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Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

3 out of 5
2608 East Malone Ave, Miner Sikeston MO
  • 7 min drive from Sikeston Depot Museum
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9.6/10 Exceptional! (1,006 reviews)
We decided we will stay here next year on our trip home from Texas.

Reviewed on Apr 3, 2026

Drury Inn & Suites Sikeston, MO
Hampton Inn Sikeston

Hampton Inn Sikeston

2.5 out of 5
1240 Commerce Drive Sikeston MO
  • 28 min walk from Sikeston Depot Museum
Stay at this hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions Central ...
9/10 Wonderful! (526 reviews)
Yes, breakfast was fresh. Room temperature was comfortable. Overall stay was good. Would stay there again

Reviewed on Mar 31, 2026

Hampton Inn Sikeston
Best Western Plus Sikeston I-55

Best Western Plus Sikeston I-55

2.5 out of 5
120 S Interstate Drive Sikeston MO
  • 7 min drive from Sikeston Depot Museum
Stay at this hotel in Sikeston. Enjoy free breakfast, free parking, and a fitness center. Our guests praise the breakfast and the helpful staff in our reviews. ...
8.4/10 Very Good! (1,000 reviews)
The bed and chair was hard. Will not go back

Reviewed on Mar 30, 2026

Best Western Plus Sikeston I-55
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

2.5 out of 5
100 Matthews Lane Sikeston MO
  • 7 min drive from Sikeston Depot Museum
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8.4/10 Very Good! (760 reviews)
Yes

Reviewed on Apr 3, 2026

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston

2 out of 5
220 S Interstate Dr Sikeston MO
  • 7 min drive from Sikeston Depot Museum
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7.2/10 Good! (1,001 reviews)
The floor in the room was dirty. It needed sweeping. There was a large ball of human hair on the floor near the bed. The bed spread had 2 red stains on the cover. The sink in the bathroom had a defective stopper. The cover control rod was not working. To flush the toilet, you had to continuously ...

Reviewed on Mar 30, 2026

Days Inn and Suites by Wyndham Sikeston
Holiday Inn Express & Suites Sikeston Southwest by IHG

Holiday Inn Express & Suites Sikeston Southwest by IHG

2.5 out of 5
115 Hospitality Dr Sikeston MO
  • 26 min walk from Sikeston Depot Museum
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
Holiday Inn Express & Suites Sikeston Southwest by IHG
Super 8 by Wyndham Sikeston/Miner Area

Super 8 by Wyndham Sikeston/Miner Area

2 out of 5
2609 E Malone Ave Sikeston MO
  • 6 min drive from Sikeston Depot Museum
Stay at this hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Central Park and Sikeston Depot Museum are located ...
6.8/10 (603 reviews)
Room was supposed to be non smoking room but smelled of smoke.

Reviewed on Mar 16, 2026

Super 8 by Wyndham Sikeston/Miner Area
Fairfield Inn & Suites by Marriott Sikeston

Fairfield Inn & Suites by Marriott Sikeston

3 out of 5
1239 Commerce Drive Sikeston MO
  • 29 min walk from Sikeston Depot Museum
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Central Park and Sikeston Depot ...
9.4/10 Exceptional! (67 reviews)
The hotel is beautiful and absolutely gorgeous!! Brand new. Very clean and the staff were all very friendly and welcoming and I mean All of the staff down to housekeeping. I would have given 5 stars but the pool heater wasn’t working and it was a bit too cold to swim so that was a little disappointing. ...

Reviewed on Mar 29, 2026

Fairfield Inn & Suites by Marriott Sikeston
Country Yard Inn and Suite

Country Yard Inn and Suite

2 out of 5
110 South Interstate Drive Sikeston MO
  • 7 min drive from Sikeston Depot Museum
Stay at this motel in Sikeston. Enjoy free WiFi, free parking, and a 24-hour front desk. Popular attractions Central Park and Sikeston Depot Museum are located ...
6.8/10 (134 reviews)
Yes, parking seemed just like a regular parkikg area. Well lit i believe. The room was able to be kept sufficiently cool.

Reviewed on Mar 25, 2026

Country Yard Inn and Suite
TownePlace Suites by Marriott Sikeston

TownePlace Suites by Marriott Sikeston

3 out of 5
1239 Commerce Drive Sikeston MO
  • 28 min walk from Sikeston Depot Museum
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Central Park and Sikeston Depot ...
TownePlace Suites by Marriott Sikeston
Comfort Inn & Suites Sikeston I-55

Comfort Inn & Suites Sikeston I-55

2.5 out of 5
109 Matthews Ln Sikeston MO
  • 7 min drive from Sikeston Depot Museum
Book a stay at this business-friendly hotel in Sikeston. Enjoy free WiFi, free parking, and a fitness center. Our guests praise the helpful staff in our reviews. ...
8.4/10 Very Good! (291 reviews)
I had a very disappointing experience during my stay at this hotel. From the moment I checked in, there was a strong, unpleasant odor throughout the property that made it uncomfortable to even be in the room. It’s clear that the hotel is in serious need of renovation and better upkeep. The cleanliness ...

Reviewed on Mar 30, 2026

Comfort Inn & Suites Sikeston I-55
Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center

3 out of 5
3351 Percy Drive Cape Girardeau MO
  • 1 hour drive from Sikeston Depot Museum
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.6/10 Exceptional! (1,003 reviews)
Great stay as always.

Reviewed on Apr 3, 2026

Drury Plaza Hotel Cape Girardeau Conference Center
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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