Search Cheap Flights to
Sikeston

Photo by Ryan Coleman

Search 400 airlines and 321,000 hotels worldwide.

Stop Planning & Start Exploring

FREE 24 hour cancellation on most flights

Sikeston Flights as Low as $126

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

Frontier Airlines
Wed, Jul 23 - Wed, Jul 30
DEN
Denver Intl.
STL
Lambert-St. Louis Intl.
$126 Roundtrip, found 4 hours ago
$126
Roundtrip
found 4 hours ago
Select Frontier Airlines flight, departing Wed, Jul 23 from Denver Intl. to Lambert-St. Louis Intl., returning Wed, Jul 30, priced at $126 found 4 hours ago
Frontier Airlines
Sat, Jul 26 - Sat, Aug 2
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$130 Roundtrip, found 13 hours ago
$130
Roundtrip
found 13 hours ago
Select Frontier Airlines flight, departing Sat, Jul 26 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Sat, Aug 2, priced at $130 found 13 hours ago
Frontier Airlines
Sat, Jun 14 - Sat, Jun 21
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$133 Roundtrip, found 1 day ago
$133
Roundtrip
found 1 day ago
Select Frontier Airlines flight, departing Sat, Jun 14 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Sat, Jun 21, priced at $133 found 1 day ago
Frontier Airlines
Mon, Jul 21 - Wed, Jul 30
DEN
Denver Intl.
STL
Lambert-St. Louis Intl.
$136 Roundtrip, found 4 hours ago
$136
Roundtrip
found 4 hours ago
Select Frontier Airlines flight, departing Mon, Jul 21 from Denver Intl. to Lambert-St. Louis Intl., returning Wed, Jul 30, priced at $136 found 4 hours ago
Frontier Airlines
Mon, Jun 30 - Wed, Jul 9
DEN
Denver Intl.
STL
Lambert-St. Louis Intl.
$138 Roundtrip, just found
$138
Roundtrip
just found
Select Frontier Airlines flight, departing Mon, Jun 30 from Denver Intl. to Lambert-St. Louis Intl., returning Wed, Jul 9, priced at $138 just found
Frontier Airlines
Sat, Jul 26 - Thu, Jul 31
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$139 Roundtrip, found 13 hours ago
$139
Roundtrip
found 13 hours ago
Select Frontier Airlines flight, departing Sat, Jul 26 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Thu, Jul 31, priced at $139 found 13 hours ago
Frontier Airlines
Sat, Jun 14 - Sat, Jun 21
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$144 Roundtrip, found 1 day ago
$144
Roundtrip
found 1 day ago
Select Frontier Airlines flight, departing Sat, Jun 14 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Sat, Jun 21, priced at $144 found 1 day ago
Frontier Airlines
Sat, Jul 26 - Sat, Aug 2
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$146 Roundtrip, found 13 hours ago
$146
Roundtrip
found 13 hours ago
Select Frontier Airlines flight, departing Sat, Jul 26 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Sat, Aug 2, priced at $146 found 13 hours ago
Frontier Airlines
Wed, Jul 23 - Sun, Jul 27
DEN
Denver Intl.
STL
Lambert-St. Louis Intl.
$151 Roundtrip, just found
$151
Roundtrip
just found
Select Frontier Airlines flight, departing Wed, Jul 23 from Denver Intl. to Lambert-St. Louis Intl., returning Sun, Jul 27, priced at $151 just found
Frontier Airlines
Mon, Jul 21 - Mon, Jul 28
DEN
Denver Intl.
STL
Lambert-St. Louis Intl.
$156 Roundtrip, found 4 hours ago
$156
Roundtrip
found 4 hours ago
Select Frontier Airlines flight, departing Mon, Jul 21 from Denver Intl. to Lambert-St. Louis Intl., returning Mon, Jul 28, priced at $156 found 4 hours ago
Frontier Airlines
Mon, Jul 21 - Sat, Jul 26
DEN
Denver Intl.
STL
Lambert-St. Louis Intl.
$161 Roundtrip, found 4 hours ago
$161
Roundtrip
found 4 hours ago
Select Frontier Airlines flight, departing Mon, Jul 21 from Denver Intl. to Lambert-St. Louis Intl., returning Sat, Jul 26, priced at $161 found 4 hours ago
Delta
Sat, Jul 12 - Sat, Jul 12
DEN
Denver Intl.
STL
Lambert-St. Louis Intl.
$194 Roundtrip, found 13 hours ago
$194
Roundtrip
found 13 hours ago
Select Delta flight, departing Sat, Jul 12 from Denver Intl. to Lambert-St. Louis Intl., returning Sat, Jul 12, priced at $194 found 13 hours ago
Frontier Airlines
Tue, May 27 - Sat, Jun 7
PHX
Sky Harbor Intl.
STL
Lambert-St. Louis Intl.
$208 Roundtrip, found 2 days ago
$208
Roundtrip
found 2 days ago
Select Frontier Airlines flight, departing Tue, May 27 from Sky Harbor Intl. to Lambert-St. Louis Intl., returning Sat, Jun 7, priced at $208 found 2 days ago
Frontier Airlines
Wed, May 28 - Wed, Jun 4
PHL
Philadelphia Intl.
STL
Lambert-St. Louis Intl.
$213 Roundtrip, found 13 hours ago
$213
Roundtrip
found 13 hours ago
Select Frontier Airlines flight, departing Wed, May 28 from Philadelphia Intl. to Lambert-St. Louis Intl., returning Wed, Jun 4, priced at $213 found 13 hours ago
American Airlines
Sat, Jul 26 - Sat, Aug 2
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$217 Roundtrip, found 13 hours ago
$217
Roundtrip
found 13 hours ago
Select American Airlines flight, departing Sat, Jul 26 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Sat, Aug 2, priced at $217 found 13 hours ago
Bargain Flight
Sun, May 25 - Wed, May 28
PHL
Philadelphia Intl.
STL
Lambert-St. Louis Intl.
$218 Roundtrip, found 14 hours ago
$218
Roundtrip
found 14 hours ago
Select Bargain Flight flight, departing Sun, May 25 from Philadelphia Intl. to Lambert-St. Louis Intl., returning Wed, May 28, priced at $218 found 14 hours ago

Cheap Flights to Sikeston

Fall in love at first flight with your vacation to Sikeston by saving a ton of cash on your last-minute cheap flight. There’s no more scouring the internet for a good deal—book your flight to Sikeston on Hotwire, and you’ll be up, up, and on a getaway in no time.

Because once the wheels are down in Sikeston, the good times start rolling. So buckle up, you’re in for a fun ride.

Frequently Asked Questions About flights to Sikeston

Don’t waste your time on endless searches for cheap airline tickets oneway or roundtrip. We’ll have you on your way to Sikeston with a tiny bag of pretzels in your hand before you can say “tray tables in the upright position”—and for a ticket price that works for your vacay budget.

So all you have to worry about is where you’re headed after the STL airport.

What is the cheapest month to fly to Sikeston?

Airline ticket prices fluctuate all the time, depending on the day of the week or the month of the year. The cheapest round trip flights to Sikeston are in July, but when you book your flight on Hotwire, savings are always in season.

How many airlines fly to Sikeston?

Variety is the spice of life, even when it comes to booking your next trip. Want options for airlines? You’ll find 15 to choose from for your flight to Sikeston.

What airport is best to fly into Sikeston?

When you’re planning your trip to Sikeston, convenience is the name of the game. Luckily, Sikeston Cairo Regional Airport is nearby so you can deplane and get going on checking off everything on your Sikeston must-do list.

How much are flights to Sikeston?

Got very cheap flights on your vacation itinerary? When you book your airline tickets to Sikeston on Hotwire, you may just get what’s on your getaway wish list. With tickets as low as $126, you’ll have leftover cash for at least a magazine and a bottle of water at the airport book store.

How to get cheap flights to Sikeston?

The trick to saving a stack of cash on your flight to Sikeston? Snatch up that Hotwire flight deal when you see a killer rate because it could be gone in a flash. And with flights as low as $126 right now, why wait?

Sikeston Flight Information
Destination airport
Lambert-St. Louis Intl.
Destination airport IATA code
STL
Roundtrip price
$126

Last Minute Hotel Deals in Sikeston

Pear Tree Inn Sikeston
Pear Tree Inn Sikeston
2.5 out of 5
2602 E Malone Avenue, Sikeston, MO
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the helpful ...
9.2/10 Wonderful! (1,003 reviews)
"Possibly the best overnight stay we have experienced in our travels."

Reviewed on May 8, 2025

Get rates
Pear Tree Inn Sikeston
Best Western Plus Sikeston
Best Western Plus Sikeston
2.5 out of 5
120 S Interstate Drive, Sikeston, MO
Stay at this hotel in Sikeston. Enjoy free breakfast, free parking, and a fitness center. Our guests praise the breakfast and the helpful staff in our reviews. ...
8.2/10 Very Good! (1,006 reviews)
"Our room was very nice and clean. We did not have any noise distractions. The breakfast was good and had several options. The front desk staff that checked us in was very welcoming. The only thing that was not the best was that we realized the morning we checked out that our door didn't lock from ..."

Reviewed on May 10, 2025

Get rates
Best Western Plus Sikeston
Days Inn and Suites by Wyndham Sikeston
Days Inn and Suites by Wyndham Sikeston
2 out of 5
220 S Interstate Dr, Sikeston, MO
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7.2/10 Good! (1,002 reviews)
"Nice and clean"

Reviewed on Apr 14, 2025

Get rates
Days Inn and Suites by Wyndham Sikeston
Drury Inn & Suites Sikeston, MO
Drury Inn & Suites Sikeston, MO
3 out of 5
2608 East Malone Ave, Miner, Sikeston, MO
Stay at this 3-star business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9.4/10 Exceptional! (1,004 reviews)
great stay
"Staff was kind and rooms comfortable"

Reviewed on May 11, 2025

Get rates
Drury Inn & Suites Sikeston, MO
Hampton Inn Sikeston
Hampton Inn Sikeston
2.5 out of 5
1240 Commerce Drive, Sikeston, MO
Stay at this hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions Central ...
8.8/10 Excellent! (346 reviews)
"Perfect"

Reviewed on May 9, 2025

Get rates
Hampton Inn Sikeston
Country Yard Inn and Suite
Country Yard Inn and Suite
2 out of 5
110 South Interstate Drive, Sikeston, MO
Stay at this motel in Sikeston. Enjoy free WiFi, free parking, and a 24-hour front desk. Popular attractions The Book Bug and Boot Heel Golf Club are located ...
7/10 Good! (90 reviews)
"Good but WiFi weak"

Reviewed on Apr 10, 2025

Get rates
Country Yard Inn and Suite
Holiday Inn Express & Suites Sikeston Southwest by IHG
Holiday Inn Express & Suites Sikeston Southwest by IHG
2.5 out of 5
115 Hospitality Dr, Sikeston, MO
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8.6/10 Excellent! (405 reviews)
"Fast, friendly front desk clerks. Amazed how clean the room was. This is the place to stay in the area!!"

Reviewed on May 7, 2025

Get rates
Holiday Inn Express & Suites Sikeston Southwest by IHG
Comfort Inn & Suites Sikeston I-55
Comfort Inn & Suites Sikeston I-55
2.5 out of 5
109 Matthews Ln, Sikeston, MO
Book a stay at this business-friendly hotel in Sikeston. Enjoy free WiFi, free parking, and a fitness center. Our guests praise the helpful staff in our reviews. ...
8.4/10 Very Good! (256 reviews)
"The facility was very nice."

Reviewed on May 14, 2025

Get rates
Comfort Inn & Suites Sikeston I-55
See all 265 properties in Sikeston
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.