Search Cheap Flights to
Sikeston

Search 400 airlines and 321,000 hotels worldwide.

Stop Planning & Start Exploring

FREE 24 hour cancellation on most flights

Sikeston Flights as Low as $63

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

Frontier Airlines
Wed, Jul 8 - Wed, Jul 15
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$63 Roundtrip, found 1 day ago
$63
Roundtrip
found 1 day ago
Select Frontier Airlines flight, departing Wed, Jul 8 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Wed, Jul 15, priced at $63 found 1 day ago
Frontier Airlines
Wed, Jul 8 - Fri, Jul 17
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$73 Roundtrip, found 1 day ago
$73
Roundtrip
found 1 day ago
Select Frontier Airlines flight, departing Wed, Jul 8 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Fri, Jul 17, priced at $73 found 1 day ago
Frontier Airlines
Thu, Aug 13 - Thu, Aug 20
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$76 Roundtrip, found 2 hours ago
$76
Roundtrip
found 2 hours ago
Select Frontier Airlines flight, departing Thu, Aug 13 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Thu, Aug 20, priced at $76 found 2 hours ago
Frontier Airlines
Mon, Aug 10 - Thu, Aug 20
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$78 Roundtrip, found 1 day ago
$78
Roundtrip
found 1 day ago
Select Frontier Airlines flight, departing Mon, Aug 10 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Thu, Aug 20, priced at $78 found 1 day ago
Frontier Airlines
Sat, Jul 11 - Wed, Jul 15
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$84 Roundtrip, found 1 day ago
$84
Roundtrip
found 1 day ago
Select Frontier Airlines flight, departing Sat, Jul 11 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Wed, Jul 15, priced at $84 found 1 day ago
Frontier Airlines
Thu, Aug 27 - Sat, Sep 12
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$86 Roundtrip, found 7 hours ago
$86
Roundtrip
found 7 hours ago
Select Frontier Airlines flight, departing Thu, Aug 27 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Sat, Sep 12, priced at $86 found 7 hours ago
Frontier Airlines
Wed, Jul 29 - Sat, Aug 15
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$88 Roundtrip, found 7 hours ago
$88
Roundtrip
found 7 hours ago
Select Frontier Airlines flight, departing Wed, Jul 29 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Sat, Aug 15, priced at $88 found 7 hours ago
Delta
Tue, Jul 28 - Sat, Aug 8
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$97 Roundtrip, found 1 day ago
$97
Roundtrip
found 1 day ago
Select Delta flight, departing Tue, Jul 28 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Sat, Aug 8, priced at $97 found 1 day ago
Frontier Airlines
Fri, Aug 21 - Fri, Sep 11
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$97 Roundtrip, found 7 hours ago
$97
Roundtrip
found 7 hours ago
Select Frontier Airlines flight, departing Fri, Aug 21 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Fri, Sep 11, priced at $97 found 7 hours ago
Delta
Tue, Sep 1 - Tue, Sep 15
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$117 Roundtrip, found 7 hours ago
$117
Roundtrip
found 7 hours ago
Select Delta flight, departing Tue, Sep 1 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Tue, Sep 15, priced at $117 found 7 hours ago
United
Tue, Jul 28 - Sat, Aug 8
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$197 Roundtrip, found 1 day ago
$197
Roundtrip
found 1 day ago
Select United flight, departing Tue, Jul 28 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Sat, Aug 8, priced at $197 found 1 day ago
American Airlines
Tue, Jul 28 - Sat, Aug 8
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$197 Roundtrip, found 1 day ago
$197
Roundtrip
found 1 day ago
Select American Airlines flight, departing Tue, Jul 28 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Sat, Aug 8, priced at $197 found 1 day ago
Bargain Flight
Wed, Sep 9 - Tue, Sep 15
AUS
Austin-Bergstrom Intl.
STL
Lambert-St. Louis Intl.
$216 Roundtrip, found 3 days ago
$216
Roundtrip
found 3 days ago
Select Bargain Flight flight, departing Wed, Sep 9 from Austin-Bergstrom Intl. to Lambert-St. Louis Intl., returning Tue, Sep 15, priced at $216 found 3 days ago
Delta
Wed, Oct 14 - Wed, Oct 14
DAL
Love Field
STL
Lambert-St. Louis Intl.
$257 Roundtrip, found 13 hours ago
$257
Roundtrip
found 13 hours ago
Select Delta flight, departing Wed, Oct 14 from Love Field to Lambert-St. Louis Intl., returning Wed, Oct 14, priced at $257 found 13 hours ago
Delta
Tue, Jul 21 - Wed, Jul 29
JAN
Evers Intl.
STL
Lambert-St. Louis Intl.
$279 Roundtrip, found 12 hours ago
$279
Roundtrip
found 12 hours ago
Select Delta flight, departing Tue, Jul 21 from Evers Intl. to Lambert-St. Louis Intl., returning Wed, Jul 29, priced at $279 found 12 hours ago
Delta
Fri, Jul 3 - Wed, Jul 15
DAL
Love Field
PAH
Barkley Regional
$1,691 Roundtrip, found 15 hours ago
$1,691
Roundtrip
found 15 hours ago
Select Delta flight, departing Fri, Jul 3 from Love Field to Barkley Regional, returning Wed, Jul 15, priced at $1,691 found 15 hours ago

Cheap Flights to Sikeston

Fall in love at first flight with your vacation to Sikeston by saving a ton of cash on your last-minute cheap flight. There’s no more scouring the internet for a good deal—book your flight to Sikeston on Hotwire, and you’ll be up, up, and on a getaway in no time.

Because once the wheels are down in Sikeston, the good times start rolling. So buckle up, you’re in for a fun ride.

Frequently Asked Questions About flights to Sikeston

Don’t waste your time on endless searches for cheap airline tickets oneway or roundtrip. We’ll have you on your way to Sikeston with a tiny bag of pretzels in your hand before you can say “tray tables in the upright position”—and for a ticket price that works for your vacay budget.

So all you have to worry about is where you’re headed after the STL airport.

What is the cheapest month to fly to Sikeston?

Airline ticket prices fluctuate all the time, depending on the day of the week or the month of the year. The cheapest round trip flights to Sikeston are in July, but when you book your flight on Hotwire, savings are always in season.

How many airlines fly to Sikeston?

Variety is the spice of life, even when it comes to booking your next trip. Want options for airlines? You’ll find 15 to choose from for your flight to Sikeston.

What airport is best to fly into Sikeston?

When you’re planning your trip to Sikeston, convenience is the name of the game. Luckily, Sikeston Cairo Regional Airport is nearby so you can deplane and get going on checking off everything on your Sikeston must-do list.

How much are flights to Sikeston?

Got very cheap flights on your vacation itinerary? When you book your airline tickets to Sikeston on Hotwire, you may just get what’s on your getaway wish list. With tickets as low as $63, you’ll have leftover cash for at least a magazine and a bottle of water at the airport book store.

How to get cheap flights to Sikeston?

The trick to saving a stack of cash on your flight to Sikeston? Snatch up that Hotwire flight deal when you see a killer rate because it could be gone in a flash. And with flights as low as $63 right now, why wait?

Sikeston Flight Information
Destination airport
Lambert-St. Louis Intl.
Destination airport IATA code
STL
Roundtrip price
$236

Last Minute Hotel Deals in Sikeston

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

3 out of 5
2608 East Malone Ave, Miner Sikeston MO
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9.6/10 Exceptional! (1,002 reviews)
"This was a wonderful stay for the night while traveling. Thankful for the recommendation from the front desk to eat at Lamberts restaurant 3 minutes down the road. So fun!"

Reviewed on Jun 15, 2026

Get rates
Drury Inn & Suites Sikeston, MO
Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston

2 out of 5
220 S Interstate Dr Sikeston MO
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7.2/10 Good! (1,001 reviews)
"Rooms are nice and clean although fixtures could be updated. There is no central air and heat, room is cooled by a wall unit. Room was extremely hot when I first entered."

Reviewed on Jun 24, 2026

Get rates
Days Inn and Suites by Wyndham Sikeston
Best Western Plus Sikeston I-55

Best Western Plus Sikeston I-55

2.5 out of 5
120 S Interstate Drive Sikeston MO
Stay at this hotel in Sikeston. Enjoy free breakfast, free parking, and a fitness center. Our guests praise the breakfast and the helpful staff in our reviews. ...
8.4/10 Very Good! (1,000 reviews)
"The first room I was assigned had air conditioning that was not blowing cold. The second room had no working air conditioning at all. The third room was fine. The hallway was extremely warm. The woman working the overnight at the desk was extremely apologetic and nice."

Reviewed on Jun 25, 2026

Get rates
Best Western Plus Sikeston I-55
Hampton Inn Sikeston

Hampton Inn Sikeston

2.5 out of 5
1240 Commerce Drive Sikeston MO
Stay at this hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions Central ...
9/10 Wonderful! (581 reviews)
"Enjoyed my stay very clean and comfortable"

Reviewed on Jun 23, 2026

Get rates
Hampton Inn Sikeston
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

2.5 out of 5
100 Matthews Lane Sikeston MO
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8.4/10 Very Good! (793 reviews)
"Clean updated room, but thin walls, so can be noisy when there are a lot of guests. Bed was comfortable. Excellent value for the cost. Good location - near lots of green space for dogs. Also next door to McDonalds and Burger King."

Reviewed on Jun 25, 2026

Get rates
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
Fairfield Inn & Suites by Marriott Sikeston

Fairfield Inn & Suites by Marriott Sikeston

3 out of 5
1239 Commerce Drive Sikeston MO
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Central Park and Sikeston Depot ...
9.4/10 Exceptional! (96 reviews)
"It was absolutely wonderful! The staff was helpful, and I loved how clean everything was!"

Reviewed on Jun 24, 2026

Get rates
Fairfield Inn & Suites by Marriott Sikeston
Super 8 by Wyndham Sikeston/Miner Area

Super 8 by Wyndham Sikeston/Miner Area

2 out of 5
2609 E Malone Ave Sikeston MO
Stay at this hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Central Park and Sikeston Depot Museum are located ...
7/10 Good! (654 reviews)
"cold ac"

Reviewed on Jun 18, 2026

Get rates
Super 8 by Wyndham Sikeston/Miner Area
Holiday Inn Express & Suites Sikeston Southwest by IHG

Holiday Inn Express & Suites Sikeston Southwest by IHG

2.5 out of 5
115 Hospitality Dr Sikeston MO
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8.6/10 Excellent! (472 reviews)
"They double charged me. The employee suggested I call corporate because she said the manager wouldn’t do anything but tell me what I wanted to hear but wouldn’t really do anything. She was 100% right! I was promised conjoining rooms are time I put in reservations. Man I spoke to said he say my reservations ..."

Reviewed on Jun 26, 2026

Get rates
Holiday Inn Express & Suites Sikeston Southwest by IHG
See all 314 properties in Sikeston
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.