Search for Cheap Deals onLuxury Hotels in Cape Girardeau
Photo by Skyy
Check Last Minute Cape Girardeau Hotel Deals
You choose what matters — star rating, location, amenities.
We pick the perfect hotel, packed with all your must-haves.
Your hotel is revealed right after booking!
Featured Luxury Cape Girardeau
Pear Tree Inn Cape Girardeau Near the Medical Center
3248 William St, Cape Girardeau, MO
Fully refundableReserve now, pay when you stay
Stay at this hotel in Cape Girardeau. Enjoy free WiFi, a 24-hour front desk, and daily housekeeping. Our guests praise the helpful staff and the clean rooms ...
Quality Inn
2011 North Kingshighway, Cape Girardeau, MO
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our ...
Drury Inn & Suites Cape Girardeau
3303 Campster Drive, Cape Girardeau, MO
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the ...
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Hotels by Star Rating
More Hotel Options in Cape Girardeau
- Hotels with Free Parking in Cape Girardeau
- Family Hotels in Cape Girardeau
- Hotels with a Pool in Cape Girardeau
- Casinos in Cape Girardeau
- Pet-friendly Hotels in Cape Girardeau
- Hotels with an Indoor Pool in Cape Girardeau
- Hotels with Hot Tubs in Cape Girardeau
- Hotel Wedding Venues in Cape Girardeau
- Apartment Hotel in Cape Girardeau
- Resorts & Hotels with Spas in Cape Girardeau
Top Points of Interests in Cape Girardeau
- Hotels near Southeast Missouri State University
- Hotels near Isle Casino Cape Girardeau
- Hotels near Riverfront Bridge Park
- Hotels near Cape Splash Family Aquatic Center
- Hotels near Riverfront Park
- Hotels near Hunter Valley Winery
- Hotels near Cape Rock Park
- Hotels near eDen Spa & Salon
- Hotels near Cape Girardeau Conservation Nature Center
- Hotels near Fort D Historic Site
- Hotels near Lazy L Safari Park
- Hotels near Shawnee National Forest
- Hotels near Mississippi River
- Hotels near Trail of Tears State Park
Cities near Cape Girardeau
- Carbondale Hotels (33.45 mi)
- Sikeston Hotels (29.82 mi)
- Ozarks Hotels (163.98 mi)
- Southern Illinois Hotels (85.27 mi)
- Jackson Hotels (9.69 mi)
- Perryville Hotels (34.87 mi)
- Murphysboro Hotels (33.6 mi)
- Makanda Hotels (27.39 mi)
- Anna Hotels (18.3 mi)
- Cobden Hotels (21.29 mi)
- Cairo Hotels (28 mi)
- Charleston Hotels (28 mi)
- Alto Pass Hotels (21.31 mi)
- Southeast Missouri Hotels (50.24 mi)
- Pomona Hotels (24.37 mi)
- Buncombe Hotels (31.81 mi)
- Marble Hill Hotels (25.49 mi)
- Jonesboro Hotels (17.02 mi)
- Dongola Hotels (19.71 mi)
- Central United States Hotels (256.31 mi)
Car Rentals Near Cape Girardeau
- Car rentals in Carbondale
- Car rentals in Sikeston
- Car rentals in Ozarks
- Car rentals in Southern Illinois
- Car rentals in Jackson
- Car rentals in Perryville
- Car rentals in Murphysboro
- Car rentals in Makanda
- Car rentals in Anna
- Car rentals in Cobden
- Car rentals in Cairo
- Car rentals in Charleston
- Car rentals in Alto Pass
- Car rentals in Southeast Missouri
- Car rentals in Pomona
- Car rentals in Buncombe
Top Luxury Hotel Destinations
- Amarillo Luxury Hotels
- Sioux Falls Luxury Hotels
- Fort Wayne Luxury Hotels
- South Padre Island Luxury Hotels
- Cheyenne Luxury Hotels
- Corpus Christi Luxury Hotels
- Gettysburg Luxury Hotels
- Fresno Luxury Hotels
- Fayetteville Luxury Hotels
- Springfield Luxury Hotels
- Flagstaff Luxury Hotels
- Tuscaloosa Luxury Hotels
- Toledo Luxury Hotels
- Traverse City Luxury Hotels
- Twin Falls Luxury Hotels
- Scranton Luxury Hotels
- Columbia Luxury Hotels
- Catalina Island Luxury Hotels
- Shreveport Luxury Hotels
- Tallahassee Luxury Hotels