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Sikeston

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Sikeston Flights as Low as $66

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

Frontier Airlines
Wed, Aug 12 - Tue, Aug 25
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$66 Roundtrip, found 2 hours ago
$66
Roundtrip
found 2 hours ago
Select Frontier Airlines flight, departing Wed, Aug 12 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Tue, Aug 25, priced at $66 found 2 hours ago
Frontier Airlines
Tue, Jul 14 - Tue, Jul 14
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$68 Roundtrip, found 2 hours ago
$68
Roundtrip
found 2 hours ago
Select Frontier Airlines flight, departing Tue, Jul 14 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Tue, Jul 14, priced at $68 found 2 hours ago
Frontier Airlines
Wed, Jul 8 - Sun, Jul 26
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$79 Roundtrip, found 1 hour ago
$79
Roundtrip
found 1 hour ago
Select Frontier Airlines flight, departing Wed, Jul 8 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Sun, Jul 26, priced at $79 found 1 hour ago
Frontier Airlines
Wed, Jun 24 - Wed, Jul 1
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$84 Roundtrip, found 2 hours ago
$84
Roundtrip
found 2 hours ago
Select Frontier Airlines flight, departing Wed, Jun 24 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Wed, Jul 1, priced at $84 found 2 hours ago
Frontier Airlines
Tue, Jun 23 - Tue, Jun 23
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$90 Roundtrip, found 2 hours ago
$90
Roundtrip
found 2 hours ago
Select Frontier Airlines flight, departing Tue, Jun 23 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Tue, Jun 23, priced at $90 found 2 hours ago
Frontier Airlines
Tue, Jun 23 - Mon, Jun 29
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$96 Roundtrip, found 2 days ago
$96
Roundtrip
found 2 days ago
Select Frontier Airlines flight, departing Tue, Jun 23 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Mon, Jun 29, priced at $96 found 2 days ago
Delta
Wed, Aug 12 - Tue, Aug 25
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$97 Roundtrip, found 2 hours ago
$97
Roundtrip
found 2 hours ago
Select Delta flight, departing Wed, Aug 12 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Tue, Aug 25, priced at $97 found 2 hours ago
Frontier Airlines
Wed, Jul 8 - Sun, Jul 26
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$109 Roundtrip, found 1 hour ago
$109
Roundtrip
found 1 hour ago
Select Frontier Airlines flight, departing Wed, Jul 8 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Sun, Jul 26, priced at $109 found 1 hour ago
Delta
Wed, Jul 8 - Sun, Jul 26
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$110 Roundtrip, found 1 hour ago
$110
Roundtrip
found 1 hour ago
Select Delta flight, departing Wed, Jul 8 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Sun, Jul 26, priced at $110 found 1 hour ago
Delta
Tue, Jul 14 - Tue, Jul 14
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$124 Roundtrip, found 2 hours ago
$124
Roundtrip
found 2 hours ago
Select Delta flight, departing Tue, Jul 14 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Tue, Jul 14, priced at $124 found 2 hours ago
American Airlines
Wed, Aug 12 - Tue, Aug 25
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$217 Roundtrip, found 2 hours ago
$217
Roundtrip
found 2 hours ago
Select American Airlines flight, departing Wed, Aug 12 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Tue, Aug 25, priced at $217 found 2 hours ago
Delta
Sat, Oct 17 - Tue, Oct 20
DAL
Love Field
STL
Lambert-St. Louis Intl.
$263 Roundtrip, found 2 hours ago
$263
Roundtrip
found 2 hours ago
Select Delta flight, departing Sat, Oct 17 from Love Field to Lambert-St. Louis Intl., returning Tue, Oct 20, priced at $263 found 2 hours ago
American Airlines
Wed, Nov 11 - Sat, Nov 14
DCA
Ronald Reagan Washington National
STL
Lambert-St. Louis Intl.
$265 Roundtrip, found 2 hours ago
$265
Roundtrip
found 2 hours ago
Select American Airlines flight, departing Wed, Nov 11 from Ronald Reagan Washington National to Lambert-St. Louis Intl., returning Sat, Nov 14, priced at $265 found 2 hours ago
Bargain Flight
Tue, Jun 9 - Fri, Jun 19
DCA
Ronald Reagan Washington National
STL
Lambert-St. Louis Intl.
$272 Roundtrip, found 1 day ago
$272
Roundtrip
found 1 day ago
Select Bargain Flight flight, departing Tue, Jun 9 from Ronald Reagan Washington National to Lambert-St. Louis Intl., returning Fri, Jun 19, priced at $272 found 1 day ago
United
Tue, Sep 1 - Tue, Sep 15
AMA
Rick Husband Amarillo Intl.
STL
Lambert-St. Louis Intl.
$337 Roundtrip, found 2 hours ago
$337
Roundtrip
found 2 hours ago
Select United flight, departing Tue, Sep 1 from Rick Husband Amarillo Intl. to Lambert-St. Louis Intl., returning Tue, Sep 15, priced at $337 found 2 hours ago
United
Wed, Jun 10 - Thu, Jun 18
ATL
Hartsfield-Jackson Atlanta Intl.
PAH
Barkley Regional
$564 Roundtrip, found 1 day ago
$564
Roundtrip
found 1 day ago
Select United flight, departing Wed, Jun 10 from Hartsfield-Jackson Atlanta Intl. to Barkley Regional, returning Thu, Jun 18, priced at $564 found 1 day ago

Cheap Flights to Sikeston

Fall in love at first flight with your vacation to Sikeston by saving a ton of cash on your last-minute cheap flight. There’s no more scouring the internet for a good deal—book your flight to Sikeston on Hotwire, and you’ll be up, up, and on a getaway in no time.

Because once the wheels are down in Sikeston, the good times start rolling. So buckle up, you’re in for a fun ride.

Frequently Asked Questions About flights to Sikeston

Don’t waste your time on endless searches for cheap airline tickets oneway or roundtrip. We’ll have you on your way to Sikeston with a tiny bag of pretzels in your hand before you can say “tray tables in the upright position”—and for a ticket price that works for your vacay budget.

So all you have to worry about is where you’re headed after the STL airport.

What is the cheapest month to fly to Sikeston?

Airline ticket prices fluctuate all the time, depending on the day of the week or the month of the year. The cheapest round trip flights to Sikeston are in August, but when you book your flight on Hotwire, savings are always in season.

How many airlines fly to Sikeston?

Variety is the spice of life, even when it comes to booking your next trip. Want options for airlines? You’ll find 15 to choose from for your flight to Sikeston.

What airport is best to fly into Sikeston?

When you’re planning your trip to Sikeston, convenience is the name of the game. Luckily, Sikeston Cairo Regional Airport is nearby so you can deplane and get going on checking off everything on your Sikeston must-do list.

How much are flights to Sikeston?

Got very cheap flights on your vacation itinerary? When you book your airline tickets to Sikeston on Hotwire, you may just get what’s on your getaway wish list. With tickets as low as $66, you’ll have leftover cash for at least a magazine and a bottle of water at the airport book store.

How to get cheap flights to Sikeston?

The trick to saving a stack of cash on your flight to Sikeston? Snatch up that Hotwire flight deal when you see a killer rate because it could be gone in a flash. And with flights as low as $66 right now, why wait?

Sikeston Flight Information
Destination airport
Lambert-St. Louis Intl.
Destination airport IATA code
STL
Roundtrip price
$66

Last Minute Hotel Deals in Sikeston

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

3 out of 5
2608 East Malone Ave, Miner Sikeston MO
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9.6/10 Exceptional! (1,006 reviews)
"Clean rooms and was ready when we arrived. We did not use the pool but other guests were enjoying it. Breakfast and Kick back were both great meals."

Reviewed on Jun 4, 2026

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Drury Inn & Suites Sikeston, MO
Hampton Inn Sikeston

Hampton Inn Sikeston

2.5 out of 5
1240 Commerce Drive Sikeston MO
Stay at this hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions Central ...
9/10 Wonderful! (573 reviews)
"The doughnuts and fry potatoes for breakfast were delicious"

Reviewed on Jun 2, 2026

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Hampton Inn Sikeston
Best Western Plus Sikeston I-55

Best Western Plus Sikeston I-55

2.5 out of 5
120 S Interstate Drive Sikeston MO
Stay at this hotel in Sikeston. Enjoy free breakfast, free parking, and a fitness center. Our guests praise the breakfast and the helpful staff in our reviews. ...
8.4/10 Very Good! (1,004 reviews)
"Very convenient and staff was great."

Reviewed on Jun 2, 2026

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Best Western Plus Sikeston I-55
Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston

2 out of 5
220 S Interstate Dr Sikeston MO
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7.2/10 Good! (1,002 reviews)
"Ll"

Reviewed on May 25, 2026

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Days Inn and Suites by Wyndham Sikeston
Super 8 by Wyndham Sikeston/Miner Area

Super 8 by Wyndham Sikeston/Miner Area

2 out of 5
2609 E Malone Ave Sikeston MO
Stay at this hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Central Park and Sikeston Depot Museum are located ...
6.8/10 (636 reviews)
"Had a good stay. The room was nice."

Reviewed on Jun 3, 2026

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Super 8 by Wyndham Sikeston/Miner Area
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

2.5 out of 5
100 Matthews Lane Sikeston MO
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8.4/10 Very Good! (786 reviews)
"We had been in different hotels for 8 previous nights, so we were tired of waffles and bread for breakfast. But the room was comfortable although I think the whole hotel needs deep carpet cleaning. It smelled slightly like an ash tray. The staff was very friendly and helpful."

Reviewed on Jun 3, 2026

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Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
Fairfield Inn & Suites by Marriott Sikeston

Fairfield Inn & Suites by Marriott Sikeston

3 out of 5
1239 Commerce Drive Sikeston MO
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Central Park and Sikeston Depot ...
9.4/10 Exceptional! (84 reviews)
"Great stay, kind staff, very clean property."

Reviewed on May 30, 2026

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Fairfield Inn & Suites by Marriott Sikeston
Holiday Inn Express & Suites Sikeston Southwest by IHG

Holiday Inn Express & Suites Sikeston Southwest by IHG

2.5 out of 5
115 Hospitality Dr Sikeston MO
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8.6/10 Excellent! (466 reviews)
"Only stayed one night, no complaints"

Reviewed on May 29, 2026

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Holiday Inn Express & Suites Sikeston Southwest by IHG
See all 306 properties in Sikeston
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.