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Choose from 89 East Prairie Hotel Deals

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

3 out of 5
2608 East Malone Ave, Miner Sikeston MO
  • 47 min drive from Big Oak Tree State Park
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9.6/10 Exceptional! (1,006 reviews)
"Clean rooms and was ready when we arrived. We did not use the pool but other guests were enjoying it. Breakfast and Kick back were both great meals."

Reviewed on Jun 4, 2026

Drury Inn & Suites Sikeston, MO
Hampton Inn Sikeston

Hampton Inn Sikeston

2.5 out of 5
1240 Commerce Drive Sikeston MO
  • 44 min drive from Big Oak Tree State Park
Stay at this hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions Central ...
9/10 Wonderful! (573 reviews)
"The doughnuts and fry potatoes for breakfast were delicious"

Reviewed on Jun 2, 2026

Hampton Inn Sikeston
Best Western Plus Sikeston I-55

Best Western Plus Sikeston I-55

2.5 out of 5
120 S Interstate Drive Sikeston MO
  • 47 min drive from Big Oak Tree State Park
Stay at this hotel in Sikeston. Enjoy free breakfast, free parking, and a fitness center. Our guests praise the breakfast and the helpful staff in our reviews. ...
8.4/10 Very Good! (1,004 reviews)
"Very convenient and staff was great."

Reviewed on Jun 2, 2026

Best Western Plus Sikeston I-55
Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston

2 out of 5
220 S Interstate Dr Sikeston MO
  • 46 min drive from Big Oak Tree State Park
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7.2/10 Good! (1,002 reviews)
"Ll"

Reviewed on May 25, 2026

Days Inn and Suites by Wyndham Sikeston
Super 8 by Wyndham Sikeston/Miner Area

Super 8 by Wyndham Sikeston/Miner Area

2 out of 5
2609 E Malone Ave Sikeston MO
  • 47 min drive from Big Oak Tree State Park
Stay at this hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Central Park and Sikeston Depot Museum are located ...
6.8/10 (636 reviews)
"Had a good stay. The room was nice."

Reviewed on Jun 3, 2026

Super 8 by Wyndham Sikeston/Miner Area
Sleep Inn at Discovery Park of America

Sleep Inn at Discovery Park of America

2.5 out of 5
1111 BLue Heron Lane Union City TN
  • 38 min drive from Big Oak Tree State Park
Book a stay at this business-friendly hotel in Union City. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Discovery Park of America and ...
9.2/10 Wonderful! (396 reviews)
"I slept well! Very clean and comfortable!"

Reviewed on Jun 5, 2026

Sleep Inn at Discovery Park of America
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

2.5 out of 5
100 Matthews Lane Sikeston MO
  • 47 min drive from Big Oak Tree State Park
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8.4/10 Very Good! (786 reviews)
"We had been in different hotels for 8 previous nights, so we were tired of waffles and bread for breakfast. But the room was comfortable although I think the whole hotel needs deep carpet cleaning. It smelled slightly like an ash tray. The staff was very friendly and helpful."

Reviewed on Jun 3, 2026

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
Fairfield Inn & Suites by Marriott Sikeston

Fairfield Inn & Suites by Marriott Sikeston

3 out of 5
1239 Commerce Drive Sikeston MO
  • 44 min drive from Big Oak Tree State Park
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Central Park and Sikeston Depot ...
9.4/10 Exceptional! (84 reviews)
"Great stay, kind staff, very clean property."

Reviewed on May 30, 2026

Fairfield Inn & Suites by Marriott Sikeston
Reelfoot Lake Inn

Reelfoot Lake Inn

2 out of 5
1520 State Route 21 East Tiptonville TN
  • 46 min drive from Big Oak Tree State Park
Stay at this motel in Tiptonville. Enjoy free WiFi, a 24-hour front desk, and daily housekeeping. Our guests praise the helpful staff in our reviews. Popular ...
7.2/10 Good! (494 reviews)
"This place, although the pictures look nice is not what it was… it needs to be updated a lot. There are no amenities. Just the bar basics and you can get other places to go for around the same price with a lot more cleanliness and amenities included. We opted for a bed-and-breakfast instead up the ..."

Reviewed on Jun 1, 2026

Reelfoot Lake Inn
Quality Inn Union City US 51

Quality Inn Union City US 51

2.5 out of 5
2201 W Reelfoot Ave Union City TN
  • 43 min drive from Big Oak Tree State Park
Stay at this hotel in Union City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions ...
8.4/10 Very Good! (518 reviews)
"The pick of this motel was a last minute find, because we were so tired of traveling. It was scone night stay to rest and get a good night's sleep. I was hard to find out room on the property because they did not give us a map, only showed it to us on a map in the office. The room was okay clean ..."

Reviewed on May 31, 2026

Quality Inn Union City US 51
Super 8 by Wyndham Charleston/Sikeston East MO

Super 8 by Wyndham Charleston/Sikeston East MO

2 out of 5
310 S Story St Charleston MO
  • 46 min drive from Big Oak Tree State Park
Stay at this motel in Charleston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews.
6.6/10 (637 reviews)
"Clean rooms,"

Reviewed on May 31, 2026

Super 8 by Wyndham Charleston/Sikeston East MO
New Orleans Inn Portageville

New Orleans Inn Portageville

2.5 out of 5
600 US-61 Portageville MO
  • 44 min drive from Big Oak Tree State Park
Stay at this motel in Portageville. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff and the clean rooms in our ...
8/10 Very Good! (767 reviews)
"Great stay with Great people, very clean and welcoming"

Reviewed on Jun 1, 2026

New Orleans Inn Portageville
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find cheap hotels in East Prairie

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How many hotels are there in East Prairie?

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