Search for Cheap Deals on
Hotels in Sikeston

Photo by Ryan Coleman

Choose from 260 Sikeston Hotel Deals

Pear Tree Inn Sikeston
Pear Tree Inn Sikeston
2.5 out of 5
2602 E Malone Avenue, Sikeston, MO
  • 3 min walk from The Book Bug
The price is $98 per night from Apr 20 to Apr 21
$98
includes taxes & fees
Apr 20 - Apr 21
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the helpful ...
9.2/10 Wonderful! (1,005 reviews)
"Nice room and comfortable bed. Only complain my would be the shower head. Needed a good clean. Water pressure was also low."

Reviewed on Apr 13, 2025

Pear Tree Inn Sikeston
Best Western Plus Sikeston
Best Western Plus Sikeston
2.5 out of 5
120 S Interstate Drive, Sikeston, MO
  • 7 min walk from The Book Bug
The price is $102 per night from Apr 20 to Apr 21
$102
includes taxes & fees
Apr 20 - Apr 21
Stay at this hotel in Sikeston. Enjoy free breakfast, free parking, and a fitness center. Our guests praise the breakfast and the helpful staff in our reviews. ...
8.2/10 Very Good! (1,001 reviews)
Nice place to stay , quiet and clean
"The gentleman at the front desk was super nice , friendly and just fun when we checked in , we had a quick overnight stay in town ! Pool was clean nice and warm , the next morning breakfast was nice clean and stocked and the young lady cleaning and keeping it full was very friendly also , plus we ..."

Reviewed on Mar 30, 2025

Best Western Plus Sikeston
Drury Inn & Suites Sikeston, MO
Drury Inn & Suites Sikeston, MO
3 out of 5
2608 East Malone Ave, Miner, Sikeston, MO
  • 5 min walk from The Book Bug
The price is $114 per night from Apr 19 to Apr 20
$114
includes taxes & fees
Apr 19 - Apr 20
Stay at this 3-star business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9.4/10 Exceptional! (1,001 reviews)
"Wonder stay! Excellent hotel."

Reviewed on Apr 13, 2025

Drury Inn & Suites Sikeston, MO
Hampton Inn Sikeston
Hampton Inn Sikeston
2.5 out of 5
1240 Commerce Drive, Sikeston, MO
  • 7 min drive from The Book Bug
The price is $124 per night from Apr 21 to Apr 22
$124
includes taxes & fees
Apr 21 - Apr 22
Stay at this hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions Central ...
8.8/10 Excellent! (330 reviews)
"Staff was really nice"

Reviewed on Apr 10, 2025

Hampton Inn Sikeston
Days Inn and Suites by Wyndham Sikeston
Days Inn and Suites by Wyndham Sikeston
2 out of 5
220 S Interstate Dr, Sikeston, MO
  • 7 min walk from The Book Bug
The price is $92 per night from Apr 20 to Apr 21
$92
includes taxes & fees
Apr 20 - Apr 21
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7.2/10 Good! (1,003 reviews)
"Very accommodating staff"

Reviewed on Apr 10, 2025

Days Inn and Suites by Wyndham Sikeston
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
2.5 out of 5
100 Matthews Lane, Sikeston, MO
  • 2 min walk from The Book Bug
The price is $86 per night from Apr 15 to Apr 16
$86
includes taxes & fees
Apr 15 - Apr 16
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8.4/10 Very Good! (645 reviews)
"Inside hallways. Sink had a leak."

Reviewed on Mar 30, 2025

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
Holiday Inn Express & Suites Sikeston Southwest by IHG
Holiday Inn Express & Suites Sikeston Southwest by IHG
2.5 out of 5
115 Hospitality Dr, Sikeston, MO
  • 7 min drive from The Book Bug
The price is $139 per night from Apr 27 to Apr 28
$139
includes taxes & fees
Apr 27 - Apr 28
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8.4/10 Very Good! (400 reviews)
"Nothing"

Reviewed on Apr 11, 2025

Holiday Inn Express & Suites Sikeston Southwest by IHG
Country Yard Inn and Suite
Country Yard Inn and Suite
2 out of 5
110 South Interstate Drive, Sikeston, MO
  • 8 min walk from The Book Bug
The price is $77 per night from Apr 15 to Apr 16
$77
includes taxes & fees
Apr 15 - Apr 16
Stay at this motel in Sikeston. Enjoy free WiFi, free parking, and a 24-hour front desk. Popular attractions The Book Bug and Boot Heel Golf Club are located ...
6.8/10 (86 reviews)
"Good but WiFi weak"

Reviewed on Apr 10, 2025

Country Yard Inn and Suite
Comfort Inn & Suites Sikeston I-55
Comfort Inn & Suites Sikeston I-55
2.5 out of 5
109 Matthews Ln, Sikeston, MO
  • 2 min walk from The Book Bug
The price is $106 per night from May 11 to May 12
$106
includes taxes & fees
May 11 - May 12
Book a stay at this business-friendly hotel in Sikeston. Enjoy free WiFi, free parking, and a fitness center. Our guests praise the helpful staff in our reviews. ...
8.2/10 Very Good! (249 reviews)
"It was okay, quiet and helpful."

Reviewed on Apr 5, 2025

Comfort Inn & Suites Sikeston I-55
Super 8 by Wyndham Sikeston/Miner Area
Super 8 by Wyndham Sikeston/Miner Area
2 out of 5
2609 E Malone Ave, Sikeston, MO
  • 3 min walk from The Book Bug
The price is $79 per night from May 11 to May 12
$79
includes taxes & fees
May 11 - May 12
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Popular attractions The Book Bug and Boot Heel Golf ...
6.6/10 (523 reviews)
"Amazing"

Reviewed on Apr 4, 2025

Super 8 by Wyndham Sikeston/Miner Area
TownePlace Suites by Marriott Sikeston
TownePlace Suites by Marriott Sikeston
3 out of 5
1239 Commerce Drive, Sikeston, MO
  • 8 min drive from The Book Bug
The price is $157 per night from Apr 20 to Apr 21
$157
includes taxes & fees
Apr 20 - Apr 21
Stay at this 3-star hotel in Sikeston. Popular attractions Central Park and Sikeston Depot Museum are located nearby.
TownePlace Suites by Marriott Sikeston
The Riverview
The Riverview
3.5 out of 5
777 Main St, Cape Girardeau, MO
  • 1 hour drive from The Book Bug
The price is $109 per night from Apr 20 to Apr 21
$109
includes taxes & fees
Apr 20 - Apr 21
Stay at this 3.5-star hotel in Cape Girardeau. Enjoy free WiFi, free parking, and 2 restaurants. Popular attractions Isle Casino Cape Girardeau and Riverfront ...
9.2/10 Wonderful! (225 reviews)
"I enjoyed the Casino Access, Nice clean large rooms. Peaceful atmosphere."

Reviewed on Apr 11, 2025

The Riverview
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find cheap hotels in Sikeston

You’re not an average traveler—and Hotwire knows it. Your wanderlust takes you off the beaten path to discover unique adventures and every travel destination’s lesser-known tourist scenes. Hotwire has the hookup! Book your Sikeston hotel with Hotwire to complete your one-of-a-kind travel checklist.

For you, intrepid voyager, Hotwire has a large selection of the best hotels in Sikeston.

Choosing the right hotel in Missouri has everything to do with the way you want your trip to go. If you’ve scribbled a few obscure destinations on your itinerary, you probably already have a good sense of how your getaway is taking shape. Lean into that by booking one of Sikeston’s 260 hotels. Choose the one that best catches your trip’s tourist drift.

If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $77. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get great Sikeston hotel deals at the last minute.

While traveling, where you stay plays a major role in your overall vacation enjoyment. Choosing the right hotel is just as important as making sure you book the right flight and car rental. If you’re traveling with family or friends, you may need to book a hotel with connecting rooms. If you enjoy an elegant and relaxing hotel ambiance, opt for one of Hotwire’s luxury hotels in Sikeston. No matter your reason for visiting Sikeston, with Hotwire’s large selection of hotels in the area, you’re sure to book a hotel that meets all your accommodation needs.

Frequently Asked Questions About Sikeston hotels

Where can I find the best last-minute travel deals?

If you’re traveling in the spirit of spontaneity, you’ll love the idea of leaving your exact hotel choice up to chance. With Hotwire Hot Rates, you can unlock great deals on your next flight, hotel, or car rental. Just plug in your general preferences and let Hotwire choose last-minute hotel deals in Sikeston for as low as $77.

How many hotels are there in Sikeston?

With over 260 hotels in Sikeston, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $77.

How to find cheap car rentals in Sikeston?

Finding a cheap car rental deal in Sikeston is as easy as scoring cheap hotels in Sikeston. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can unlock great car rental deals if you book a Hotwire Hot Rate at the last minute.