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Hotels in Central United States

Choose from 286903 Central United States Hotel Deals

Congress Plaza Hotel
Congress Plaza Hotel
3.5 out of 5
520 South Michigan Avenue, Chicago, IL
  • 18 hours drive from Great Smoky Mountains National Park
Book a stay at this business-friendly hotel in Chicago. Enjoy free WiFi, 2 restaurants, and 2 bars/lounges. Our guests praise the helpful staff and the clean ...
7.8/10 Good! (8,797 reviews)
"Great experience overall. Rooms were “modern” compared to beautiful lobby and building. Rooms ad beautiful view of Millenium park."

Reviewed on May 11, 2025

Congress Plaza Hotel
Embassy Suites by Hilton Chicago Downtown River North
Embassy Suites by Hilton Chicago Downtown River North
4 out of 5
600 N State St, Chicago, IL
  • 18 hours drive from Great Smoky Mountains National Park
Stay at this 4-star hotel in Chicago. Enjoy free breakfast, room service, and a fitness center. Our guests praise the breakfast and the pool in our reviews. ...
8.2/10 Very Good! (4,024 reviews)
"Need bigger sign of parking"

Reviewed on May 9, 2025

Embassy Suites by Hilton Chicago Downtown River North
Hilton Chicago/Magnificent Mile Suites
Hilton Chicago/Magnificent Mile Suites
3.5 out of 5
198 E Delaware Pl, Chicago, IL
  • 18 hours drive from Great Smoky Mountains National Park
Book a stay at this business-friendly hotel in Chicago. Enjoy a fitness center, valet parking (surcharge), and a 24-hour front desk. Our guests praise the helpful ...
8.8/10 Excellent! (2,206 reviews)
"Lobby employees are fantastic"

Reviewed on May 11, 2025

Hilton Chicago/Magnificent Mile Suites
Warwick Allerton - Chicago
Warwick Allerton - Chicago
4 out of 5
701 North Michigan Avenue, Chicago, IL
  • 18 hours drive from Great Smoky Mountains National Park
Stay at this 4-star family-friendly hotel in Chicago. Enjoy a 24-hour fitness center, valet parking (surcharge), and in-room massages. Our guests praise the ...
8/10 Very Good! (2,851 reviews)
"Great little spot in the middle of the city. Conveniently located to all the places"

Reviewed on May 8, 2025

Warwick Allerton - Chicago
The Westin Michigan Avenue Chicago
The Westin Michigan Avenue Chicago
4.5 out of 5
909 North Michigan Ave, Chicago, IL
  • 18 hours drive from Great Smoky Mountains National Park
Stay at this 4.5-star luxury hotel in Chicago. Enjoy a full-service spa, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the helpful staff ...
8.6/10 Excellent! (1,008 reviews)
"We had classes at the John Hancock Center. This hotel was directly across the street! The staff were nice. Dining was a little confusing as there is one entrance for breakfast and a different entrance for the same restaurant for dinner. I would definitely stay here again!"

Reviewed on May 11, 2025

The Westin Michigan Avenue Chicago
Wyndham New Orleans - French Quarter
Wyndham New Orleans - French Quarter
4 out of 5
124 Royal St, New Orleans, LA
  • 15 hours drive from Great Smoky Mountains National Park
Book a stay at this business-friendly hotel in New Orleans. Enjoy free WiFi, a fitness center, and valet parking (surcharge). Our guests praise the pool and ...
8.6/10 Excellent! (3,913 reviews)
"Location is great for walking to sight see."

Reviewed on May 9, 2025

Wyndham New Orleans - French Quarter
Bourbon Orleans Hotel
Bourbon Orleans Hotel
4 out of 5
717 Orleans St., New Orleans, LA
  • 15 hours drive from Great Smoky Mountains National Park
Book a stay at this historic hotel in New Orleans. Enjoy free WiFi, breakfast (surcharge), and a fitness center. Our guests praise the pool and the bar in our ...
9/10 Wonderful! (3,770 reviews)
Bourbon Street Fun!
"Central location was good for Bourbon Street, Jackson Park, and other French Quarter sites. Petite king room was tiny so trust the description. The Bellman was nice and helpful. Check in was not great as our room was delayed and the manager was not helpful. The nightclub had good entertainment."

Reviewed on May 9, 2025

Bourbon Orleans Hotel
Riverwalk Plaza
Riverwalk Plaza
4 out of 5
100 Villita Street, Dwyer/Main Plaza, San Antonio, TX
  • 25 hours drive from Great Smoky Mountains National Park
Stay at this 4-star family-friendly hotel in San Antonio. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the restaurant and the ...
8/10 Very Good! (5,168 reviews)
"Very nice room. Close to Riverwalk."

Reviewed on May 9, 2025

Riverwalk Plaza
Cambria Hotel Nashville Midtown
Cambria Hotel Nashville Midtown
3 out of 5
1612 Church Street, Nashville, TN
  • 56 min drive from Great Smoky Mountains National Park
Stay at this 3-star business-friendly hotel in Nashville. Enjoy free WiFi, 2 restaurants, and 2 bars/lounges. Our guests praise the helpful staff and the clean ...
8.8/10 Excellent! (785 reviews)
"Very nice staff! Everyone was very helpful and friendly. The room was beautiful and very spacious. Close proximity to downtown; just a quick uber ride away to all the best stuff in Nashville!"

Reviewed on May 11, 2025

Cambria Hotel Nashville Midtown
Margaritaville Beach Resort South Padre Island
Margaritaville Beach Resort South Padre Island
4 out of 5
310 Padre Blvd, South Padre Island, TX
  • 18 hours drive from Great Smoky Mountains National Park
Stay at this 4-star beach hotel in South Padre Island. Enjoy a full-service spa, a beach locale, and breakfast (surcharge). Our guests praise the pool and the ...
8.6/10 Excellent! (1,244 reviews)
"The pool bar is great when its open"

Reviewed on May 8, 2025

Margaritaville Beach Resort South Padre Island
Gaylord Opryland Resort & Convention Center
Gaylord Opryland Resort & Convention Center
4 out of 5
2800 Opryland Drive, Nashville, TN
Stay at this 4-star spa resort in Nashville. Enjoy 2 outdoor pools, a full-service spa, and 18 restaurants. Our guests praise the helpful staff and the clean ...
8.6/10 Excellent! (1,619 reviews)
"I loved everything about it! It was amazing and breath taking"

Reviewed on May 6, 2025

Gaylord Opryland Resort & Convention Center
Club Quarters Hotel Downtown, Houston
Club Quarters Hotel Downtown, Houston
4 out of 5
1085 Rusk Street, Houston, TX
  • 18 hours drive from Great Smoky Mountains National Park
Stay at this 4-star business-friendly hotel in Houston. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the restaurant and the helpful ...
8.2/10 Very Good! (3,319 reviews)
"Great stay for the price. Very convenient for astros and music hall! Would definitely stay here again."

Reviewed on May 10, 2025

Club Quarters Hotel Downtown, Houston
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find cheap hotels in Central United States

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For you, intrepid voyager, Hotwire has a large selection of the best hotels in Central United States.

Choosing the right hotel in has everything to do with the way you want your trip to go. If you’ve scribbled a few obscure destinations on your itinerary, you probably already have a good sense of how your getaway is taking shape. Lean into that by booking one of Central United States’s 286,903 hotels. Choose the one that best catches your trip’s tourist drift.

If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as . In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get great Central United States hotel deals at the last minute.

While traveling, where you stay plays a major role in your overall vacation enjoyment. Choosing the right hotel is just as important as making sure you book the right flight and car rental. If you’re traveling with family or friends, you may need to book a hotel with connecting rooms. If you enjoy an elegant and relaxing hotel ambiance, opt for one of Hotwire’s luxury hotels in Central United States. No matter your reason for visiting Central United States, with Hotwire’s large selection of hotels in the area, you’re sure to book a hotel that meets all your accommodation needs.

Frequently Asked Questions About Central United States hotels

Where can I find the best last-minute travel deals?

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How many hotels are there in Central United States?

With over 286,903 hotels in Central United States, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as .

How to find cheap car rentals in Central United States?

Finding a cheap car rental deal in Central United States is as easy as scoring cheap hotels in Central United States. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can unlock great car rental deals if you book a Hotwire Hot Rate at the last minute.