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Featured 5 Star Uptown Hotels
Fully refundableReserve now, pay when you stay
Book a stay at this luxury hotel in St. Louis. Enjoy free WiFi, a full-service spa, and a rooftop terrace. Our guests praise the helpful staff in our reviews. ...
Book a stay at this luxury hotel in St. Louis. Enjoy 2 restaurants, 3 bars/lounges, and breakfast (surcharge). Our guests praise the helpful staff and the room ...
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Popular Uptown Hotels
- Magnolia Hotel St. Louis, a Tribute Portfolio Hotel
- Hyatt Regency St. Louis at The Arch
- Forest Park Hotel by MDR
- Clayton Plaza Hotel & Extended Stay
- Hampton Inn St. Louis-Downtown (At the Gateway Arch)
- Embassy Suites by Hilton St. Louis Downtown
- Angad Arts Hotel St. Louis, Tapestry Collection by Hilton
Top Attractions in Uptown
- Hotels near World's Largest Catsup Bottle (0.51 mi)
- Hotels near Kruta Bakery (0.45 mi)
- Hotels near St. Louis Union Station (11.95 mi)
- Hotels near Gateway Arch (10.86 mi)
- Hotels near St. Louis Zoo (16.31 mi)
- Hotels near Enterprise Center (11.75 mi)
- Hotels near Busch Stadium (11.33 mi)
- Hotels near Washington University in St. Louis (17.23 mi)
- Hotels near Dome at America’s Center (10.94 mi)
- Hotels near Barnes Jewish Hospital (14.94 mi)
- Hotels near City Museum (11.55 mi)
- Hotels near Forest Park (15.61 mi)
- Hotels near America's Center Convention Complex (11.09 mi)
- Hotels near Mississippi River (87.1 mi)
- Hotels near St. Louis University (13.23 mi)
- Hotels near Fox Theater (13.14 mi)
- Hotels near Horseshoe St. Louis Casino (10.71 mi)
- Hotels near Anheuser-Busch Brewery (12.78 mi)
- Hotels near Missouri Botanical Gardens and Arboretum (14.96 mi)
- Hotels near Scott Air Force Base (10.46 mi)
Nearby Cities
- O'Fallon Hotels (6.7 mi)
- Fairview Heights Hotels (5.15 mi)
- Alton Hotels (18.64 mi)
- Collinsville Hotels (0.35 mi)
- Edwardsville Hotels (9.2 mi)
- Belleville Hotels (10.13 mi)
- Richmond Heights Hotels (17.92 mi)
- Ozarks Hotels (171.91 mi)
- Southern Illinois Hotels (65.36 mi)
- Brentwood Hotels (19.63 mi)
- Webster Groves Hotels (20.42 mi)
- East St. Louis Hotels (9.39 mi)