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Hotels in Sikeston

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Choose from 262 Sikeston Hotel Deals

Best Western Plus Sikeston
Best Western Plus Sikeston
2.5 out of 5
120 S Interstate Drive, Sikeston, MO
  • 7 min drive from Sikeston Depot Museum
Stay at this hotel in Sikeston. Enjoy free breakfast, free parking, and a fitness center. Our guests praise the breakfast and the helpful staff in our reviews. ...
8.2/10 Very Good! (1,009 reviews)
"We were travelling through and were pleasantly surprised at how well maintained the hotel was. Also breakfast was great with eggs and biscuits and gravy. Would definitely stay again."

Reviewed on Jul 8, 2025

Best Western Plus Sikeston
Drury Inn & Suites Sikeston, MO
Drury Inn & Suites Sikeston, MO
3 out of 5
2608 East Malone Ave, Miner, Sikeston, MO
  • 7 min drive from Sikeston Depot Museum
Stay at this 3-star business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9.4/10 Exceptional! (1,005 reviews)
"The staff here from check in to the morning breakfast were welcoming and friendly. Cost was reasonable. I loved seeing the dogs and that it is pet friendly. Everything was clean. The location was close to places to eat - we even walked to El Bracero for dinner. I would highly recommend"

Reviewed on Jul 11, 2025

Drury Inn & Suites Sikeston, MO
Pear Tree Inn Sikeston
Pear Tree Inn Sikeston
2.5 out of 5
2602 E Malone Avenue, Sikeston, MO
  • 7 min drive from Sikeston Depot Museum
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the helpful ...
9.2/10 Wonderful! (1,004 reviews)
"Excellent place to stay. Good breakfast choices. Good pool and hot tub."

Reviewed on Jul 9, 2025

Pear Tree Inn Sikeston
Hampton Inn Sikeston
Hampton Inn Sikeston
2.5 out of 5
1240 Commerce Drive, Sikeston, MO
  • 27 min walk from Sikeston Depot Museum
Stay at this hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions Central ...
8.8/10 Excellent! (361 reviews)
"Not bad"

Reviewed on Jul 6, 2025

Hampton Inn Sikeston
Days Inn and Suites by Wyndham Sikeston
Days Inn and Suites by Wyndham Sikeston
2 out of 5
220 S Interstate Dr, Sikeston, MO
  • 7 min drive from Sikeston Depot Museum
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7.2/10 Good! (1,000 reviews)
Keep up the renovations
"This hotel looked like an old apartment building renovation into a hotel with much wrk in progress. Decent stay. Spacious. Very minimal breakfast offerings. The geese outside sure left messes everywhere but the greeting cat was a nice touch"

Reviewed on Jun 28, 2025

Days Inn and Suites by Wyndham Sikeston
Fairfield by Marriott Inn & Suites Sikeston
Fairfield by Marriott Inn & Suites Sikeston
2.5 out of 5
1239 Commerce Drive, Sikeston, MO
  • 29 min walk from Sikeston Depot Museum
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Central Park and Sikeston Depot ...
9.8/10 Exceptional! (14 reviews)
"The staff was amazing. Hotel was beautiful"

Reviewed on Jul 13, 2025

Fairfield by Marriott Inn & Suites Sikeston
Comfort Inn & Suites Sikeston I-55
Comfort Inn & Suites Sikeston I-55
2.5 out of 5
109 Matthews Ln, Sikeston, MO
  • 7 min drive from Sikeston Depot Museum
Book a stay at this business-friendly hotel in Sikeston. Enjoy free WiFi, free parking, and a fitness center. Our guests praise the helpful staff in our reviews. ...
8.2/10 Very Good! (267 reviews)
"It was cool"

Reviewed on Jun 24, 2025

Comfort Inn & Suites Sikeston I-55
Country Yard Inn and Suite
Country Yard Inn and Suite
2 out of 5
110 South Interstate Drive, Sikeston, MO
  • 7 min drive from Sikeston Depot Museum
Stay at this motel in Sikeston. Enjoy free WiFi, free parking, and a 24-hour front desk. Popular attractions Central Park and Sikeston Depot Museum are located ...
7/10 Good! (96 reviews)
"Good but WiFi weak"

Reviewed on Apr 10, 2025

Country Yard Inn and Suite
Holiday Inn Express & Suites Sikeston Southwest by IHG
Holiday Inn Express & Suites Sikeston Southwest by IHG
2.5 out of 5
115 Hospitality Dr, Sikeston, MO
  • 26 min walk from Sikeston Depot Museum
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8.6/10 Excellent! (411 reviews)
"People were friendly and helpful. Room was clean"

Reviewed on Jul 11, 2025

Holiday Inn Express & Suites Sikeston Southwest by IHG
The Riverview
The Riverview
2 out of 5
777 Main St, Cape Girardeau, MO
  • 1 hour drive from Sikeston Depot Museum
Stay at this hotel in Cape Girardeau. Enjoy free WiFi, free parking, and 2 restaurants. Popular attractions Isle Casino Cape Girardeau and Riverfront Park are ...
9.2/10 Wonderful! (332 reviews)
"Very nice place to stay. Close to restaurants and easy access."

Reviewed on Jul 11, 2025

The Riverview
Drury Plaza Hotel Cape Girardeau Conference Center
Drury Plaza Hotel Cape Girardeau Conference Center
3 out of 5
3351 Percy Drive, Cape Girardeau, MO
  • 1 hour drive from Sikeston Depot Museum
Stay at this 3-star business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.4/10 Exceptional! (1,008 reviews)
Great stay
"Awesome hotel. Beds are comfortable. Rooms are quiet. Breakfast was awesome."

Reviewed on Jul 13, 2025

Drury Plaza Hotel Cape Girardeau Conference Center
Tru By Hilton Cape Girardeau
Tru By Hilton Cape Girardeau
2.5 out of 5
2520 Veterans Memorial Dr, Cape Girardeau, MO
  • 1 hour drive from Sikeston Depot Museum
Stay at this hotel in Cape Girardeau. Enjoy free breakfast, free parking, and a fitness center. Popular attractions Cape Girardeau Conservation Nature Center ...
9.6/10 Exceptional! (41 reviews)
"Very nice to stay in a brand new hotel. So clean. Everyone seemed very nice and helpful. Love the extra games and pool table to keep the kids busy. Loved that you had cookies and milk although we didn't make it down for that. I thought it was a wonderful idea."

Reviewed on Jul 11, 2025

Tru By Hilton Cape Girardeau
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find cheap hotels in Sikeston

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