Search Cheap Flights to
Sikeston

Photo by Ryan Coleman

Search 400 airlines and 321,000 hotels worldwide.

Stop Planning & Start Exploring

FREE 24 hour cancellation on most flights

Sikeston Flights as Low as $151

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

Delta
Delta
Delta
Delta
Delta
Delta
Delta
Delta
Delta
Delta
Delta
Delta
Bargain Flight
American Airlines
Spirit Airlines
American Airlines

Cheap Flights to Sikeston

Fall in love at first flight with your vacation to Sikeston by saving a ton of cash on your last-minute cheap flight. There’s no more scouring the internet for a good deal—book your flight to Sikeston on Hotwire, and you’ll be up, up, and on a getaway in no time.

Because once the wheels are down in Sikeston, the good times start rolling. So buckle up, you’re in for a fun ride.

Frequently Asked Questions About flights to Sikeston

Don’t waste your time on endless searches for cheap airline tickets oneway or roundtrip. We’ll have you on your way to Sikeston with a tiny bag of pretzels in your hand before you can say “tray tables in the upright position”—and for a ticket price that works for your vacay budget.

So all you have to worry about is where you’re headed after the STL airport.

What is the cheapest month to fly to Sikeston?

Airline ticket prices fluctuate all the time, depending on the day of the week or the month of the year. The cheapest round trip flights to Sikeston are in August, but when you book your flight on Hotwire, savings are always in season.

How many airlines fly to Sikeston?

Variety is the spice of life, even when it comes to booking your next trip. Want options for airlines? You’ll find 15 to choose from for your flight to Sikeston.

What airport is best to fly into Sikeston?

When you’re planning your trip to Sikeston, convenience is the name of the game. Luckily, Sikeston Cairo Regional Airport is nearby so you can deplane and get going on checking off everything on your Sikeston must-do list.

How much are flights to Sikeston?

Got very cheap flights on your vacation itinerary? When you book your airline tickets to Sikeston on Hotwire, you may just get what’s on your getaway wish list. With tickets as low as $151, you’ll have leftover cash for at least a magazine and a bottle of water at the airport book store.

How to get cheap flights to Sikeston?

The trick to saving a stack of cash on your flight to Sikeston? Snatch up that Hotwire flight deal when you see a killer rate because it could be gone in a flash. And with flights as low as $151 right now, why wait?

Sikeston Flight Information
Destination airport
Lambert-St. Louis Intl.
Destination airport IATA code
STL
Roundtrip price
$116

Last Minute Hotel Deals in Sikeston

Pear Tree Inn Sikeston
Pear Tree Inn Sikeston
2.5 out of 5
2602 E Malone Avenue, Sikeston, MO
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the helpful ...
9.2/10 Wonderful! (1,002 reviews)
"Very nice,i love peartree."

Reviewed on Jun 5, 2025

Pear Tree Inn Sikeston
Best Western Plus Sikeston
Best Western Plus Sikeston
2.5 out of 5
120 S Interstate Drive, Sikeston, MO
Stay at this hotel in Sikeston. Enjoy free breakfast, free parking, and a fitness center. Our guests praise the breakfast and the helpful staff in our reviews. ...
8.2/10 Very Good! (1,003 reviews)
"Pleasant staff. The rooms aren't very soundproof. Could hear hallway traffic frequently and rooms to either side of me."

Reviewed on Jun 3, 2025

Best Western Plus Sikeston
Drury Inn & Suites Sikeston, MO
Drury Inn & Suites Sikeston, MO
3 out of 5
2608 East Malone Ave, Miner, Sikeston, MO
Stay at this 3-star business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9.4/10 Exceptional! (1,000 reviews)
"The bed was so comfortable. The front desk service was outstanding. I had my dog with me. Very accommodating."

Reviewed on May 29, 2025

Drury Inn & Suites Sikeston, MO
Days Inn and Suites by Wyndham Sikeston
Days Inn and Suites by Wyndham Sikeston
2 out of 5
220 S Interstate Dr, Sikeston, MO
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7.2/10 Good! (1,000 reviews)
"We were there to get a good nights sleep and we did."

Reviewed on Jun 2, 2025

Days Inn and Suites by Wyndham Sikeston
Hampton Inn Sikeston
Hampton Inn Sikeston
2.5 out of 5
1240 Commerce Drive, Sikeston, MO
Stay at this hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions Central ...
8.8/10 Excellent! (353 reviews)
"R"

Reviewed on Jun 2, 2025

Hampton Inn Sikeston
Holiday Inn Express & Suites Sikeston Southwest by IHG
Holiday Inn Express & Suites Sikeston Southwest by IHG
2.5 out of 5
115 Hospitality Dr, Sikeston, MO
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8.6/10 Excellent! (408 reviews)
"We pulled in late one evening. The ladies at the front desk were extremely nice and so helpful."

Reviewed on May 26, 2025

Holiday Inn Express & Suites Sikeston Southwest by IHG
Country Yard Inn and Suite
Country Yard Inn and Suite
2 out of 5
110 South Interstate Drive, Sikeston, MO
Stay at this motel in Sikeston. Enjoy free WiFi, free parking, and a 24-hour front desk. Popular attractions The Book Bug and Boot Heel Golf Club are located ...
7/10 Good! (92 reviews)
"Good but WiFi weak"

Reviewed on Apr 10, 2025

Country Yard Inn and Suite
Super 8 by Wyndham Sikeston/Miner Area
Super 8 by Wyndham Sikeston/Miner Area
2 out of 5
2609 E Malone Ave, Sikeston, MO
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Popular attractions The Book Bug and Boot Heel Golf ...
6.6/10 (536 reviews)
"It was great"

Reviewed on Jun 4, 2025

Super 8 by Wyndham Sikeston/Miner Area
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.