Search for Cheap Deals on
Hotels in Cape Girardeau

Photo by Skyy

Check Last Minute Cape Girardeau Hotel Deals

Tonight May 31 - Jun 1Next weekend Jun 6 - Jun 8

Choose from 164 Cape Girardeau Hotel Deals

Drury Plaza Hotel Cape Girardeau Conference Center
Drury Plaza Hotel Cape Girardeau Conference Center
3 out of 5
3351 Percy Drive, Cape Girardeau, MO
  • 8 min drive from Southeast Missouri State University
Stay at this 3-star business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.4/10 Exceptional! (1,001 reviews)
Great Place
"Friendly staff clean rooms."

Reviewed on May 26, 2025

Drury Plaza Hotel Cape Girardeau Conference Center
The Riverview
The Riverview
2 out of 5
777 Main St, Cape Girardeau, MO
  • 18 min walk from Southeast Missouri State University
Stay at this hotel in Cape Girardeau. Enjoy free WiFi, free parking, and 2 restaurants. Popular attractions Isle Casino Cape Girardeau and Riverfront Park are ...
9.2/10 Wonderful! (276 reviews)
"Yes"

Reviewed on May 30, 2025

The Riverview
Pear Tree Inn Cape Girardeau Near the Medical Center
Pear Tree Inn Cape Girardeau Near the Medical Center
2.5 out of 5
3248 William St, Cape Girardeau, MO
  • 7 min drive from Southeast Missouri State University
Stay at this hotel in Cape Girardeau. Enjoy free WiFi, an outdoor pool, and a 24-hour front desk. Our guests praise the helpful staff and the clean rooms in ...
8.8/10 Excellent! (1,007 reviews)
"Clean and comfortable"

Reviewed on May 26, 2025

Pear Tree Inn Cape Girardeau Near the Medical Center
Candlewood Suites Cape Girardeau by IHG
Candlewood Suites Cape Girardeau by IHG
2.5 out of 5
485 S Mount Auburn Rd, Cape Girardeau, MO
  • 8 min drive from Southeast Missouri State University
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free WiFi, free parking, and a fitness center. Our guests praise the helpful staff and the ...
8/10 Very Good! (795 reviews)
"The gym conference room and games my basketball team enjoyed the stay service was excellent also"

Reviewed on May 26, 2025

Candlewood Suites Cape Girardeau by IHG
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
2.5 out of 5
3253 William Street, Cape Girardeau, MO
  • 7 min drive from Southeast Missouri State University
Book a stay at this spa hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in ...
9.4/10 Exceptional! (1,002 reviews)
"I thought the property was very clean and appealing. Our check in clerk for our 1st night stay on May 22nd was very friendly, and helpful, however our 2nd stay on May 25th our clerk was unpleasant never said hello never smiled. She wasn't rude but she seemed very unfriendly and like she didn't want ..."

Reviewed on May 27, 2025

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Pear Tree Inn Cape Girardeau West
Pear Tree Inn Cape Girardeau West
2.5 out of 5
103 Cape West Pkwy, Cape Girardeau, MO
  • 8 min drive from Southeast Missouri State University
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the ...
9/10 Wonderful! (1,001 reviews)
"Poor breakfast, no hot food except waffles not even any bread for toast"

Reviewed on May 30, 2025

Pear Tree Inn Cape Girardeau West
Courtyard by Marriott Cape Girardeau Downtown
Courtyard by Marriott Cape Girardeau Downtown
3 out of 5
400 Broadway St., Cape Girardeau, MO
  • 14 min walk from Southeast Missouri State University
Stay at this 3-star business-friendly hotel in Cape Girardeau. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff ...
9.4/10 Exceptional! (414 reviews)
Overall great stay!
"Overall we had a great stay here for just a night in town for a soccer tournament. I had filtered out hotels that had a pool and somehow this one slipped through but it does not have a pool. I also filtered by hotels that included free breakfast, this hotel has a restaurant but breakfast is not free. ..."

Reviewed on May 19, 2025

Courtyard by Marriott Cape Girardeau Downtown
Quality Inn
Quality Inn
2.5 out of 5
2011 North Kingshighway, Cape Girardeau, MO
  • 9 min drive from Southeast Missouri State University
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our ...
7/10 Good! (587 reviews)
"Great room, great experience"

Reviewed on May 27, 2025

Quality Inn
Drury Inn & Suites Cape Girardeau
Drury Inn & Suites Cape Girardeau
3 out of 5
3303 Campster Drive, Cape Girardeau, MO
  • 8 min drive from Southeast Missouri State University
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the ...
9.2/10 Wonderful! (932 reviews)
"Room was very clean and staff was excellent!"

Reviewed on May 25, 2025

Drury Inn & Suites Cape Girardeau
Fairfield Inn & Suites by Marriott Cape Girardeau
Fairfield Inn & Suites by Marriott Cape Girardeau
2.5 out of 5
433 CAPE WEST CROSSINGS, Cape Girardeau, MO
  • 8 min drive from Southeast Missouri State University
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Fort D Historic Site and ...
9.2/10 Wonderful! (104 reviews)
"Professional staff. We walked in on a deep clean that had not started. The staff member was professional and handled it so well. You have an employee there that is a big asset."

Reviewed on Apr 27, 2025

Fairfield Inn & Suites by Marriott Cape Girardeau
Tru By Hilton Cape Girardeau
Tru By Hilton Cape Girardeau
2.5 out of 5
2520 Veterans Memorial Dr, Cape Girardeau, MO
  • 12 min drive from Southeast Missouri State University
Stay at this hotel in Cape Girardeau. Enjoy free breakfast, free parking, and a fitness center. Popular attractions Cape Girardeau Conservation Nature Center ...
9.6/10 Exceptional! (17 reviews)
Great stay
"Awesome stay. Second time I have stayed here. Beds comfortable. Quiet."

Reviewed on May 21, 2025

Tru By Hilton Cape Girardeau
Hampton Inn Cape Girardeau I 55 East
Hampton Inn Cape Girardeau I 55 East
2.5 out of 5
207 S Mt Auburn Rd, Cape Girardeau, MO
  • 7 min drive from Southeast Missouri State University
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the ...
9.6/10 Exceptional! (712 reviews)
"Great place to stay convenient walking to multiple restaurants"

Reviewed on May 24, 2025

Hampton Inn Cape Girardeau I 55 East
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find cheap hotels in Cape Girardeau

You’re not an average traveler—and Hotwire knows it. Your wanderlust takes you off the beaten path to discover unique adventures and every travel destination’s lesser-known tourist scenes. Hotwire has the hookup! Book your Cape Girardeau hotel with Hotwire to complete your one-of-a-kind travel checklist.

For you, intrepid voyager, Hotwire has a large selection of the best hotels in Cape Girardeau.

Choosing the right hotel in Missouri has everything to do with the way you want your trip to go. If you’ve scribbled a few obscure destinations on your itinerary, you probably already have a good sense of how your getaway is taking shape. Lean into that by booking one of Cape Girardeau’s 164 hotels. Choose the one that best catches your trip’s tourist drift.

If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $66. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get great Cape Girardeau hotel deals at the last minute.

While traveling, where you stay plays a major role in your overall vacation enjoyment. Choosing the right hotel is just as important as making sure you book the right flight and car rental. If you’re traveling with family or friends, you may need to book a hotel with connecting rooms. If you enjoy an elegant and relaxing hotel ambiance, opt for one of Hotwire’s luxury hotels in Cape Girardeau. No matter your reason for visiting Cape Girardeau, with Hotwire’s large selection of hotels in the area, you’re sure to book a hotel that meets all your accommodation needs.

Frequently Asked Questions About Cape Girardeau hotels

Where can I find the best last-minute travel deals?

If you’re traveling in the spirit of spontaneity, you’ll love the idea of leaving your exact hotel choice up to chance. With Hotwire Hot Rates, you can unlock great deals on your next flight, hotel, or car rental. Just plug in your general preferences and let Hotwire choose last-minute hotel deals in Cape Girardeau for as low as $66.

How many hotels are there in Cape Girardeau?

With over 164 hotels in Cape Girardeau, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $66.

How to find cheap car rentals in Cape Girardeau?

Finding a cheap car rental deal in Cape Girardeau is as easy as scoring cheap hotels in Cape Girardeau. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can unlock great car rental deals if you book a Hotwire Hot Rate at the last minute.