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Southeast Missouri

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Southeast Missouri Flights as Low as $110

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

Frontier Airlines
Thu, Aug 7 - Thu, Aug 14
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$110 Roundtrip, found 2 hours ago
$110
Roundtrip
found 2 hours ago
Select Frontier Airlines flight, departing Thu, Aug 7 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Thu, Aug 14, priced at $110 found 2 hours ago
Frontier Airlines
Sat, Jul 26 - Sat, Aug 2
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$115 Roundtrip, found 1 hour ago
$115
Roundtrip
found 1 hour ago
Select Frontier Airlines flight, departing Sat, Jul 26 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Sat, Aug 2, priced at $115 found 1 hour ago
Frontier Airlines
Thu, Jul 24 - Sat, Jul 26
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$120 Roundtrip, found 8 hours ago
$120
Roundtrip
found 8 hours ago
Select Frontier Airlines flight, departing Thu, Jul 24 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Sat, Jul 26, priced at $120 found 8 hours ago
Frontier Airlines
Sun, Jul 27 - Thu, Jul 31
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$125 Roundtrip, found 8 hours ago
$125
Roundtrip
found 8 hours ago
Select Frontier Airlines flight, departing Sun, Jul 27 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Thu, Jul 31, priced at $125 found 8 hours ago
Frontier Airlines
Sat, Oct 4 - Sat, Oct 11
DEN
Denver Intl.
STL
Lambert-St. Louis Intl.
$129 Roundtrip, found 22 hours ago
$129
Roundtrip
found 22 hours ago
Select Frontier Airlines flight, departing Sat, Oct 4 from Denver Intl. to Lambert-St. Louis Intl., returning Sat, Oct 11, priced at $129 found 22 hours ago
Frontier Airlines
Wed, Jul 16 - Sat, Jul 19
DEN
Denver Intl.
STL
Lambert-St. Louis Intl.
$129 Roundtrip, found 5 days ago
$129
Roundtrip
found 5 days ago
Select Frontier Airlines flight, departing Wed, Jul 16 from Denver Intl. to Lambert-St. Louis Intl., returning Sat, Jul 19, priced at $129 found 5 days ago
Frontier Airlines
Mon, Oct 6 - Sat, Oct 11
DEN
Denver Intl.
STL
Lambert-St. Louis Intl.
$134 Roundtrip, found 1 day ago
$134
Roundtrip
found 1 day ago
Select Frontier Airlines flight, departing Mon, Oct 6 from Denver Intl. to Lambert-St. Louis Intl., returning Sat, Oct 11, priced at $134 found 1 day ago
Spirit Airlines
Thu, Aug 7 - Thu, Aug 14
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$135 Roundtrip, found 2 hours ago
$135
Roundtrip
found 2 hours ago
Select Spirit Airlines flight, departing Thu, Aug 7 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Thu, Aug 14, priced at $135 found 2 hours ago
Frontier Airlines
Wed, Jul 23 - Wed, Jul 30
DEN
Denver Intl.
STL
Lambert-St. Louis Intl.
$142 Roundtrip, found 2 days ago
$142
Roundtrip
found 2 days ago
Select Frontier Airlines flight, departing Wed, Jul 23 from Denver Intl. to Lambert-St. Louis Intl., returning Wed, Jul 30, priced at $142 found 2 days ago
American Airlines
Thu, Sep 4 - Thu, Sep 11
BWI
Baltimore Washington Intl. Thurgood Marshall
STL
Lambert-St. Louis Intl.
$157 Roundtrip, found 5 hours ago
$157
Roundtrip
found 5 hours ago
Select American Airlines flight, departing Thu, Sep 4 from Baltimore Washington Intl. Thurgood Marshall to Lambert-St. Louis Intl., returning Thu, Sep 11, priced at $157 found 5 hours ago
United
Sat, Oct 4 - Sat, Oct 11
DEN
Denver Intl.
STL
Lambert-St. Louis Intl.
$157 Roundtrip, found 22 hours ago
$157
Roundtrip
found 22 hours ago
Select United flight, departing Sat, Oct 4 from Denver Intl. to Lambert-St. Louis Intl., returning Sat, Oct 11, priced at $157 found 22 hours ago
Delta
Sat, Dec 6 - Sat, Dec 6
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$172 Roundtrip, found 8 hours ago
$172
Roundtrip
found 8 hours ago
Select Delta flight, departing Sat, Dec 6 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Sat, Dec 6, priced at $172 found 8 hours ago
American Airlines
Sat, Oct 4 - Sat, Oct 11
DEN
Denver Intl.
STL
Lambert-St. Louis Intl.
$177 Roundtrip, found 22 hours ago
$177
Roundtrip
found 22 hours ago
Select American Airlines flight, departing Sat, Oct 4 from Denver Intl. to Lambert-St. Louis Intl., returning Sat, Oct 11, priced at $177 found 22 hours ago
Delta
Tue, Aug 5 - Tue, Aug 5
CLT
Charlotte-Douglas Intl.
STL
Lambert-St. Louis Intl.
$240 Roundtrip, found 10 hours ago
$240
Roundtrip
found 10 hours ago
Select Delta flight, departing Tue, Aug 5 from Charlotte-Douglas Intl. to Lambert-St. Louis Intl., returning Tue, Aug 5, priced at $240 found 10 hours ago
American Airlines
Tue, Aug 5 - Thu, Aug 14
ATL
Hartsfield-Jackson Atlanta Intl.
CGI
Cape Girardeau Municipal
$264 Roundtrip, found 3 days ago
$264
Roundtrip
found 3 days ago
Select American Airlines flight, departing Tue, Aug 5 from Hartsfield-Jackson Atlanta Intl. to Cape Girardeau Municipal, returning Thu, Aug 14, priced at $264 found 3 days ago
American Airlines
Tue, Aug 19 - Fri, Aug 22
DEN
Denver Intl.
PAH
Barkley Regional
$339 Roundtrip, found 3 days ago
$339
Roundtrip
found 3 days ago
Select American Airlines flight, departing Tue, Aug 19 from Denver Intl. to Barkley Regional, returning Fri, Aug 22, priced at $339 found 3 days ago

Cheap Flights to Southeast Missouri

Fall in love at first flight with your vacation to Southeast Missouri by saving a ton of cash on your last-minute cheap flight. There’s no more scouring the internet for a good deal—book your flight to Southeast Missouri on Hotwire, and you’ll be up, up, and on a getaway in no time.

Because once the wheels are down in Southeast Missouri, the good times start rolling. So buckle up, you’re in for a fun ride.

Frequently Asked Questions About flights to Southeast Missouri

Don’t waste your time on endless searches for cheap airline tickets oneway or roundtrip. We’ll have you on your way to Southeast Missouri with a tiny bag of pretzels in your hand before you can say “tray tables in the upright position”—and for a ticket price that works for your vacay budget.

So all you have to worry about is where you’re headed after the STL airport.

What is the cheapest month to fly to Southeast Missouri?

Airline ticket prices fluctuate all the time, depending on the day of the week or the month of the year. The cheapest round trip flights to Southeast Missouri are in August, but when you book your flight on Hotwire, savings are always in season.

How many airlines fly to Southeast Missouri?

Variety is the spice of life, even when it comes to booking your next trip. Want options for airlines? You’ll find 16 to choose from for your flight to Southeast Missouri.

What airport is best to fly into Southeast Missouri?

When you’re planning your trip to Southeast Missouri, convenience is the name of the game. Luckily, Southeast Missouri Cape Girardeau Municipal Airport is nearby so you can deplane and get going on checking off everything on your Southeast Missouri must-do list.

How much are flights to Southeast Missouri?

Got very cheap flights on your vacation itinerary? When you book your airline tickets to Southeast Missouri on Hotwire, you may just get what’s on your getaway wish list. With tickets as low as $110, you’ll have leftover cash for at least a magazine and a bottle of water at the airport book store.

How to get cheap flights to Southeast Missouri?

The trick to saving a stack of cash on your flight to Southeast Missouri? Snatch up that Hotwire flight deal when you see a killer rate because it could be gone in a flash. And with flights as low as $110 right now, why wait?

Southeast Missouri Flight Information
Destination airport
Lambert-St. Louis Intl.
Destination airport IATA code
STL
Roundtrip price
$109

Last Minute Hotel Deals in Southeast Missouri

Baymont Inn and Suites by Wyndham Farmington, MO
Baymont Inn and Suites by Wyndham Farmington, MO
2.5 out of 5
1625 W Columbia St, Farmington, MO
Book a stay at this business-friendly hotel in Farmington. Enjoy free breakfast, free parking, and an outdoor pool. Our guests praise the breakfast and the helpful ...
8/10 Very Good! (1,006 reviews)
"Overall great place. Would stay again"

Reviewed on Jul 9, 2025

Get rates
Baymont Inn and Suites by Wyndham Farmington, MO
The Riverview
The Riverview
2 out of 5
777 Main St, Cape Girardeau, MO
Stay at this hotel in Cape Girardeau. Enjoy free WiFi, free parking, and 2 restaurants. Popular attractions Isle Casino Cape Girardeau and Riverfront Park are ...
9.2/10 Wonderful! (332 reviews)
"Very nice place to stay. Close to restaurants and easy access."

Reviewed on Jul 11, 2025

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The Riverview
Drury Plaza Hotel Cape Girardeau Conference Center
Drury Plaza Hotel Cape Girardeau Conference Center
3 out of 5
3351 Percy Drive, Cape Girardeau, MO
Stay at this 3-star business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.4/10 Exceptional! (1,008 reviews)
Great stay
"Awesome hotel. Beds are comfortable. Rooms are quiet. Breakfast was awesome."

Reviewed on Jul 13, 2025

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Drury Plaza Hotel Cape Girardeau Conference Center
Motel 6 Poplar Bluff, MO
Motel 6 Poplar Bluff, MO
2 out of 5
4101 Highway 67 N, Poplar Bluff, MO
Stay at this motel in Poplar Bluff. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff and the clean rooms in our reviews. ...
7.8/10 Good! (1,012 reviews)
"The room was very clean and relaxing"

Reviewed on Jul 13, 2025

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Motel 6 Poplar Bluff, MO
The Farmstead Hotel
The Farmstead Hotel
2.5 out of 5
778 E 3rd St, Caruthersville, MO
Stay at this hotel in Caruthersville. Enjoy free WiFi, free parking, and a casino. Our guests praise the helpful staff and the clean rooms in our reviews. Popular ...
8.6/10 Excellent! (378 reviews)
"very clean and the staff is amazing"

Reviewed on Jul 12, 2025

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The Farmstead Hotel
Best Western Plus Sikeston
Best Western Plus Sikeston
2.5 out of 5
120 S Interstate Drive, Sikeston, MO
Stay at this hotel in Sikeston. Enjoy free breakfast, free parking, and a fitness center. Our guests praise the breakfast and the helpful staff in our reviews. ...
8.2/10 Very Good! (1,009 reviews)
"We were travelling through and were pleasantly surprised at how well maintained the hotel was. Also breakfast was great with eggs and biscuits and gravy. Would definitely stay again."

Reviewed on Jul 8, 2025

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Best Western Plus Sikeston
Tru By Hilton Cape Girardeau
Tru By Hilton Cape Girardeau
2.5 out of 5
2520 Veterans Memorial Dr, Cape Girardeau, MO
Stay at this hotel in Cape Girardeau. Enjoy free breakfast, free parking, and a fitness center. Popular attractions Cape Girardeau Conservation Nature Center ...
9.6/10 Exceptional! (41 reviews)
"Very nice to stay in a brand new hotel. So clean. Everyone seemed very nice and helpful. Love the extra games and pool table to keep the kids busy. Loved that you had cookies and milk although we didn't make it down for that. I thought it was a wonderful idea."

Reviewed on Jul 11, 2025

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Tru By Hilton Cape Girardeau
Comfort Inn Festus - St Louis South
Comfort Inn Festus - St Louis South
2.5 out of 5
1303 Veterans Blvd, Festus, MO
Book a stay at this business-friendly hotel in Festus. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
7.8/10 Good! (835 reviews)
Family vaca
"Great breakfast nice layover on our way to Florida"

Reviewed on Jun 24, 2025

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Comfort Inn Festus - St Louis South
See all 582 properties in Southeast Missouri
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.