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Featured Southeast Missouri Resorts & Hotels with Spas
Crown Pointe Lodge, BW Signature Collection
4245 Hunt Rd, Farmington, MO
Fully refundableReserve now, pay when you stay
Book a stay at this golf hotel in Farmington. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular ...
Drury Inn & Suites Cape Girardeau
3303 Campster Drive, Cape Girardeau, MO
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the ...
Drury Inn & Suites Hayti Caruthersville
1317 E Highway 84, Hayti, MO
Fully refundableReserve now, pay when you stay
Stay at this 3-star business-friendly hotel in Hayti. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
Drury Inn & Suites Jackson MO
225 Drury Lane, Jackson, MO
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Jackson. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
Drury Inn & Suites Poplar Bluff
2220 N Westwood Blvd, Poplar Bluff, MO
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Poplar Bluff. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
Drury Plaza Hotel Cape Girardeau Conference Center
3351 Percy Drive, Cape Girardeau, MO
Fully refundableReserve now, pay when you stay
Stay at this 3-star business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
Eagle Inn Charleston
2811 East Marshall Street, Charleston, MO
Fully refundableReserve now, pay when you stay
Stay at this motel in Charleston. Enjoy free WiFi, free parking, and a health club.
Hampton Inn Farmington
850 Valley Creek Dr, Farmington, MO
Fully refundableReserve now, pay when you stay
Stay at this hotel in Farmington. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions ...
Holiday Inn Club Vacations Timber Creek Resort at De Soto by IHG
4800 U.S. Highway 67, De Soto, MO
Fully refundable
Stay at this 3.5-star family-friendly aparthotel in De Soto. Enjoy free parking, an outdoor pool, and a fitness center. Our guests praise the property condition ...
Super 8 by Wyndham Perryville
1119 Vincent Dr, Perryville, MO
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly motel in Perryville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
Super 8 by Wyndham Pevely
1711 Highway Z, Pevely, MO
Book a stay at this business-friendly motel in Pevely. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Pevely Park and Sun Valley Park ...
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Hotels by Star Rating
More Hotel Options in Southeast Missouri
- Hotels with Free Parking in Southeast Missouri
- Family Hotels in Southeast Missouri
- Pet-friendly Hotels in Southeast Missouri
- Hotels with a Pool in Southeast Missouri
- Hotels with an Indoor Pool in Southeast Missouri
- Hotels with Hot Tubs in Southeast Missouri
- Hotel Wedding Venues in Southeast Missouri
- Casinos in Southeast Missouri
- Luxury Hotels in Southeast Missouri
- Apartment Hotel in Southeast Missouri
Southeast Missouri Neighborhoods
Top Points of Interests in Southeast Missouri
- Hotels near Southeast Missouri State University
- Hotels near Elephant Rocks State Park
- Hotels near Johnson's Shut-ins State Park
- Hotels near Echo Bluff State Park
- Hotels near Lake Wappapello
- Hotels near Ozark National Scenic Riverways
- Hotels near Century Casino Caruthersville
- Hotels near Isle Casino Cape Girardeau
- Hotels near Big Spring
- Hotels near Bonne Terre Mine
- Hotels near Alley Spring & Mill
- Hotels near Sainte Genevieve Winery
- Hotels near Taum Sauk Mountain State Park
- Hotels near Rocky Falls
- Hotels near Current River State Park
- Hotels near Black River Coliseum
- Hotels near Trail of Tears State Park
- Hotels near Pickle Springs Natural Area
- Hotels near Crown Valley Winery
- Hotels near Riverfront Bridge Park
Cities near Southeast Missouri
- Chesterfield Hotels (99.53 mi)
- Cape Girardeau Hotels (50.24 mi)
- Carbondale Hotels (74.86 mi)
- Ste Genevieve Hotels (56.1 mi)
- Sikeston Hotels (51.94 mi)
- Ozarks Hotels (113.87 mi)
- Poplar Bluff Hotels (32.28 mi)
- Richmond Heights Hotels (97.19 mi)
- Fenton Hotels (89.01 mi)
- Eminence Hotels (51.47 mi)
- Farmington Hotels (38.48 mi)
- Kirkwood Hotels (93.89 mi)
- East St. Louis Hotels (96.94 mi)
- Southern Illinois Hotels (119.89 mi)
- Wildwood Hotels (94.69 mi)
- Arnold Hotels (83.54 mi)
- Brentwood Hotels (96.34 mi)
- West Plains Hotels (85.42 mi)
- Dyersburg Hotels (100.34 mi)
- Blytheville Hotels (94.02 mi)
Car Rentals Near Southeast Missouri
- Car rentals in Chesterfield
- Car rentals in Cape Girardeau
- Car rentals in Carbondale
- Car rentals in Ste Genevieve
- Car rentals in Sikeston
- Car rentals in Ozarks
- Car rentals in Poplar Bluff
- Car rentals in Richmond Heights
- Car rentals in Fenton
- Car rentals in Eminence
- Car rentals in Farmington
- Car rentals in Kirkwood
- Car rentals in East St. Louis
- Car rentals in Southern Illinois
- Car rentals in Wildwood
- Car rentals in Arnold
Top Spa Resort Destinations
- Annapolis Spa Hotels
- Ottawa Valley Spa Hotels
- Tallahassee Spa Hotels
- Appalachian Mountains Spa Hotels
- Corpus Christi Spa Hotels
- Raleigh Spa Hotels
- Syracuse Spa Hotels
- Chattanooga Spa Hotels
- Grand Canyon Spa Hotels
- Toledo Spa Hotels
- Edmonton Spa Hotels
- El Paso Spa Hotels
- Omaha Spa Hotels
- Cincinnati Spa Hotels
- Fargo Spa Hotels
- Des Moines Spa Hotels
- Dayton Spa Hotels
- Flagstaff Spa Hotels
- Little Rock Spa Hotels
- Waco Spa Hotels