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Featured 4 Star Uptown Hotels
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in St. Louis. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the helpful staff and the ...
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in St. Louis. Enjoy free WiFi, 3 restaurants, and 2 bars/lounges. Our guests praise the helpful staff and the clean ...
Fully refundableReserve now, pay when you stay
Book a stay at this luxury hotel in St. Louis. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the pool and the restaurant in our ...
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Book a stay at this boutique hotel in Richmond Heights. Enjoy free breakfast, free WiFi, and an outdoor pool. Our guests praise the breakfast and the helpful ...
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in St. Louis. Enjoy free WiFi, a rooftop terrace, and breakfast (surcharge). Our guests praise the helpful staff ...
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in St. Louis. Enjoy free WiFi, a rooftop terrace, and breakfast (surcharge). Our guests praise the bar and the helpful ...
Fully refundableReserve now, pay when you stay
Book a stay at this luxury hotel in St. Louis. Enjoy breakfast (surcharge), 24-hour room service, and valet parking (surcharge). Our guests praise the helpful ...
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in St. Louis. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the helpful staff and the ...
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in St. Louis. Enjoy free parking, 5 restaurants, and a casino. Our guests praise the helpful staff and the clean ...
Fully refundableReserve now, pay when you stay
Book a stay at this historic hotel in St. Louis. Enjoy free WiFi, an outdoor pool, and 7 restaurants. Our guests praise the helpful staff and the clean rooms ...
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in St. Louis. Enjoy breakfast (surcharge), 24-hour room service, and a 24-hour fitness center. Our guests praise ...
Fully refundableReserve now, pay when you stay
Book a stay at this boutique hotel in St. Louis. Enjoy free WiFi, free parking, and 2 bars/lounges. Our guests praise the restaurant and the helpful staff in ...
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Popular Uptown Hotels
- Magnolia Hotel St. Louis, a Tribute Portfolio Hotel
- Hyatt Regency St. Louis at The Arch
- Forest Park Hotel by MDR
- Clayton Plaza Hotel & Extended Stay
- Hampton Inn St. Louis-Downtown (At the Gateway Arch)
- Embassy Suites by Hilton St. Louis Downtown
- Angad Arts Hotel St. Louis, Tapestry Collection by Hilton
Top Attractions in Uptown
- Hotels near World's Largest Catsup Bottle (0.51 mi)
- Hotels near Kruta Bakery (0.45 mi)
- Hotels near St. Louis Union Station (11.95 mi)
- Hotels near Gateway Arch (10.86 mi)
- Hotels near St. Louis Zoo (16.31 mi)
- Hotels near Enterprise Center (11.75 mi)
- Hotels near Busch Stadium (11.33 mi)
- Hotels near Washington University in St. Louis (17.23 mi)
- Hotels near Dome at America’s Center (10.94 mi)
- Hotels near Barnes Jewish Hospital (14.94 mi)
- Hotels near City Museum (11.55 mi)
- Hotels near Forest Park (15.61 mi)
- Hotels near America's Center Convention Complex (11.09 mi)
- Hotels near Mississippi River (87.1 mi)
- Hotels near St. Louis University (13.23 mi)
- Hotels near Fox Theater (13.14 mi)
- Hotels near Horseshoe St. Louis Casino (10.71 mi)
- Hotels near Anheuser-Busch Brewery (12.78 mi)
- Hotels near Missouri Botanical Gardens and Arboretum (14.96 mi)
- Hotels near Scott Air Force Base (10.46 mi)
Nearby Cities
- O'Fallon Hotels (6.7 mi)
- Fairview Heights Hotels (5.15 mi)
- Alton Hotels (18.64 mi)
- Collinsville Hotels (0.35 mi)
- Edwardsville Hotels (9.2 mi)
- Belleville Hotels (10.13 mi)
- Richmond Heights Hotels (17.92 mi)
- Ozarks Hotels (171.91 mi)
- Southern Illinois Hotels (65.36 mi)
- Brentwood Hotels (19.63 mi)
- Webster Groves Hotels (20.42 mi)
- East St. Louis Hotels (9.39 mi)