Search for Cheap Deals onHotels in East Prairie
Choose from 86 East Prairie Hotel Deals
Drury Inn & Suites Sikeston, MO
As always it was a perfect visit
Reviewed on Jan 19, 2026
Hampton Inn Sikeston
very clean room
Reviewed on Jan 23, 2026
Best Western Plus Sikeston
Clean and well-kept
Reviewed on Jan 19, 2026
Days Inn and Suites by Wyndham Sikeston
Everything was excellent
Reviewed on Jan 18, 2026
Sleep Inn at Discovery Park of America
Though I didn't partake in breakfast, I was treated to outstanding check-in AND check-out processes! Both ladies were incredibly kind, welcoming, sincere, professional, sweet and expedient. I couldn't have been more pleased with them OR the room. And, speaking of the ROOM - OMG!! It was very clean, ...
Reviewed on Jan 16, 2026
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
Saw a baby roach but other than that no complaints
Reviewed on Jan 3, 2026
Pear Tree Inn Sikeston
Clean room. Nice facilities. Pool is half inside half outside so even though it was heated it was still very cold
Reviewed on Jan 19, 2026
Super 8 by Wyndham Sikeston/Miner Area
Could be cleaner but good value for price.
Reviewed on Jan 19, 2026
Hospitality House Union City I 69 / US 51
The room was clean and the staff were very friendly. Too cold to use the pool but it too was clean.
Reviewed on Jan 12, 2026
Fairfield Inn & Suites by Marriott Sikeston
Very clean, staff pleasant and helpful
Reviewed on Jan 6, 2026
Hampton Inn Union City
Clean room, good location
Reviewed on Jan 9, 2026
Reelfoot Lake Inn
Nice in clean room
Reviewed on Jan 19, 2026
Find cheap hotels in East Prairie
You’re not an average traveler—and Hotwire knows it. Your wanderlust takes you off the beaten path to discover unique adventures and every travel destination’s lesser-known tourist scenes. Hotwire has the hookup! Book your East Prairie hotel with Hotwire to complete your one-of-a-kind travel checklist.
For you, intrepid voyager, Hotwire has a large selection of the best hotels in East Prairie.
Choosing the right hotel in Missouri has everything to do with the way you want your trip to go. If you’ve scribbled a few obscure destinations on your itinerary, you probably already have a good sense of how your getaway is taking shape. Lean into that by booking one of East Prairie’s 86 hotels. Choose the one that best catches your trip’s tourist drift.
If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $60. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get great East Prairie hotel deals at the last minute.
While traveling, where you stay plays a major role in your overall vacation enjoyment. Choosing the right hotel is just as important as making sure you book the right flight and car rental. If you’re traveling with family or friends, you may need to book a hotel with connecting rooms. If you enjoy an elegant and relaxing hotel ambiance, opt for one of Hotwire’s luxury hotels in East Prairie. No matter your reason for visiting East Prairie, with Hotwire’s large selection of hotels in the area, you’re sure to book a hotel that meets all your accommodation needs.
Frequently Asked Questions About East Prairie hotels
Where can I find the best last-minute travel deals?
If you’re traveling in the spirit of spontaneity, you’ll love the idea of leaving your exact hotel choice up to chance. With Hotwire Hot Rates, you can unlock great deals on your next flight, hotel, or car rental. Just plug in your general preferences and let Hotwire choose last-minute hotel deals in East Prairie for as low as $60.
How many hotels are there in East Prairie?
With over 86 hotels in East Prairie, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $60.
How to find cheap car rentals in East Prairie?
Finding a cheap car rental deal in East Prairie is as easy as scoring cheap hotels in East Prairie. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can unlock great car rental deals if you book a Hotwire Hot Rate at the last minute.
- Hotels near Big Oak Tree State Park
- Hotels near Mississippi River
- Hotels near Reelfoot Lake State Park
- Hotels near Ohio River
- Hotels near Discovery Park of America
- Hotels near Ohio River Valley
- Hotels near Columbus-Belmont State Park
- Hotels near Sikeston Depot Museum
- Hotels near Marston Community Center
- Hotels near Central Park
- Hotels near Campbell's Point
- Hotels near New Madrid Historical Museum
- Hotels near Union City Masquerade Theatre
- Hotels near River Ridge Winery
- Sikeston Hotels
- Southern Illinois Hotels
- Union City Hotels
- Southeastern United States Hotels
- Tiptonville Hotels
- Cairo Hotels
- Marston Hotels
- Hornbeak Hotels
- Charleston Hotels
- Portageville Hotels
- Southeast Missouri Hotels
- Western Tennessee Hotels
- Fulton Hotels
- Western Kentucky Hotels
- Samburg Hotels
- The South Hotels
- New Madrid Hotels
- Central United States Hotels
- Clinton Hotels
