Hotels NearUptown
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Featured Uptown Hotels
![Hyatt Regency St. Louis at The Arch](https://images.trvl-media.com/lodging/1000000/20000/14900/14877/d8601c6d_y.jpg?impolicy=fcrop&w=420&h=224&q=medium)
Reviewed on Feb 6, 2025
![Drury Plaza Hotel St. Louis at the Arch](https://images.trvl-media.com/lodging/1000000/550000/546300/546271/56fc52a7_y.jpg?impolicy=fcrop&w=420&h=224&q=medium)
Reviewed on Feb 9, 2025
![21C Museum Hotel St Louis](https://images.trvl-media.com/lodging/90000000/89170000/89164600/89164592/6e778fbc_y.jpg?impolicy=fcrop&w=420&h=224&q=medium)
Reviewed on Jan 31, 2025
![River City Casino & Hotel](https://images.trvl-media.com/lodging/7000000/6460000/6456500/6456459/4c09ced4_y.jpg?impolicy=fcrop&w=420&h=224&q=medium)
Reviewed on Feb 9, 2025
![Clayton Plaza Hotel & Extended Stay](https://images.trvl-media.com/lodging/1000000/20000/18200/18144/b3c5d3cd_y.jpg?impolicy=fcrop&w=420&h=224&q=medium)
Reviewed on Feb 7, 2025
![Hampton Inn St. Louis-Downtown (At the Gateway Arch)](https://images.trvl-media.com/lodging/1000000/30000/22600/22520/w3839h2400x0y0-22cc8710_y.jpg?impolicy=fcrop&w=420&h=224&q=medium)
Reviewed on Feb 2, 2025
![Embassy Suites by Hilton St. Louis Downtown](https://images.trvl-media.com/lodging/5000000/4540000/4531500/4531472/95eb864f_y.jpg?impolicy=fcrop&w=420&h=224&q=medium)
Reviewed on Feb 1, 2025
![Moonrise Hotel](https://images.trvl-media.com/lodging/3000000/2300000/2292900/2292856/fe8445aa_y.jpg?impolicy=fcrop&w=420&h=224&q=medium)
Reviewed on Feb 10, 2025
![St. Louis Union Station Hotel, Curio Collection by Hilton](https://images.trvl-media.com/lodging/1000000/10000/8800/8738/eb9f8f16_y.jpg?impolicy=fcrop&w=420&h=224&q=medium)
Reviewed on Feb 2, 2025
![The Last Hotel](https://images.trvl-media.com/lodging/33000000/32130000/32126100/32126024/cde29916_y.jpg?impolicy=fcrop&w=420&h=224&q=medium)
Reviewed on Feb 9, 2025
![Live by Loews - St.Louis](https://images.trvl-media.com/lodging/40000000/39170000/39161300/39161277/3052c15f_y.jpg?impolicy=fcrop&w=420&h=224&q=medium)
Reviewed on Feb 10, 2025
![Pear Tree Inn St. Louis Near Union Station](https://images.trvl-media.com/lodging/1000000/30000/26600/26572/bfd71d01_y.jpg?impolicy=fcrop&w=420&h=224&q=medium)
Reviewed on Feb 3, 2025
Hotels in Uptown
Collinsville is a city that has a lot going on, but you have your sights set on Uptown. This part of town is perfect for what you want to be doing, and that is everything that is not on everyone’s radar. For all that Uptown has going on, you’ll still need a place to crash, eventually. But you don’t want any old shack, you need something that fits the trip. We have a slew of Uptown hotels that will do the trick.
A beautiful day in the neighborhood
As much as you like getting out there, it’s also good to know a part of Collinsville so well you’ll be telling the tourists where to go. Make friends with the concierge or be bold and chat up a local. It’s your trip, so choose your own adventure. And when you get in at night, you’ll have a comfy room and plenty of amenities to help you settle in. Call a friend and spin tales from the Uptown underground. What’s a journey without a good story to go with it?
Beyond the block
We’re not talking about the Uptown city block. We’re talking about looking beyond that block of hotels you always focus on. We give you tons of ways to sort our stash of Uptown cheap hotels. And if you feel like living a little, but not killing your vacation vibes, choose the Hotwire Hot Rate deal. Filter by:
- Hotwire Hot Rate: Snag some of the best hotels in Uptown at an almost too good to be true rate. After you book, we’ll reveal the name of the hotel. You can get a luxury hotel at a budget price.
- Price: You have a price in mind, and we have solutions. Hotels start as low as $111
- Amenities: Rooftop lounge, designer furniture, 24-7 room service, and everything else you look for to live it up large.
Find the Uptown hotel you want, book it, and never look back. Because your great escape is ahead of you.
Hotels by Star Rating
Top Attractions in Uptown
- Hotels near World's Largest Catsup Bottle (0.51 mi)
- Hotels near Kruta Bakery (0.45 mi)
- Hotels near St. Louis Union Station (11.95 mi)
- Hotels near Busch Stadium (11.33 mi)
- Hotels near Gateway Arch (10.86 mi)
- Hotels near St. Louis Zoo (16.31 mi)
- Hotels near Washington University in St. Louis (17.23 mi)
- Hotels near Enterprise Center (11.75 mi)
- Hotels near City Museum (11.55 mi)
- Hotels near Barnes Jewish Hospital (14.94 mi)
- Hotels near Forest Park (15.61 mi)
- Hotels near Mississippi River (87.1 mi)
- Hotels near Dome at America’s Center (10.94 mi)
- Hotels near St. Louis University (13.23 mi)
- Hotels near America's Center Convention Complex (11.09 mi)
- Hotels near Fox Theater (13.14 mi)
- Hotels near Horseshoe St. Louis Casino (10.71 mi)
- Hotels near St. Louis Aquarium at Union Station (11.99 mi)
- Hotels near Anheuser-Busch Brewery (12.78 mi)
- Hotels near Missouri Botanical Gardens and Arboretum (14.96 mi)
Cities near Uptown
- O'Fallon Hotels (6.7 mi)
- Ozarks Hotels (171.91 mi)
- Collinsville Hotels (0.35 mi)
- Alton Hotels (18.64 mi)
- Edwardsville Hotels (9.2 mi)
- Richmond Heights Hotels (17.92 mi)
- Fairview Heights Hotels (5.15 mi)
- Southern Illinois Hotels (65.36 mi)
- Belleville Hotels (10.13 mi)
- Brentwood Hotels (19.63 mi)
- East St. Louis Hotels (9.39 mi)
- Florissant Hotels (19.77 mi)
- Granite City Hotels (8.84 mi)
- Troy Hotels (5.8 mi)
- Webster Groves Hotels (20.42 mi)
- Highland Hotels (17.94 mi)
- Caseyville Hotels (2.45 mi)
- Central Illinois Hotels (119.65 mi)
- Wood River Hotels (14.51 mi)
- Columbia Hotels (19.13 mi)
Car Rentals Near Uptown
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- Car rentals in Belleville
- Car rentals in Brentwood
- Car rentals in East St. Louis
- Car rentals in Florissant
- Car rentals in Granite City
- Car rentals in Troy
- Car rentals in Webster Groves
- Car rentals in Highland
Top Neighborhood Hotel Destinations
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