Search Cheap Flights to
Sikeston

Search 400 airlines and 321,000 hotels worldwide.

Stop Planning & Start Exploring

FREE 24 hour cancellation on most flights

Sikeston Flights as Low as $95

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

Frontier Airlines
Thu, Sep 17 - Mon, Sep 28
DFW
Dallas-Fort Worth Intl.
STL
Lambert-St. Louis Intl.
$95 Roundtrip, found 5 days ago
$95
Roundtrip
found 5 days ago
Select Frontier Airlines flight, departing Thu, Sep 17 from Dallas-Fort Worth Intl. to Lambert-St. Louis Intl., returning Mon, Sep 28, priced at $95 found 5 days ago
Frontier Airlines
Thu, Aug 6 - Tue, Aug 25
DFW
Dallas-Fort Worth Intl.
STL
Lambert-St. Louis Intl.
$111 Roundtrip, found 2 days ago
$111
Roundtrip
found 2 days ago
Select Frontier Airlines flight, departing Thu, Aug 6 from Dallas-Fort Worth Intl. to Lambert-St. Louis Intl., returning Tue, Aug 25, priced at $111 found 2 days ago
Frontier Airlines
Tue, Sep 8 - Fri, Sep 11
DFW
Dallas-Fort Worth Intl.
STL
Lambert-St. Louis Intl.
$121 Roundtrip, found 8 hours ago
$121
Roundtrip
found 8 hours ago
Select Frontier Airlines flight, departing Tue, Sep 8 from Dallas-Fort Worth Intl. to Lambert-St. Louis Intl., returning Fri, Sep 11, priced at $121 found 8 hours ago
Frontier Airlines
Tue, Sep 1 - Mon, Sep 14
DFW
Dallas-Fort Worth Intl.
STL
Lambert-St. Louis Intl.
$125 Roundtrip, found 5 hours ago
$125
Roundtrip
found 5 hours ago
Select Frontier Airlines flight, departing Tue, Sep 1 from Dallas-Fort Worth Intl. to Lambert-St. Louis Intl., returning Mon, Sep 14, priced at $125 found 5 hours ago
Frontier Airlines
Tue, Sep 1 - Sun, Sep 13
DFW
Dallas-Fort Worth Intl.
STL
Lambert-St. Louis Intl.
$126 Roundtrip, found 12 hours ago
$126
Roundtrip
found 12 hours ago
Select Frontier Airlines flight, departing Tue, Sep 1 from Dallas-Fort Worth Intl. to Lambert-St. Louis Intl., returning Sun, Sep 13, priced at $126 found 12 hours ago
Frontier Airlines
Tue, Sep 8 - Thu, Sep 10
DFW
Dallas-Fort Worth Intl.
STL
Lambert-St. Louis Intl.
$136 Roundtrip, found 8 hours ago
$136
Roundtrip
found 8 hours ago
Select Frontier Airlines flight, departing Tue, Sep 8 from Dallas-Fort Worth Intl. to Lambert-St. Louis Intl., returning Thu, Sep 10, priced at $136 found 8 hours ago
Frontier Airlines
Tue, Sep 8 - Sun, Sep 13
DFW
Dallas-Fort Worth Intl.
STL
Lambert-St. Louis Intl.
$137 Roundtrip, found 8 hours ago
$137
Roundtrip
found 8 hours ago
Select Frontier Airlines flight, departing Tue, Sep 8 from Dallas-Fort Worth Intl. to Lambert-St. Louis Intl., returning Sun, Sep 13, priced at $137 found 8 hours ago
Frontier Airlines
Sun, Sep 13 - Mon, Sep 14
DFW
Dallas-Fort Worth Intl.
STL
Lambert-St. Louis Intl.
$151 Roundtrip, found 8 hours ago
$151
Roundtrip
found 8 hours ago
Select Frontier Airlines flight, departing Sun, Sep 13 from Dallas-Fort Worth Intl. to Lambert-St. Louis Intl., returning Mon, Sep 14, priced at $151 found 8 hours ago
Frontier Airlines
Thu, Sep 17 - Mon, Sep 28
DFW
Dallas-Fort Worth Intl.
STL
Lambert-St. Louis Intl.
$153 Roundtrip, found 5 days ago
$153
Roundtrip
found 5 days ago
Select Frontier Airlines flight, departing Thu, Sep 17 from Dallas-Fort Worth Intl. to Lambert-St. Louis Intl., returning Mon, Sep 28, priced at $153 found 5 days ago
American Airlines
Thu, Aug 6 - Tue, Aug 25
DFW
Dallas-Fort Worth Intl.
STL
Lambert-St. Louis Intl.
$156 Roundtrip, found 2 days ago
$156
Roundtrip
found 2 days ago
Select American Airlines flight, departing Thu, Aug 6 from Dallas-Fort Worth Intl. to Lambert-St. Louis Intl., returning Tue, Aug 25, priced at $156 found 2 days ago
Frontier Airlines
Thu, Sep 17 - Mon, Sep 28
DFW
Dallas-Fort Worth Intl.
STL
Lambert-St. Louis Intl.
$165 Roundtrip, found 5 days ago
$165
Roundtrip
found 5 days ago
Select Frontier Airlines flight, departing Thu, Sep 17 from Dallas-Fort Worth Intl. to Lambert-St. Louis Intl., returning Mon, Sep 28, priced at $165 found 5 days ago
American Airlines
Thu, Sep 17 - Mon, Sep 28
DFW
Dallas-Fort Worth Intl.
STL
Lambert-St. Louis Intl.
$197 Roundtrip, found 5 days ago
$197
Roundtrip
found 5 days ago
Select American Airlines flight, departing Thu, Sep 17 from Dallas-Fort Worth Intl. to Lambert-St. Louis Intl., returning Mon, Sep 28, priced at $197 found 5 days ago
Delta
Sat, Oct 17 - Wed, Oct 21
DAL
Love Field
STL
Lambert-St. Louis Intl.
$217 Roundtrip, found 5 days ago
$217
Roundtrip
found 5 days ago
Select Delta flight, departing Sat, Oct 17 from Love Field to Lambert-St. Louis Intl., returning Wed, Oct 21, priced at $217 found 5 days ago
United
Thu, Aug 6 - Tue, Aug 25
DFW
Dallas-Fort Worth Intl.
STL
Lambert-St. Louis Intl.
$222 Roundtrip, found 2 days ago
$222
Roundtrip
found 2 days ago
Select United flight, departing Thu, Aug 6 from Dallas-Fort Worth Intl. to Lambert-St. Louis Intl., returning Tue, Aug 25, priced at $222 found 2 days ago
United
Thu, Sep 3 - Sun, Sep 13
DFW
Dallas-Fort Worth Intl.
PAH
Barkley Regional
$305 Roundtrip, found 11 hours ago
$305
Roundtrip
found 11 hours ago
Select United flight, departing Thu, Sep 3 from Dallas-Fort Worth Intl. to Barkley Regional, returning Sun, Sep 13, priced at $305 found 11 hours ago
Delta
Thu, Sep 3 - Sun, Sep 13
DAL
Love Field
PAH
Barkley Regional
$1,582 Roundtrip, found 6 days ago
$1,582
Roundtrip
found 6 days ago
Select Delta flight, departing Thu, Sep 3 from Love Field to Barkley Regional, returning Sun, Sep 13, priced at $1,582 found 6 days ago

Cheap Flights to Sikeston

Fall in love at first flight with your vacation to Sikeston by saving a ton of cash on your last-minute cheap flight. There’s no more scouring the internet for a good deal—book your flight to Sikeston on Hotwire, and you’ll be up, up, and on a getaway in no time.

Because once the wheels are down in Sikeston, the good times start rolling. So buckle up, you’re in for a fun ride.

Frequently Asked Questions About flights to Sikeston

Don’t waste your time on endless searches for cheap airline tickets oneway or roundtrip. We’ll have you on your way to Sikeston with a tiny bag of pretzels in your hand before you can say “tray tables in the upright position”—and for a ticket price that works for your vacay budget.

So all you have to worry about is where you’re headed after the STL airport.

What is the cheapest month to fly to Sikeston?

Airline ticket prices fluctuate all the time, depending on the day of the week or the month of the year. The cheapest round trip flights to Sikeston are in September, but when you book your flight on Hotwire, savings are always in season.

How many airlines fly to Sikeston?

Variety is the spice of life, even when it comes to booking your next trip. Want options for airlines? You’ll find 16 to choose from for your flight to Sikeston.

What airport is best to fly into Sikeston?

When you’re planning your trip to Sikeston, convenience is the name of the game. Luckily, Sikeston Cairo Regional Airport is nearby so you can deplane and get going on checking off everything on your Sikeston must-do list.

How much are flights to Sikeston?

Got very cheap flights on your vacation itinerary? When you book your airline tickets to Sikeston on Hotwire, you may just get what’s on your getaway wish list. With tickets as low as $95, you’ll have leftover cash for at least a magazine and a bottle of water at the airport book store.

How to get cheap flights to Sikeston?

The trick to saving a stack of cash on your flight to Sikeston? Snatch up that Hotwire flight deal when you see a killer rate because it could be gone in a flash. And with flights as low as $95 right now, why wait?

Sikeston Flight Information
Destination airport
Lambert-St. Louis Intl.
Destination airport IATA code
STL
Roundtrip price
$95

Last Minute Hotel Deals in Sikeston

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

3 out of 5
2608 East Malone Ave, Miner Sikeston MO
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
Get rates
Drury Inn & Suites Sikeston, MO
Best Western Plus Sikeston I-55

Best Western Plus Sikeston I-55

2.5 out of 5
120 S Interstate Drive Sikeston MO
Stay at this hotel in Sikeston. Enjoy free breakfast, free parking, and a fitness center. Our guests praise the breakfast and the helpful staff in our reviews. ...
8.4/10 Very Good! (1,000 reviews)
"Old but well maintained for quick overnight stay"

Reviewed on Jul 17, 2026

Get rates
Best Western Plus Sikeston I-55
Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston

2 out of 5
220 S Interstate Dr Sikeston MO
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7.2/10 Good! (1,000 reviews)
"I had a stay at this hotel. The rooms were clean, comfortable, and well maintained. The staff was friendly, professional, and always willing to help. The location was in a convenient place for us to take a quick rest The breakfast was delicious with plenty of options, and the overall atmosphere was ..."

Reviewed on Jul 4, 2026

Get rates
Days Inn and Suites by Wyndham Sikeston
Hampton Inn Sikeston

Hampton Inn Sikeston

2.5 out of 5
1240 Commerce Drive Sikeston MO
Stay at this hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions Central ...
9/10 Wonderful! (592 reviews)
"My 21 year old son stayed at this Hampton Inn on his way back to college in IL. He enjoyed the gym, the indoor pool, the large selection of breakfast items, and the close proximity to I-55. The room was clean and the staff was friendly, even to a 21 year old young man traveling alone. Thank you for ..."

Reviewed on Jul 15, 2026

Get rates
Hampton Inn Sikeston
Holiday Inn Express & Suites Sikeston Southwest by IHG

Holiday Inn Express & Suites Sikeston Southwest by IHG

2.5 out of 5
115 Hospitality Dr Sikeston MO
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8.6/10 Excellent! (480 reviews)
"The indoor pool was extremely nice for our kids to burn off energy from our trip. The room was clean and spacious. We had to go request towels and washclothes even though we reserved it for 6 people, it was set up for 2. The sofa bed was old and mattress needed to be replaced. Would stay again."

Reviewed on Jul 16, 2026

Get rates
Holiday Inn Express & Suites Sikeston Southwest by IHG
Fairfield Inn & Suites by Marriott Sikeston

Fairfield Inn & Suites by Marriott Sikeston

3 out of 5
1239 Commerce Drive Sikeston MO
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Central Park and Sikeston Depot ...
9.4/10 Exceptional! (99 reviews)
"Always glad to have a smooth check in a little bit of breakfast in the morning. Everything was clean just what you would expect."

Reviewed on Jul 11, 2026

Get rates
Fairfield Inn & Suites by Marriott Sikeston
Super 8 by Wyndham Sikeston/Miner Area

Super 8 by Wyndham Sikeston/Miner Area

2 out of 5
2609 E Malone Ave Sikeston MO
Stay at this hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Central Park and Sikeston Depot Museum are located ...
7/10 Good! (657 reviews)
"The place smelled funny (cleaning supplies? Furniture was old and dirty Meeger breakfast choices Staff was helpful. Check-in was very good"

Reviewed on Jun 30, 2026

Get rates
Super 8 by Wyndham Sikeston/Miner Area
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

2.5 out of 5
100 Matthews Lane Sikeston MO
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8.4/10 Very Good! (800 reviews)
"Clean room breakfast no meat"

Reviewed on Jul 17, 2026

Get rates
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
See all 319 properties in Sikeston
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.