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5 Star Hotels in Central United States

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Tonight May 3 - May 4Next weekend May 9 - May 11

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Featured 5 Star Central United States Hotels

The Langham, Chicago
5 out of 5
Fully refundableReserve now, pay when you stay
  • 18 hours drive from Great Smoky Mountains National Park
The price is $557 per night from May 26 to May 27
$557
includes taxes & fees
May 26 - May 27
Stay at this 5-star luxury hotel in Chicago. Enjoy free WiFi, a full-service spa, and breakfast (surcharge). Our guests praise the helpful staff and the clean ...
The Langham, Chicago
Four Seasons Hotel Chicago
5 out of 5
Fully refundableReserve now, pay when you stay
  • 18 hours drive from Great Smoky Mountains National Park
The price is $593 per night from May 26 to May 27
$593
includes taxes & fees
May 26 - May 27
Stay at this 5-star luxury hotel in Chicago. Enjoy free WiFi, a full-service spa, and breakfast (surcharge). Our guests praise the helpful staff and the property ...
Four Seasons Hotel Chicago
The Roosevelt New Orleans, A Waldorf Astoria Hotel
5 out of 5
Fully refundableReserve now, pay when you stay
  • 15 hours drive from Great Smoky Mountains National Park
The price is $200 per night from May 26 to May 27
$200
includes taxes & fees
May 26 - May 27
Stay at this 5-star luxury hotel in New Orleans. Enjoy a full-service spa, 4 restaurants, and 2 bars/lounges. Our guests praise the helpful staff and the clean ...
The Roosevelt New Orleans, A Waldorf Astoria Hotel
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Conrad Nashville
5 out of 5
Fully refundableReserve now, pay when you stay
  • 59 min drive from Great Smoky Mountains National Park
The price is $398 per night from May 11 to May 12
$398
includes taxes & fees
May 11 - May 12
Stay at this 5-star luxury hotel in Nashville. Enjoy free WiFi, 2 restaurants, and breakfast (surcharge). Our guests praise the helpful staff and the clean rooms ...
Conrad Nashville
Trump International Hotel & Tower Chicago
5 out of 5
Fully refundableReserve now, pay when you stay
  • 18 hours drive from Great Smoky Mountains National Park
The price is $524 per night from May 11 to May 12
$524
includes taxes & fees
May 11 - May 12
Stay at this 5-star luxury hotel in Chicago. Enjoy free WiFi, a full-service spa, and breakfast (surcharge). Our guests praise the helpful staff and the clean ...
Trump International Hotel & Tower Chicago
1 Hotel Nashville
5 out of 5
  • 56 min drive from Great Smoky Mountains National Park
The price is $334 per night from May 11 to May 12
$334
includes taxes & fees
May 11 - May 12
Stay at this 5-star luxury hotel in Nashville. Enjoy free WiFi, a full-service spa, and 2 restaurants. Our guests praise the helpful staff and the property condition ...
1 Hotel Nashville
Waldorf Astoria Chicago
5 out of 5
  • 18 hours drive from Great Smoky Mountains National Park
The price is $545 per night from May 26 to May 27
$545
includes taxes & fees
May 26 - May 27
Stay at this 5-star luxury hotel in Chicago. Enjoy free WiFi, a full-service spa, and breakfast (surcharge). Our guests praise the helpful staff in our reviews. ...
Waldorf Astoria Chicago
The Peninsula Chicago
5 out of 5
Fully refundableReserve now, pay when you stay
  • 18 hours drive from Great Smoky Mountains National Park
The price is $675 per night from May 26 to May 27
$675
includes taxes & fees
May 26 - May 27
Stay at this 5-star luxury hotel in Chicago. Enjoy free WiFi, a full-service spa, and 2 restaurants. Our guests praise the helpful staff and the property condition ...
The Peninsula Chicago
Thompson San Antonio - Riverwalk, by Hyatt
5 out of 5
Fully refundableReserve now, pay when you stay
  • 25 hours drive from Great Smoky Mountains National Park
The price is $279 per night from Jun 1 to Jun 2
$279
includes taxes & fees
Jun 1 - Jun 2
Stay at this 5-star luxury hotel in San Antonio. Enjoy free WiFi, a full-service spa, and breakfast (surcharge). Our guests praise the bar and the helpful staff ...
Thompson San Antonio - Riverwalk, by Hyatt
The Ritz-Carlton, New Orleans
5 out of 5
Fully refundableReserve now, pay when you stay
  • 15 hours drive from Great Smoky Mountains National Park
The price is $329 per night from May 26 to May 27
$329
includes taxes & fees
May 26 - May 27
Stay at this 5-star luxury hotel in New Orleans. Enjoy a full-service spa, breakfast (surcharge), and 24-hour room service. Our guests praise the helpful staff ...
The Ritz-Carlton, New Orleans
Hotel Crescent Court
5 out of 5
The price is $417 per night from May 18 to May 19
$417
includes taxes & fees
May 18 - May 19
Stay at this 5-star luxury hotel in Dallas. Enjoy free WiFi, a full-service spa, and 3 restaurants. Our guests praise the helpful staff and the property condition ...
Hotel Crescent Court
The Post Oak Hotel at Uptown Houston
5 out of 5
  • 18 hours drive from Great Smoky Mountains National Park
The price is $632 per night from May 26 to May 27
$632
includes taxes & fees
May 26 - May 27
Stay at this 5-star luxury hotel in Houston. Enjoy free WiFi, a full-service spa, and 4 restaurants. Our guests praise the helpful staff and the room service ...
The Post Oak Hotel at Uptown Houston
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

5-Star Hotel in Central United States

It’s time. No more meh motels and so-so stays. This vacation it’s all about living it up, and that starts with a great hotel. You want first-class service and award-winning restaurants. Well, let us introduce you to a 5-star hotel in Central United States.

So nice you’ll blink twice

What makes a hotel worthy of supreme star-age? For starters, the service has to be top-notch and personalized. These hotels often have 24-hour room service, a welcome gift upon your arrival, and help you with your bags—even if you travel light.

Are they nicer? Heck yeah, they are! Most 5-star hotels have jaw-dropping aesthetics that give an authentic feel of class. And we’re not talking about that faux-gold soap dish your Aunt Tilda puts out for the guests—it’s the real deal.

Stars in your eyes

Are 5-stars hotels worth it? If you like the finer things in life, then yes, they sure are. But we also know you’re the type that likes to get your caviar on a fish stick budget. We’re right there with you, and that is why we make it easy to find the best 5-star hotel in Central United States for you. Sort by:

  • Price: Want to live large, but keep that budget balanced? We got you. We have 5-star hotels starting at $200.

  • Amenities: Central United States skyline view? Maybe a heated indoor pool? Looking for a Michelin-star restaurant? Search for the hotels that have the amenities you desire.

  • Hotwire Hot Rate: We’ll tell you the name of the hotel after you book, and you might just save a ton.

When you’re looking for the top 5-star hotels in Central United States—but don’t want to pay top dollar—let us help you out. You can get that posh palace of your dreams, and have money left to take on Central United States your way.