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Choose from 85 East Prairie Hotel Deals

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

3 out of 5
2608 East Malone Ave, Miner Sikeston MO
  • 47 min drive from Big Oak Tree State Park
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9.6/10 Exceptional! (1,004 reviews)
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Reviewed on Apr 19, 2026

Drury Inn & Suites Sikeston, MO
Hampton Inn Sikeston

Hampton Inn Sikeston

2.5 out of 5
1240 Commerce Drive Sikeston MO
  • 44 min drive from Big Oak Tree State Park
Stay at this hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions Central ...
9/10 Wonderful! (545 reviews)
Property was pet friendly. They have nice dog park in the back of the building.

Reviewed on Apr 24, 2026

Hampton Inn Sikeston
Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston

2 out of 5
220 S Interstate Dr Sikeston MO
  • 46 min drive from Big Oak Tree State Park
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7.2/10 Good! (1,001 reviews)
I stayed in Room 214. The room was clean, but there were some furniture and appliance problems. The smoke detector in the off room with the sofa was disconnected from the ceiling and hanging by its wires. The caulking around the sink in the bathroom was coming a loose. The hair drier was melted at ...

Reviewed on Apr 21, 2026

Days Inn and Suites by Wyndham Sikeston
Best Western Plus Sikeston I-55

Best Western Plus Sikeston I-55

2.5 out of 5
120 S Interstate Drive Sikeston MO
  • 47 min drive from Big Oak Tree State Park
Stay at this hotel in Sikeston. Enjoy free breakfast, free parking, and a fitness center. Our guests praise the breakfast and the helpful staff in our reviews. ...
8.4/10 Very Good! (1,000 reviews)
Bathroom had pee stains around the toilet. On their add they use a picture of a large beautiful room where you check in. Not This motel is old and run down.

Reviewed on Apr 22, 2026

Best Western Plus Sikeston I-55
Sleep Inn at Discovery Park of America

Sleep Inn at Discovery Park of America

2.5 out of 5
1111 BLue Heron Lane Union City TN
  • 38 min drive from Big Oak Tree State Park
Book a stay at this business-friendly hotel in Union City. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Discovery Park of America and ...
9.2/10 Wonderful! (382 reviews)
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Reviewed on Apr 23, 2026

Sleep Inn at Discovery Park of America
Fairfield Inn & Suites by Marriott Sikeston

Fairfield Inn & Suites by Marriott Sikeston

3 out of 5
1239 Commerce Drive Sikeston MO
  • 44 min drive from Big Oak Tree State Park
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Central Park and Sikeston Depot ...
9.4/10 Exceptional! (72 reviews)
The breakfast was good, the service was good, and the staff was very friendly

Reviewed on Apr 12, 2026

Fairfield Inn & Suites by Marriott Sikeston
Super 8 by Wyndham Sikeston/Miner Area

Super 8 by Wyndham Sikeston/Miner Area

2 out of 5
2609 E Malone Ave Sikeston MO
  • 47 min drive from Big Oak Tree State Park
Stay at this hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Central Park and Sikeston Depot Museum are located ...
6.8/10 (613 reviews)
Cheap room not bad for the price. Would stay again if I was in the area.

Reviewed on Apr 19, 2026

Super 8 by Wyndham Sikeston/Miner Area
Reelfoot Lake Inn

Reelfoot Lake Inn

2 out of 5
1520 State Route 21 East Tiptonville TN
  • 46 min drive from Big Oak Tree State Park
Stay at this motel in Tiptonville. Enjoy free WiFi, a 24-hour front desk, and daily housekeeping. Our guests praise the helpful staff in our reviews. Popular ...
7.2/10 Good! (481 reviews)
The lake view was beautiful and staff was amazing

Reviewed on Apr 24, 2026

Reelfoot Lake Inn
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

2.5 out of 5
100 Matthews Lane Sikeston MO
  • 47 min drive from Big Oak Tree State Park
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8.4/10 Very Good! (769 reviews)
Check in was friendly and efficient. The room was very nice, but the bed was so hard and uncomfortable we weren’t able to sleep well.

Reviewed on Apr 24, 2026

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
Quality Inn Union City US 51

Quality Inn Union City US 51

2.5 out of 5
2201 W Reelfoot Ave Union City TN
  • 43 min drive from Big Oak Tree State Park
Stay at this hotel in Union City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions ...
8.4/10 Very Good! (504 reviews)
Staff was really slow, fist room we were given hadn’t been cleaned, which wouldn’t have bothered me so much if I hadn’t had to wait so long for the front desk woman to check me in.

Reviewed on Apr 17, 2026

Quality Inn Union City US 51
Country Hearth Inn & Suites Union City

Country Hearth Inn & Suites Union City

2.5 out of 5
2009 West Reelfoot Avenue Union City TN
  • 42 min drive from Big Oak Tree State Park
Stay at this motel in Union City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms in our reviews. ...
8.6/10 Excellent! (564 reviews)
Very clean and nice place and people.

Reviewed on Apr 18, 2026

Country Hearth Inn & Suites Union City
Holiday Inn Express & Suites Sikeston Southwest by IHG

Holiday Inn Express & Suites Sikeston Southwest by IHG

2.5 out of 5
115 Hospitality Dr Sikeston MO
  • 44 min drive from Big Oak Tree State Park
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8.6/10 Excellent! (460 reviews)
Our room was clean. The pool was nice. Breakfast was acceptable. The price a bit steep, but less because we got it thru hotels.com.

Reviewed on Apr 18, 2026

Holiday Inn Express & Suites Sikeston Southwest by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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