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Featured Cape Girardeau Family Hotels
Drury Inn & Suites Cape Girardeau
3303 Campster Drive, Cape Girardeau, MO
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the ...
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
3253 William Street, Cape Girardeau, MO
Fully refundable
Book a stay at this spa hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in ...
Pear Tree Inn Cape Girardeau Near the Medical Center
3248 William St, Cape Girardeau, MO
Fully refundableReserve now, pay when you stay
Stay at this hotel in Cape Girardeau. Enjoy free WiFi, an outdoor pool, and a 24-hour front desk. Our guests praise the helpful staff and the clean rooms in ...
Hampton Inn Cape Girardeau I 55 East
207 S Mt Auburn Rd, Cape Girardeau, MO
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the ...
Pear Tree Inn Cape Girardeau West
103 Cape West Pkwy, Cape Girardeau, MO
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the ...
Candlewood Suites Cape Girardeau by IHG
485 S Mount Auburn Rd, Cape Girardeau, MO
Fully refundable
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free WiFi, free parking, and a fitness center. Our guests praise the helpful staff and the ...
Quality Inn
2011 North Kingshighway, Cape Girardeau, MO
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our ...
Drury Plaza Hotel Cape Girardeau Conference Center
3351 Percy Drive, Cape Girardeau, MO
Fully refundableReserve now, pay when you stay
Stay at this 3-star business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Hotels with Pools in Cape Girardeau
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
3253 William Street, Cape Girardeau, MO
Book a stay at this spa hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in ...
9.4/10 Exceptional! (1,003 reviews)
"Staff is phenomenal, and the room was very clean, accommodating all my needs."
Reviewed on May 31, 2025
Pear Tree Inn Cape Girardeau Near the Medical Center
3248 William St, Cape Girardeau, MO
Stay at this hotel in Cape Girardeau. Enjoy free WiFi, an outdoor pool, and a 24-hour front desk. Our guests praise the helpful staff and the clean rooms in ...
8.8/10 Excellent! (1,000 reviews)
"Clean and comfortable"
Reviewed on May 26, 2025
Drury Inn & Suites Cape Girardeau
3303 Campster Drive, Cape Girardeau, MO
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the ...
9.2/10 Wonderful! (934 reviews)
"Front desk staff was so helpful and friendly. We didnt know there was complimentary dinner and drinks, in addition to a fabulcius and tasty breakfast. We will stay here again"
Reviewed on May 31, 2025
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Hotels With Connecting Rooms in Cape Girardeau
Drury Inn & Suites Cape Girardeau
3303 Campster Drive, Cape Girardeau, MO
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the ...
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
3253 William Street, Cape Girardeau, MO
Book a stay at this spa hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in ...
Pear Tree Inn Cape Girardeau Near the Medical Center
3248 William St, Cape Girardeau, MO
Stay at this hotel in Cape Girardeau. Enjoy free WiFi, an outdoor pool, and a 24-hour front desk. Our guests praise the helpful staff and the clean rooms in ...
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Hotels by Star Rating
More Hotel Options
- Hotels with Free Parking in Cape Girardeau
- Hotels with a Pool in Cape Girardeau
- Casinos in Cape Girardeau
- Pet-friendly Hotels in Cape Girardeau
- Hotels with an Indoor Pool in Cape Girardeau
- Hotels with Hot Tubs in Cape Girardeau
- Hotel Wedding Venues in Cape Girardeau
- Apartment Hotel in Cape Girardeau
- Luxury Hotels in Cape Girardeau
- Resorts & Hotels with Spas in Cape Girardeau
Top Points of Interests in Cape Girardeau
- Hotels near Southeast Missouri State University
- Hotels near Isle Casino Cape Girardeau
- Hotels near Riverfront Bridge Park
- Hotels near Cape Splash Family Aquatic Center
- Hotels near Riverfront Park
- Hotels near Hunter Valley Winery
- Hotels near Cape Rock Park
- Hotels near eDen Spa & Salon
- Hotels near Cape Girardeau Conservation Nature Center
- Hotels near Lazy L Safari Park
- Hotels near Fort D Historic Site
- Hotels near Shawnee National Forest
- Hotels near Mississippi River
- Hotels near Trail of Tears State Park
Cities near Cape Girardeau
- Carbondale Hotels (33.45 mi)
- Sikeston Hotels (29.82 mi)
- Ozarks Hotels (163.98 mi)
- Southern Illinois Hotels (85.27 mi)
- Jackson Hotels (9.69 mi)
- Perryville Hotels (34.87 mi)
- Makanda Hotels (27.39 mi)
- Anna Hotels (18.3 mi)
- Murphysboro Hotels (33.6 mi)
- Cobden Hotels (21.29 mi)
- Alto Pass Hotels (21.31 mi)
- Charleston Hotels (28 mi)
- Cairo Hotels (28 mi)
- Jonesboro Hotels (17.02 mi)
- Southeast Missouri Hotels (50.24 mi)
- Pomona Hotels (24.37 mi)
- Buncombe Hotels (31.81 mi)
- Marble Hill Hotels (25.49 mi)
- Dongola Hotels (19.71 mi)
- Bloomfield Hotels (36.79 mi)
Car Rentals Near Cape Girardeau
- Car rentals in Carbondale
- Car rentals in Sikeston
- Car rentals in Ozarks
- Car rentals in Southern Illinois
- Car rentals in Jackson
- Car rentals in Perryville
- Car rentals in Makanda
- Car rentals in Anna
- Car rentals in Murphysboro
- Car rentals in Cobden
- Car rentals in Alto Pass
- Car rentals in Charleston
- Car rentals in Cairo
- Car rentals in Jonesboro
- Car rentals in Southeast Missouri
- Car rentals in Pomona
Top Family Hotel Destinations
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