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Hotels in Central United States

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Congress Plaza Hotel

Congress Plaza Hotel

3.5 out of 5
520 South Michigan Avenue Chicago IL
  • 18 hours drive from Great Smoky Mountains National Park
Book a stay at this business-friendly hotel in Chicago. Enjoy 2 restaurants, 2 bars/lounges, and breakfast (surcharge). Our guests praise the helpful staff and ...
8/10 Very Good! (10,185 reviews)
"Al momento de realizar la reserva se nos informó que el desayuno tipo buffet estaba incluido. Sin embargo, cuando bajamos al restaurante del hotel nos indicaron que no estaba incluido y que debíamos pagarlo aparte, lo cual fue una sorpresa desagradable. Además, las instalaciones del hotel se encuentran ..."

Reviewed on Jun 7, 2026

Congress Plaza Hotel
The Chicago Hotel Collection - Magnificent Mile

The Chicago Hotel Collection - Magnificent Mile

4 out of 5
166 E Superior Street Chicago IL
  • 18 hours drive from Great Smoky Mountains National Park
Book a stay at this boutique hotel in Chicago. Enjoy free WiFi, 2 restaurants, and 2 bars/lounges. Our guests praise the helpful staff and the clean rooms in ...
7.8/10 Good! (1,526 reviews)
"The room was clean not as spacious but great view. The bar was fun!"

Reviewed on Jun 6, 2026

The Chicago Hotel Collection - Magnificent Mile
Hyatt Regency O'Hare Chicago

Hyatt Regency O'Hare Chicago

4 out of 5
9300 Bryn Mawr Ave Rosemont IL
  • 18 hours drive from Great Smoky Mountains National Park
Book a stay at this business-friendly hotel in Rosemont. Enjoy free WiFi, breakfast (surcharge), and a free airport shuttle. Our guests praise the helpful staff ...
8.8/10 Excellent! (2,622 reviews)
"Nice place"

Reviewed on Jun 7, 2026

Hyatt Regency O'Hare Chicago
Hotel Riu Plaza Chicago

Hotel Riu Plaza Chicago

4 out of 5
150 East Ontario Street Chicago IL
  • 18 hours drive from Great Smoky Mountains National Park
Book a stay at this business-friendly hotel in Chicago. Enjoy free breakfast, free WiFi, and 2 bars/lounges. Popular attractions Michigan Avenue and Chicago ...
9.4/10 Exceptional! (4,362 reviews)
"Excelente ubicación, las instalaciones limpias y recientes, y todo el personal muy amable. Lo recomiendo ampliamente."

Reviewed on Jun 6, 2026

Hotel Riu Plaza Chicago
Hyatt Place Nashville Downtown

Hyatt Place Nashville Downtown

3 out of 5
301 3rd Ave S Nashville TN
  • 55 min drive from Great Smoky Mountains National Park
Book a stay at this business-friendly hotel in Nashville. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast and ...
9.2/10 Wonderful! (6,100 reviews)
"staff was really great"

Reviewed on Jun 7, 2026

Hyatt Place Nashville Downtown
The Chicago Hotel Collection Ambassador Gold Coast

The Chicago Hotel Collection Ambassador Gold Coast

4 out of 5
1301 N State Pkwy Chicago IL
  • 18 hours drive from Great Smoky Mountains National Park
Book a stay at this business-friendly hotel in Chicago. Enjoy free WiFi, a 24-hour fitness center, and valet parking (surcharge). Our guests praise the helpful ...
8.2/10 Very Good! (1,554 reviews)
"Great stay! I wasn’t sure what to expect since I didn’t know much about the hotel beforehand, but I was pleasantly surprised. The staff was friendly and welcoming, especially the team at the bar, who provided excellent service throughout our stay. The rooms were spacious and comfortable, with plenty ..."

Reviewed on Jun 7, 2026

The Chicago Hotel Collection Ambassador Gold Coast
Beachside Resort Hotel

Beachside Resort Hotel

2 out of 5
610 W Beach Blvd Gulf Shores AL
  • 14 hours drive from Great Smoky Mountains National Park
Stay at this hotel in Gulf Shores. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the pool and the helpful staff in our reviews. ...
8/10 Very Good! (1,653 reviews)
"Room was fine but property in need of TLC!"

Reviewed on Jun 6, 2026

Beachside Resort Hotel
Margaritaville Beach Resort South Padre Island

Margaritaville Beach Resort South Padre Island

4 out of 5
310 Padre Blvd South Padre Island TX
  • 18 hours drive from Great Smoky Mountains National Park
Book a stay at this beach hotel in South Padre Island. Enjoy a full-service spa, a beach locale, and breakfast (surcharge). Our guests praise the pool and the ...
8.6/10 Excellent! (2,306 reviews)
"The pool and staff were nice. Margaritaville no longer has access to the Sapphire gym. When my husband asked about it they just said they don’t have access anymore. Later on, we found out you can get vouchers to Shoreline Barbell Club in Port Isabel. That would have been helpful to know. The grounds ..."

Reviewed on Jun 6, 2026

Margaritaville Beach Resort South Padre Island
Hotel Zaza Houston Museum District

Hotel Zaza Houston Museum District

4.5 out of 5
5701 Main Street Houston TX
  • 18 hours drive from Great Smoky Mountains National Park
Book a stay at this luxury hotel in Houston. Enjoy free WiFi, a full-service spa, and breakfast (surcharge). Our guests praise the helpful staff in our reviews. ...
9.2/10 Wonderful! (1,012 reviews)
"Overall great hotel. Definitely will be staying here again. Shout out to the staff crew."

Reviewed on May 30, 2026

Hotel Zaza Houston Museum District
Placemakr Premier SoBro

Placemakr Premier SoBro

4 out of 5
205 Demonbreun St Nashville TN
  • 54 min drive from Great Smoky Mountains National Park
Stay at this aparthotel in Nashville. Enjoy free WiFi, a rooftop terrace, and room service. Our guests praise the pool and the helpful staff in our reviews. ...
9.4/10 Exceptional! (3,485 reviews)
"Have stayed here multiple times and will continue to stay at placemakr but they need to do better about pool towels. Other than that. Great stay, great proximity to everything downtown and surrounding neighborhoods."

Reviewed on Jun 6, 2026

Placemakr Premier SoBro
Sand Rose Beach Resort

Sand Rose Beach Resort

3 out of 5
7000 Padre Blvd South Padre Island TX
  • 19 hours drive from Great Smoky Mountains National Park
Book a stay at this beach hotel in South Padre Island. Enjoy free breakfast, free WiFi, and a beach locale. Our guests praise the breakfast and the helpful staff ...
8.6/10 Excellent! (3,225 reviews)
"Was told there would be a hot tub there wasn’t any. Wasn’t a lot of help either. Towels weren’t clean all the way. And you have to pay for parking which makes no sense. If I’m staying there. Pool wasn’t clean couldn’t get in."

Reviewed on Jun 6, 2026

Sand Rose Beach Resort
Best Western Downtown Plus Music Row

Best Western Downtown Plus Music Row

3.5 out of 5
1407 Division Street Nashville TN
  • 1 hour drive from Great Smoky Mountains National Park
Book a stay at this family-friendly hotel in Nashville. Enjoy free breakfast, an outdoor pool, and a fitness center. Our guests praise the breakfast and the ...
8.8/10 Excellent! (3,690 reviews)
"The location is convenient but the property requires repairs and upgrades."

Reviewed on Jun 6, 2026

Best Western Downtown Plus Music Row
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find cheap hotels in Central United States

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Choosing the right hotel in has everything to do with the way you want your trip to go. If you’ve scribbled a few obscure destinations on your itinerary, you probably already have a good sense of how your getaway is taking shape. Lean into that by booking one of Central United States’s 312,894 hotels. Choose the one that best catches your trip’s tourist drift.

If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $119. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get great Central United States hotel deals at the last minute.

While traveling, where you stay plays a major role in your overall vacation enjoyment. Choosing the right hotel is just as important as making sure you book the right flight and car rental. If you’re traveling with family or friends, you may need to book a hotel with connecting rooms. If you enjoy an elegant and relaxing hotel ambiance, opt for one of Hotwire’s luxury hotels in Central United States. No matter your reason for visiting Central United States, with Hotwire’s large selection of hotels in the area, you’re sure to book a hotel that meets all your accommodation needs.

Frequently Asked Questions About Central United States hotels

Where can I find the best last-minute travel deals?

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How many hotels are there in Central United States?

With over 312,894 hotels in Central United States, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $119.

How to find cheap car rentals in Central United States?

Finding a cheap car rental deal in Central United States is as easy as scoring cheap hotels in Central United States. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can unlock great car rental deals if you book a Hotwire Hot Rate at the last minute.