Hotels NearUptown
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Featured Uptown Hotels

Hyatt Regency St. Louis at The Arch
Would not recommend
Reviewed on Jan 2, 2026

Hampton Inn St. Louis-Downtown (At the Gateway Arch)
Staff was nice, room clean. Good breakfast.
Reviewed on Dec 31, 2025

Magnolia Hotel St. Louis, a Tribute Portfolio Hotel
Hotel and room were very clean
Reviewed on Jan 4, 2026

21C Museum Hotel St Louis
Ambiance
Reviewed on Jan 2, 2026

Clayton Plaza Hotel & Extended Stay
Rooms were clean and comfortable. We asked for connecting rooms and we got connecting rooms. Great hotel very nice staff.
Reviewed on Jan 4, 2026

Drury Plaza Hotel St. Louis at the Arch
Just one issue i would have is i don't eat pork at all and some days dinner would be all pork 😳 everything else is good 🙏
Reviewed on Jan 2, 2026

Home2 Suites by Hilton St. Louis Downtown
Actual ceramic plates and metal silverware!!! Side Note: The roatary toaster is the bomb! 😃
Reviewed on Jan 2, 2026

Live by Loews - St.Louis
Great service
Reviewed on Jan 1, 2026

Angad Arts Hotel St. Louis, Tapestry Collection by Hilton
Beautiful hotel
Reviewed on Jan 1, 2026

Drury Inn & Suites St. Louis Union Station
Clean room | Staff | Breakfast
Reviewed on Jan 1, 2026

DoubleTree by Hilton St. Louis Forest Park
Staff was helpful.
Reviewed on Dec 31, 2025

Marriott St. Louis Grand
The gentleman at the bar was amazing. Great conversation the food. Was great I got your hot wings and sweet potato fries. Front desk, staff overnight and day staff was amazing. Very kind.
Reviewed on Dec 26, 2025
Hotels in Uptown
Collinsville is a city that has a lot going on, but you have your sights set on Uptown. This part of town is perfect for what you want to be doing, and that is everything that is not on everyone’s radar. For all that Uptown has going on, you’ll still need a place to crash, eventually. But you don’t want any old shack, you need something that fits the trip. We have a slew of Uptown hotels that will do the trick.
A beautiful day in the neighborhood
As much as you like getting out there, it’s also good to know a part of Collinsville so well you’ll be telling the tourists where to go. Make friends with the concierge or be bold and chat up a local. It’s your trip, so choose your own adventure. And when you get in at night, you’ll have a comfy room and plenty of amenities to help you settle in. Call a friend and spin tales from the Uptown underground. What’s a journey without a good story to go with it?
Beyond the block
We’re not talking about the Uptown city block. We’re talking about looking beyond that block of hotels you always focus on. We give you tons of ways to sort our stash of Uptown cheap hotels. And if you feel like living a little, but not killing your vacation vibes, choose the Hotwire Hot Rate deal. Filter by:
- Hotwire Hot Rate: Snag some of the best hotels in Uptown at an almost too good to be true rate. After you book, we’ll reveal the name of the hotel. You can get a luxury hotel at a budget price.
- Price: You have a price in mind, and we have solutions. Hotels start as low as $91
- Amenities: Rooftop lounge, designer furniture, 24-7 room service, and everything else you look for to live it up large.
Find the Uptown hotel you want, book it, and never look back. Because your great escape is ahead of you.
Hotels by Star Rating
Uptown Neighborhoods
Top Attractions in Uptown
- Hotels near World's Largest Catsup Bottle (0.51 mi)
- Hotels near Kruta Bakery (0.45 mi)
- Hotels near St. Louis Union Station (11.95 mi)
- Hotels near Busch Stadium (11.33 mi)
- Hotels near Gateway Arch (10.86 mi)
- Hotels near Dome at America’s Center (10.94 mi)
- Hotels near Enterprise Center (11.75 mi)
- Hotels near Washington University in St. Louis (17.23 mi)
- Hotels near St. Louis Zoo (16.31 mi)
- Hotels near Barnes Jewish Hospital (14.94 mi)
- Hotels near America's Center Convention Complex (11.09 mi)
- Hotels near City Museum (11.55 mi)
- Hotels near Forest Park (15.61 mi)
- Hotels near St. Louis University (13.23 mi)
- Hotels near Mississippi River (87.1 mi)
- Hotels near Fox Theater (13.14 mi)
- Hotels near Horseshoe St. Louis Casino (10.71 mi)
- Hotels near Anheuser-Busch Brewery (12.78 mi)
- Hotels near Missouri Botanical Gardens and Arboretum (14.96 mi)
- Hotels near St. Louis Aquarium at Union Station (11.99 mi)
Cities near Uptown
- O'Fallon Hotels (6.7 mi)
- Fairview Heights Hotels (5.15 mi)
- Florissant Hotels (19.77 mi)
- Troy Hotels (5.8 mi)
- Edwardsville Hotels (9.2 mi)
- Collinsville Hotels (0.35 mi)
- Highland Hotels (17.94 mi)
- Ozarks Hotels (171.91 mi)
- Belleville Hotels (10.13 mi)
- Alton Hotels (18.64 mi)
- Brentwood Hotels (19.63 mi)
- Richmond Heights Hotels (17.92 mi)
- East St. Louis Hotels (9.39 mi)
- Southern Illinois Hotels (65.36 mi)
- Webster Groves Hotels (20.42 mi)
- Granite City Hotels (8.84 mi)
- Overland Hotels (20.53 mi)
- Swansea Hotels (9.16 mi)
- Jennings Hotels (15.24 mi)
- Columbia Hotels (19.13 mi)
