Search Cheap Flights to
East Prairie

Search 400 airlines and 321,000 hotels worldwide.

Stop Planning & Start Exploring

FREE 24 hour cancellation on most flights

East Prairie Flights as Low as $580

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

American Airlines
Wed, Jan 22 - Tue, Jan 28
ORD
O'Hare Intl.
PAH
Barkley Regional
$580 Roundtrip, found 2 hours ago
$580
Roundtrip
found 2 hours ago
Select American Airlines flight, departing Wed, Jan 22 from O'Hare Intl. to Barkley Regional, returning Tue, Jan 28, priced at $580 found 2 hours ago
American Airlines
Wed, Jan 22 - Tue, Jan 28
ORD
O'Hare Intl.
PAH
Barkley Regional
$590 Roundtrip, found 2 hours ago
$590
Roundtrip
found 2 hours ago
Select American Airlines flight, departing Wed, Jan 22 from O'Hare Intl. to Barkley Regional, returning Tue, Jan 28, priced at $590 found 2 hours ago
American Airlines
Wed, Jan 22 - Tue, Jan 28
ORD
O'Hare Intl.
PAH
Barkley Regional
$599 Roundtrip, found 2 hours ago
$599
Roundtrip
found 2 hours ago
Select American Airlines flight, departing Wed, Jan 22 from O'Hare Intl. to Barkley Regional, returning Tue, Jan 28, priced at $599 found 2 hours ago
American Airlines
Wed, Jan 22 - Tue, Jan 28
ORD
O'Hare Intl.
PAH
Barkley Regional
$623 Roundtrip, found 1 day ago
$623
Roundtrip
found 1 day ago
Select American Airlines flight, departing Wed, Jan 22 from O'Hare Intl. to Barkley Regional, returning Tue, Jan 28, priced at $623 found 1 day ago
American Airlines
Thu, Nov 21 - Mon, Dec 2
ORD
O'Hare Intl.
PAH
Barkley Regional
$626 Roundtrip, found 23 hours ago
$626
Roundtrip
found 23 hours ago
Select American Airlines flight, departing Thu, Nov 21 from O'Hare Intl. to Barkley Regional, returning Mon, Dec 2, priced at $626 found 23 hours ago
American Airlines
Wed, Jan 22 - Tue, Jan 28
ORD
O'Hare Intl.
PAH
Barkley Regional
$632 Roundtrip, found 1 day ago
$632
Roundtrip
found 1 day ago
Select American Airlines flight, departing Wed, Jan 22 from O'Hare Intl. to Barkley Regional, returning Tue, Jan 28, priced at $632 found 1 day ago
American Airlines
Fri, Nov 22 - Mon, Dec 2
ORD
O'Hare Intl.
PAH
Barkley Regional
$636 Roundtrip, found 2 days ago
$636
Roundtrip
found 2 days ago
Select American Airlines flight, departing Fri, Nov 22 from O'Hare Intl. to Barkley Regional, returning Mon, Dec 2, priced at $636 found 2 days ago
American Airlines
Wed, Jan 22 - Tue, Jan 28
ORD
O'Hare Intl.
PAH
Barkley Regional
$636 Roundtrip, found 1 day ago
$636
Roundtrip
found 1 day ago
Select American Airlines flight, departing Wed, Jan 22 from O'Hare Intl. to Barkley Regional, returning Tue, Jan 28, priced at $636 found 1 day ago
American Airlines
Wed, Jan 22 - Tue, Jan 28
ORD
O'Hare Intl.
PAH
Barkley Regional
$646 Roundtrip, found 1 day ago
$646
Roundtrip
found 1 day ago
Select American Airlines flight, departing Wed, Jan 22 from O'Hare Intl. to Barkley Regional, returning Tue, Jan 28, priced at $646 found 1 day ago
American Airlines
Wed, Jan 22 - Tue, Jan 28
ORD
O'Hare Intl.
PAH
Barkley Regional
$651 Roundtrip, found 2 hours ago
$651
Roundtrip
found 2 hours ago
Select American Airlines flight, departing Wed, Jan 22 from O'Hare Intl. to Barkley Regional, returning Tue, Jan 28, priced at $651 found 2 hours ago
American Airlines
Wed, Jan 22 - Tue, Jan 28
ORD
O'Hare Intl.
PAH
Barkley Regional
$661 Roundtrip, found 2 hours ago
$661
Roundtrip
found 2 hours ago
Select American Airlines flight, departing Wed, Jan 22 from O'Hare Intl. to Barkley Regional, returning Tue, Jan 28, priced at $661 found 2 hours ago
American Airlines
Sat, Nov 23 - Mon, Dec 2
ORD
O'Hare Intl.
PAH
Barkley Regional
$667 Roundtrip, found 23 hours ago
$667
Roundtrip
found 23 hours ago
Select American Airlines flight, departing Sat, Nov 23 from O'Hare Intl. to Barkley Regional, returning Mon, Dec 2, priced at $667 found 23 hours ago
American Airlines
Wed, Jan 22 - Tue, Jan 28
ORD
O'Hare Intl.
PAH
Barkley Regional
$675 Roundtrip, found 3 days ago
$675
Roundtrip
found 3 days ago
Select American Airlines flight, departing Wed, Jan 22 from O'Hare Intl. to Barkley Regional, returning Tue, Jan 28, priced at $675 found 3 days ago
American Airlines
Thu, Nov 21 - Tue, Dec 3
ORD
O'Hare Intl.
PAH
Barkley Regional
$676 Roundtrip, found 23 hours ago
$676
Roundtrip
found 23 hours ago
Select American Airlines flight, departing Thu, Nov 21 from O'Hare Intl. to Barkley Regional, returning Tue, Dec 3, priced at $676 found 23 hours ago
American Airlines
Thu, Nov 21 - Sun, Dec 1
ORD
O'Hare Intl.
PAH
Barkley Regional
$686 Roundtrip, found 23 hours ago
$686
Roundtrip
found 23 hours ago
Select American Airlines flight, departing Thu, Nov 21 from O'Hare Intl. to Barkley Regional, returning Sun, Dec 1, priced at $686 found 23 hours ago
American Airlines
Sat, Dec 28 - Wed, Jan 1
DFW
Dallas-Fort Worth Intl.
PAH
Barkley Regional
$729 Roundtrip, found 1 day ago
$729
Roundtrip
found 1 day ago
Select American Airlines flight, departing Sat, Dec 28 from Dallas-Fort Worth Intl. to Barkley Regional, returning Wed, Jan 1, priced at $729 found 1 day ago

Cheap Flights to East Prairie

Fall in love at first flight with your vacation to East Prairie by saving a ton of cash on your last-minute cheap flight. There’s no more scouring the internet for a good deal—book your flight to East Prairie on Hotwire, and you’ll be up, up, and on a getaway in no time.

Because once the wheels are down in East Prairie, the good times start rolling. So buckle up, you’re in for a fun ride.

Frequently Asked Questions About flights to East Prairie

Don’t waste your time on endless searches for cheap airline tickets oneway or roundtrip. We’ll have you on your way to East Prairie with a tiny bag of pretzels in your hand before you can say “tray tables in the upright position”—and for a ticket price that works for your vacay budget.

So all you have to worry about is where you’re headed after the CGI airport.

What is the cheapest month to fly to East Prairie?

Airline ticket prices fluctuate all the time, depending on the day of the week or the month of the year. The cheapest round trip flights to East Prairie are in January, but when you book your flight on Hotwire, savings are always in season.

How many airlines fly to East Prairie?

Variety is the spice of life, even when it comes to booking your next trip. Want options for airlines? You’ll find 16 to choose from for your flight to East Prairie.

What airport is best to fly into East Prairie?

When you’re planning your trip to East Prairie, convenience is the name of the game. Luckily, East Prairie Cairo Regional Airport is nearby so you can deplane and get going on checking off everything on your East Prairie must-do list.

How much are flights to East Prairie?

Got very cheap flights on your vacation itinerary? When you book your airline tickets to East Prairie on Hotwire, you may just get what’s on your getaway wish list. With tickets as low as $580, you’ll have leftover cash for at least a magazine and a bottle of water at the airport book store.

How to get cheap flights to East Prairie?

The trick to saving a stack of cash on your flight to East Prairie? Snatch up that Hotwire flight deal when you see a killer rate because it could be gone in a flash. And with flights as low as $580 right now, why wait?

East Prairie Flight Information
Destination airport
Barkley Regional
Destination airport IATA code
PAH
Roundtrip price
$580

Last Minute Hotel Deals in East Prairie

Drury Inn & Suites Sikeston, MO
Drury Inn & Suites Sikeston, MO
3 out of 5
2608 East Malone Ave, Sikeston, MO
The price is $114 per night from Nov 17 to Nov 18
$114
includes taxes & fees
Nov 17 - Nov 18
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9.2/10 Wonderful! (1,003 reviews)
"Very impressed with the customer service!"

Reviewed on Nov 9, 2024

Drury Inn & Suites Sikeston, MO
Pear Tree Inn Sikeston
Pear Tree Inn Sikeston
2.5 out of 5
2602 E Malone Avenue, Sikeston, MO
The price is $93 per night from Nov 16 to Nov 17
$93
includes taxes & fees
Nov 16 - Nov 17
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the helpful ...
9.2/10 Wonderful! (1,004 reviews)
"Nice, clean"

Reviewed on Nov 9, 2024

Pear Tree Inn Sikeston
Days Inn and Suites by Wyndham Sikeston
Days Inn and Suites by Wyndham Sikeston
2 out of 5
220 S Interstate Dr, Sikeston, MO
The price is $74 per night from Nov 14 to Nov 15
$74
includes taxes & fees
Nov 14 - Nov 15
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7/10 Good! (1,001 reviews)
"T"

Reviewed on Nov 10, 2024

Days Inn and Suites by Wyndham Sikeston
Best Western Plus Sikeston
Best Western Plus Sikeston
2.5 out of 5
120 S Interstate Drive, Sikeston, MO
The price is $102 per night from Nov 12 to Nov 13
$102
includes taxes & fees
Nov 12 - Nov 13
Stay at this hotel in Sikeston. Enjoy free breakfast, free parking, and a fitness center. Our guests praise the breakfast and the helpful staff in our reviews. ...
8.2/10 Very Good! (1,002 reviews)
"Good hotel. Stains on light shade and lining of bed ripped on the bottom."

Reviewed on Nov 4, 2024

Best Western Plus Sikeston
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
2.5 out of 5
100 Matthews Lane, Sikeston, MO
The price is $72 per night from Nov 12 to Nov 13
$72
includes taxes & fees
Nov 12 - Nov 13
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8.4/10 Very Good! (597 reviews)
"Convenience"

Reviewed on Oct 26, 2024

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
New Orleans Inn Portageville
New Orleans Inn Portageville
2.5 out of 5
600 US-61, Portageville, MO
The price is $68 per night from Nov 17 to Nov 18
$68
includes taxes & fees
Nov 17 - Nov 18
Stay at this motel in Portageville. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff and the clean rooms in our ...
8/10 Very Good! (535 reviews)
"Truly looks like a New Orleans establishment with the railings and decor. Nicole is great!"

Reviewed on Nov 7, 2024

New Orleans Inn Portageville
Quality Inn Union City US 51
Quality Inn Union City US 51
2.5 out of 5
2201 W Reelfoot Ave, Union City, TN
The price is $88 per night from Nov 27 to Nov 28
$88
includes taxes & fees
Nov 27 - Nov 28
Stay at this hotel in Union City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions ...
8.4/10 Very Good! (405 reviews)
"Everything was very good!!!"

Reviewed on Oct 23, 2024

Quality Inn Union City US 51
Holiday Inn Express & Suites Sikeston Southwest, an IHG Hotel
Holiday Inn Express & Suites Sikeston Southwest, an IHG Hotel
2.5 out of 5
115 Hospitality Dr, Sikeston, MO
The price is $139 per night from Nov 24 to Nov 25
$139
includes taxes & fees
Nov 24 - Nov 25
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8.4/10 Very Good! (378 reviews)
"Hotel was clean and staff were friendly. Breakfast was good. Room was good."

Reviewed on Nov 6, 2024

Holiday Inn Express & Suites Sikeston Southwest, an IHG Hotel
See all 77 properties in East Prairie
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.