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5 Star Hotels in Central United States

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Featured 5 Star Central United States Hotels

The Roosevelt New Orleans, A Waldorf Astoria Hotel
5 out of 5
The price is $341 per night from Feb 24 to Feb 25
$341
includes taxes & fees
Feb 24 - Feb 25
Stay at this 5-star luxury hotel in New Orleans. Enjoy a full-service spa, 4 restaurants, and 2 bars/lounges. Our guests praise the helpful staff and the clean ...
The Roosevelt New Orleans, A Waldorf Astoria Hotel
Four Seasons Hotel Chicago
5 out of 5
Fully refundableReserve now, pay when you stay
  • 36 hours drive from Port of Galveston Cruise Terminal
The price is $487 per night from Mar 2 to Mar 3
$487
includes taxes & fees
Mar 2 - Mar 3
Stay at this 5-star luxury hotel in Chicago. Enjoy free WiFi, a full-service spa, and breakfast (surcharge). Our guests praise the helpful staff and the property ...
Four Seasons Hotel Chicago
Trump International Hotel & Tower Chicago
5 out of 5
Fully refundableReserve now, pay when you stay
  • 36 hours drive from Port of Galveston Cruise Terminal
The price is $374 per night from Mar 2 to Mar 3
$374
includes taxes & fees
Mar 2 - Mar 3
Stay at this 5-star luxury hotel in Chicago. Enjoy free WiFi, a full-service spa, and breakfast (surcharge). Our guests praise the helpful staff and the clean ...
Trump International Hotel & Tower Chicago
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The Windsor Court
5 out of 5
The price is $483 per night from Mar 5 to Mar 6
$483
includes taxes & fees
Mar 5 - Mar 6
Stay at this 5-star luxury hotel in New Orleans. Enjoy a full-service spa, 2 bars/lounges, and breakfast (surcharge). Popular attractions Caesars New Orleans ...
The Windsor Court
The Langham, Chicago
5 out of 5
Fully refundableReserve now, pay when you stay
  • 36 hours drive from Port of Galveston Cruise Terminal
The price is $460 per night from Mar 23 to Mar 24
$460
includes taxes & fees
Mar 23 - Mar 24
Stay at this 5-star luxury hotel in Chicago. Enjoy free WiFi, a full-service spa, and breakfast (surcharge). Our guests praise the helpful staff and the clean ...
The Langham, Chicago
1 Hotel Nashville
5 out of 5
Fully refundableReserve now, pay when you stay
  • 19 hours drive from Port of Galveston Cruise Terminal
The price is $299 per night from Feb 23 to Feb 24
$299
includes taxes & fees
Feb 23 - Feb 24
Stay at this 5-star luxury hotel in Nashville. Enjoy free WiFi, a full-service spa, and 2 restaurants. Our guests praise the helpful staff and the property condition ...
1 Hotel Nashville
Conrad Nashville
5 out of 5
Fully refundableReserve now, pay when you stay
  • 19 hours drive from Port of Galveston Cruise Terminal
The price is $349 per night from Mar 2 to Mar 3
$349
includes taxes & fees
Mar 2 - Mar 3
Stay at this 5-star luxury hotel in Nashville. Enjoy free WiFi, 2 restaurants, and breakfast (surcharge). Our guests praise the helpful staff and the clean rooms ...
Conrad Nashville
Waldorf Astoria Chicago
5 out of 5
Fully refundableReserve now, pay when you stay
  • 36 hours drive from Port of Galveston Cruise Terminal
The price is $423 per night from Mar 6 to Mar 7
$423
includes taxes & fees
Mar 6 - Mar 7
Stay at this 5-star luxury hotel in Chicago. Enjoy free WiFi, a full-service spa, and breakfast (surcharge). Our guests praise the helpful staff in our reviews. ...
Waldorf Astoria Chicago
Thompson San Antonio - Riverwalk, by Hyatt
5 out of 5
Fully refundableReserve now, pay when you stay
  • 5 hours drive from Port of Galveston Cruise Terminal
The price is $252 per night from Mar 9 to Mar 10
$252
includes taxes & fees
Mar 9 - Mar 10
Stay at this 5-star luxury hotel in San Antonio. Enjoy free WiFi, a full-service spa, and breakfast (surcharge). Our guests praise the bar and the helpful staff ...
Thompson San Antonio - Riverwalk, by Hyatt
Austin Proper Hotel, a Member of Design Hotels
5 out of 5
Fully refundableReserve now, pay when you stay
The price is $534 per night from Feb 23 to Feb 24
$534
includes taxes & fees
Feb 23 - Feb 24
Stay at this 5-star luxury hotel in Austin. Enjoy a full-service spa, 2 restaurants, and 2 bars/lounges. Popular attractions Sixth Street and Zilker Park are ...
Austin Proper Hotel, a Member of Design Hotels
Rosewood Mansion on Turtle Creek
5 out of 5
Fully refundableReserve now, pay when you stay
  • 10 hours drive from Port of Galveston Cruise Terminal
The price is $813 per night from Mar 16 to Mar 17
$813
includes taxes & fees
Mar 16 - Mar 17
Book a stay at this spa aparthotel in Dallas. Enjoy free WiFi, a full-service spa, and breakfast (surcharge). Our guests praise the helpful staff and the property ...
Rosewood Mansion on Turtle Creek
The Peninsula Chicago
5 out of 5
Fully refundableReserve now, pay when you stay
  • 36 hours drive from Port of Galveston Cruise Terminal
The price is $558 per night from Feb 23 to Feb 24
$558
includes taxes & fees
Feb 23 - Feb 24
Stay at this 5-star luxury hotel in Chicago. Enjoy free WiFi, a full-service spa, and 2 restaurants. Our guests praise the helpful staff and the property condition ...
The Peninsula Chicago
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5-Star Hotel in Central United States

It’s time. No more meh motels and so-so stays. This vacation it’s all about living it up, and that starts with a great hotel. You want first-class service and award-winning restaurants. Well, let us introduce you to a 5-star hotel in Central United States.

So nice you’ll blink twice

What makes a hotel worthy of supreme star-age? For starters, the service has to be top-notch and personalized. These hotels often have 24-hour room service, a welcome gift upon your arrival, and help you with your bags—even if you travel light.

Are they nicer? Heck yeah, they are! Most 5-star hotels have jaw-dropping aesthetics that give an authentic feel of class. And we’re not talking about that faux-gold soap dish your Aunt Tilda puts out for the guests—it’s the real deal.

Stars in your eyes

Are 5-stars hotels worth it? If you like the finer things in life, then yes, they sure are. But we also know you’re the type that likes to get your caviar on a fish stick budget. We’re right there with you, and that is why we make it easy to find the best 5-star hotel in Central United States for you. Sort by:

  • Price: Want to live large, but keep that budget balanced? We got you. We have 5-star hotels starting at $252.

  • Amenities: Central United States skyline view? Maybe a heated indoor pool? Looking for a Michelin-star restaurant? Search for the hotels that have the amenities you desire.

  • Hotwire Hot Rate: We’ll tell you the name of the hotel after you book, and you might just save a ton.

When you’re looking for the top 5-star hotels in Central United States—but don’t want to pay top dollar—let us help you out. You can get that posh palace of your dreams, and have money left to take on Central United States your way.