Hotels Near
Uptown

You choose what matters — star rating, location, amenities.

We pick the perfect hotel, packed with all your must-haves.

Your hotel is revealed right after booking!


Featured Uptown Hotels

Hyatt Regency St. Louis at The Arch
Hyatt Regency St. Louis at The Arch
4 out of 5
315 Chestnut St, St. Louis, MO
Fully refundableReserve now, pay when you stay
Stay at this 4-star business-friendly hotel in St. Louis. Enjoy free WiFi, 3 restaurants, and 2 bars/lounges. Our guests praise the helpful staff and the clean ...
8.4/10 Very Good! (3,601 reviews)
"For such a nice hotel, it wasn't a comfortable stay. The room was tiny, there was no breakfast included, elevators were not working, signs were confusing."

Reviewed on Mar 18, 2025

Hyatt Regency St. Louis at The Arch
Clayton Plaza Hotel & Extended Stay
Clayton Plaza Hotel & Extended Stay
3.5 out of 5
7750 Carondelet Avenue, St. Louis, MO
Fully refundableReserve now, pay when you stay
Stay at this 3.5-star business-friendly hotel in St. Louis. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast and ...
8.8/10 Excellent! (2,990 reviews)
My go to place !
"The employees here are very friendly and helpful, I always enjoy the staff in the kitchen and be sure to tip them they work very hard to make sure your experience is great."

Reviewed on Mar 19, 2025

Clayton Plaza Hotel & Extended Stay
River City Casino & Hotel
River City Casino & Hotel
4 out of 5
777 River City Casino Blvd, St. Louis, MO
Fully refundableReserve now, pay when you stay
Stay at this 4-star business-friendly hotel in St. Louis. Enjoy free parking, 5 restaurants, and a casino. Our guests praise the helpful staff and the clean ...
9/10 Wonderful! (1,125 reviews)
"Clean hotel and casino. Average at best as far as bedding and comfort."

Reviewed on Mar 16, 2025

River City Casino & Hotel
Moonrise Hotel
Moonrise Hotel
4 out of 5
6177 Delmar Blvd, St. Louis, MO
Fully refundableReserve now, pay when you stay
Stay at this 4-star boutique hotel in St. Louis. Enjoy free WiFi, free parking, and 2 bars/lounges. Our guests praise the restaurant and the bar in our reviews. ...
9/10 Wonderful! (1,619 reviews)
"It was nice, it didn’t have a microwave though, and the people next door to us were really loud and banged on the wall. Very rude. The employees were extremely nice!"

Reviewed on Mar 16, 2025

Moonrise Hotel
Drury Plaza Hotel St. Louis at the Arch
Drury Plaza Hotel St. Louis at the Arch
3 out of 5
2 South 4th Street, St. Louis, MO
Fully refundableReserve now, pay when you stay
Stay at this 3-star business-friendly hotel in St. Louis. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the pool ...
9.4/10 Exceptional! (2,415 reviews)
"I just love this place,it's our 3rd or 4th time staying here . We will be back 💯 FYI my son's loves your breakfast 🙌"

Reviewed on Mar 16, 2025

Drury Plaza Hotel St. Louis at the Arch
21C Museum Hotel St Louis
21C Museum Hotel St Louis
4.5 out of 5
1528 Locust street, St. Louis, MO
Fully refundableReserve now, pay when you stay
Stay at this 4.5-star luxury hotel in St. Louis. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the pool and the restaurant in our ...
9/10 Wonderful! (1,020 reviews)
"Great boutique hotel in downtown St. Louis, the hotel was busy when we checked in and the front desk staff was a bit harried, but they gave us the essential information we needed. The art gallery on the second floor was a great addition to our stay, as was the on sight restaurant, The Idol Wolf, ..."

Reviewed on Mar 17, 2025

21C Museum Hotel St Louis
Live by Loews - St.Louis
Live by Loews - St.Louis
4 out of 5
799 Clark ave, St. Louis, MO
Fully refundableReserve now, pay when you stay
Stay at this 4-star business-friendly hotel in St. Louis. Enjoy free WiFi, a rooftop terrace, and breakfast (surcharge). Our guests praise the bar and the helpful ...
9.2/10 Wonderful! (1,007 reviews)
"Always a great place to stay!!"

Reviewed on Mar 17, 2025

Live by Loews - St.Louis
The Last Hotel
The Last Hotel
4.5 out of 5
1501 Washington Ave, St. Louis, MO
Stay at this 4.5-star luxury hotel in St. Louis. Enjoy free WiFi, a 24-hour fitness center, and valet parking (surcharge). Our guests praise the pool and the ...
7.6/10 Good! (1,186 reviews)
"10/10 this hotel has the nicest staff, cozy rooms, and a dope skyline view with a pool on the top. Highly recommend!"

Reviewed on Mar 7, 2025

The Last Hotel
Le Méridien St. Louis Clayton
Le Méridien St. Louis Clayton
4 out of 5
7730 Bonhomme Ave, St. Louis, MO
Fully refundableReserve now, pay when you stay
Book a stay at this eco-certified hotel in St. Louis. Enjoy an outdoor pool, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the helpful ...
8.8/10 Excellent! (579 reviews)
Ok but not up to par.
"Strange process of having to request a free refrigerator be delivered instead of having them in the room permanently. In addition, there was no valet when I needed my car at 5:00a.m. after being told the night before that there would be one."

Reviewed on Mar 17, 2025

Le Méridien St. Louis Clayton
Embassy Suites by Hilton St. Louis Downtown
Embassy Suites by Hilton St. Louis Downtown
4 out of 5
610 N 7th St, St. Louis, MO
Fully refundableReserve now, pay when you stay
Stay at this 4-star business-friendly hotel in St. Louis. Enjoy free breakfast, a fitness center, and WiFi (surcharge). Our guests praise the breakfast and the ...
8.6/10 Excellent! (1,104 reviews)
"Nice"

Reviewed on Mar 17, 2025

Embassy Suites by Hilton St. Louis Downtown
Casino Queen Hotel
Casino Queen Hotel
3 out of 5
200 Front Street, East St. Louis, IL
Fully refundableReserve now, pay when you stay
Stay at this 3-star business-friendly hotel in East St. Louis. Enjoy free WiFi, free parking, and a casino. Our guests praise the helpful staff and the clean ...
7.8/10 Good! (1,748 reviews)
"Passing through St Louis and chose this hotel with a view of the Golden Arch from our 6th floor window. Check-in was quick and simple. Our room was very spacious, modern and clean. Would recommend this Hotel."

Reviewed on Mar 16, 2025

Casino Queen Hotel
Hampton Inn St. Louis-Downtown (At the Gateway Arch)
Hampton Inn St. Louis-Downtown (At the Gateway Arch)
2.5 out of 5
333 Washington Ave, St. Louis, MO
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in St. Louis. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast and ...
8.6/10 Excellent! (1,011 reviews)
"Very cool hotel. We appreciated the close walking proximity to the Arch!"

Reviewed on Mar 18, 2025

Hampton Inn St. Louis-Downtown (At the Gateway Arch)
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels in Uptown

Collinsville is a city that has a lot going on, but you have your sights set on Uptown. This part of town is perfect for what you want to be doing, and that is everything that is not on everyone’s radar. For all that Uptown has going on, you’ll still need a place to crash, eventually. But you don’t want any old shack, you need something that fits the trip. We have a slew of Uptown hotels that will do the trick.

A beautiful day in the neighborhood

As much as you like getting out there, it’s also good to know a part of Collinsville so well you’ll be telling the tourists where to go. Make friends with the concierge or be bold and chat up a local. It’s your trip, so choose your own adventure. And when you get in at night, you’ll have a comfy room and plenty of amenities to help you settle in. Call a friend and spin tales from the Uptown underground. What’s a journey without a good story to go with it?

Beyond the block

We’re not talking about the Uptown city block. We’re talking about looking beyond that block of hotels you always focus on. We give you tons of ways to sort our stash of Uptown cheap hotels. And if you feel like living a little, but not killing your vacation vibes, choose the Hotwire Hot Rate deal. Filter by:

  • Hotwire Hot Rate: Snag some of the best hotels in Uptown at an almost too good to be true rate. After you book, we’ll reveal the name of the hotel. You can get a luxury hotel at a budget price.
  • Price: You have a price in mind, and we have solutions. Hotels start as low as $105
  • Amenities: Rooftop lounge, designer furniture, 24-7 room service, and everything else you look for to live it up large.

Find the Uptown hotel you want, book it, and never look back. Because your great escape is ahead of you.