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Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

3 out of 5
2608 East Malone Ave, Miner Sikeston MO
  • 7 min drive from Sikeston Depot Museum
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9.6/10 Exceptional! (1,002 reviews)
"This was a wonderful stay for the night while traveling. Thankful for the recommendation from the front desk to eat at Lamberts restaurant 3 minutes down the road. So fun!"

Reviewed on Jun 15, 2026

Drury Inn & Suites Sikeston, MO
Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston

2 out of 5
220 S Interstate Dr Sikeston MO
  • 7 min drive from Sikeston Depot Museum
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7.2/10 Good! (1,001 reviews)
"Rooms are nice and clean although fixtures could be updated. There is no central air and heat, room is cooled by a wall unit. Room was extremely hot when I first entered."

Reviewed on Jun 24, 2026

Days Inn and Suites by Wyndham Sikeston
Hampton Inn Sikeston

Hampton Inn Sikeston

2.5 out of 5
1240 Commerce Drive Sikeston MO
  • 28 min walk from Sikeston Depot Museum
Stay at this hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions Central ...
9/10 Wonderful! (581 reviews)
"Enjoyed my stay very clean and comfortable"

Reviewed on Jun 23, 2026

Hampton Inn Sikeston
Best Western Plus Sikeston I-55

Best Western Plus Sikeston I-55

2.5 out of 5
120 S Interstate Drive Sikeston MO
  • 7 min drive from Sikeston Depot Museum
Stay at this hotel in Sikeston. Enjoy free breakfast, free parking, and a fitness center. Our guests praise the breakfast and the helpful staff in our reviews. ...
8.4/10 Very Good! (1,000 reviews)
"The first room I was assigned had air conditioning that was not blowing cold. The second room had no working air conditioning at all. The third room was fine. The hallway was extremely warm. The woman working the overnight at the desk was extremely apologetic and nice."

Reviewed on Jun 25, 2026

Best Western Plus Sikeston I-55
Super 8 by Wyndham Sikeston/Miner Area

Super 8 by Wyndham Sikeston/Miner Area

2 out of 5
2609 E Malone Ave Sikeston MO
  • 6 min drive from Sikeston Depot Museum
Stay at this hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Central Park and Sikeston Depot Museum are located ...
7/10 Good! (654 reviews)
"cold ac"

Reviewed on Jun 18, 2026

Super 8 by Wyndham Sikeston/Miner Area
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

2.5 out of 5
100 Matthews Lane Sikeston MO
  • 7 min drive from Sikeston Depot Museum
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8.4/10 Very Good! (793 reviews)
"Clean updated room, but thin walls, so can be noisy when there are a lot of guests. Bed was comfortable. Excellent value for the cost. Good location - near lots of green space for dogs. Also next door to McDonalds and Burger King."

Reviewed on Jun 25, 2026

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
Fairfield Inn & Suites by Marriott Sikeston

Fairfield Inn & Suites by Marriott Sikeston

3 out of 5
1239 Commerce Drive Sikeston MO
  • 29 min walk from Sikeston Depot Museum
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Central Park and Sikeston Depot ...
9.4/10 Exceptional! (96 reviews)
"It was absolutely wonderful! The staff was helpful, and I loved how clean everything was!"

Reviewed on Jun 24, 2026

Fairfield Inn & Suites by Marriott Sikeston
Holiday Inn Express & Suites Sikeston Southwest by IHG

Holiday Inn Express & Suites Sikeston Southwest by IHG

2.5 out of 5
115 Hospitality Dr Sikeston MO
  • 26 min walk from Sikeston Depot Museum
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8.6/10 Excellent! (472 reviews)
"They double charged me. The employee suggested I call corporate because she said the manager wouldn’t do anything but tell me what I wanted to hear but wouldn’t really do anything. She was 100% right! I was promised conjoining rooms are time I put in reservations. Man I spoke to said he say my reservations ..."

Reviewed on Jun 26, 2026

Holiday Inn Express & Suites Sikeston Southwest by IHG
TownePlace Suites by Marriott Sikeston

TownePlace Suites by Marriott Sikeston

3 out of 5
1239 Commerce Drive Sikeston MO
  • 28 min walk from Sikeston Depot Museum
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Central Park and Sikeston Depot ...
9.2/10 Wonderful! (18 reviews)
"The breakfast staff was not good. The cream needed to be refilled. Oatmeal was not cooked. We had to wait for waffle machine to be fixed."

Reviewed on May 25, 2026

TownePlace Suites by Marriott Sikeston
Country Yard Inn and Suite

Country Yard Inn and Suite

2 out of 5
110 South Interstate Drive Sikeston MO
  • 7 min drive from Sikeston Depot Museum
Stay at this motel in Sikeston. Enjoy free WiFi, free parking, and a 24-hour front desk. Popular attractions Central Park and Sikeston Depot Museum are located ...
6.8/10 (139 reviews)
"Clean"

Reviewed on May 19, 2026

Country Yard Inn and Suite
Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center

3 out of 5
3351 Percy Drive Cape Girardeau MO
  • 1 hour drive from Sikeston Depot Museum
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.6/10 Exceptional! (1,005 reviews)
"Great room and wonderful staff"

Reviewed on Jun 25, 2026

Drury Plaza Hotel Cape Girardeau Conference Center
The Riverview

The Riverview

4 out of 5
777 Main St Cape Girardeau MO
  • 1 hour drive from Sikeston Depot Museum
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free WiFi, free parking, and 2 restaurants. Popular attractions Century Casino & Hotel Cape ...
9.4/10 Exceptional! (611 reviews)
"Very Nice Place we enjoyed our stay"

Reviewed on Jun 25, 2026

The Riverview
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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