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Featured Sikeston Family Hotels
Drury Inn & Suites Sikeston, MO
2608 East Malone Ave, Miner Sikeston MO
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
Pear Tree Inn Sikeston
2602 E Malone Avenue Sikeston MO
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the helpful ...
Best Western Plus Sikeston
120 S Interstate Drive Sikeston MO
Fully refundableReserve now, pay when you stay
Stay at this hotel in Sikeston. Enjoy free breakfast, free parking, and a fitness center. Our guests praise the breakfast and the helpful staff in our reviews. ...
Drury Inn & Suites Cape Girardeau
3303 Campster Drive Cape Girardeau MO
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the ...
Comfort Suites Jackson-Cape Girardeau
2904 Old Orchard Rd Jackson MO
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Jackson. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Cape Girardeau Conservation Nature ...
Drury Inn & Suites Jackson MO
225 Drury Lane Jackson MO
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Jackson. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
3253 William Street Cape Girardeau MO
Book a stay at this spa hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in ...
Dexter Inn
1807 W Business US Highway 60 Dexter MO
Fully refundable
Stay at this hotel in Dexter. Enjoy free WiFi, free parking, and an outdoor pool. Our guests praise the helpful staff in our reviews. Popular attractions The ...
Pear Tree Inn Cape Girardeau Near the Medical Center
3248 William St Cape Girardeau MO
Fully refundableReserve now, pay when you stay
Stay at this hotel in Cape Girardeau. Enjoy free WiFi, a 24-hour front desk, and daily housekeeping. Our guests praise the helpful staff and the clean rooms ...
Hampton Inn Cape Girardeau I 55 East
207 S Mt Auburn Rd Cape Girardeau MO
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the ...
Pear Tree Inn Cape Girardeau West
103 Cape West Pkwy Cape Girardeau MO
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the ...
Travelodge by Wyndham Dexter
1608 E Business US 60 Dexter MO
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Dexter. Enjoy free WiFi, free parking, and a 24-hour front desk. Popular attractions The Heritage House and Keller ...
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Hotels with Pools in Sikeston
Pear Tree Inn Sikeston
2602 E Malone Avenue Sikeston MO
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the helpful ...
9.2/10 Wonderful! (1,000 reviews)
My wife has mobility issues and when the reception staff noticed this she changed our room without our even requesting to one close to the lobby. We greatly appreciated this. Plus it’s a great place with friendly people.
Reviewed on Dec 30, 2025
Drury Inn & Suites Sikeston, MO
2608 East Malone Ave, Miner Sikeston MO
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9.4/10 Exceptional! (1,005 reviews)
The room was very nice and the bathroom was very clean. Everything was very nice and the breakfast was good. We were very pleased with everything. I recommend it highly.
Reviewed on Jan 2, 2026
Drury Inn & Suites Jackson MO
225 Drury Lane Jackson MO
Book a stay at this business-friendly hotel in Jackson. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
9.6/10 Exceptional! (1,003 reviews)
It was so wonderful. I really enjoyed my time there. My children enjoyed their time there. The workers was all nice and very sweet and caring and help me with so much that I need to help with. I definitely would like to come back.
Reviewed on Jan 2, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Hotels With Connecting Rooms in Sikeston
Drury Inn & Suites Cape Girardeau
3303 Campster Drive Cape Girardeau MO
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the ...
Drury Inn & Suites Jackson MO
225 Drury Lane Jackson MO
Book a stay at this business-friendly hotel in Jackson. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
Drury Inn & Suites Sikeston, MO
2608 East Malone Ave, Miner Sikeston MO
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Hotels by Star Rating
More Hotel Options
- Hotels with Free Parking in Sikeston
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- Hotels with Hot Tubs in Sikeston
- Casinos in Sikeston
- Luxury Hotels in Sikeston
- Hotel Wedding Venues in Sikeston
- Apartment Hotel in Sikeston
- Historic Hotels in Sikeston
Top Points of Interests in Sikeston
- Hotels near Sikeston Depot Museum
- Hotels near Central Park
- Hotels near Mississippi River
- Hotels near Shawnee National Forest
- Hotels near Ohio River
- Hotels near Southeast Missouri State University
- Hotels near Ohio River Valley
- Hotels near Riverfront Bridge Park
- Hotels near Riverfront Park
- Hotels near Marston Community Center
- Hotels near New Madrid Historical Museum
- Hotels near Big Oak Tree State Park
- Hotels near River Ridge Winery
- Hotels near eDen Spa & Salon
- Hotels near Hunter-Dawson State Historic Site
- Hotels near The Heritage House
- Hotels near Dexter Welcome Center Depot and Museum
- Hotels near Mound City National Cemetery
- Hotels near Front Street Studio & Art Gallery
- Hotels near Stoddard County Civil War Memorial Cemetery
Cities near Sikeston
- Cape Girardeau Hotels (29.82 mi)
- Ozarks Hotels (161.27 mi)
- Southern Illinois Hotels (113.94 mi)
- Southeastern United States Hotels (420.75 mi)
- Dexter Hotels (21.18 mi)
- Cairo Hotels (24.44 mi)
- Tiptonville Hotels (35.09 mi)
- Charleston Hotels (13.59 mi)
- Marston Hotels (24.82 mi)
- Southeast Missouri Hotels (51.94 mi)
- Western Tennessee Hotels (89.28 mi)
- Portageville Hotels (31.83 mi)
- Western Kentucky Hotels (109.03 mi)
- The South Hotels (242.82 mi)
- Malden Hotels (30.43 mi)
- New Madrid Hotels (20.41 mi)
- Central United States Hotels (267.86 mi)
- Bloomfield Hotels (18.77 mi)