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Hotels in Cape Girardeau

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Choose from 173 Cape Girardeau Hotel Deals

Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center

3 out of 5
3351 Percy Drive Cape Girardeau MO
  • 8 min drive from Southeast Missouri State University
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.4/10 Exceptional! (1,010 reviews)
Great value.

Reviewed on Jan 4, 2026

Drury Plaza Hotel Cape Girardeau Conference Center
The Riverview

The Riverview

4 out of 5
777 Main St Cape Girardeau MO
  • 18 min walk from Southeast Missouri State University
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free WiFi, free parking, and 2 restaurants. Popular attractions Isle Casino Cape Girardeau ...
9.2/10 Wonderful! (483 reviews)
Excellent stay. Will come again

Reviewed on Dec 30, 2025

The Riverview
Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau

3 out of 5
3303 Campster Drive Cape Girardeau MO
  • 8 min drive from Southeast Missouri State University
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the ...
9.4/10 Exceptional! (1,007 reviews)
Hot tub was great, service was excellent, friendly staff, clean room, comfy bed, and great amenities. We stayed two nights with no complaints.

Reviewed on Jan 4, 2026

Drury Inn & Suites Cape Girardeau
Candlewood Suites Cape Girardeau by IHG

Candlewood Suites Cape Girardeau by IHG

2.5 out of 5
485 S Mount Auburn Rd Cape Girardeau MO
  • 8 min drive from Southeast Missouri State University
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free WiFi, free parking, and a fitness center. Our guests praise the helpful staff and the ...
8/10 Very Good! (887 reviews)
We enjoyed the cleanliness of the room, the Christmas decorations, and the location.

Reviewed on Jan 4, 2026

Candlewood Suites Cape Girardeau by IHG
Courtyard by Marriott Cape Girardeau Downtown

Courtyard by Marriott Cape Girardeau Downtown

3 out of 5
400 Broadway St. Cape Girardeau MO
  • 14 min walk from Southeast Missouri State University
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff ...
9.4/10 Exceptional! (475 reviews)
Amazing hotel that has great amenities, clean and friendly staff.

Reviewed on Jan 3, 2026

Courtyard by Marriott Cape Girardeau Downtown
Pear Tree Inn Cape Girardeau Near the Medical Center

Pear Tree Inn Cape Girardeau Near the Medical Center

2.5 out of 5
3248 William St Cape Girardeau MO
  • 7 min drive from Southeast Missouri State University
Stay at this hotel in Cape Girardeau. Enjoy free WiFi, a 24-hour front desk, and daily housekeeping. Our guests praise the helpful staff and the clean rooms ...
8.8/10 Excellent! (1,005 reviews)
Clean room. Comfortable bed

Reviewed on Jan 3, 2026

Pear Tree Inn Cape Girardeau Near the Medical Center
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

2.5 out of 5
3253 William Street Cape Girardeau MO
  • 7 min drive from Southeast Missouri State University
Book a stay at this spa hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in ...
9.4/10 Exceptional! (1,003 reviews)
Everyone kind & place very clean.

Reviewed on Jan 4, 2026

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Quality Inn

Quality Inn

2.5 out of 5
2011 North Kingshighway Cape Girardeau MO
  • 9 min drive from Southeast Missouri State University
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our ...
7/10 Good! (689 reviews)
The room was clean and nice. The breakfast was really good.

Reviewed on Dec 28, 2025

Quality Inn
Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West

2.5 out of 5
103 Cape West Pkwy Cape Girardeau MO
  • 8 min drive from Southeast Missouri State University
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the ...
9/10 Wonderful! (1,002 reviews)
The rooms super immaculate super clean extremely comfortable the staff was very kind courteous and very competent in every way

Reviewed on Jan 2, 2026

Pear Tree Inn Cape Girardeau West
Hampton Inn Cape Girardeau I 55 East

Hampton Inn Cape Girardeau I 55 East

2.5 out of 5
207 S Mt Auburn Rd Cape Girardeau MO
  • 7 min drive from Southeast Missouri State University
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the ...
9.6/10 Exceptional! (785 reviews)
Cleanliest hotel I’ve ever stayed at! Staff was friendly. Room was spacious. Bed was comfortable. I would 100% recommend! Close to the university. Across the street from Starbucks and many other places to eat.

Reviewed on Dec 15, 2025

Hampton Inn Cape Girardeau I 55 East
Fairfield Inn & Suites by Marriott Cape Girardeau

Fairfield Inn & Suites by Marriott Cape Girardeau

2.5 out of 5
433 CAPE WEST CROSSINGS Cape Girardeau MO
  • 8 min drive from Southeast Missouri State University
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Fort D Historic Site and ...
9.4/10 Exceptional! (148 reviews)
Friendly staff, Clean room

Reviewed on Jan 5, 2026

Fairfield Inn & Suites by Marriott Cape Girardeau
Tru By Hilton Cape Girardeau

Tru By Hilton Cape Girardeau

2.5 out of 5
2520 Veterans Memorial Dr Cape Girardeau MO
  • 12 min drive from Southeast Missouri State University
Stay at this hotel in Cape Girardeau. Enjoy free breakfast, free parking, and a fitness center. Popular attractions Cape Girardeau Conservation Nature Center ...
9.4/10 Exceptional! (104 reviews)
They were great

Reviewed on Dec 26, 2025

Tru By Hilton Cape Girardeau
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find cheap hotels in Cape Girardeau

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Frequently Asked Questions About Cape Girardeau hotels

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How many hotels are there in Cape Girardeau?

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