Airlines flight, departing Tue, Mar 4 from George Bush Intercontinental to Lambert-St. Louis Intl., returning Tue, Mar 11, priced at $134 found 4 days ago
Frontier Airlines
Wed, Mar 5 - Thu, Mar 6
IAH
George Bush Intercontinental
STL
Lambert-St. Louis Intl.
$135 Roundtrip, found 4 days ago
$135
Roundtrip
found 4 days ago
Select Frontier Airlines flight, departing Wed, Mar 5 from George Bush Intercontinental to Lambert-St. Louis Intl., returning Thu, Mar 6, priced at $135 found 4 days ago
Frontier Airlines
Tue, Mar 4 - Sun, Mar 9
IAH
George Bush Intercontinental
STL
Lambert-St. Louis Intl.
$145 Roundtrip, found 4 days ago
$145
Roundtrip
found 4 days ago
Select Frontier Airlines flight, departing Tue, Mar 4 from George Bush Intercontinental to Lambert-St. Louis Intl., returning Sun, Mar 9, priced at $145 found 4 days ago
Frontier Airlines
Sun, Mar 9 - Mon, Mar 10
IAH
George Bush Intercontinental
STL
Lambert-St. Louis Intl.
$150 Roundtrip, found 4 days ago
$150
Roundtrip
found 4 days ago
Select Frontier Airlines flight, departing Sun, Mar 9 from George Bush Intercontinental to Lambert-St. Louis Intl., returning Mon, Mar 10, priced at $150 found 4 days ago
Frontier Airlines
Thu, Mar 6 - Tue, Mar 11
IAH
George Bush Intercontinental
STL
Lambert-St. Louis Intl.
$154 Roundtrip, found 4 days ago
$154
Roundtrip
found 4 days ago
Select Frontier Airlines flight, departing Thu, Mar 6 from George Bush Intercontinental to Lambert-St. Louis Intl., returning Tue, Mar 11, priced at $154 found 4 days ago
Frontier Airlines
Thu, Mar 6 - Sat, Mar 8
IAH
George Bush Intercontinental
STL
Lambert-St. Louis Intl.
$155 Roundtrip, found 4 days ago
$155
Roundtrip
found 4 days ago
Select Frontier Airlines flight, departing Thu, Mar 6 from George Bush Intercontinental to Lambert-St. Louis Intl., returning Sat, Mar 8, priced at $155 found 4 days ago
Frontier Airlines
Tue, Feb 25 - Mon, Mar 3
IAH
George Bush Intercontinental
STL
Lambert-St. Louis Intl.
$160 Roundtrip, found 2 days ago
$160
Roundtrip
found 2 days ago
Select Frontier Airlines flight, departing Tue, Feb 25 from George Bush Intercontinental to Lambert-St. Louis Intl., returning Mon, Mar 3, priced at $160 found 2 days ago
United
Sat, Mar 15 - Mon, Mar 17
IAH
George Bush Intercontinental
STL
Lambert-St. Louis Intl.
$243 Roundtrip, found 2 days ago
$243
Roundtrip
found 2 days ago
Select United flight, departing Sat, Mar 15 from George Bush Intercontinental to Lambert-St. Louis Intl., returning Mon, Mar 17, priced at $243 found 2 days ago
American Airlines
Sat, Mar 15 - Mon, Mar 17
IAH
George Bush Intercontinental
STL
Lambert-St. Louis Intl.
$307 Roundtrip, found 2 days ago
$307
Roundtrip
found 2 days ago
Select American Airlines flight, departing Sat, Mar 15 from George Bush Intercontinental to Lambert-St. Louis Intl., returning Mon, Mar 17, priced at $307 found 2 days ago
Spirit Airlines
Thu, Mar 13 - Sat, Mar 15
IAH
George Bush Intercontinental
STL
Lambert-St. Louis Intl.
$365 Roundtrip, found 3 days ago
$365
Roundtrip
found 3 days ago
Select Spirit Airlines flight, departing Thu, Mar 13 from George Bush Intercontinental to Lambert-St. Louis Intl., returning Sat, Mar 15, priced at $365 found 3 days ago
American Airlines
Sat, Apr 12 - Tue, Apr 15
IAH
George Bush Intercontinental
EVV
Evansville Regional
$385 Roundtrip, found 1 day ago
$385
Roundtrip
found 1 day ago
Select American Airlines flight, departing Sat, Apr 12 from George Bush Intercontinental to Evansville Regional, returning Tue, Apr 15, priced at $385 found 1 day ago
Delta
Sat, Apr 12 - Wed, Apr 16
IAH
George Bush Intercontinental
EVV
Evansville Regional
$390 Roundtrip, found 1 day ago
$390
Roundtrip
found 1 day ago
Select Delta flight, departing Sat, Apr 12 from George Bush Intercontinental to Evansville Regional, returning Wed, Apr 16, priced at $390 found 1 day ago
Delta
Tue, Jun 17 - Sun, Jun 29
OKC
Will Rogers World
EVV
Evansville Regional
$419 Roundtrip, found 21 hours ago
$419
Roundtrip
found 21 hours ago
Select Delta flight, departing Tue, Jun 17 from Will Rogers World to Evansville Regional, returning Sun, Jun 29, priced at $419 found 21 hours ago
United
Tue, Mar 18 - Sat, Mar 22
IAH
George Bush Intercontinental
DEC
Decatur
$474 Roundtrip, found 5 days ago
$474
Roundtrip
found 5 days ago
Select United flight, departing Tue, Mar 18 from George Bush Intercontinental to Decatur, returning Sat, Mar 22, priced at $474 found 5 days ago

Cheap Flights to Southern Illinois

Fall in love at first flight with your vacation to Southern Illinois by saving a ton of cash on your last-minute cheap flight. There’s no more scouring the internet for a good deal—book your flight to Southern Illinois on Hotwire, and you’ll be up, up, and on a getaway in no time.

Because once the wheels are down in Southern Illinois, the good times start rolling. So buckle up, you’re in for a fun ride.

Frequently Asked Questions About flights to Southern Illinois

Don’t waste your time on endless searches for cheap airline tickets oneway or roundtrip. We’ll have you on your way to Southern Illinois with a tiny bag of pretzels in your hand before you can say “tray tables in the upright position”—and for a ticket price that works for your vacay budget.

So all you have to worry about is where you’re headed after the STL airport.

What is the cheapest month to fly to Southern Illinois?

Airline ticket prices fluctuate all the time, depending on the day of the week or the month of the year. The cheapest round trip flights to Southern Illinois are in March, but when you book your flight on Hotwire, savings are always in season.

How many airlines fly to Southern Illinois?

Variety is the spice of life, even when it comes to booking your next trip. Want options for airlines? You’ll find 16 to choose from for your flight to Southern Illinois.

What airport is best to fly into Southern Illinois?

When you’re planning your trip to Southern Illinois, convenience is the name of the game. Luckily, Southern Illinois Williamson County Regional Airport is nearby so you can deplane and get going on checking off everything on your Southern Illinois must-do list.

How much are flights to Southern Illinois?

Got very cheap flights on your vacation itinerary? When you book your airline tickets to Southern Illinois on Hotwire, you may just get what’s on your getaway wish list. With tickets as low as $110, you’ll have leftover cash for at least a magazine and a bottle of water at the airport book store.

How to get cheap flights to Southern Illinois?

The trick to saving a stack of cash on your flight to Southern Illinois? Snatch up that Hotwire flight deal when you see a killer rate because it could be gone in a flash. And with flights as low as $110 right now, why wait?

Southern Illinois Flight Information
Destination airport
Lambert-St. Louis Intl.
Destination airport IATA code
STL
Roundtrip price
$137

Last Minute Hotel Deals in Southern Illinois

Drury Plaza Hotel Mt. Vernon
Drury Plaza Hotel Mt. Vernon
3 out of 5
145 North 44th Street , Mount Vernon, IL
The price is $127 per night from Mar 2 to Mar 3
$127
includes taxes & fees
Mar 2 - Mar 3
Stay at this 3-star business-friendly hotel in Mount Vernon. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.6/10 Exceptional! (1,234 reviews)
Great night stay
"The mattresses could use an update, other than that the room was quiet, comfortable and clean, just way we needed for the night. We were on our way home from a figure skating competition. In the morning, breakfast was delicious! Ms. V was enthusiastic, encouraging to my daughter and bubbly! She was ..."

Reviewed on Feb 18, 2025

Drury Plaza Hotel Mt. Vernon
Drury Inn & Suites St. Louis O'Fallon, IL
Drury Inn & Suites St. Louis O'Fallon, IL
3 out of 5
1118 Central Park Drive, O'Fallon, IL
The price is $125 per night from Mar 2 to Mar 3
$125
includes taxes & fees
Mar 2 - Mar 3
Stay at this 3-star business-friendly hotel in O'Fallon. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9.4/10 Exceptional! (1,001 reviews)
"I love the fact that it was so close to every store and restaurant. Facility was very welcoming and room was very clean."

Reviewed on Feb 17, 2025

Drury Inn & Suites St. Louis O'Fallon, IL
Super 8 by Wyndham O'Fallon
Super 8 by Wyndham O'Fallon
2 out of 5
1100 Eastgate Dr, O'Fallon, IL
The price is $59 per night from Mar 1 to Mar 2
$59
includes taxes & fees
Mar 1 - Mar 2
Book a stay at this business-friendly hotel in O'Fallon. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7.6/10 Good! (1,002 reviews)
"Quiet"

Reviewed on Feb 19, 2025

Super 8 by Wyndham O'Fallon
Red Lion Inn & Suites Pontoon Beach
Red Lion Inn & Suites Pontoon Beach
2.5 out of 5
1240 E Chain Of Rocks Rd, Granite City, IL
The price is $67 per night from Feb 23 to Feb 24
$67
includes taxes & fees
Feb 23 - Feb 24
Stay at this hotel in Granite City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions ...
8/10 Very Good! (272 reviews)
"Fast friendly efficient check in. Good room for the value."

Reviewed on Feb 17, 2025

Red Lion Inn & Suites Pontoon Beach
Walker's Bluff Casino Resort
Walker's Bluff Casino Resort
4.5 out of 5
777 Walkers Bluff Way, Carterville, IL
The price is $144 per night from Feb 23 to Feb 24
$144
includes taxes & fees
Feb 23 - Feb 24
Stay at this 4.5-star luxury resort in Carterville. Enjoy free WiFi, free parking, and an outdoor pool. Our guests praise the helpful staff and the clean rooms ...
9.2/10 Wonderful! (283 reviews)
"First time there will not be last. 2 hour drive we took country route road was fine. Got there no problems. Inside is great too. 2 night stay in hotel 5 stars, pool hot tub, employees in the whole place, shops, casino, bars, hotel, excellent staff. Dining was great too can't say enough."

Reviewed on Feb 11, 2025

Walker's Bluff Casino Resort
Baymont by Wyndham Marion
Baymont by Wyndham Marion
2.5 out of 5
2608 W Main St, Marion, IL
The price is $97 per night from Feb 23 to Feb 24
$97
includes taxes & fees
Feb 23 - Feb 24
Book a stay at this business-friendly hotel in Marion. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
8.2/10 Very Good! (1,005 reviews)
"Perfect for a one night stay. Comfortable beds , clean and quiet. I would stay again."

Reviewed on Feb 22, 2025

Baymont by Wyndham Marion
Drury Inn & Suites St. Louis Fairview Heights
Drury Inn & Suites St. Louis Fairview Heights
3 out of 5
12 Ludwig Dr, Fairview Heights, IL
The price is $111 per night from Feb 26 to Feb 27
$111
includes taxes & fees
Feb 26 - Feb 27
Book a stay at this business-friendly hotel in Fairview Heights. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9/10 Wonderful! (1,001 reviews)
"Great place to stay, sage and clean"

Reviewed on Feb 20, 2025

Drury Inn & Suites St. Louis Fairview Heights
Harrah's Metropolis Hotel & Casino
Harrah's Metropolis Hotel & Casino
3.5 out of 5
100 E Front St, Metropolis, IL
The price is $125 per night from Mar 23 to Mar 24
$125
includes taxes & fees
Mar 23 - Mar 24
Stay at this 3.5-star hotel in Metropolis. Enjoy free parking, 2 restaurants, and a casino. Our guests praise the helpful staff and the clean rooms in our reviews. ...
8.2/10 Very Good! (1,001 reviews)
"Was fun and nice"

Reviewed on Feb 15, 2025

Harrah's Metropolis Hotel & Casino
See all 974 properties in Southern Illinois
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.