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Sikeston

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Sikeston Flights as Low as $195

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

Bargain Flight
Wed, Sep 9 - Wed, Sep 16
DTW
Detroit Metropolitan Wayne County
STL
Lambert-St. Louis Intl.
$195 Roundtrip, found 2 days ago
$195
Roundtrip
found 2 days ago
Select Bargain Flight flight, departing Wed, Sep 9 from Detroit Metropolitan Wayne County to Lambert-St. Louis Intl., returning Wed, Sep 16, priced at $195 found 2 days ago
Bargain Flight
Wed, Sep 9 - Mon, Sep 14
DTW
Detroit Metropolitan Wayne County
STL
Lambert-St. Louis Intl.
$196 Roundtrip, found 3 days ago
$196
Roundtrip
found 3 days ago
Select Bargain Flight flight, departing Wed, Sep 9 from Detroit Metropolitan Wayne County to Lambert-St. Louis Intl., returning Mon, Sep 14, priced at $196 found 3 days ago
Frontier Airlines
Wed, Sep 9 - Wed, Sep 16
DTW
Detroit Metropolitan Wayne County
STL
Lambert-St. Louis Intl.
$228 Roundtrip, found 2 days ago
$228
Roundtrip
found 2 days ago
Select Frontier Airlines flight, departing Wed, Sep 9 from Detroit Metropolitan Wayne County to Lambert-St. Louis Intl., returning Wed, Sep 16, priced at $228 found 2 days ago
Frontier Airlines
Wed, Sep 9 - Mon, Sep 14
DTW
Detroit Metropolitan Wayne County
STL
Lambert-St. Louis Intl.
$233 Roundtrip, found 3 days ago
$233
Roundtrip
found 3 days ago
Select Frontier Airlines flight, departing Wed, Sep 9 from Detroit Metropolitan Wayne County to Lambert-St. Louis Intl., returning Mon, Sep 14, priced at $233 found 3 days ago
Bargain Flight
Wed, Sep 9 - Sat, Sep 12
DTW
Detroit Metropolitan Wayne County
STL
Lambert-St. Louis Intl.
$243 Roundtrip, found 1 day ago
$243
Roundtrip
found 1 day ago
Select Bargain Flight flight, departing Wed, Sep 9 from Detroit Metropolitan Wayne County to Lambert-St. Louis Intl., returning Sat, Sep 12, priced at $243 found 1 day ago
Frontier Airlines
Wed, Sep 9 - Wed, Sep 16
DTW
Detroit Metropolitan Wayne County
STL
Lambert-St. Louis Intl.
$244 Roundtrip, found 2 days ago
$244
Roundtrip
found 2 days ago
Select Frontier Airlines flight, departing Wed, Sep 9 from Detroit Metropolitan Wayne County to Lambert-St. Louis Intl., returning Wed, Sep 16, priced at $244 found 2 days ago
Frontier Airlines
Wed, Sep 9 - Wed, Sep 16
DTW
Detroit Metropolitan Wayne County
STL
Lambert-St. Louis Intl.
$252 Roundtrip, found 2 days ago
$252
Roundtrip
found 2 days ago
Select Frontier Airlines flight, departing Wed, Sep 9 from Detroit Metropolitan Wayne County to Lambert-St. Louis Intl., returning Wed, Sep 16, priced at $252 found 2 days ago
Frontier Airlines
Wed, Sep 9 - Wed, Sep 16
DTW
Detroit Metropolitan Wayne County
STL
Lambert-St. Louis Intl.
$258 Roundtrip, found 2 days ago
$258
Roundtrip
found 2 days ago
Select Frontier Airlines flight, departing Wed, Sep 9 from Detroit Metropolitan Wayne County to Lambert-St. Louis Intl., returning Wed, Sep 16, priced at $258 found 2 days ago
Frontier Airlines
Wed, Sep 9 - Mon, Sep 14
DTW
Detroit Metropolitan Wayne County
STL
Lambert-St. Louis Intl.
$258 Roundtrip, found 3 days ago
$258
Roundtrip
found 3 days ago
Select Frontier Airlines flight, departing Wed, Sep 9 from Detroit Metropolitan Wayne County to Lambert-St. Louis Intl., returning Mon, Sep 14, priced at $258 found 3 days ago
Frontier Airlines
Wed, Sep 9 - Wed, Sep 16
DTW
Detroit Metropolitan Wayne County
STL
Lambert-St. Louis Intl.
$293 Roundtrip, found 2 days ago
$293
Roundtrip
found 2 days ago
Select Frontier Airlines flight, departing Wed, Sep 9 from Detroit Metropolitan Wayne County to Lambert-St. Louis Intl., returning Wed, Sep 16, priced at $293 found 2 days ago
Frontier Airlines
Wed, Sep 9 - Wed, Sep 16
DTW
Detroit Metropolitan Wayne County
STL
Lambert-St. Louis Intl.
$298 Roundtrip, found 2 days ago
$298
Roundtrip
found 2 days ago
Select Frontier Airlines flight, departing Wed, Sep 9 from Detroit Metropolitan Wayne County to Lambert-St. Louis Intl., returning Wed, Sep 16, priced at $298 found 2 days ago
Frontier Airlines
Wed, Sep 9 - Wed, Sep 16
DTW
Detroit Metropolitan Wayne County
STL
Lambert-St. Louis Intl.
$309 Roundtrip, found 2 days ago
$309
Roundtrip
found 2 days ago
Select Frontier Airlines flight, departing Wed, Sep 9 from Detroit Metropolitan Wayne County to Lambert-St. Louis Intl., returning Wed, Sep 16, priced at $309 found 2 days ago
Southwest Airlines
Wed, Sep 9 - Wed, Sep 16
DTW
Detroit Metropolitan Wayne County
STL
Lambert-St. Louis Intl.
$361 Roundtrip, found 2 days ago
$361
Roundtrip
found 2 days ago
Select Southwest Airlines flight, departing Wed, Sep 9 from Detroit Metropolitan Wayne County to Lambert-St. Louis Intl., returning Wed, Sep 16, priced at $361 found 2 days ago
Delta
Wed, Sep 9 - Mon, Sep 14
DTW
Detroit Metropolitan Wayne County
STL
Lambert-St. Louis Intl.
$361 Roundtrip, found 3 days ago
$361
Roundtrip
found 3 days ago
Select Delta flight, departing Wed, Sep 9 from Detroit Metropolitan Wayne County to Lambert-St. Louis Intl., returning Mon, Sep 14, priced at $361 found 3 days ago
American Airlines
Wed, Sep 9 - Wed, Sep 16
DTW
Detroit Metropolitan Wayne County
STL
Lambert-St. Louis Intl.
$381 Roundtrip, found 2 days ago
$381
Roundtrip
found 2 days ago
Select American Airlines flight, departing Wed, Sep 9 from Detroit Metropolitan Wayne County to Lambert-St. Louis Intl., returning Wed, Sep 16, priced at $381 found 2 days ago
United
Mon, Aug 31 - Wed, Sep 2
DTW
Detroit Metropolitan Wayne County
CGI
Cape Girardeau Municipal
$765 Roundtrip, found 17 hours ago
$765
Roundtrip
found 17 hours ago
Select United flight, departing Mon, Aug 31 from Detroit Metropolitan Wayne County to Cape Girardeau Municipal, returning Wed, Sep 2, priced at $765 found 17 hours ago

Cheap Flights to Sikeston

Fall in love at first flight with your vacation to Sikeston by saving a ton of cash on your last-minute cheap flight. There’s no more scouring the internet for a good deal—book your flight to Sikeston on Hotwire, and you’ll be up, up, and on a getaway in no time.

Because once the wheels are down in Sikeston, the good times start rolling. So buckle up, you’re in for a fun ride.

Frequently Asked Questions About flights to Sikeston

Don’t waste your time on endless searches for cheap airline tickets oneway or roundtrip. We’ll have you on your way to Sikeston with a tiny bag of pretzels in your hand before you can say “tray tables in the upright position”—and for a ticket price that works for your vacay budget.

So all you have to worry about is where you’re headed after the STL airport.

What is the cheapest month to fly to Sikeston?

Airline ticket prices fluctuate all the time, depending on the day of the week or the month of the year. The cheapest round trip flights to Sikeston are in September, but when you book your flight on Hotwire, savings are always in season.

How many airlines fly to Sikeston?

Variety is the spice of life, even when it comes to booking your next trip. Want options for airlines? You’ll find 13 to choose from for your flight to Sikeston.

What airport is best to fly into Sikeston?

When you’re planning your trip to Sikeston, convenience is the name of the game. Luckily, Sikeston Cairo Regional Airport is nearby so you can deplane and get going on checking off everything on your Sikeston must-do list.

How much are flights to Sikeston?

Got very cheap flights on your vacation itinerary? When you book your airline tickets to Sikeston on Hotwire, you may just get what’s on your getaway wish list. With tickets as low as $195, you’ll have leftover cash for at least a magazine and a bottle of water at the airport book store.

How to get cheap flights to Sikeston?

The trick to saving a stack of cash on your flight to Sikeston? Snatch up that Hotwire flight deal when you see a killer rate because it could be gone in a flash. And with flights as low as $195 right now, why wait?

Sikeston Flight Information
Destination airport
Lambert-St. Louis Intl.
Destination airport IATA code
STL
Roundtrip price
$38

Last Minute Hotel Deals in Sikeston

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

3 out of 5
2608 East Malone Ave, Miner Sikeston MO
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9.6/10 Exceptional! (1,001 reviews)
"Dana wasn’t very happy while check in"

Reviewed on Aug 27, 2026

Get rates
Drury Inn & Suites Sikeston, MO
Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston

2 out of 5
220 S Interstate Dr Sikeston MO
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7.2/10 Good! (1,000 reviews)
"I stayed in so many this trip but they were all basically clean,polite staff."

Reviewed on Aug 22, 2026

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Days Inn and Suites by Wyndham Sikeston
Best Western Plus Sikeston I-55

Best Western Plus Sikeston I-55

2.5 out of 5
120 S Interstate Drive Sikeston MO
Stay at this hotel in Sikeston. Enjoy free breakfast, free parking, and a fitness center. Our guests praise the breakfast and the helpful staff in our reviews. ...
8.4/10 Very Good! (1,016 reviews)
"This place was very clean. We were given a 2nd floor room. I asked if there was an elevator. Yes. When we brought our things in to go to our room, we found the elevator was temporarily out of order. My friend cannot climb stairs. We were immediately given a 1st floor room close to an entrance near ..."

Reviewed on Aug 26, 2026

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Best Western Plus Sikeston I-55
Holiday Inn Express & Suites Sikeston Southwest by IHG

Holiday Inn Express & Suites Sikeston Southwest by IHG

2.5 out of 5
115 Hospitality Dr Sikeston MO
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
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Holiday Inn Express & Suites Sikeston Southwest by IHG
Hampton Inn Sikeston

Hampton Inn Sikeston

2.5 out of 5
1240 Commerce Drive Sikeston MO
Stay at this hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions Central ...
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Hampton Inn Sikeston
Fairfield Inn & Suites by Marriott Sikeston

Fairfield Inn & Suites by Marriott Sikeston

3 out of 5
1239 Commerce Drive Sikeston MO
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Central Park and Sikeston Depot ...
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Fairfield Inn & Suites by Marriott Sikeston
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

2.5 out of 5
100 Matthews Lane Sikeston MO
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
Get rates
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
Super 8 by Wyndham Sikeston/Miner Area

Super 8 by Wyndham Sikeston/Miner Area

2 out of 5
2609 E Malone Ave Sikeston MO
Stay at this hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Central Park and Sikeston Depot Museum are located ...
Get rates
Super 8 by Wyndham Sikeston/Miner Area
See all 311 properties in Sikeston
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.