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Hotels in Cape Girardeau

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Choose from 169 Cape Girardeau Hotel Deals

Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center

3 out of 5
3351 Percy Drive Cape Girardeau MO
  • 10 min drive from Isle Casino Cape Girardeau
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.6/10 Exceptional! (1,016 reviews)
Clean room , nice staff

Reviewed on Mar 6, 2026

Drury Plaza Hotel Cape Girardeau Conference Center
The Riverview

The Riverview

4 out of 5
777 Main St Cape Girardeau MO
  • 3 min walk from Isle Casino Cape Girardeau
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free WiFi, free parking, and 2 restaurants. Popular attractions Isle Casino Cape Girardeau ...
9.4/10 Exceptional! (523 reviews)
Friendly staff, very clean room. Love staying at this hotel!

Reviewed on Mar 7, 2026

The Riverview
Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau

3 out of 5
3303 Campster Drive Cape Girardeau MO
  • 10 min drive from Isle Casino Cape Girardeau
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the ...
9.4/10 Exceptional! (1,007 reviews)
Great experience. We will pick Drury every time we travel.

Reviewed on Mar 8, 2026

Drury Inn & Suites Cape Girardeau
Candlewood Suites Cape Girardeau by IHG

Candlewood Suites Cape Girardeau by IHG

2.5 out of 5
485 S Mount Auburn Rd Cape Girardeau MO
  • 9 min drive from Isle Casino Cape Girardeau
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free WiFi, free parking, and a fitness center. Our guests praise the helpful staff and the ...
8.2/10 Very Good! (901 reviews)
Pet friendly but charge a ridiculous amount of $75 Per pet!! Didn’t disclose untill check on.

Reviewed on Mar 5, 2026

Candlewood Suites Cape Girardeau by IHG
Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West

2.5 out of 5
103 Cape West Pkwy Cape Girardeau MO
  • 10 min drive from Isle Casino Cape Girardeau
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the ...
9/10 Wonderful! (1,007 reviews)
Yes to all the above.

Reviewed on Mar 2, 2026

Pear Tree Inn Cape Girardeau West
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

2.5 out of 5
3253 William Street Cape Girardeau MO
  • 9 min drive from Isle Casino Cape Girardeau
Book a stay at this spa hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in ...
9.4/10 Exceptional! (1,006 reviews)
Clean room staff is very nice parking it great

Reviewed on Mar 6, 2026

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Quality Inn Cape Girardeau North

Quality Inn Cape Girardeau North

2.5 out of 5
2011 North Kingshighway Cape Girardeau MO
  • 11 min drive from Isle Casino Cape Girardeau
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our ...
7.2/10 Good! (706 reviews)
Noisy. Could hear noise from parking lot and from upstairs. Did not like required refundable $50 deposit. After hearing a shower running from another room, our shower leaked from the wall connection. Staff said there was no one available to fix. Staff offered to move us. but we were unpacked ready ...

Reviewed on Mar 4, 2026

Quality Inn Cape Girardeau North
Courtyard by Marriott Cape Girardeau Downtown

Courtyard by Marriott Cape Girardeau Downtown

3 out of 5
400 Broadway St. Cape Girardeau MO
  • 9 min walk from Isle Casino Cape Girardeau
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff ...
9.6/10 Exceptional! (493 reviews)
The bed was so comfortable. Everything was very clean. Location was right in downtown so it was very convenient.

Reviewed on Mar 6, 2026

Courtyard by Marriott Cape Girardeau Downtown
Fairfield Inn & Suites by Marriott Cape Girardeau

Fairfield Inn & Suites by Marriott Cape Girardeau

3 out of 5
433 CAPE WEST CROSSINGS Cape Girardeau MO
  • 9 min drive from Isle Casino Cape Girardeau
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Fort D Historic Site and ...
9.4/10 Exceptional! (162 reviews)
Staff was wonderful

Reviewed on Mar 3, 2026

Fairfield Inn & Suites by Marriott Cape Girardeau
Tru By Hilton Cape Girardeau

Tru By Hilton Cape Girardeau

2.5 out of 5
2520 Veterans Memorial Dr Cape Girardeau MO
  • 14 min drive from Isle Casino Cape Girardeau
Stay at this hotel in Cape Girardeau. Enjoy free breakfast, free parking, and a fitness center. Popular attractions Cape Girardeau Conservation Nature Center ...
9.6/10 Exceptional! (114 reviews)
New! Love the lobby layout, design and seating. Staff is super friendly and welcoming. Location is right next to the sports complex.

Reviewed on Feb 24, 2026

Tru By Hilton Cape Girardeau
Hampton Inn Cape Girardeau I 55 East

Hampton Inn Cape Girardeau I 55 East

2.5 out of 5
207 S Mt Auburn Rd Cape Girardeau MO
  • 9 min drive from Isle Casino Cape Girardeau
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the ...
9.6/10 Exceptional! (795 reviews)
Great place to stay. Clean and close to restaurants!

Reviewed on Mar 2, 2026

Hampton Inn Cape Girardeau I 55 East
Town House Inn Cape Giradreau

Town House Inn Cape Giradreau

2.5 out of 5
505 North Kingshighway Street Cape Girardeau MO
  • 6 min drive from Isle Casino Cape Girardeau
Stay at this motel in Cape Girardeau. Enjoy free WiFi, free parking, and a 24-hour front desk. Popular attractions Cape Splash Family Aquatic Center and Show ...
6/10 (212 reviews)
Room was lacking in all aspects, no coffee maker and the phone did not work. And i got bit by bed bugs. Che ked out early even though it was non-refundable

Reviewed on Feb 22, 2026

Town House Inn Cape Giradreau
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find cheap hotels in Cape Girardeau

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How many hotels are there in Cape Girardeau?

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