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Featured Sikeston Resorts & Hotels with Spas

Drury Inn & Suites Cape Girardeau
3303 Campster Drive, Cape Girardeau, MO
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the ...

Drury Inn & Suites Jackson MO
225 Drury Lane, Jackson, MO
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Jackson. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...

Drury Plaza Hotel Cape Girardeau Conference Center
3351 Percy Drive, Cape Girardeau, MO
Fully refundableReserve now, pay when you stay
Stay at this 3-star business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...

Eagle Inn Charleston
2811 East Marshall Street, Charleston, MO
Fully refundableReserve now, pay when you stay
Stay at this motel in Charleston. Enjoy free WiFi, free parking, and a health club.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Hotels by Star Rating
More Hotel Options in Sikeston
- Hotels with Free Parking in Sikeston
- Family Hotels in Sikeston
- Pet-friendly Hotels in Sikeston
- Hotels with a Pool in Sikeston
- Hotels with an Indoor Pool in Sikeston
- Hotels with Hot Tubs in Sikeston
- Casinos in Sikeston
- Luxury Hotels in Sikeston
- Hotel Wedding Venues in Sikeston
- Apartment Hotel in Sikeston
Top Points of Interests in Sikeston
- Hotels near Boot Heel Golf Club
- Hotels near The Book Bug
- Hotels near Sikeston Depot Museum
- Hotels near Central Park
- Hotels near Shawnee National Forest
- Hotels near Mississippi River
- Hotels near Ohio River
- Hotels near Southeast Missouri State University
- Hotels near Riverfront Bridge Park
- Hotels near Riverfront Park
- Hotels near Big Oak Tree State Park
- Hotels near Mound City National Cemetery
- Hotels near Fort Defiance State Park
- Hotels near eDen Spa & Salon
- Hotels near New Madrid Historical Museum
- Hotels near Fort D Historic Site
- Hotels near Stoddard County Civil War Memorial Cemetery
- Hotels near River Ridge Winery
- Hotels near Dexter Welcome Center Depot and Museum
- Hotels near The Heritage House
Cities near Sikeston
- Cape Girardeau Hotels (29.82 mi)
- Ozarks Hotels (161.27 mi)
- Southern Illinois Hotels (113.94 mi)
- Southeastern United States Hotels (420.75 mi)
- Central United States Hotels (267.86 mi)
- Dexter Hotels (21.18 mi)
- Tiptonville Hotels (35.09 mi)
- Marston Hotels (24.82 mi)
- Charleston Hotels (13.59 mi)
- Portageville Hotels (31.83 mi)
- Western Kentucky Hotels (109.03 mi)
- Western Tennessee Hotels (89.28 mi)
- Southeast Missouri Hotels (51.94 mi)
- Cairo Hotels (24.44 mi)
- The South Hotels (242.82 mi)
- New Madrid Hotels (20.41 mi)
- Malden Hotels (30.43 mi)
- East Prairie Hotels (13.15 mi)
Car Rentals Near Sikeston
- Car rentals in Cape Girardeau
- Car rentals in Ozarks
- Car rentals in Southern Illinois
- Car rentals in Southeastern United States
- Car rentals in Central United States
- Car rentals in Dexter
- Car rentals in Tiptonville
- Car rentals in Marston
- Car rentals in Charleston
- Car rentals in Portageville
- Car rentals in Western Kentucky
- Car rentals in Western Tennessee
- Car rentals in Southeast Missouri
- Car rentals in Cairo
- Car rentals in The South
- Car rentals in New Madrid
Top Spa Resort Destinations
- Annapolis Spa Hotels
- Ottawa Valley Spa Hotels
- Tallahassee Spa Hotels
- Appalachian Mountains Spa Hotels
- Corpus Christi Spa Hotels
- Raleigh Spa Hotels
- Syracuse Spa Hotels
- Chattanooga Spa Hotels
- Grand Canyon Spa Hotels
- Toledo Spa Hotels
- Edmonton Spa Hotels
- El Paso Spa Hotels
- Omaha Spa Hotels
- Cincinnati Spa Hotels
- Fargo Spa Hotels
- Des Moines Spa Hotels
- Dayton Spa Hotels
- Flagstaff Spa Hotels
- Little Rock Spa Hotels
- Waco Spa Hotels