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Hotels in Central United States

Choose from 312894 Central United States Hotel Deals

Congress Plaza Hotel

Congress Plaza Hotel

3.5 out of 5
520 South Michigan Avenue Chicago IL
  • 18 hours drive from Great Smoky Mountains National Park
Book a stay at this business-friendly hotel in Chicago. Enjoy 2 restaurants, 2 bars/lounges, and breakfast (surcharge). Our guests praise the helpful staff and ...
8/10 Very Good! (10,213 reviews)
"The only redeeming quality of this hotel is the location. For the price it is NOT worth it. The bed is a rock that doesn't even have a fitted sheet on it and did not come with adequate blankets. The AC works well, but with the thin blankets it was almost unbearable. And oh man, the bathroom! Severely ..."

Reviewed on Jun 8, 2026

Congress Plaza Hotel
Gaylord Opryland Resort & Convention Center

Gaylord Opryland Resort & Convention Center

4 out of 5
2800 Opryland Drive Nashville TN
Book a stay at this spa resort in Nashville. Enjoy 2 outdoor pools, a full-service spa, and 18 restaurants. Our guests praise the helpful staff and the clean ...
8.8/10 Excellent! (1,788 reviews)
"Perfect"

Reviewed on Jun 7, 2026

Gaylord Opryland Resort & Convention Center
The Chicago Hotel Collection - Magnificent Mile

The Chicago Hotel Collection - Magnificent Mile

4 out of 5
166 E Superior Street Chicago IL
  • 18 hours drive from Great Smoky Mountains National Park
Book a stay at this boutique hotel in Chicago. Enjoy free WiFi, 2 restaurants, and 2 bars/lounges. Our guests praise the helpful staff and the clean rooms in ...
7.8/10 Good! (1,539 reviews)
"They were awesome to clean our room before we checked out . Which we checked out 2 days later"

Reviewed on Jun 8, 2026

The Chicago Hotel Collection - Magnificent Mile
Hyatt Regency O'Hare Chicago

Hyatt Regency O'Hare Chicago

4 out of 5
9300 Bryn Mawr Ave Rosemont IL
  • 18 hours drive from Great Smoky Mountains National Park
Book a stay at this business-friendly hotel in Rosemont. Enjoy free WiFi, breakfast (surcharge), and a free airport shuttle. Our guests praise the helpful staff ...
8.8/10 Excellent! (2,634 reviews)
"Very clean & will stay in this hotel again"

Reviewed on Jun 8, 2026

Hyatt Regency O'Hare Chicago
Beachside Resort Hotel

Beachside Resort Hotel

2 out of 5
610 W Beach Blvd Gulf Shores AL
  • 14 hours drive from Great Smoky Mountains National Park
Stay at this hotel in Gulf Shores. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the pool and the helpful staff in our reviews. ...
8/10 Very Good! (1,657 reviews)
"Room was fine but property in need of TLC!"

Reviewed on Jun 6, 2026

Beachside Resort Hotel
The Chicago Hotel Collection Ambassador Gold Coast

The Chicago Hotel Collection Ambassador Gold Coast

4 out of 5
1301 N State Pkwy Chicago IL
  • 18 hours drive from Great Smoky Mountains National Park
Book a stay at this business-friendly hotel in Chicago. Enjoy free WiFi, a 24-hour fitness center, and valet parking (surcharge). Our guests praise the helpful ...
8.2/10 Very Good! (1,566 reviews)
"We just stayed one night but the hotel served its purpose. We would stay here again. We also liked the lobby of the hotel and bar"

Reviewed on Jun 8, 2026

The Chicago Hotel Collection Ambassador Gold Coast
Hyatt Place Nashville Downtown

Hyatt Place Nashville Downtown

3 out of 5
301 3rd Ave S Nashville TN
  • 55 min drive from Great Smoky Mountains National Park
Book a stay at this business-friendly hotel in Nashville. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast and ...
9.2/10 Wonderful! (6,106 reviews)
"Fantastic breakfast and great location just a few blocks from Broadway, but the hotel offers a “higher floor” upgrade for a fee to see the city, which we paid, but the hotel is surrounded by taller buildings, so we paid to see the sides of other hotels and parking garage."

Reviewed on Jun 8, 2026

Hyatt Place Nashville Downtown
Margaritaville Beach Resort South Padre Island

Margaritaville Beach Resort South Padre Island

4 out of 5
310 Padre Blvd South Padre Island TX
  • 18 hours drive from Great Smoky Mountains National Park
Book a stay at this beach hotel in South Padre Island. Enjoy a full-service spa, a beach locale, and breakfast (surcharge). Our guests praise the pool and the ...
8.6/10 Excellent! (2,311 reviews)
"Clean room, great staff and nice restaurants"

Reviewed on Jun 8, 2026

Margaritaville Beach Resort South Padre Island
Freehand Chicago

Freehand Chicago

4 out of 5
19 East Ohio Street Chicago IL
  • 18 hours drive from Great Smoky Mountains National Park
Stay at this hotel in Chicago. Enjoy free WiFi, room service, and a 24-hour fitness center. Our guests praise the helpful staff and the clean rooms in our reviews. ...
8/10 Very Good! (3,081 reviews)
"The room was okay, not very spacious, didn't have any soap in the shower, otherwise was okay."

Reviewed on Jun 8, 2026

Freehand Chicago
Placemakr Premier SoBro

Placemakr Premier SoBro

4 out of 5
205 Demonbreun St Nashville TN
  • 54 min drive from Great Smoky Mountains National Park
Stay at this aparthotel in Nashville. Enjoy free WiFi, a rooftop terrace, and room service. Our guests praise the pool and the helpful staff in our reviews. ...
9.4/10 Exceptional! (3,491 reviews)
"Not every room is set up like the photo and that's very inconvenient if you're looking for something specific."

Reviewed on Jun 8, 2026

Placemakr Premier SoBro
Best Western Downtown Plus Music Row

Best Western Downtown Plus Music Row

3.5 out of 5
1407 Division Street Nashville TN
  • 1 hour drive from Great Smoky Mountains National Park
Book a stay at this family-friendly hotel in Nashville. Enjoy free breakfast, an outdoor pool, and a fitness center. Our guests praise the breakfast and the ...
8.8/10 Excellent! (3,702 reviews)
"The hotel was in a safe nationhood and the rooms were very clean and updated!"

Reviewed on Jun 8, 2026

Best Western Downtown Plus Music Row
Sand Rose Beach Resort

Sand Rose Beach Resort

3 out of 5
7000 Padre Blvd South Padre Island TX
  • 19 hours drive from Great Smoky Mountains National Park
Book a stay at this beach hotel in South Padre Island. Enjoy free breakfast, free WiFi, and a beach locale. Our guests praise the breakfast and the helpful staff ...
8.6/10 Excellent! (3,236 reviews)
"Staff should acknowledge one someone is speaking to them, they were paying more attention to their cell and to other personal conversations among themselves. I had to go to the Starbucks area, to have someone help me, because the person that was at the check in station would not acknowledge I was ..."

Reviewed on Jun 7, 2026

Sand Rose Beach Resort
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find cheap hotels in Central United States

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For you, intrepid voyager, Hotwire has a large selection of the best hotels in Central United States.

Choosing the right hotel in has everything to do with the way you want your trip to go. If you’ve scribbled a few obscure destinations on your itinerary, you probably already have a good sense of how your getaway is taking shape. Lean into that by booking one of Central United States’s 312,894 hotels. Choose the one that best catches your trip’s tourist drift.

If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $119. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get great Central United States hotel deals at the last minute.

While traveling, where you stay plays a major role in your overall vacation enjoyment. Choosing the right hotel is just as important as making sure you book the right flight and car rental. If you’re traveling with family or friends, you may need to book a hotel with connecting rooms. If you enjoy an elegant and relaxing hotel ambiance, opt for one of Hotwire’s luxury hotels in Central United States. No matter your reason for visiting Central United States, with Hotwire’s large selection of hotels in the area, you’re sure to book a hotel that meets all your accommodation needs.

Frequently Asked Questions About Central United States hotels

Where can I find the best last-minute travel deals?

If you’re traveling in the spirit of spontaneity, you’ll love the idea of leaving your exact hotel choice up to chance. With Hotwire Hot Rates, you can unlock great deals on your next flight, hotel, or car rental. Just plug in your general preferences and let Hotwire choose last-minute hotel deals in Central United States for as low as $119.

How many hotels are there in Central United States?

With over 312,894 hotels in Central United States, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $119.

How to find cheap car rentals in Central United States?

Finding a cheap car rental deal in Central United States is as easy as scoring cheap hotels in Central United States. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can unlock great car rental deals if you book a Hotwire Hot Rate at the last minute.