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5 Star Hotels in Central United States

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Featured 5 Star Central United States Hotels

The Roosevelt New Orleans, A Waldorf Astoria Hotel
5 out of 5
The price is $252 per night from Dec 22 to Dec 23
$252
includes taxes & fees
Dec 22 - Dec 23
Stay at this 5-star luxury hotel in New Orleans. Enjoy a full-service spa, 4 restaurants, and 2 bars/lounges. Our guests praise the helpful staff and the clean ...
The Roosevelt New Orleans, A Waldorf Astoria Hotel
Trump International Hotel & Tower Chicago
5 out of 5
Fully refundableReserve now, pay when you stay
  • 36 hours drive from Port of Galveston Cruise Terminal
The price is $374 per night from Jan 2 to Jan 3
$374
includes taxes & fees
Jan 2 - Jan 3, 2025
Stay at this 5-star luxury hotel in Chicago. Enjoy free WiFi, a full-service spa, and breakfast (surcharge). Our guests praise the helpful staff and the clean ...
Trump International Hotel & Tower Chicago
The Windsor Court
5 out of 5
The price is $399 per night from Jan 2 to Jan 3
$399
includes taxes & fees
Jan 2 - Jan 3, 2025
Stay at this 5-star luxury hotel in New Orleans. Enjoy a full-service spa, 2 bars/lounges, and breakfast (surcharge). Popular attractions Caesars New Orleans ...
The Windsor Court
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Waldorf Astoria Chicago
5 out of 5
Fully refundableReserve now, pay when you stay
  • 36 hours drive from Port of Galveston Cruise Terminal
The price is $502 per night from Jan 19 to Jan 20
$502
includes taxes & fees
Jan 19 - Jan 20, 2025
Stay at this 5-star luxury hotel in Chicago. Enjoy free WiFi, a full-service spa, and breakfast (surcharge). Our guests praise the helpful staff in our reviews. ...
Waldorf Astoria Chicago
Austin Proper Hotel, a Member of Design Hotels
5 out of 5
Fully refundableReserve now, pay when you stay
The price is $416 per night from Dec 23 to Dec 24
$416
includes taxes & fees
Dec 23 - Dec 24
Stay at this 5-star luxury hotel in Austin. Enjoy a full-service spa, 2 restaurants, and 2 bars/lounges. Popular attractions Sixth Street and Moody Theater are ...
Austin Proper Hotel, a Member of Design Hotels
The Langham, Chicago
5 out of 5
Fully refundableReserve now, pay when you stay
  • 36 hours drive from Port of Galveston Cruise Terminal
The price is $411 per night from Jan 6 to Jan 7
$411
includes taxes & fees
Jan 6 - Jan 7, 2025
Stay at this 5-star luxury hotel in Chicago. Enjoy free WiFi, a full-service spa, and breakfast (surcharge). Our guests praise the helpful staff and the clean ...
The Langham, Chicago
Park Hyatt Chicago
5 out of 5
Fully refundableReserve now, pay when you stay
  • 36 hours drive from Port of Galveston Cruise Terminal
The price is $434 per night from Jan 19 to Jan 20
$434
includes taxes & fees
Jan 19 - Jan 20, 2025
Stay at this 5-star luxury hotel in Chicago. Enjoy free WiFi, a full-service spa, and breakfast (surcharge). Our guests praise the helpful staff in our reviews. ...
Park Hyatt Chicago
Thompson San Antonio - Riverwalk, by Hyatt
5 out of 5
Fully refundableReserve now, pay when you stay
  • 5 hours drive from Port of Galveston Cruise Terminal
The price is $250 per night from Jan 2 to Jan 3
$250
includes taxes & fees
Jan 2 - Jan 3, 2025
Stay at this 5-star luxury hotel in San Antonio. Enjoy free WiFi, a full-service spa, and breakfast (surcharge). Our guests praise the bar and the helpful staff ...
Thompson San Antonio - Riverwalk, by Hyatt
The Joule
5 out of 5
Fully refundableReserve now, pay when you stay
  • 9 hours drive from Port of Galveston Cruise Terminal
The price is $281 per night from Dec 23 to Dec 24
$281
includes taxes & fees
Dec 23 - Dec 24
Stay at this 5-star luxury hotel in Dallas. Enjoy free WiFi, an outdoor pool, and a full-service spa. Our guests praise the helpful staff and the clean rooms ...
The Joule
The Peninsula Chicago
5 out of 5
Fully refundableReserve now, pay when you stay
  • 36 hours drive from Port of Galveston Cruise Terminal
The price is $558 per night from Jan 5 to Jan 6
$558
includes taxes & fees
Jan 5 - Jan 6, 2025
Stay at this 5-star luxury hotel in Chicago. Enjoy free WiFi, a full-service spa, and 2 restaurants. Our guests praise the helpful staff and the property condition ...
The Peninsula Chicago
The Post Oak Hotel at Uptown Houston
5 out of 5
Fully refundableReserve now, pay when you stay
  • 1 hour drive from Port of Galveston Cruise Terminal
The price is $653 per night from Jan 5 to Jan 6
$653
includes taxes & fees
Jan 5 - Jan 6, 2025
Stay at this 5-star luxury hotel in Houston. Enjoy free WiFi, a full-service spa, and 4 restaurants. Our guests praise the helpful staff and the room service ...
The Post Oak Hotel at Uptown Houston
1 Hotel Nashville
5 out of 5
Fully refundableReserve now, pay when you stay
  • 19 hours drive from Port of Galveston Cruise Terminal
The price is $342 per night from Jan 19 to Jan 20
$342
includes taxes & fees
Jan 19 - Jan 20, 2025
Stay at this 5-star luxury hotel in Nashville. Enjoy free WiFi, a full-service spa, and 2 restaurants. Our guests praise the helpful staff and the property condition ...
1 Hotel Nashville
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

5-Star Hotel in Central United States

It’s time. No more meh motels and so-so stays. This vacation it’s all about living it up, and that starts with a great hotel. You want first-class service and award-winning restaurants. Well, let us introduce you to a 5-star hotel in Central United States.

So nice you’ll blink twice

What makes a hotel worthy of supreme star-age? For starters, the service has to be top-notch and personalized. These hotels often have 24-hour room service, a welcome gift upon your arrival, and help you with your bags—even if you travel light.

Are they nicer? Heck yeah, they are! Most 5-star hotels have jaw-dropping aesthetics that give an authentic feel of class. And we’re not talking about that faux-gold soap dish your Aunt Tilda puts out for the guests—it’s the real deal.

Stars in your eyes

Are 5-stars hotels worth it? If you like the finer things in life, then yes, they sure are. But we also know you’re the type that likes to get your caviar on a fish stick budget. We’re right there with you, and that is why we make it easy to find the best 5-star hotel in Central United States for you. Sort by:

  • Price: Want to live large, but keep that budget balanced? We got you. We have 5-star hotels starting at $250.

  • Amenities: Central United States skyline view? Maybe a heated indoor pool? Looking for a Michelin-star restaurant? Search for the hotels that have the amenities you desire.

  • Hotwire Hot Rate: We’ll tell you the name of the hotel after you book, and you might just save a ton.

When you’re looking for the top 5-star hotels in Central United States—but don’t want to pay top dollar—let us help you out. You can get that posh palace of your dreams, and have money left to take on Central United States your way.