Hotels Near
Uptown

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Featured Uptown Hotels

Drury Plaza Hotel St. Louis at the Arch
Drury Plaza Hotel St. Louis at the Arch
3 out of 5
2 South 4th Street, St. Louis, MO
Fully refundableReserve now, pay when you stay
Stay at this 3-star business-friendly hotel in St. Louis. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the pool ...
9.4/10 Exceptional! (2,446 reviews)
"I enjoyed the proximity to the gateway arch. Also the great views from the hotel observation deck."

Reviewed on Apr 10, 2025

Drury Plaza Hotel St. Louis at the Arch
Hyatt Regency St. Louis at The Arch
Hyatt Regency St. Louis at The Arch
4 out of 5
315 Chestnut St, St. Louis, MO
Fully refundableReserve now, pay when you stay
Stay at this 4-star business-friendly hotel in St. Louis. Enjoy free WiFi, 3 restaurants, and 2 bars/lounges. Our guests praise the helpful staff and the clean ...
8.4/10 Very Good! (3,622 reviews)
Nice stay
"It was at the busy part of town but the room itself was quiet.The souvenir shop,restaurant,and bar was a plus"

Reviewed on Apr 12, 2025

Hyatt Regency St. Louis at The Arch
Clayton Plaza Hotel & Extended Stay
Clayton Plaza Hotel & Extended Stay
3.5 out of 5
7750 Carondelet Avenue, St. Louis, MO
Fully refundableReserve now, pay when you stay
Stay at this 3.5-star business-friendly hotel in St. Louis. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast and ...
8.8/10 Excellent! (2,991 reviews)
"It was a good stay. But the pool was not very clean. And half the games in the arcade were out of order"

Reviewed on Apr 12, 2025

Clayton Plaza Hotel & Extended Stay
Moonrise Hotel
Moonrise Hotel
4 out of 5
6177 Delmar Blvd, St. Louis, MO
Fully refundableReserve now, pay when you stay
Stay at this 4-star boutique hotel in St. Louis. Enjoy free WiFi, free parking, and 2 bars/lounges. Our guests praise the restaurant and the bar in our reviews. ...
9/10 Wonderful! (1,660 reviews)
"Absolutely stunning roof top bar with spectacular service, will certainly be returning."

Reviewed on Apr 10, 2025

Moonrise Hotel
Hampton Inn St. Louis-Downtown (At the Gateway Arch)
Hampton Inn St. Louis-Downtown (At the Gateway Arch)
2.5 out of 5
333 Washington Ave, St. Louis, MO
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in St. Louis. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast and ...
8.6/10 Excellent! (1,040 reviews)
"Clean hotel, within walking distance of a lot of places. Most of the staff were extremely nice. Only downside was could hear the street traffic but once got a fan that made a big difference"

Reviewed on Apr 8, 2025

Hampton Inn St. Louis-Downtown (At the Gateway Arch)
River City Casino & Hotel
River City Casino & Hotel
4 out of 5
777 River City Casino Blvd, St. Louis, MO
Fully refundableReserve now, pay when you stay
Stay at this 4-star business-friendly hotel in St. Louis. Enjoy free parking, 5 restaurants, and a casino. Our guests praise the helpful staff and the clean ...
9/10 Wonderful! (1,156 reviews)
"We had a very nice stay. It was clean and comfortable."

Reviewed on Apr 11, 2025

River City Casino & Hotel
Magnolia Hotel St. Louis, a Tribute Portfolio Hotel
Magnolia Hotel St. Louis, a Tribute Portfolio Hotel
4 out of 5
421 N 8th St, St. Louis, MO
Fully refundableReserve now, pay when you stay
Stay at this 4-star business-friendly hotel in St. Louis. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the bar and the helpful ...
8.6/10 Excellent! (1,000 reviews)
"Excellent"

Reviewed on Apr 6, 2025

Magnolia Hotel St. Louis, a Tribute Portfolio Hotel
Le Méridien St. Louis Clayton
Le Méridien St. Louis Clayton
4 out of 5
7730 Bonhomme Ave, St. Louis, MO
Book a stay at this eco-certified hotel in St. Louis. Enjoy an outdoor pool, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the helpful ...
8.8/10 Excellent! (590 reviews)
"N/A"

Reviewed on Apr 11, 2025

Le Méridien St. Louis Clayton
21C Museum Hotel St Louis
21C Museum Hotel St Louis
4.5 out of 5
1528 Locust street, St. Louis, MO
Fully refundableReserve now, pay when you stay
Stay at this 4.5-star luxury hotel in St. Louis. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the pool and the restaurant in our ...
9/10 Wonderful! (1,062 reviews)
"Beautiful hotel, the art work made the space feel unique and special. The gallery was amazing and it was nice that it's open to everyone anytime of day. The fitness and pool area looked amazing...too bad we didn't spend as much time there as we wished. Our kids liked the room and had a good time, ..."

Reviewed on Apr 12, 2025

21C Museum Hotel St Louis
Live by Loews - St.Louis
Live by Loews - St.Louis
4 out of 5
799 Clark ave, St. Louis, MO
Stay at this 4-star business-friendly hotel in St. Louis. Enjoy free WiFi, a rooftop terrace, and breakfast (surcharge). Our guests praise the bar and the helpful ...
9.2/10 Wonderful! (1,007 reviews)
"Great hotel and staff"

Reviewed on Apr 12, 2025

Live by Loews - St.Louis
Casino Queen Hotel
Casino Queen Hotel
3 out of 5
200 Front Street, East St. Louis, IL
Fully refundableReserve now, pay when you stay
Stay at this 3-star business-friendly hotel in East St. Louis. Enjoy free WiFi, free parking, and a casino. Our guests praise the helpful staff and the clean ...
7.8/10 Good! (1,773 reviews)
"Love the Sports Book!!"

Reviewed on Apr 11, 2025

Casino Queen Hotel
Hilton St. Louis at the Ballpark
Hilton St. Louis at the Ballpark
4 out of 5
1 S Broadway, St. Louis, MO
Fully refundableReserve now, pay when you stay
Stay at this 4-star business-friendly hotel in St. Louis. Enjoy 3 restaurants, 3 bars/lounges, and a rooftop terrace. Our guests praise the clean rooms in our ...
7.4/10 Good! (1,004 reviews)
"Staff was very helpful when a problem occurred and was very quick to resolve the situation."

Reviewed on Apr 11, 2025

Hilton St. Louis at the Ballpark
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels in Uptown

Collinsville is a city that has a lot going on, but you have your sights set on Uptown. This part of town is perfect for what you want to be doing, and that is everything that is not on everyone’s radar. For all that Uptown has going on, you’ll still need a place to crash, eventually. But you don’t want any old shack, you need something that fits the trip. We have a slew of Uptown hotels that will do the trick.

A beautiful day in the neighborhood

As much as you like getting out there, it’s also good to know a part of Collinsville so well you’ll be telling the tourists where to go. Make friends with the concierge or be bold and chat up a local. It’s your trip, so choose your own adventure. And when you get in at night, you’ll have a comfy room and plenty of amenities to help you settle in. Call a friend and spin tales from the Uptown underground. What’s a journey without a good story to go with it?

Beyond the block

We’re not talking about the Uptown city block. We’re talking about looking beyond that block of hotels you always focus on. We give you tons of ways to sort our stash of Uptown cheap hotels. And if you feel like living a little, but not killing your vacation vibes, choose the Hotwire Hot Rate deal. Filter by:

  • Hotwire Hot Rate: Snag some of the best hotels in Uptown at an almost too good to be true rate. After you book, we’ll reveal the name of the hotel. You can get a luxury hotel at a budget price.
  • Price: You have a price in mind, and we have solutions. Hotels start as low as $115
  • Amenities: Rooftop lounge, designer furniture, 24-7 room service, and everything else you look for to live it up large.

Find the Uptown hotel you want, book it, and never look back. Because your great escape is ahead of you.