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Southern Illinois

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Southern Illinois Flights as Low as $267

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

United
Sat, Mar 7 - Wed, Mar 11
ALB
Albany Intl.
PAH
Barkley Regional
$267 Roundtrip, found 17 hours ago
$267
Roundtrip
found 17 hours ago
Select United flight, departing Sat, Mar 7 from Albany Intl. to Barkley Regional, returning Wed, Mar 11, priced at $267 found 17 hours ago
United
Sat, Mar 7 - Tue, Mar 10
ALB
Albany Intl.
PAH
Barkley Regional
$270 Roundtrip, found 4 hours ago
$270
Roundtrip
found 4 hours ago
Select United flight, departing Sat, Mar 7 from Albany Intl. to Barkley Regional, returning Tue, Mar 10, priced at $270 found 4 hours ago
United
Tue, Mar 10 - Tue, Mar 17
ALB
Albany Intl.
PAH
Barkley Regional
$338 Roundtrip, just found
$338
Roundtrip
just found
Select United flight, departing Tue, Mar 10 from Albany Intl. to Barkley Regional, returning Tue, Mar 17, priced at $338 just found
United
Sat, Mar 7 - Wed, Mar 11
ALB
Albany Intl.
PAH
Barkley Regional
$338 Roundtrip, found 17 hours ago
$338
Roundtrip
found 17 hours ago
Select United flight, departing Sat, Mar 7 from Albany Intl. to Barkley Regional, returning Wed, Mar 11, priced at $338 found 17 hours ago
United
Fri, Mar 6 - Wed, Mar 11
ALB
Albany Intl.
PAH
Barkley Regional
$342 Roundtrip, found 10 hours ago
$342
Roundtrip
found 10 hours ago
Select United flight, departing Fri, Mar 6 from Albany Intl. to Barkley Regional, returning Wed, Mar 11, priced at $342 found 10 hours ago
United
Fri, Mar 6 - Wed, Mar 11
ALB
Albany Intl.
PAH
Barkley Regional
$346 Roundtrip, found 10 hours ago
$346
Roundtrip
found 10 hours ago
Select United flight, departing Fri, Mar 6 from Albany Intl. to Barkley Regional, returning Wed, Mar 11, priced at $346 found 10 hours ago
United
Thu, Mar 5 - Wed, Mar 11
ALB
Albany Intl.
PAH
Barkley Regional
$347 Roundtrip, just found
$347
Roundtrip
just found
Select United flight, departing Thu, Mar 5 from Albany Intl. to Barkley Regional, returning Wed, Mar 11, priced at $347 just found
United
Sun, Mar 8 - Sat, Mar 14
ALB
Albany Intl.
PAH
Barkley Regional
$350 Roundtrip, just found
$350
Roundtrip
just found
Select United flight, departing Sun, Mar 8 from Albany Intl. to Barkley Regional, returning Sat, Mar 14, priced at $350 just found
United
Sun, Mar 8 - Sat, Mar 14
ALB
Albany Intl.
PAH
Barkley Regional
$366 Roundtrip, just found
$366
Roundtrip
just found
Select United flight, departing Sun, Mar 8 from Albany Intl. to Barkley Regional, returning Sat, Mar 14, priced at $366 just found
United
Fri, Mar 6 - Tue, Mar 17
ALB
Albany Intl.
PAH
Barkley Regional
$384 Roundtrip, just found
$384
Roundtrip
just found
Select United flight, departing Fri, Mar 6 from Albany Intl. to Barkley Regional, returning Tue, Mar 17, priced at $384 just found
United
Fri, Mar 6 - Wed, Mar 11
ALB
Albany Intl.
PAH
Barkley Regional
$388 Roundtrip, just found
$388
Roundtrip
just found
Select United flight, departing Fri, Mar 6 from Albany Intl. to Barkley Regional, returning Wed, Mar 11, priced at $388 just found
United
Mon, Mar 9 - Tue, Mar 17
ALB
Albany Intl.
PAH
Barkley Regional
$389 Roundtrip, just found
$389
Roundtrip
just found
Select United flight, departing Mon, Mar 9 from Albany Intl. to Barkley Regional, returning Tue, Mar 17, priced at $389 just found
United
Sat, Mar 7 - Wed, Mar 11
ALB
Albany Intl.
PAH
Barkley Regional
$409 Roundtrip, found 17 hours ago
$409
Roundtrip
found 17 hours ago
Select United flight, departing Sat, Mar 7 from Albany Intl. to Barkley Regional, returning Wed, Mar 11, priced at $409 found 17 hours ago
United
Fri, Mar 6 - Wed, Mar 11
ALB
Albany Intl.
PAH
Barkley Regional
$413 Roundtrip, found 10 hours ago
$413
Roundtrip
found 10 hours ago
Select United flight, departing Fri, Mar 6 from Albany Intl. to Barkley Regional, returning Wed, Mar 11, priced at $413 found 10 hours ago
United
Sat, Mar 7 - Tue, Mar 10
ALB
Albany Intl.
PAH
Barkley Regional
$414 Roundtrip, found 4 hours ago
$414
Roundtrip
found 4 hours ago
Select United flight, departing Sat, Mar 7 from Albany Intl. to Barkley Regional, returning Tue, Mar 10, priced at $414 found 4 hours ago
United
Fri, Mar 6 - Wed, Mar 11
ALB
Albany Intl.
PAH
Barkley Regional
$417 Roundtrip, found 10 hours ago
$417
Roundtrip
found 10 hours ago
Select United flight, departing Fri, Mar 6 from Albany Intl. to Barkley Regional, returning Wed, Mar 11, priced at $417 found 10 hours ago

Cheap Flights to Southern Illinois

Fall in love at first flight with your vacation to Southern Illinois by saving a ton of cash on your last-minute cheap flight. There’s no more scouring the internet for a good deal—book your flight to Southern Illinois on Hotwire, and you’ll be up, up, and on a getaway in no time.

Because once the wheels are down in Southern Illinois, the good times start rolling. So buckle up, you’re in for a fun ride.

Frequently Asked Questions About flights to Southern Illinois

Don’t waste your time on endless searches for cheap airline tickets oneway or roundtrip. We’ll have you on your way to Southern Illinois with a tiny bag of pretzels in your hand before you can say “tray tables in the upright position”—and for a ticket price that works for your vacay budget.

So all you have to worry about is where you’re headed after the STL airport.

What is the cheapest month to fly to Southern Illinois?

Airline ticket prices fluctuate all the time, depending on the day of the week or the month of the year. The cheapest round trip flights to Southern Illinois are in March, but when you book your flight on Hotwire, savings are always in season.

How many airlines fly to Southern Illinois?

Variety is the spice of life, even when it comes to booking your next trip. Want options for airlines? You’ll find 16 to choose from for your flight to Southern Illinois.

What airport is best to fly into Southern Illinois?

When you’re planning your trip to Southern Illinois, convenience is the name of the game. Luckily, Southern Illinois Williamson County Regional Airport is nearby so you can deplane and get going on checking off everything on your Southern Illinois must-do list.

How much are flights to Southern Illinois?

Got very cheap flights on your vacation itinerary? When you book your airline tickets to Southern Illinois on Hotwire, you may just get what’s on your getaway wish list. With tickets as low as $267, you’ll have leftover cash for at least a magazine and a bottle of water at the airport book store.

How to get cheap flights to Southern Illinois?

The trick to saving a stack of cash on your flight to Southern Illinois? Snatch up that Hotwire flight deal when you see a killer rate because it could be gone in a flash. And with flights as low as $267 right now, why wait?

Southern Illinois Flight Information
Destination airport
Lambert-St. Louis Intl.
Destination airport IATA code
STL
Roundtrip price
$72

Last Minute Hotel Deals in Southern Illinois

Best Western Delta Inn

Best Western Delta Inn

2.5 out of 5
1509 Hampton Dr Effingham IL
Book a stay at this business-friendly hotel in Effingham. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
9/10 Wonderful! (1,000 reviews)
Room was good Seemed qell maintained. I qas exhausted so went straight to ned and left before breakfast

Reviewed on Jan 19, 2026

Get rates
Best Western Delta Inn
Drury Plaza Hotel Mt. Vernon

Drury Plaza Hotel Mt. Vernon

3 out of 5
145 North 44th Street  Mount Vernon IL
Book a stay at this business-friendly hotel in Mount Vernon. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.6/10 Exceptional! (1,637 reviews)
Courteous staff. Great onsite meals

Reviewed on Jan 22, 2026

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Drury Plaza Hotel Mt. Vernon
Drury Inn & Suites St. Louis Fairview Heights

Drury Inn & Suites St. Louis Fairview Heights

3 out of 5
12 Ludwig Dr Fairview Heights IL
Book a stay at this business-friendly hotel in Fairview Heights. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9/10 Wonderful! (1,015 reviews)
All was good. Breakfast especially at 100%.

Reviewed on Jan 22, 2026

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Drury Inn & Suites St. Louis Fairview Heights
Super 8 by Wyndham O'Fallon

Super 8 by Wyndham O'Fallon

2 out of 5
1100 Eastgate Dr O'Fallon IL
Book a stay at this business-friendly hotel in O'Fallon. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7/10 Good! (1,004 reviews)
The staff was very friendly and the room looked fantastic

Reviewed on Jan 6, 2026

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Super 8 by Wyndham O'Fallon
Comfort Suites Mount Vernon

Comfort Suites Mount Vernon

2.5 out of 5
404 South 44th Street Mount Vernon IL
Book a stay at this business-friendly hotel in Mount Vernon. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
8.8/10 Excellent! (1,000 reviews)
Yes

Reviewed on Jan 19, 2026

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Comfort Suites Mount Vernon
Drury Inn & Suites Marion

Drury Inn & Suites Marion

3 out of 5
2706 W DeYoung St Marion IL
Book a stay at this business-friendly hotel in Marion. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9.2/10 Wonderful! (1,007 reviews)
Everything was great!

Reviewed on Jan 22, 2026

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Drury Inn & Suites Marion
Drury Inn & Suites St. Louis O'Fallon, IL

Drury Inn & Suites St. Louis O'Fallon, IL

3 out of 5
1118 Central Park Drive O'Fallon IL
Book a stay at this business-friendly hotel in O'Fallon. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9.4/10 Exceptional! (1,007 reviews)
The staff and was friendly and so helpful

Reviewed on Jan 22, 2026

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Drury Inn & Suites St. Louis O'Fallon, IL
La Quinta Inn & Suites by Wyndham O'Fallon, IL - St. Louis

La Quinta Inn & Suites by Wyndham O'Fallon, IL - St. Louis

3 out of 5
136 Regency Park O'Fallon IL
Book a stay at this business-friendly hotel in O'Fallon. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the clean rooms in our reviews. ...
5.8/10 (1,002 reviews)
Everything was really good.

Reviewed on Jan 18, 2026

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La Quinta Inn & Suites by Wyndham O'Fallon, IL - St. Louis
See all 1,112 properties in Southern Illinois
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.