Search Cheap Flights to
Southern Illinois

Search 400 airlines and 321,000 hotels worldwide.

Stop Planning & Start Exploring

FREE 24 hour cancellation on most flights

Southern Illinois Flights as Low as $70

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

Frontier Airlines
Sat, Oct 4 - Wed, Oct 8
DEN
Denver Intl.
STL
Lambert-St. Louis Intl.
$70 Roundtrip, found 8 hours ago
$70
Roundtrip
found 8 hours ago
Select Frontier Airlines flight, departing Sat, Oct 4 from Denver Intl. to Lambert-St. Louis Intl., returning Wed, Oct 8, priced at $70 found 8 hours ago
Frontier Airlines
Mon, Oct 6 - Tue, Oct 14
DEN
Denver Intl.
STL
Lambert-St. Louis Intl.
$75 Roundtrip, found 6 hours ago
$75
Roundtrip
found 6 hours ago
Select Frontier Airlines flight, departing Mon, Oct 6 from Denver Intl. to Lambert-St. Louis Intl., returning Tue, Oct 14, priced at $75 found 6 hours ago
Frontier Airlines
Sat, Oct 4 - Thu, Oct 9
DEN
Denver Intl.
STL
Lambert-St. Louis Intl.
$80 Roundtrip, found 4 hours ago
$80
Roundtrip
found 4 hours ago
Select Frontier Airlines flight, departing Sat, Oct 4 from Denver Intl. to Lambert-St. Louis Intl., returning Thu, Oct 9, priced at $80 found 4 hours ago
Frontier Airlines
Thu, Oct 9 - Thu, Oct 9
DEN
Denver Intl.
STL
Lambert-St. Louis Intl.
$82 Roundtrip, found 14 hours ago
$82
Roundtrip
found 14 hours ago
Select Frontier Airlines flight, departing Thu, Oct 9 from Denver Intl. to Lambert-St. Louis Intl., returning Thu, Oct 9, priced at $82 found 14 hours ago
Frontier Airlines
Mon, Oct 6 - Sat, Oct 11
DEN
Denver Intl.
STL
Lambert-St. Louis Intl.
$99 Roundtrip, found 12 hours ago
$99
Roundtrip
found 12 hours ago
Select Frontier Airlines flight, departing Mon, Oct 6 from Denver Intl. to Lambert-St. Louis Intl., returning Sat, Oct 11, priced at $99 found 12 hours ago
United
Sat, Oct 4 - Wed, Oct 8
DEN
Denver Intl.
STL
Lambert-St. Louis Intl.
$120 Roundtrip, found 8 hours ago
$120
Roundtrip
found 8 hours ago
Select United flight, departing Sat, Oct 4 from Denver Intl. to Lambert-St. Louis Intl., returning Wed, Oct 8, priced at $120 found 8 hours ago
Frontier Airlines
Fri, Oct 3 - Thu, Oct 9
DEN
Denver Intl.
STL
Lambert-St. Louis Intl.
$124 Roundtrip, found 4 days ago
$124
Roundtrip
found 4 days ago
Select Frontier Airlines flight, departing Fri, Oct 3 from Denver Intl. to Lambert-St. Louis Intl., returning Thu, Oct 9, priced at $124 found 4 days ago
American Airlines
Mon, Oct 6 - Tue, Oct 14
DEN
Denver Intl.
STL
Lambert-St. Louis Intl.
$130 Roundtrip, found 6 hours ago
$130
Roundtrip
found 6 hours ago
Select American Airlines flight, departing Mon, Oct 6 from Denver Intl. to Lambert-St. Louis Intl., returning Tue, Oct 14, priced at $130 found 6 hours ago
Frontier Airlines
Fri, Oct 3 - Sat, Oct 11
DEN
Denver Intl.
STL
Lambert-St. Louis Intl.
$133 Roundtrip, found 3 days ago
$133
Roundtrip
found 3 days ago
Select Frontier Airlines flight, departing Fri, Oct 3 from Denver Intl. to Lambert-St. Louis Intl., returning Sat, Oct 11, priced at $133 found 3 days ago
Frontier Airlines
Fri, Oct 3 - Wed, Oct 8
DEN
Denver Intl.
STL
Lambert-St. Louis Intl.
$134 Roundtrip, found 3 days ago
$134
Roundtrip
found 3 days ago
Select Frontier Airlines flight, departing Fri, Oct 3 from Denver Intl. to Lambert-St. Louis Intl., returning Wed, Oct 8, priced at $134 found 3 days ago
United
Sat, Oct 4 - Sat, Oct 11
DEN
Denver Intl.
STL
Lambert-St. Louis Intl.
$157 Roundtrip, found 7 hours ago
$157
Roundtrip
found 7 hours ago
Select United flight, departing Sat, Oct 4 from Denver Intl. to Lambert-St. Louis Intl., returning Sat, Oct 11, priced at $157 found 7 hours ago
American Airlines
Mon, Oct 6 - Tue, Oct 14
DEN
Denver Intl.
STL
Lambert-St. Louis Intl.
$177 Roundtrip, found 6 hours ago
$177
Roundtrip
found 6 hours ago
Select American Airlines flight, departing Mon, Oct 6 from Denver Intl. to Lambert-St. Louis Intl., returning Tue, Oct 14, priced at $177 found 6 hours ago
Delta
Sat, Oct 4 - Sat, Oct 11
DEN
Denver Intl.
STL
Lambert-St. Louis Intl.
$197 Roundtrip, found 7 hours ago
$197
Roundtrip
found 7 hours ago
Select Delta flight, departing Sat, Oct 4 from Denver Intl. to Lambert-St. Louis Intl., returning Sat, Oct 11, priced at $197 found 7 hours ago
American Airlines
Thu, Aug 21 - Mon, Aug 25
DEN
Denver Intl.
PAH
Barkley Regional
$359 Roundtrip, found 3 days ago
$359
Roundtrip
found 3 days ago
Select American Airlines flight, departing Thu, Aug 21 from Denver Intl. to Barkley Regional, returning Mon, Aug 25, priced at $359 found 3 days ago
American Airlines
Sun, Sep 14 - Sun, Sep 21
RAP
Rapid City Regional
EVV
Evansville Regional
$418 Roundtrip, found 20 hours ago
$418
Roundtrip
found 20 hours ago
Select American Airlines flight, departing Sun, Sep 14 from Rapid City Regional to Evansville Regional, returning Sun, Sep 21, priced at $418 found 20 hours ago
United
Tue, Aug 12 - Tue, Aug 19
RAP
Rapid City Regional
PAH
Barkley Regional
$618 Roundtrip, found 4 days ago
$618
Roundtrip
found 4 days ago
Select United flight, departing Tue, Aug 12 from Rapid City Regional to Barkley Regional, returning Tue, Aug 19, priced at $618 found 4 days ago

Cheap Flights to Southern Illinois

Fall in love at first flight with your vacation to Southern Illinois by saving a ton of cash on your last-minute cheap flight. There’s no more scouring the internet for a good deal—book your flight to Southern Illinois on Hotwire, and you’ll be up, up, and on a getaway in no time.

Because once the wheels are down in Southern Illinois, the good times start rolling. So buckle up, you’re in for a fun ride.

Frequently Asked Questions About flights to Southern Illinois

Don’t waste your time on endless searches for cheap airline tickets oneway or roundtrip. We’ll have you on your way to Southern Illinois with a tiny bag of pretzels in your hand before you can say “tray tables in the upright position”—and for a ticket price that works for your vacay budget.

So all you have to worry about is where you’re headed after the STL airport.

What is the cheapest month to fly to Southern Illinois?

Airline ticket prices fluctuate all the time, depending on the day of the week or the month of the year. The cheapest round trip flights to Southern Illinois are in October, but when you book your flight on Hotwire, savings are always in season.

How many airlines fly to Southern Illinois?

Variety is the spice of life, even when it comes to booking your next trip. Want options for airlines? You’ll find 16 to choose from for your flight to Southern Illinois.

What airport is best to fly into Southern Illinois?

When you’re planning your trip to Southern Illinois, convenience is the name of the game. Luckily, Southern Illinois Williamson County Regional Airport is nearby so you can deplane and get going on checking off everything on your Southern Illinois must-do list.

How much are flights to Southern Illinois?

Got very cheap flights on your vacation itinerary? When you book your airline tickets to Southern Illinois on Hotwire, you may just get what’s on your getaway wish list. With tickets as low as $70, you’ll have leftover cash for at least a magazine and a bottle of water at the airport book store.

How to get cheap flights to Southern Illinois?

The trick to saving a stack of cash on your flight to Southern Illinois? Snatch up that Hotwire flight deal when you see a killer rate because it could be gone in a flash. And with flights as low as $70 right now, why wait?

Southern Illinois Flight Information
Destination airport
Lambert-St. Louis Intl.
Destination airport IATA code
STL
Roundtrip price
$70

Last Minute Hotel Deals in Southern Illinois

Red Lion Inn & Suites Pontoon Beach

Red Lion Inn & Suites Pontoon Beach

2.5 out of 5
1240 E Chain Of Rocks Rd, Granite City, IL
Stay at this hotel in Granite City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions ...
7.8/10 Good! (455 reviews)
Comfortable and affordable stay
"Both people I interacted with at the front desk were very kind and helpful. I did not see an elevator anywhere, but maybe we missed it. The heat was on full blast when we entered our room even though it was 90 degrees outside which was pretty uncomfortable and frustrating at first, however the room ..."

Reviewed on Jul 23, 2025

Get rates
Red Lion Inn & Suites Pontoon Beach
Drury Plaza Hotel Mt. Vernon

Drury Plaza Hotel Mt. Vernon

3 out of 5
145 North 44th Street , Mount Vernon, IL
Stay at this 3-star business-friendly hotel in Mount Vernon. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.6/10 Exceptional! (1,400 reviews)
"Amazing! Great food, comfortable beds and very clean."

Reviewed on Jul 22, 2025

Get rates
Drury Plaza Hotel Mt. Vernon
Best Western Plus Pontoon Beach

Best Western Plus Pontoon Beach

3 out of 5
4 Regency Pkwy, Granite City, IL
Stay at this 3-star business-friendly hotel in Granite City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
8.4/10 Very Good! (712 reviews)
Nice, comfortable stay.
"Decent hotel and was clean with a friendly staff. Didn’t spend much time on property because we were in town for a baseball tournament. Best rate close to Edwardsville."

Reviewed on Jul 21, 2025

Get rates
Best Western Plus Pontoon Beach
Super 8 by Wyndham O'Fallon

Super 8 by Wyndham O'Fallon

2 out of 5
1100 Eastgate Dr, O'Fallon, IL
Book a stay at this business-friendly hotel in O'Fallon. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7.4/10 Good! (1,023 reviews)
Overall nice stay
"They are remodeling the rooms, beds were comfortable, room was clean, air conditioner was cold. Only downfall was other guests didn't clean up after their pets, or their trash which they left out in the grass area."

Reviewed on Jul 23, 2025

Get rates
Super 8 by Wyndham O'Fallon
Drury Inn & Suites St. Louis Fairview Heights

Drury Inn & Suites St. Louis Fairview Heights

3 out of 5
12 Ludwig Dr, Fairview Heights, IL
Book a stay at this business-friendly hotel in Fairview Heights. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9/10 Wonderful! (1,008 reviews)
"Good area"

Reviewed on Jul 23, 2025

Get rates
Drury Inn & Suites St. Louis Fairview Heights
Days Inn & Suites by Wyndham Caseyville

Days Inn & Suites by Wyndham Caseyville

2.5 out of 5
2423 Old Country Inn Drive, Caseyville, IL
Book a stay at this business-friendly hotel in Caseyville. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Pleasant Ridge Park and Cahokia ...
3.8/10 (263 reviews)
"Maybe they need to repair the ice machine and bring back the snacks machines with card options. Maybe a convenient store inside. Repair the coin washer plus other things. But I still think it’s the best option to do the main things you do on a room: rest and be relaxed."

Reviewed on Jun 30, 2025

Get rates
Days Inn & Suites by Wyndham Caseyville
Drury Inn & Suites Marion

Drury Inn & Suites Marion

3 out of 5
2706 W DeYoung St, Marion, IL
Stay at this 3-star business-friendly hotel in Marion. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9.2/10 Wonderful! (1,012 reviews)
"Well worth the money. Clean and all the staff were very nice and friendly."

Reviewed on Jul 24, 2025

Get rates
Drury Inn & Suites Marion
La Quinta Inn & Suites by Wyndham O'Fallon, IL - St. Louis

La Quinta Inn & Suites by Wyndham O'Fallon, IL - St. Louis

3 out of 5
136 Regency Park, O'Fallon, IL
Stay at this 3-star business-friendly hotel in O'Fallon. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the clean rooms in our reviews. ...
6/10 (1,006 reviews)
Honest review
"Room was clean and everything else. However the smell when you go through those doors are not the best, stink really bad."

Reviewed on Jun 30, 2025

Get rates
La Quinta Inn & Suites by Wyndham O'Fallon, IL - St. Louis
See all 1,043 properties in Southern Illinois
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.