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Sikeston

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Sikeston Flights as Low as $169

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

Spirit Airlines
Sun, Aug 17 - Mon, Aug 18
PHL
Philadelphia Intl.
STL
Lambert-St. Louis Intl.
$169 Roundtrip, found 3 days ago
$169
Roundtrip
found 3 days ago
Select Spirit Airlines flight, departing Sun, Aug 17 from Philadelphia Intl. to Lambert-St. Louis Intl., returning Mon, Aug 18, priced at $169 found 3 days ago
Spirit Airlines
Thu, Aug 7 - Thu, Aug 14
PHL
Philadelphia Intl.
STL
Lambert-St. Louis Intl.
$185 Roundtrip, found 3 days ago
$185
Roundtrip
found 3 days ago
Select Spirit Airlines flight, departing Thu, Aug 7 from Philadelphia Intl. to Lambert-St. Louis Intl., returning Thu, Aug 14, priced at $185 found 3 days ago
Spirit Airlines
Thu, Aug 7 - Thu, Aug 14
PHL
Philadelphia Intl.
STL
Lambert-St. Louis Intl.
$189 Roundtrip, found 3 days ago
$189
Roundtrip
found 3 days ago
Select Spirit Airlines flight, departing Thu, Aug 7 from Philadelphia Intl. to Lambert-St. Louis Intl., returning Thu, Aug 14, priced at $189 found 3 days ago
Spirit Airlines
Thu, Aug 14 - Fri, Aug 15
PHL
Philadelphia Intl.
STL
Lambert-St. Louis Intl.
$201 Roundtrip, found 2 days ago
$201
Roundtrip
found 2 days ago
Select Spirit Airlines flight, departing Thu, Aug 14 from Philadelphia Intl. to Lambert-St. Louis Intl., returning Fri, Aug 15, priced at $201 found 2 days ago
Frontier Airlines
Sun, Aug 17 - Mon, Aug 18
PHL
Philadelphia Intl.
STL
Lambert-St. Louis Intl.
$206 Roundtrip, found 3 days ago
$206
Roundtrip
found 3 days ago
Select Frontier Airlines flight, departing Sun, Aug 17 from Philadelphia Intl. to Lambert-St. Louis Intl., returning Mon, Aug 18, priced at $206 found 3 days ago
Frontier Airlines
Sat, Aug 2 - Sat, Aug 9
MDT
Harrisburg Intl.
STL
Lambert-St. Louis Intl.
$211 Roundtrip, found 1 day ago
$211
Roundtrip
found 1 day ago
Select Frontier Airlines flight, departing Sat, Aug 2 from Harrisburg Intl. to Lambert-St. Louis Intl., returning Sat, Aug 9, priced at $211 found 1 day ago
Spirit Airlines
Thu, Aug 14 - Sat, Aug 16
PHL
Philadelphia Intl.
STL
Lambert-St. Louis Intl.
$212 Roundtrip, found 2 days ago
$212
Roundtrip
found 2 days ago
Select Spirit Airlines flight, departing Thu, Aug 14 from Philadelphia Intl. to Lambert-St. Louis Intl., returning Sat, Aug 16, priced at $212 found 2 days ago
Spirit Airlines
Wed, Sep 3 - Sun, Sep 21
LAS
Harry Reid Intl.
STL
Lambert-St. Louis Intl.
$214 Roundtrip, found 16 hours ago
$214
Roundtrip
found 16 hours ago
Select Spirit Airlines flight, departing Wed, Sep 3 from Harry Reid Intl. to Lambert-St. Louis Intl., returning Sun, Sep 21, priced at $214 found 16 hours ago
Frontier Airlines
Thu, Sep 11 - Fri, Sep 26
LAS
Harry Reid Intl.
STL
Lambert-St. Louis Intl.
$228 Roundtrip, found 15 hours ago
$228
Roundtrip
found 15 hours ago
Select Frontier Airlines flight, departing Thu, Sep 11 from Harry Reid Intl. to Lambert-St. Louis Intl., returning Fri, Sep 26, priced at $228 found 15 hours ago
Frontier Airlines
Thu, Oct 16 - Fri, Oct 17
TTN
Mercer
STL
Lambert-St. Louis Intl.
$228 Roundtrip, found 1 day ago
$228
Roundtrip
found 1 day ago
Select Frontier Airlines flight, departing Thu, Oct 16 from Mercer to Lambert-St. Louis Intl., returning Fri, Oct 17, priced at $228 found 1 day ago
Delta
Tue, Sep 9 - Tue, Sep 16
PHL
Philadelphia Intl.
STL
Lambert-St. Louis Intl.
$237 Roundtrip, found 21 hours ago
$237
Roundtrip
found 21 hours ago
Select Delta flight, departing Tue, Sep 9 from Philadelphia Intl. to Lambert-St. Louis Intl., returning Tue, Sep 16, priced at $237 found 21 hours ago
Frontier Airlines
Thu, Sep 11 - Sat, Sep 20
SJC
Norman Y. Mineta San Jose Intl.
STL
Lambert-St. Louis Intl.
$252 Roundtrip, found 19 hours ago
$252
Roundtrip
found 19 hours ago
Select Frontier Airlines flight, departing Thu, Sep 11 from Norman Y. Mineta San Jose Intl. to Lambert-St. Louis Intl., returning Sat, Sep 20, priced at $252 found 19 hours ago
Bargain Flight
Wed, Sep 10 - Tue, Sep 16
SJC
Norman Y. Mineta San Jose Intl.
STL
Lambert-St. Louis Intl.
$264 Roundtrip, found 19 hours ago
$264
Roundtrip
found 19 hours ago
Select Bargain Flight flight, departing Wed, Sep 10 from Norman Y. Mineta San Jose Intl. to Lambert-St. Louis Intl., returning Tue, Sep 16, priced at $264 found 19 hours ago
Alaska Airlines
Thu, Nov 6 - Mon, Nov 10
LAS
Harry Reid Intl.
STL
Lambert-St. Louis Intl.
$277 Roundtrip, found 6 days ago
$277
Roundtrip
found 6 days ago
Select Alaska Airlines flight, departing Thu, Nov 6 from Harry Reid Intl. to Lambert-St. Louis Intl., returning Mon, Nov 10, priced at $277 found 6 days ago
American Airlines
Thu, Nov 6 - Mon, Nov 10
LAS
Harry Reid Intl.
STL
Lambert-St. Louis Intl.
$277 Roundtrip, found 6 days ago
$277
Roundtrip
found 6 days ago
Select American Airlines flight, departing Thu, Nov 6 from Harry Reid Intl. to Lambert-St. Louis Intl., returning Mon, Nov 10, priced at $277 found 6 days ago
Hawaiian Airlines
Wed, Sep 10 - Sun, Sep 28
LAS
Harry Reid Intl.
STL
Lambert-St. Louis Intl.
$336 Roundtrip, found 16 hours ago
$336
Roundtrip
found 16 hours ago
Select Hawaiian Airlines flight, departing Wed, Sep 10 from Harry Reid Intl. to Lambert-St. Louis Intl., returning Sun, Sep 28, priced at $336 found 16 hours ago

Cheap Flights to Sikeston

Fall in love at first flight with your vacation to Sikeston by saving a ton of cash on your last-minute cheap flight. There’s no more scouring the internet for a good deal—book your flight to Sikeston on Hotwire, and you’ll be up, up, and on a getaway in no time.

Because once the wheels are down in Sikeston, the good times start rolling. So buckle up, you’re in for a fun ride.

Frequently Asked Questions About flights to Sikeston

Don’t waste your time on endless searches for cheap airline tickets oneway or roundtrip. We’ll have you on your way to Sikeston with a tiny bag of pretzels in your hand before you can say “tray tables in the upright position”—and for a ticket price that works for your vacay budget.

So all you have to worry about is where you’re headed after the STL airport.

What is the cheapest month to fly to Sikeston?

Airline ticket prices fluctuate all the time, depending on the day of the week or the month of the year. The cheapest round trip flights to Sikeston are in August, but when you book your flight on Hotwire, savings are always in season.

How many airlines fly to Sikeston?

Variety is the spice of life, even when it comes to booking your next trip. Want options for airlines? You’ll find 15 to choose from for your flight to Sikeston.

What airport is best to fly into Sikeston?

When you’re planning your trip to Sikeston, convenience is the name of the game. Luckily, Sikeston Cairo Regional Airport is nearby so you can deplane and get going on checking off everything on your Sikeston must-do list.

How much are flights to Sikeston?

Got very cheap flights on your vacation itinerary? When you book your airline tickets to Sikeston on Hotwire, you may just get what’s on your getaway wish list. With tickets as low as $169, you’ll have leftover cash for at least a magazine and a bottle of water at the airport book store.

How to get cheap flights to Sikeston?

The trick to saving a stack of cash on your flight to Sikeston? Snatch up that Hotwire flight deal when you see a killer rate because it could be gone in a flash. And with flights as low as $169 right now, why wait?

Sikeston Flight Information
Destination airport
Lambert-St. Louis Intl.
Destination airport IATA code
STL
Roundtrip price
$85

Last Minute Hotel Deals in Sikeston

Best Western Plus Sikeston

Best Western Plus Sikeston

2.5 out of 5
120 S Interstate Drive, Sikeston, MO
Stay at this hotel in Sikeston. Enjoy free breakfast, free parking, and a fitness center. Our guests praise the breakfast and the helpful staff in our reviews. ...
8.2/10 Very Good! (1,010 reviews)
"The area was clean and in a good area older room but had been renovated comfy bed and the a/c worked really well"

Reviewed on Jul 28, 2025

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Best Western Plus Sikeston
Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

3 out of 5
2608 East Malone Ave, Miner, Sikeston, MO
Stay at this 3-star business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9.4/10 Exceptional! (1,005 reviews)
"Enjoyed everything"

Reviewed on Jul 19, 2025

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Drury Inn & Suites Sikeston, MO
Pear Tree Inn Sikeston

Pear Tree Inn Sikeston

2.5 out of 5
2602 E Malone Avenue, Sikeston, MO
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the helpful ...
9.2/10 Wonderful! (1,008 reviews)
Nice hotel.
"Very nice hotel. Very friendly and clean. Breakfast was good. Will stay here again when back in region."

Reviewed on Jul 25, 2025

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Pear Tree Inn Sikeston
Hampton Inn Sikeston

Hampton Inn Sikeston

2.5 out of 5
1240 Commerce Drive, Sikeston, MO
Stay at this hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions Central ...
8.8/10 Excellent! (366 reviews)
"Didn’t care for homeless walking through"

Reviewed on Jul 26, 2025

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Hampton Inn Sikeston
Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston

2 out of 5
220 S Interstate Dr, Sikeston, MO
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7.2/10 Good! (1,005 reviews)
Nice, comfortable
"The staff and room were nice. I did not like that they actually took a deposit out of my account and put it back instead of just held it like other hotels I've been at."

Reviewed on Jul 26, 2025

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Days Inn and Suites by Wyndham Sikeston
Fairfield by Marriott Inn & Suites Sikeston

Fairfield by Marriott Inn & Suites Sikeston

2.5 out of 5
1239 Commerce Drive, Sikeston, MO
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Central Park and Sikeston Depot ...
9.8/10 Exceptional! (16 reviews)
"Absolutely excellent. Brand new hotel. Spotless. Staff were friendly and welcoming."

Reviewed on Jul 26, 2025

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Fairfield by Marriott Inn & Suites Sikeston
Holiday Inn Express & Suites Sikeston Southwest by IHG

Holiday Inn Express & Suites Sikeston Southwest by IHG

2.5 out of 5
115 Hospitality Dr, Sikeston, MO
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8.6/10 Excellent! (419 reviews)
"Thank you to the courteous staff. Great night's rest after a really long day of travel"

Reviewed on Jul 27, 2025

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Holiday Inn Express & Suites Sikeston Southwest by IHG
Comfort Inn & Suites Sikeston I-55

Comfort Inn & Suites Sikeston I-55

2.5 out of 5
109 Matthews Ln, Sikeston, MO
Book a stay at this business-friendly hotel in Sikeston. Enjoy free WiFi, free parking, and a fitness center. Our guests praise the helpful staff in our reviews. ...
8.2/10 Very Good! (271 reviews)
"It was a very nice stay. The pool was clean and enjoying!"

Reviewed on Jul 18, 2025

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Comfort Inn & Suites Sikeston I-55
See all 264 properties in Sikeston
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.