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Spa Resort Hotels in Southeast Missouri

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Featured Southeast Missouri Resorts & Hotels with Spas

Crown Pointe Lodge, BW Signature Collection
Crown Pointe Lodge, BW Signature Collection
2.5 out of 5
4245 Hunt Rd, Farmington, MO
Fully refundableReserve now, pay when you stay
Book a stay at this golf hotel in Farmington. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular ...
Crown Pointe Lodge, BW Signature Collection
Drury Inn & Suites Cape Girardeau
Drury Inn & Suites Cape Girardeau
3 out of 5
3303 Campster Drive, Cape Girardeau, MO
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the ...
Drury Inn & Suites Cape Girardeau
Drury Inn & Suites Hayti Caruthersville
Drury Inn & Suites Hayti Caruthersville
3 out of 5
1317 E Highway 84, Hayti, MO
Fully refundableReserve now, pay when you stay
Stay at this 3-star business-friendly hotel in Hayti. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
Drury Inn & Suites Hayti Caruthersville
Drury Inn & Suites Jackson MO
Drury Inn & Suites Jackson MO
3 out of 5
225 Drury Lane, Jackson, MO
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Jackson. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
Drury Inn & Suites Jackson MO
Drury Inn & Suites Poplar Bluff
Drury Inn & Suites Poplar Bluff
3 out of 5
2220 N Westwood Blvd, Poplar Bluff, MO
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Poplar Bluff. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
Drury Inn & Suites Poplar Bluff
Drury Plaza Hotel Cape Girardeau Conference Center
Drury Plaza Hotel Cape Girardeau Conference Center
3 out of 5
3351 Percy Drive, Cape Girardeau, MO
Fully refundableReserve now, pay when you stay
Stay at this 3-star business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
Drury Plaza Hotel Cape Girardeau Conference Center
Eagle Inn Charleston
Eagle Inn Charleston
2 out of 5
2811 East Marshall Street, Charleston, MO
Fully refundableReserve now, pay when you stay
Stay at this motel in Charleston. Enjoy free WiFi, free parking, and a health club.
Eagle Inn Charleston
Hampton Inn Farmington
Hampton Inn Farmington
2.5 out of 5
850 Valley Creek Dr, Farmington, MO
Fully refundableReserve now, pay when you stay
Stay at this hotel in Farmington. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions ...
Hampton Inn Farmington
Holiday Inn Club Vacations Timber Creek Resort at De Soto by IHG
Holiday Inn Club Vacations Timber Creek Resort at De Soto by IHG
3.5 out of 5
4800 U.S. Highway 67, De Soto, MO
Fully refundable
Stay at this 3.5-star family-friendly aparthotel in De Soto. Enjoy free parking, an outdoor pool, and a fitness center. Our guests praise the property condition ...
Holiday Inn Club Vacations Timber Creek Resort at De Soto by IHG
Super 8 by Wyndham Perryville
Super 8 by Wyndham Perryville
2 out of 5
1119 Vincent Dr, Perryville, MO
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly motel in Perryville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
Super 8 by Wyndham Perryville
Super 8 by Wyndham Pevely
Super 8 by Wyndham Pevely
2 out of 5
1711 Highway Z, Pevely, MO
Book a stay at this business-friendly motel in Pevely. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Pevely Park and Sun Valley Park ...
Super 8 by Wyndham Pevely
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.