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Sikeston

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Sikeston Flights as Low as $93

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

American Airlines
Sat, Sep 27 - Sat, Oct 4
ORD
O'Hare Intl.
STL
Lambert-St. Louis Intl.
$93 Roundtrip, found 17 hours ago
$93
Roundtrip
found 17 hours ago
Select American Airlines flight, departing Sat, Sep 27 from O'Hare Intl. to Lambert-St. Louis Intl., returning Sat, Oct 4, priced at $93 found 17 hours ago
Frontier Airlines
Thu, Sep 11 - Sun, Sep 14
DFW
Dallas-Fort Worth Intl.
STL
Lambert-St. Louis Intl.
$114 Roundtrip, found 1 day ago
$114
Roundtrip
found 1 day ago
Select Frontier Airlines flight, departing Thu, Sep 11 from Dallas-Fort Worth Intl. to Lambert-St. Louis Intl., returning Sun, Sep 14, priced at $114 found 1 day ago
American Airlines
Sat, Oct 11 - Sat, Oct 11
ORD
O'Hare Intl.
STL
Lambert-St. Louis Intl.
$120 Roundtrip, found 3 days ago
$120
Roundtrip
found 3 days ago
Select American Airlines flight, departing Sat, Oct 11 from O'Hare Intl. to Lambert-St. Louis Intl., returning Sat, Oct 11, priced at $120 found 3 days ago
Frontier Airlines
Thu, Sep 11 - Sun, Sep 14
DFW
Dallas-Fort Worth Intl.
STL
Lambert-St. Louis Intl.
$127 Roundtrip, found 1 day ago
$127
Roundtrip
found 1 day ago
Select Frontier Airlines flight, departing Thu, Sep 11 from Dallas-Fort Worth Intl. to Lambert-St. Louis Intl., returning Sun, Sep 14, priced at $127 found 1 day ago
Frontier Airlines
Thu, Aug 28 - Thu, Sep 4
DFW
Dallas-Fort Worth Intl.
STL
Lambert-St. Louis Intl.
$130 Roundtrip, found 3 days ago
$130
Roundtrip
found 3 days ago
Select Frontier Airlines flight, departing Thu, Aug 28 from Dallas-Fort Worth Intl. to Lambert-St. Louis Intl., returning Thu, Sep 4, priced at $130 found 3 days ago
Frontier Airlines
Thu, Sep 11 - Sun, Sep 14
DFW
Dallas-Fort Worth Intl.
STL
Lambert-St. Louis Intl.
$132 Roundtrip, found 1 day ago
$132
Roundtrip
found 1 day ago
Select Frontier Airlines flight, departing Thu, Sep 11 from Dallas-Fort Worth Intl. to Lambert-St. Louis Intl., returning Sun, Sep 14, priced at $132 found 1 day ago
Frontier Airlines
Thu, Aug 28 - Thu, Sep 4
DFW
Dallas-Fort Worth Intl.
STL
Lambert-St. Louis Intl.
$134 Roundtrip, found 3 days ago
$134
Roundtrip
found 3 days ago
Select Frontier Airlines flight, departing Thu, Aug 28 from Dallas-Fort Worth Intl. to Lambert-St. Louis Intl., returning Thu, Sep 4, priced at $134 found 3 days ago
Frontier Airlines
Sun, Sep 7 - Thu, Sep 11
DFW
Dallas-Fort Worth Intl.
STL
Lambert-St. Louis Intl.
$137 Roundtrip, found 1 day ago
$137
Roundtrip
found 1 day ago
Select Frontier Airlines flight, departing Sun, Sep 7 from Dallas-Fort Worth Intl. to Lambert-St. Louis Intl., returning Thu, Sep 11, priced at $137 found 1 day ago
United
Wed, Sep 10 - Sat, Sep 13
ORD
O'Hare Intl.
STL
Lambert-St. Louis Intl.
$137 Roundtrip, found 5 days ago
$137
Roundtrip
found 5 days ago
Select United flight, departing Wed, Sep 10 from O'Hare Intl. to Lambert-St. Louis Intl., returning Sat, Sep 13, priced at $137 found 5 days ago
Southern Airways Express
Tue, Sep 9 - Mon, Sep 15
ORD
O'Hare Intl.
STL
Lambert-St. Louis Intl.
$145 Roundtrip, found 1 hour ago
$145
Roundtrip
found 1 hour ago
Select Southern Airways Express flight, departing Tue, Sep 9 from O'Hare Intl. to Lambert-St. Louis Intl., returning Mon, Sep 15, priced at $145 found 1 hour ago
Delta
Wed, Sep 17 - Thu, Sep 25
DTW
Detroit Metropolitan Wayne County
STL
Lambert-St. Louis Intl.
$177 Roundtrip, found 6 days ago
$177
Roundtrip
found 6 days ago
Select Delta flight, departing Wed, Sep 17 from Detroit Metropolitan Wayne County to Lambert-St. Louis Intl., returning Thu, Sep 25, priced at $177 found 6 days ago
Southern Airways Express
Thu, Sep 11 - Fri, Sep 12
ORD
O'Hare Intl.
STL
Lambert-St. Louis Intl.
$185 Roundtrip, found 3 days ago
$185
Roundtrip
found 3 days ago
Select Southern Airways Express flight, departing Thu, Sep 11 from O'Hare Intl. to Lambert-St. Louis Intl., returning Fri, Sep 12, priced at $185 found 3 days ago
Delta
Wed, Sep 10 - Sat, Sep 13
DAL
Love Field
STL
Lambert-St. Louis Intl.
$200 Roundtrip, found 1 day ago
$200
Roundtrip
found 1 day ago
Select Delta flight, departing Wed, Sep 10 from Love Field to Lambert-St. Louis Intl., returning Sat, Sep 13, priced at $200 found 1 day ago
Spirit Airlines
Mon, Aug 25 - Thu, Sep 4
DFW
Dallas-Fort Worth Intl.
STL
Lambert-St. Louis Intl.
$271 Roundtrip, found 6 days ago
$271
Roundtrip
found 6 days ago
Select Spirit Airlines flight, departing Mon, Aug 25 from Dallas-Fort Worth Intl. to Lambert-St. Louis Intl., returning Thu, Sep 4, priced at $271 found 6 days ago
American Airlines
Thu, Sep 11 - Sun, Sep 14
DTW
Detroit Metropolitan Wayne County
PAH
Barkley Regional
$435 Roundtrip, found 4 days ago
$435
Roundtrip
found 4 days ago
Select American Airlines flight, departing Thu, Sep 11 from Detroit Metropolitan Wayne County to Barkley Regional, returning Sun, Sep 14, priced at $435 found 4 days ago
American Airlines
Fri, Aug 22 - Mon, Aug 25
DFW
Dallas-Fort Worth Intl.
PAH
Barkley Regional
$636 Roundtrip, found 13 hours ago
$636
Roundtrip
found 13 hours ago
Select American Airlines flight, departing Fri, Aug 22 from Dallas-Fort Worth Intl. to Barkley Regional, returning Mon, Aug 25, priced at $636 found 13 hours ago

Cheap Flights to Sikeston

Fall in love at first flight with your vacation to Sikeston by saving a ton of cash on your last-minute cheap flight. There’s no more scouring the internet for a good deal—book your flight to Sikeston on Hotwire, and you’ll be up, up, and on a getaway in no time.

Because once the wheels are down in Sikeston, the good times start rolling. So buckle up, you’re in for a fun ride.

Frequently Asked Questions About flights to Sikeston

Don’t waste your time on endless searches for cheap airline tickets oneway or roundtrip. We’ll have you on your way to Sikeston with a tiny bag of pretzels in your hand before you can say “tray tables in the upright position”—and for a ticket price that works for your vacay budget.

So all you have to worry about is where you’re headed after the STL airport.

What is the cheapest month to fly to Sikeston?

Airline ticket prices fluctuate all the time, depending on the day of the week or the month of the year. The cheapest round trip flights to Sikeston are in September, but when you book your flight on Hotwire, savings are always in season.

How many airlines fly to Sikeston?

Variety is the spice of life, even when it comes to booking your next trip. Want options for airlines? You’ll find 16 to choose from for your flight to Sikeston.

What airport is best to fly into Sikeston?

When you’re planning your trip to Sikeston, convenience is the name of the game. Luckily, Sikeston Cairo Regional Airport is nearby so you can deplane and get going on checking off everything on your Sikeston must-do list.

How much are flights to Sikeston?

Got very cheap flights on your vacation itinerary? When you book your airline tickets to Sikeston on Hotwire, you may just get what’s on your getaway wish list. With tickets as low as $93, you’ll have leftover cash for at least a magazine and a bottle of water at the airport book store.

How to get cheap flights to Sikeston?

The trick to saving a stack of cash on your flight to Sikeston? Snatch up that Hotwire flight deal when you see a killer rate because it could be gone in a flash. And with flights as low as $93 right now, why wait?

Sikeston Flight Information
Destination airport
Lambert-St. Louis Intl.
Destination airport IATA code
STL
Roundtrip price
$99

Last Minute Hotel Deals in Sikeston

Best Western Plus Sikeston

Best Western Plus Sikeston

2.5 out of 5
120 S Interstate Drive, Sikeston, MO
Stay at this hotel in Sikeston. Enjoy free breakfast, free parking, and a fitness center. Our guests praise the breakfast and the helpful staff in our reviews. ...
8.2/10 Very Good! (1,003 reviews)
"Staff was friendly and room was very clean. A very comfortable stay"

Reviewed on Aug 18, 2025

Get rates
Best Western Plus Sikeston
Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

3 out of 5
2608 East Malone Ave, Miner, Sikeston, MO
Stay at this 3-star business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9.4/10 Exceptional! (1,005 reviews)
"The food options were great, the hotel was very clean, the staff were nice and friendly. The room was perfect and the bed was comfortable."

Reviewed on Aug 18, 2025

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Drury Inn & Suites Sikeston, MO
Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston

2 out of 5
220 S Interstate Dr, Sikeston, MO
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7.2/10 Good! (1,000 reviews)
"The staff were all great and happy to accommodate us when we asked to switch rooms due to an AC issue in our original room. The beds were comfortable and clean. No bugs in sight, which is a big thing for me when staying in hotels. Everything was very outdated, the rooms could definitely benefit from ..."

Reviewed on Aug 8, 2025

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Days Inn and Suites by Wyndham Sikeston
Pear Tree Inn Sikeston

Pear Tree Inn Sikeston

2.5 out of 5
2602 E Malone Avenue, Sikeston, MO
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the helpful ...
9.2/10 Wonderful! (1,003 reviews)
"Good"

Reviewed on Aug 18, 2025

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Pear Tree Inn Sikeston
Hampton Inn Sikeston

Hampton Inn Sikeston

2.5 out of 5
1240 Commerce Drive, Sikeston, MO
Stay at this hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions Central ...
8.8/10 Excellent! (374 reviews)
"Relaxing"

Reviewed on Aug 9, 2025

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Hampton Inn Sikeston
Fairfield Inn & Suites by Marriott Sikeston

Fairfield Inn & Suites by Marriott Sikeston

2.5 out of 5
1239 Commerce Drive, Sikeston, MO
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Central Park and Sikeston Depot ...
9.2/10 Wonderful! (17 reviews)
"Absolutely excellent. Brand new hotel. Spotless. Staff were friendly and welcoming."

Reviewed on Jul 26, 2025

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Fairfield Inn & Suites by Marriott Sikeston
Holiday Inn Express & Suites Sikeston Southwest by IHG

Holiday Inn Express & Suites Sikeston Southwest by IHG

2.5 out of 5
115 Hospitality Dr, Sikeston, MO
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8.6/10 Excellent! (422 reviews)
Would have been a great hotel if I felt safe
"Everything at this hotel was really nice the food was good the bed was nice the room was good the air conditioner worked good very satisfied with the overall condition and cleanliness and comfort of the room"

Reviewed on Aug 2, 2025

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Holiday Inn Express & Suites Sikeston Southwest by IHG
Super 8 by Wyndham Sikeston/Miner Area

Super 8 by Wyndham Sikeston/Miner Area

2 out of 5
2609 E Malone Ave, Sikeston, MO
Stay at this hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Central Park and Sikeston Depot Museum are located ...
6.6/10 (551 reviews)
"Good food around area and bed was comfort"

Reviewed on Aug 17, 2025

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Super 8 by Wyndham Sikeston/Miner Area
See all 256 properties in Sikeston
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.