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Choose from 88 East Prairie Hotel Deals

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

3 out of 5
2608 East Malone Ave, Miner Sikeston MO
  • 47 min drive from Big Oak Tree State Park
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9.4/10 Exceptional! (1,012 reviews)
Clean, comfortable room, plentiful parking, nice warm breakfast.

Reviewed on Mar 7, 2026

Drury Inn & Suites Sikeston, MO
Hampton Inn Sikeston

Hampton Inn Sikeston

2.5 out of 5
1240 Commerce Drive Sikeston MO
  • 44 min drive from Big Oak Tree State Park
Stay at this hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions Central ...
9/10 Wonderful! (495 reviews)
Good room and helpful staff

Reviewed on Mar 2, 2026

Hampton Inn Sikeston
Sleep Inn at Discovery Park of America

Sleep Inn at Discovery Park of America

2.5 out of 5
1111 BLue Heron Lane Union City TN
  • 38 min drive from Big Oak Tree State Park
Book a stay at this business-friendly hotel in Union City. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Discovery Park of America and ...
9.2/10 Wonderful! (361 reviews)
Nice clean rooms, pool and a good breakfast. Cant ask for anything more. We would definitely stay here again!

Reviewed on Mar 7, 2026

Sleep Inn at Discovery Park of America
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

2.5 out of 5
100 Matthews Lane Sikeston MO
  • 47 min drive from Big Oak Tree State Park
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8.4/10 Very Good! (749 reviews)
Very clean but sometimes noisy from outside traffic

Reviewed on Mar 6, 2026

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
Best Western Plus Sikeston I-55

Best Western Plus Sikeston I-55

2.5 out of 5
120 S Interstate Drive Sikeston MO
  • 47 min drive from Big Oak Tree State Park
Stay at this hotel in Sikeston. Enjoy free breakfast, free parking, and a fitness center. Our guests praise the breakfast and the helpful staff in our reviews. ...
8.4/10 Very Good! (1,005 reviews)
We started our stay with a hostile guest while trying to check in. The lack of care from the worker at check in was a new level of IDGAF, the following day they turned our

Reviewed on Mar 2, 2026

Best Western Plus Sikeston I-55
Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston

2 out of 5
220 S Interstate Dr Sikeston MO
  • 46 min drive from Big Oak Tree State Park
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7.2/10 Good! (1,005 reviews)
Fantastic room and super friendly staff. Hotel was way better than I expected. It was comfortable and clean with a great shower!

Reviewed on Mar 6, 2026

Days Inn and Suites by Wyndham Sikeston
Country Yard Inn and Suite

Country Yard Inn and Suite

2 out of 5
110 South Interstate Drive Sikeston MO
  • 47 min drive from Big Oak Tree State Park
Stay at this motel in Sikeston. Enjoy free WiFi, free parking, and a 24-hour front desk. Popular attractions Central Park and Sikeston Depot Museum are located ...
6.8/10 (126 reviews)
I love this hotel.

Reviewed on Mar 3, 2026

Country Yard Inn and Suite
Holiday Inn Express & Suites Sikeston Southwest by IHG

Holiday Inn Express & Suites Sikeston Southwest by IHG

2.5 out of 5
115 Hospitality Dr Sikeston MO
  • 44 min drive from Big Oak Tree State Park
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8.6/10 Excellent! (449 reviews)
Nice room

Reviewed on Mar 5, 2026

Holiday Inn Express & Suites Sikeston Southwest by IHG
Reelfoot Lake Inn

Reelfoot Lake Inn

2 out of 5
1520 State Route 21 East Tiptonville TN
  • 46 min drive from Big Oak Tree State Park
Stay at this motel in Tiptonville. Enjoy free WiFi, a 24-hour front desk, and daily housekeeping. Our guests praise the helpful staff in our reviews. Popular ...
7.2/10 Good! (471 reviews)
Everything great

Reviewed on Mar 2, 2026

Reelfoot Lake Inn
Hampton Inn Union City

Hampton Inn Union City

2.5 out of 5
2121 W REELFOOT AVE Union City TN
  • 43 min drive from Big Oak Tree State Park
Stay at this hotel in Union City. Enjoy free breakfast, free parking, and a fitness center. Our guests praise the helpful staff in our reviews. Popular attractions ...
9.6/10 Exceptional! (173 reviews)
It was a clean property with a normal breakfast that I expect from Hampton Inn (which is overall pleasant). I had no problems and the kids enjoyed the pool. I was pleasantly surprised with the gym equipment for a hotel.

Reviewed on Mar 5, 2026

Hampton Inn Union City
Super 8 by Wyndham Sikeston/Miner Area

Super 8 by Wyndham Sikeston/Miner Area

2 out of 5
2609 E Malone Ave Sikeston MO
  • 47 min drive from Big Oak Tree State Park
Stay at this hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Central Park and Sikeston Depot Museum are located ...
6.8/10 (600 reviews)
Staff was friendly and helpful but the towels in the bathroom seem like they had dodo stains. And the shower was hard to figure out.

Reviewed on Feb 26, 2026

Super 8 by Wyndham Sikeston/Miner Area
New Orleans Inn Portageville

New Orleans Inn Portageville

2.5 out of 5
600 US-61 Portageville MO
  • 44 min drive from Big Oak Tree State Park
Stay at this motel in Portageville. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff and the clean rooms in our ...
8/10 Very Good! (747 reviews)
The staff was great very helpful and friendly

Reviewed on Feb 25, 2026

New Orleans Inn Portageville
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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