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Hotels in Central United States

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Choose from 287510 Central United States Hotel Deals

Congress Plaza Hotel
Congress Plaza Hotel
3.5 out of 5
520 South Michigan Avenue, Chicago, IL
  • 18 hours drive from Great Smoky Mountains National Park
Book a stay at this business-friendly hotel in Chicago. Enjoy free WiFi, 2 restaurants, and 2 bars/lounges. Our guests praise the helpful staff and the clean ...
7.8/10 Good! (8,856 reviews)
"Always a great choice."

Reviewed on May 17, 2025

Congress Plaza Hotel
Margaritaville Resort Biloxi
Margaritaville Resort Biloxi
3.5 out of 5
195 Beach Blvd, Biloxi, MS
  • 13 hours drive from Great Smoky Mountains National Park
Stay at this 3.5-star beach hotel in Biloxi. Enjoy free WiFi, an outdoor pool, and 3 restaurants. Our guests praise the pool and the helpful staff in our reviews. ...
8.6/10 Excellent! (4,571 reviews)
"Always loved this property"

Reviewed on May 16, 2025

Margaritaville Resort Biloxi
Warwick Allerton - Chicago
Warwick Allerton - Chicago
4 out of 5
701 North Michigan Avenue, Chicago, IL
  • 18 hours drive from Great Smoky Mountains National Park
Stay at this 4-star family-friendly hotel in Chicago. Enjoy a 24-hour fitness center, valet parking (surcharge), and in-room massages. Our guests praise the ...
8/10 Very Good! (2,866 reviews)
"Great"

Reviewed on May 15, 2025

Warwick Allerton - Chicago
Ambassador Hotel Chicago
Ambassador Hotel Chicago
4 out of 5
1301 N State Pkwy, Chicago, IL
  • 18 hours drive from Great Smoky Mountains National Park
Stay at this 4-star business-friendly hotel in Chicago. Enjoy free WiFi, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the helpful staff ...
8.4/10 Very Good! (1,024 reviews)
"Beautiful hotel in a nice neighborhood of Chicago"

Reviewed on May 15, 2025

Ambassador Hotel Chicago
River Hotel
River Hotel
4 out of 5
75 East Wacker Drive, Chicago, IL
  • 18 hours drive from Great Smoky Mountains National Park
Stay at this 4-star business-friendly hotel in Chicago. Enjoy free WiFi, room service, and a fitness center. Our guests praise the helpful staff and the clean ...
8.6/10 Excellent! (4,166 reviews)
"I liked it because I could go for a walk, the room was clean, and I didn't find anything negative."

Reviewed on May 16, 2025

River Hotel
citizenM Chicago Downtown
citizenM Chicago Downtown
4 out of 5
80 East Wacker Place, Chicago, IL
  • 18 hours drive from Great Smoky Mountains National Park
Stay at this 4-star business-friendly hotel in Chicago. Enjoy free WiFi, breakfast (surcharge), and a fitness center. Our guests praise the breakfast and the ...
9.2/10 Wonderful! (3,056 reviews)
Great place to stay in downtown Chicago!
"Great location in a great city. Don’t miss Citizen M’s breakfast buffet! It was a great way to start the day."

Reviewed on May 15, 2025

citizenM Chicago Downtown
Wyndham New Orleans - French Quarter
Wyndham New Orleans - French Quarter
4 out of 5
124 Royal St, New Orleans, LA
  • 15 hours drive from Great Smoky Mountains National Park
Book a stay at this business-friendly hotel in New Orleans. Enjoy free WiFi, a fitness center, and valet parking (surcharge). Our guests praise the pool and ...
8.6/10 Excellent! (3,930 reviews)
"Great location"

Reviewed on May 15, 2025

Wyndham New Orleans - French Quarter
Cambria Hotel Nashville Midtown
Cambria Hotel Nashville Midtown
3 out of 5
1612 Church Street, Nashville, TN
  • 56 min drive from Great Smoky Mountains National Park
Stay at this 3-star business-friendly hotel in Nashville. Enjoy free WiFi, 2 restaurants, and 2 bars/lounges. Our guests praise the helpful staff and the clean ...
8.8/10 Excellent! (801 reviews)
"Nice hotel. Very clean and close to night life"

Reviewed on May 17, 2025

Cambria Hotel Nashville Midtown
Riverwalk Plaza
Riverwalk Plaza
4 out of 5
100 Villita Street, Dwyer/Main Plaza, San Antonio, TX
  • 25 hours drive from Great Smoky Mountains National Park
Stay at this 4-star family-friendly hotel in San Antonio. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the restaurant and the ...
8/10 Very Good! (5,216 reviews)
"Excellent location"

Reviewed on May 14, 2025

Riverwalk Plaza
Bourbon Orleans Hotel
Bourbon Orleans Hotel
4 out of 5
717 Orleans St., New Orleans, LA
  • 15 hours drive from Great Smoky Mountains National Park
Book a stay at this historic hotel in New Orleans. Enjoy free WiFi, breakfast (surcharge), and a fitness center. Our guests praise the pool and the bar in our ...
9/10 Wonderful! (3,791 reviews)
"Fun haunted hotel. Location was great!"

Reviewed on May 15, 2025

Bourbon Orleans Hotel
Knights Inn Nashville
Knights Inn Nashville
1.5 out of 5
99 Spring St, Nashville, TN
  • 33 min drive from Great Smoky Mountains National Park
Book a stay at this business-friendly motel in Nashville. Enjoy free breakfast, free WiFi, and parking (surcharge). Our guests praise the breakfast and the helpful ...
7.4/10 Good! (3,063 reviews)
Great place for the value
"It’s was nice. Little over priced but a concert was going on during my stay."

Reviewed on May 16, 2025

Knights Inn Nashville
Gaylord Opryland Resort & Convention Center
Gaylord Opryland Resort & Convention Center
4 out of 5
2800 Opryland Drive, Nashville, TN
Stay at this 4-star spa resort in Nashville. Enjoy 2 outdoor pools, a full-service spa, and 18 restaurants. Our guests praise the helpful staff and the clean ...
8.6/10 Excellent! (1,628 reviews)
"Inside the hotel had waterfalls, lush gardens & beautiful walkways. Also many restaurants, shops, pools and a water park. It was wonderful!"

Reviewed on May 13, 2025

Gaylord Opryland Resort & Convention Center
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find cheap hotels in Central United States

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Frequently Asked Questions About Central United States hotels

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How many hotels are there in Central United States?

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How to find cheap car rentals in Central United States?

Finding a cheap car rental deal in Central United States is as easy as scoring cheap hotels in Central United States. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can unlock great car rental deals if you book a Hotwire Hot Rate at the last minute.