Search for Cheap Deals on
4 Star Hotels in Uptown

Check Last Minute Uptown Hotel Deals

Tonight Apr 26 - Apr 27Next weekend May 2 - May 4

You choose what matters — star rating, location, amenities.

We pick the perfect hotel, packed with all your must-haves.

Your hotel is revealed right after booking!

Featured 4 Star Uptown Hotels

Hyatt Regency St. Louis at The Arch
4 out of 5
Fully refundableReserve now, pay when you stay
  • 21 min drive from World's Largest Catsup Bottle
The price is $136 per night from May 22 to May 23
$136
includes taxes & fees
May 22 - May 23
Stay at this 4-star business-friendly hotel in St. Louis. Enjoy free WiFi, 3 restaurants, and 2 bars/lounges. Our guests praise the helpful staff and the clean ...
Hyatt Regency St. Louis at The Arch
Moonrise Hotel
4 out of 5
Fully refundableReserve now, pay when you stay
  • 30 min drive from World's Largest Catsup Bottle
The price is $201 per night from May 4 to May 5
$201
includes taxes & fees
May 4 - May 5
Stay at this 4-star boutique hotel in St. Louis. Enjoy free WiFi, free parking, and 2 bars/lounges. Our guests praise the restaurant and the bar in our reviews. ...
Moonrise Hotel
River City Casino & Hotel
4 out of 5
Fully refundableReserve now, pay when you stay
  • 37 min drive from World's Largest Catsup Bottle
The price is $126 per night from May 7 to May 8
$126
includes taxes & fees
May 7 - May 8
Stay at this 4-star business-friendly hotel in St. Louis. Enjoy free parking, 5 restaurants, and a casino. Our guests praise the helpful staff and the clean ...
River City Casino & Hotel
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free
21C Museum Hotel St Louis
4.5 out of 5
Fully refundableReserve now, pay when you stay
  • 22 min drive from World's Largest Catsup Bottle
The price is $193 per night from May 22 to May 23
$193
includes taxes & fees
May 22 - May 23
Stay at this 4.5-star luxury hotel in St. Louis. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the pool and the restaurant in our ...
21C Museum Hotel St Louis
Live by Loews - St.Louis
4 out of 5
  • 22 min drive from World's Largest Catsup Bottle
The price is $208 per night from Apr 27 to Apr 28
$208
includes taxes & fees
Apr 27 - Apr 28
Stay at this 4-star business-friendly hotel in St. Louis. Enjoy free WiFi, a rooftop terrace, and breakfast (surcharge). Our guests praise the bar and the helpful ...
Live by Loews - St.Louis
Le Méridien St. Louis Clayton
4 out of 5
  • 34 min drive from World's Largest Catsup Bottle
The price is $168 per night from Apr 27 to Apr 28
$168
includes taxes & fees
Apr 27 - Apr 28
Book a stay at this eco-certified hotel in St. Louis. Enjoy an outdoor pool, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the helpful ...
Le Méridien St. Louis Clayton
The Last Hotel
4.5 out of 5
  • 22 min drive from World's Largest Catsup Bottle
Stay at this 4.5-star luxury hotel in St. Louis. Enjoy free WiFi, a 24-hour fitness center, and valet parking (surcharge). Our guests praise the pool and the ...
Get rates
The Last Hotel
Embassy Suites by Hilton St. Louis Downtown
4 out of 5
Fully refundableReserve now, pay when you stay
  • 21 min drive from World's Largest Catsup Bottle
The price is $153 per night from Apr 27 to Apr 28
$153
includes taxes & fees
Apr 27 - Apr 28
Stay at this 4-star business-friendly hotel in St. Louis. Enjoy free breakfast, a fitness center, and WiFi (surcharge). Our guests praise the breakfast and the ...
Embassy Suites by Hilton St. Louis Downtown
Angad Arts Hotel
4 out of 5
Fully refundableReserve now, pay when you stay
  • 24 min drive from World's Largest Catsup Bottle
The price is $176 per night from Apr 27 to Apr 28
$176
includes taxes & fees
Apr 27 - Apr 28
Stay at this 4-star business-friendly hotel in St. Louis. Enjoy free WiFi, a rooftop terrace, and breakfast (surcharge). Our guests praise the bar and the helpful ...
Angad Arts Hotel
DoubleTree by Hilton St. Louis Forest Park
4 out of 5
Fully refundableReserve now, pay when you stay
  • 27 min drive from World's Largest Catsup Bottle
The price is $194 per night from May 4 to May 5
$194
includes taxes & fees
May 4 - May 5
Stay at this 4-star business-friendly hotel in St. Louis. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the helpful staff and the ...
DoubleTree by Hilton St. Louis Forest Park
The Westin St. Louis
4.5 out of 5
  • 22 min drive from World's Largest Catsup Bottle
The price is $188 per night from May 25 to May 26
$188
includes taxes & fees
May 25 - May 26
Book a stay at this luxury hotel in St. Louis. Enjoy breakfast (surcharge), 24-hour room service, and valet parking (surcharge). Our guests praise the helpful ...
The Westin St. Louis
Hilton Pennywell St. Louis at the Arch
4 out of 5
Fully refundableReserve now, pay when you stay
  • 21 min drive from World's Largest Catsup Bottle
The price is $164 per night from Apr 27 to Apr 28
$164
includes taxes & fees
Apr 27 - Apr 28
Stay at this 4-star business-friendly hotel in St. Louis. Enjoy breakfast (surcharge), a fitness center, and valet parking (surcharge). Our guests praise the ...
Hilton Pennywell St. Louis at the Arch
Don't see what you're looking for?
See all available properties in Uptown
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.