Hotels NearUptown
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Featured Uptown Hotels

Magnolia Hotel St. Louis, a Tribute Portfolio Hotel
Our stay was amazing here, we didn't have breakfast unfortunately but we wished breakfast was complimentary like aome of the other hotels but Overall our stay was great Thank you!
Reviewed on Nov 22, 2025

Hyatt Regency St. Louis at The Arch
Taylor, at the front desk, was amazing and so helpful. She answered my questions with ease during check-in, and continued to help throughout my stay. Taylor deserves a huge Thank you!
Reviewed on Nov 22, 2025

Drury Plaza Hotel St. Louis at the Arch
Clean. Good breakfast
Reviewed on Nov 26, 2025

Forest Park Hotel by MDR
Great location
Reviewed on Nov 22, 2025

Clayton Plaza Hotel & Extended Stay
Everyone on the staff was friendly and helpful. Breakfast each morning had a nice variety of items and the quality of the offerings was very nice. Parking was extremely cost effective. The location of this property was accessible to high quality shopping and dining options.
Reviewed on Nov 23, 2025

21C Museum Hotel St Louis
Love this hotel and have stayed many times. Original room was not suitable (no iron or coffee machine, which are standard), but front desk quickly gave another room.
Reviewed on Nov 26, 2025

Hampton Inn St. Louis-Downtown (At the Gateway Arch)
great stay!!
Reviewed on Nov 24, 2025

Live by Loews - St.Louis
Alright a bit pricey. Especially 40 dollars for parking. I'm still waiting on my deposit refund. Have not received it yet.
Reviewed on Nov 25, 2025

Home2 Suites by Hilton St. Louis Downtown
Supurb service during check in, with Shay. All questions were answered and expedited customer support. Room and sheets were clean. Only suggestion, is to have at least vegetarian or non pork options for meats.
Reviewed on Nov 22, 2025

Embassy Suites by Hilton St. Louis Downtown
Everyone was friendly and great!
Reviewed on Nov 26, 2025

Pear Tree Inn St. Louis Near Union Station
The breakfast buffet was fantastic. Staff was very friendly and welcoming! Rooms were spotless and close to all attractions. Pool and hot tub was a great great added feature as well as the restaurant attached to the hotel!
Reviewed on Nov 27, 2025

Angad Arts Hotel St. Louis, Tapestry Collection by Hilton
I didn't have breakfast so can't comment. Hotel room was clean on arrival, but not cleaned on our second day and various items (tea, coffee, water, etc..) weren't replenished until I asked. I parked the car overnight in a gated lot, which cost $25 per night. I would have liked to know that information ...
Reviewed on Nov 25, 2025
Hotels in Uptown
Collinsville is a city that has a lot going on, but you have your sights set on Uptown. This part of town is perfect for what you want to be doing, and that is everything that is not on everyone’s radar. For all that Uptown has going on, you’ll still need a place to crash, eventually. But you don’t want any old shack, you need something that fits the trip. We have a slew of Uptown hotels that will do the trick.
A beautiful day in the neighborhood
As much as you like getting out there, it’s also good to know a part of Collinsville so well you’ll be telling the tourists where to go. Make friends with the concierge or be bold and chat up a local. It’s your trip, so choose your own adventure. And when you get in at night, you’ll have a comfy room and plenty of amenities to help you settle in. Call a friend and spin tales from the Uptown underground. What’s a journey without a good story to go with it?
Beyond the block
We’re not talking about the Uptown city block. We’re talking about looking beyond that block of hotels you always focus on. We give you tons of ways to sort our stash of Uptown cheap hotels. And if you feel like living a little, but not killing your vacation vibes, choose the Hotwire Hot Rate deal. Filter by:
- Hotwire Hot Rate: Snag some of the best hotels in Uptown at an almost too good to be true rate. After you book, we’ll reveal the name of the hotel. You can get a luxury hotel at a budget price.
- Price: You have a price in mind, and we have solutions. Hotels start as low as $89
- Amenities: Rooftop lounge, designer furniture, 24-7 room service, and everything else you look for to live it up large.
Find the Uptown hotel you want, book it, and never look back. Because your great escape is ahead of you.
Hotels by Star Rating
Uptown Neighborhoods
Top Attractions in Uptown
- Hotels near World's Largest Catsup Bottle (0.51 mi)
- Hotels near Kruta Bakery (0.45 mi)
- Hotels near St. Louis Union Station (11.95 mi)
- Hotels near Gateway Arch (10.86 mi)
- Hotels near St. Louis Zoo (16.31 mi)
- Hotels near Enterprise Center (11.75 mi)
- Hotels near Busch Stadium (11.33 mi)
- Hotels near Washington University in St. Louis (17.23 mi)
- Hotels near Dome at America’s Center (10.94 mi)
- Hotels near Barnes Jewish Hospital (14.94 mi)
- Hotels near City Museum (11.55 mi)
- Hotels near Forest Park (15.61 mi)
- Hotels near America's Center Convention Complex (11.09 mi)
- Hotels near Mississippi River (87.1 mi)
- Hotels near St. Louis University (13.23 mi)
- Hotels near Fox Theater (13.14 mi)
- Hotels near Horseshoe St. Louis Casino (10.71 mi)
- Hotels near Anheuser-Busch Brewery (12.78 mi)
- Hotels near Missouri Botanical Gardens and Arboretum (14.96 mi)
- Hotels near Scott Air Force Base (10.46 mi)
Cities near Uptown
- O'Fallon Hotels (6.7 mi)
- Fairview Heights Hotels (5.15 mi)
- Alton Hotels (18.64 mi)
- Collinsville Hotels (0.35 mi)
- Edwardsville Hotels (9.2 mi)
- Belleville Hotels (10.13 mi)
- Richmond Heights Hotels (17.92 mi)
- Ozarks Hotels (171.91 mi)
- Southern Illinois Hotels (65.36 mi)
- Brentwood Hotels (19.63 mi)
- Webster Groves Hotels (20.42 mi)
- East St. Louis Hotels (9.39 mi)
- Granite City Hotels (8.84 mi)
- Florissant Hotels (19.77 mi)
- Troy Hotels (5.8 mi)
- Columbia Hotels (19.13 mi)
- Caseyville Hotels (2.45 mi)
- Jennings Hotels (15.24 mi)
- Shiloh Hotels (8.84 mi)
- Overland Hotels (20.53 mi)
