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5 Star Hotels in Central United States

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Featured 5 Star Central United States Hotels

The Roosevelt New Orleans, A Waldorf Astoria Hotel
5 out of 5
Fully refundableReserve now, pay when you stay
The price is $251 per night from Oct 2 to Oct 3
$251
includes taxes & fees
Oct 2 - Oct 3
Stay at this 5-star luxury hotel in New Orleans. Enjoy a full-service spa, 4 restaurants, and 2 bars/lounges. Our guests praise the helpful staff and the clean ...
The Roosevelt New Orleans, A Waldorf Astoria Hotel
Trump International Hotel & Tower Chicago
5 out of 5
Fully refundableReserve now, pay when you stay
  • 36 hours drive from Port of Galveston Cruise Terminal
The price is $506 per night from Sep 29 to Sep 30
$506
includes taxes & fees
Sep 29 - Sep 30
Stay at this 5-star luxury hotel in Chicago. Enjoy free WiFi, a full-service spa, and breakfast (surcharge). Our guests praise the helpful staff and the clean ...
Trump International Hotel & Tower Chicago
The Joule
5 out of 5
Fully refundableReserve now, pay when you stay
  • 9 hours drive from Port of Galveston Cruise Terminal
The price is $351 per night from Sep 29 to Sep 30
$351
includes taxes & fees
Sep 29 - Sep 30
Stay at this 5-star luxury hotel in Dallas. Enjoy free WiFi, an outdoor pool, and a full-service spa. Our guests praise the helpful staff and the clean rooms ...
The Joule
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The Peninsula Chicago
5 out of 5
Fully refundableReserve now, pay when you stay
  • 36 hours drive from Port of Galveston Cruise Terminal
The price is $675 per night from Sep 22 to Sep 23
$675
includes taxes & fees
Sep 22 - Sep 23
Stay at this 5-star luxury hotel in Chicago. Enjoy free WiFi, a full-service spa, and 2 restaurants. Our guests praise the helpful staff and the property condition ...
The Peninsula Chicago
The Windsor Court
5 out of 5
Fully refundableReserve now, pay when you stay
The price is $434 per night from Sep 29 to Sep 30
$434
includes taxes & fees
Sep 29 - Sep 30
Book a stay at this spa hotel in New Orleans. Enjoy a full-service spa, 2 bars/lounges, and breakfast (surcharge). Popular attractions Caesars New Orleans Casino ...
The Windsor Court
The Langham, Chicago
5 out of 5
Fully refundableReserve now, pay when you stay
  • 36 hours drive from Port of Galveston Cruise Terminal
The price is $646 per night from Sep 22 to Sep 23
$646
includes taxes & fees
Sep 22 - Sep 23
Stay at this 5-star luxury hotel in Chicago. Enjoy free WiFi, a full-service spa, and breakfast (surcharge). Our guests praise the helpful staff and the clean ...
The Langham, Chicago
The Adolphus, Autograph Collection
5 out of 5
  • 9 hours drive from Port of Galveston Cruise Terminal
The price is $297 per night from Oct 5 to Oct 6
$297
includes taxes & fees
Oct 5 - Oct 6
Book a stay at this spa hotel in Dallas. Enjoy a full-service spa, 4 restaurants, and 3 bars/lounges. Our guests praise the helpful staff and the property condition ...
The Adolphus, Autograph Collection
Four Seasons Hotel New Orleans
5 out of 5
Fully refundableReserve now, pay when you stay
The price is $455 per night from Oct 14 to Oct 15
$455
includes taxes & fees
Oct 14 - Oct 15
Stay at this 5-star luxury hotel in New Orleans. Enjoy free WiFi, a full-service spa, and breakfast (surcharge). Our guests praise the bar and the helpful staff ...
Four Seasons Hotel New Orleans
Rosewood Mansion on Turtle Creek
5 out of 5
Fully refundableReserve now, pay when you stay
  • 10 hours drive from Port of Galveston Cruise Terminal
The price is $612 per night from Sep 30 to Oct 1
$612
includes taxes & fees
Sep 30 - Oct 1
Book a stay at this luxury aparthotel in Dallas. Enjoy free WiFi, a full-service spa, and breakfast (surcharge). Our guests praise the helpful staff and the ...
Rosewood Mansion on Turtle Creek
InterContinental Minneapolis - St. Paul Airport, an IHG Hotel
5 out of 5
Fully refundable
  • 43 hours drive from Port of Galveston Cruise Terminal
The price is $278 per night from Sep 27 to Sep 28
$278
includes taxes & fees
Sep 27 - Sep 28
Stay at this 5-star luxury hotel in Minneapolis. Enjoy free WiFi, breakfast (surcharge), and a free airport shuttle. Our guests praise the restaurant and the ...
InterContinental Minneapolis - St. Paul Airport, an IHG Hotel
Waldorf Astoria Chicago
5 out of 5
Fully refundableReserve now, pay when you stay
  • 36 hours drive from Port of Galveston Cruise Terminal
The price is $599 per night from Sep 29 to Sep 30
$599
includes taxes & fees
Sep 29 - Sep 30
Stay at this 5-star luxury hotel in Chicago. Enjoy free WiFi, a full-service spa, and breakfast (surcharge). Our guests praise the helpful staff in our reviews. ...
Waldorf Astoria Chicago
1 Hotel Nashville
5 out of 5
Fully refundableReserve now, pay when you stay
  • 19 hours drive from Port of Galveston Cruise Terminal
The price is $325 per night from Sep 22 to Sep 23
$325
includes taxes & fees
Sep 22 - Sep 23
Stay at this 5-star luxury hotel in Nashville. Enjoy free WiFi, a full-service spa, and 2 restaurants. Our guests praise the helpful staff and the property condition ...
1 Hotel Nashville
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5-Star Hotel in Central United States

It’s time. No more meh motels and so-so stays. This vacation it’s all about living it up, and that starts with a great hotel. You want first-class service and award-winning restaurants. Well, let us introduce you to a 5-star hotel in Central United States.

So nice you’ll blink twice

What makes a hotel worthy of supreme star-age? For starters, the service has to be top-notch and personalized. These hotels often have 24-hour room service, a welcome gift upon your arrival, and help you with your bags—even if you travel light.

Are they nicer? Heck yeah, they are! Most 5-star hotels have jaw-dropping aesthetics that give an authentic feel of class. And we’re not talking about that faux-gold soap dish your Aunt Tilda puts out for the guests—it’s the real deal.

Stars in your eyes

Are 5-stars hotels worth it? If you like the finer things in life, then yes, they sure are. But we also know you’re the type that likes to get your caviar on a fish stick budget. We’re right there with you, and that is why we make it easy to find the best 5-star hotel in Central United States for you. Sort by:

  • Price: Want to live large, but keep that budget balanced? We got you. We have 5-star hotels starting at $251.

  • Amenities: Central United States skyline view? Maybe a heated indoor pool? Looking for a Michelin-star restaurant? Search for the hotels that have the amenities you desire.

  • Hotwire Hot Rate: We’ll tell you the name of the hotel after you book, and you might just save a ton.

When you’re looking for the top 5-star hotels in Central United States—but don’t want to pay top dollar—let us help you out. You can get that posh palace of your dreams, and have money left to take on Central United States your way.