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Uptown

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Featured Uptown Hotels

Hyatt Regency St. Louis at The Arch
Hyatt Regency St. Louis at The Arch
4 out of 5
315 Chestnut St, St. Louis, MO
Fully refundableReserve now, pay when you stay
Stay at this 4-star business-friendly hotel in St. Louis. Enjoy free WiFi, 3 restaurants, and 2 bars/lounges. Our guests praise the helpful staff and the clean ...
8.4/10 Very Good! (3,541 reviews)
"1 night stay over was fine could use better mattresses"

Reviewed on Jan 9, 2025

Hyatt Regency St. Louis at The Arch
Drury Plaza Hotel St. Louis at the Arch
Drury Plaza Hotel St. Louis at the Arch
3 out of 5
2 South 4th Street, St. Louis, MO
Fully refundableReserve now, pay when you stay
Stay at this 3-star business-friendly hotel in St. Louis. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the pool ...
9.4/10 Exceptional! (2,361 reviews)
"Loved the pool, managers reception and breakfast. I always love staying at the Drury but the staff here were EXTRA nice and exceeded expectations. It was the perfect last 2 nights of our road trip."

Reviewed on Jan 6, 2025

Drury Plaza Hotel St. Louis at the Arch
Clayton Plaza Hotel & Extended Stay
Clayton Plaza Hotel & Extended Stay
3.5 out of 5
7750 Carondelet Avenue, St. Louis, MO
Fully refundableReserve now, pay when you stay
Stay at this 3.5-star business-friendly hotel in St. Louis. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast and ...
8.8/10 Excellent! (2,934 reviews)
"Great stay"

Reviewed on Jan 9, 2025

Clayton Plaza Hotel & Extended Stay
21C Museum Hotel St Louis
21C Museum Hotel St Louis
4.5 out of 5
1528 Locust street, St. Louis, MO
Fully refundableReserve now, pay when you stay
Stay at this 4.5-star luxury hotel in St. Louis. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the pool and the restaurant in our ...
9/10 Wonderful! (894 reviews)
"Air filter in room looks like it hadn’t been changed since they built a place. Lights in room aren’t all working."

Reviewed on Jan 5, 2025

21C Museum Hotel St Louis
The Last Hotel
The Last Hotel
4.5 out of 5
1501 Washington Ave, St. Louis, MO
Fully refundableReserve now, pay when you stay
Stay at this 4.5-star luxury hotel in St. Louis. Enjoy free WiFi, a 24-hour fitness center, and valet parking (surcharge). Our guests praise the pool and the ...
7.8/10 Good! (1,170 reviews)
Gorgeous 😍
"I was so pleased! We stayed for a concert to celebrate my birthday. The horel was beautiful and the service was phenomenal. They parked our vehicle and helped with our luggage. The whole hotel was stunning from head to toe. The block its on was a beautiful city scene. I highly recommend 10/10!"

Reviewed on Jan 6, 2025

The Last Hotel
Hampton Inn St. Louis-Downtown (At the Gateway Arch)
Hampton Inn St. Louis-Downtown (At the Gateway Arch)
2.5 out of 5
333 Washington Ave, St. Louis, MO
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in St. Louis. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast and ...
8.6/10 Excellent! (1,000 reviews)
"nice"

Reviewed on Jan 2, 2025

Hampton Inn St. Louis-Downtown (At the Gateway Arch)
Moonrise Hotel
Moonrise Hotel
4 out of 5
6177 Delmar Blvd, St. Louis, MO
Fully refundableReserve now, pay when you stay
Stay at this 4-star boutique hotel in St. Louis. Enjoy free WiFi, free parking, and 2 bars/lounges. Our guests praise the restaurant and the bar in our reviews. ...
9/10 Wonderful! (1,629 reviews)
"Super nice facility, rooms, and very convenient location"

Reviewed on Jan 4, 2025

Moonrise Hotel
St. Louis Union Station Hotel, Curio Collection by Hilton
St. Louis Union Station Hotel, Curio Collection by Hilton
4 out of 5
1820 Market Street, St. Louis, MO
Fully refundableReserve now, pay when you stay
Book a stay at this historic hotel in St. Louis. Enjoy free WiFi, an outdoor pool, and 7 restaurants. Our guests praise the helpful staff and the clean rooms ...
8.2/10 Very Good! (1,001 reviews)
"Quick check in"

Reviewed on Jan 4, 2025

St. Louis Union Station Hotel, Curio Collection by Hilton
Pear Tree Inn St. Louis Near Union Station
Pear Tree Inn St. Louis Near Union Station
3 out of 5
2211 Market Street, St. Louis, MO
Fully refundableReserve now, pay when you stay
Stay at this 3-star business-friendly hotel in St. Louis. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the restaurant ...
8.8/10 Excellent! (1,374 reviews)
Winter visit
"Owned by the Drury chain, the Peach Tree Inn has some of the features of a Drury chain - breakfast is very similar and they have the kick back service in the evening, but only beer and wine options, and only snacks like chips and popcorn."

Reviewed on Jan 5, 2025

Pear Tree Inn St. Louis Near Union Station
River City Casino & Hotel
River City Casino & Hotel
4 out of 5
777 River City Casino Blvd, St. Louis, MO
Fully refundableReserve now, pay when you stay
Stay at this 4-star business-friendly hotel in St. Louis. Enjoy free parking, 5 restaurants, and a casino. Our guests praise the helpful staff and the clean ...
9/10 Wonderful! (1,022 reviews)
"It was so nice and relaxing. Awesome view of the riverfront. Defantly one of our favorite places to stay when we come to stl."

Reviewed on Jan 4, 2025

River City Casino & Hotel
Magnolia Hotel St. Louis, a Tribute Portfolio Hotel
Magnolia Hotel St. Louis, a Tribute Portfolio Hotel
4 out of 5
421 N 8th St, St. Louis, MO
Fully refundableReserve now, pay when you stay
Stay at this 4-star business-friendly hotel in St. Louis. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the bar and the helpful ...
8.6/10 Excellent! (1,001 reviews)
"Interesting older building, but well kept. Staff was friendly and helpful."

Reviewed on Jan 3, 2025

Magnolia Hotel St. Louis, a Tribute Portfolio Hotel
Hilton St. Louis at the Ballpark
Hilton St. Louis at the Ballpark
4 out of 5
1 S Broadway, St. Louis, MO
Fully refundableReserve now, pay when you stay
Stay at this 4-star business-friendly hotel in St. Louis. Enjoy 3 restaurants, 3 bars/lounges, and a rooftop terrace. Our guests praise the clean rooms in our ...
7.4/10 Good! (1,000 reviews)
"I had a great experience"

Reviewed on Jan 6, 2025

Hilton St. Louis at the Ballpark
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels in Uptown

Collinsville is a city that has a lot going on, but you have your sights set on Uptown. This part of town is perfect for what you want to be doing, and that is everything that is not on everyone’s radar. For all that Uptown has going on, you’ll still need a place to crash, eventually. But you don’t want any old shack, you need something that fits the trip. We have a slew of Uptown hotels that will do the trick.

A beautiful day in the neighborhood

As much as you like getting out there, it’s also good to know a part of Collinsville so well you’ll be telling the tourists where to go. Make friends with the concierge or be bold and chat up a local. It’s your trip, so choose your own adventure. And when you get in at night, you’ll have a comfy room and plenty of amenities to help you settle in. Call a friend and spin tales from the Uptown underground. What’s a journey without a good story to go with it?

Beyond the block

We’re not talking about the Uptown city block. We’re talking about looking beyond that block of hotels you always focus on. We give you tons of ways to sort our stash of Uptown cheap hotels. And if you feel like living a little, but not killing your vacation vibes, choose the Hotwire Hot Rate deal. Filter by:

  • Hotwire Hot Rate: Snag some of the best hotels in Uptown at an almost too good to be true rate. After you book, we’ll reveal the name of the hotel. You can get a luxury hotel at a budget price.
  • Price: You have a price in mind, and we have solutions. Hotels start as low as $111
  • Amenities: Rooftop lounge, designer furniture, 24-7 room service, and everything else you look for to live it up large.

Find the Uptown hotel you want, book it, and never look back. Because your great escape is ahead of you.