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Southeast Missouri

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Southeast Missouri Flights as Low as $140

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

Frontier Airlines
Tue, Apr 8 - Sat, Apr 12
PHL
Philadelphia Intl.
STL
Lambert-St. Louis Intl.
$140 Roundtrip, found 2 days ago
$140
Roundtrip
found 2 days ago
Select Frontier Airlines flight, departing Tue, Apr 8 from Philadelphia Intl. to Lambert-St. Louis Intl., returning Sat, Apr 12, priced at $140 found 2 days ago
Frontier Airlines
Mon, Apr 7 - Sun, Apr 13
TTN
Mercer
STL
Lambert-St. Louis Intl.
$150 Roundtrip, found 4 days ago
$150
Roundtrip
found 4 days ago
Select Frontier Airlines flight, departing Mon, Apr 7 from Mercer to Lambert-St. Louis Intl., returning Sun, Apr 13, priced at $150 found 4 days ago
Frontier Airlines
Mon, Apr 7 - Wed, Apr 16
PHL
Philadelphia Intl.
STL
Lambert-St. Louis Intl.
$160 Roundtrip, found 4 days ago
$160
Roundtrip
found 4 days ago
Select Frontier Airlines flight, departing Mon, Apr 7 from Philadelphia Intl. to Lambert-St. Louis Intl., returning Wed, Apr 16, priced at $160 found 4 days ago
Frontier Airlines
Fri, Apr 4 - Sat, Apr 12
TTN
Mercer
STL
Lambert-St. Louis Intl.
$175 Roundtrip, found 4 days ago
$175
Roundtrip
found 4 days ago
Select Frontier Airlines flight, departing Fri, Apr 4 from Mercer to Lambert-St. Louis Intl., returning Sat, Apr 12, priced at $175 found 4 days ago
Frontier Airlines
Fri, Apr 4 - Sun, Apr 13
TTN
Mercer
STL
Lambert-St. Louis Intl.
$185 Roundtrip, found 4 days ago
$185
Roundtrip
found 4 days ago
Select Frontier Airlines flight, departing Fri, Apr 4 from Mercer to Lambert-St. Louis Intl., returning Sun, Apr 13, priced at $185 found 4 days ago
Frontier Airlines
Wed, Apr 9 - Sat, Apr 12
PHL
Philadelphia Intl.
STL
Lambert-St. Louis Intl.
$190 Roundtrip, found 4 days ago
$190
Roundtrip
found 4 days ago
Select Frontier Airlines flight, departing Wed, Apr 9 from Philadelphia Intl. to Lambert-St. Louis Intl., returning Sat, Apr 12, priced at $190 found 4 days ago
Frontier Airlines
Tue, Feb 18 - Tue, Feb 25
PHL
Philadelphia Intl.
STL
Lambert-St. Louis Intl.
$196 Roundtrip, found 1 day ago
$196
Roundtrip
found 1 day ago
Select Frontier Airlines flight, departing Tue, Feb 18 from Philadelphia Intl. to Lambert-St. Louis Intl., returning Tue, Feb 25, priced at $196 found 1 day ago
Frontier Airlines
Wed, Apr 9 - Sun, Apr 13
PHL
Philadelphia Intl.
STL
Lambert-St. Louis Intl.
$200 Roundtrip, found 4 days ago
$200
Roundtrip
found 4 days ago
Select Frontier Airlines flight, departing Wed, Apr 9 from Philadelphia Intl. to Lambert-St. Louis Intl., returning Sun, Apr 13, priced at $200 found 4 days ago
Frontier Airlines
Wed, Apr 9 - Wed, Apr 16
PHL
Philadelphia Intl.
STL
Lambert-St. Louis Intl.
$210 Roundtrip, found 4 days ago
$210
Roundtrip
found 4 days ago
Select Frontier Airlines flight, departing Wed, Apr 9 from Philadelphia Intl. to Lambert-St. Louis Intl., returning Wed, Apr 16, priced at $210 found 4 days ago
Frontier Airlines
Sat, Apr 5 - Sat, Apr 12
PHL
Philadelphia Intl.
STL
Lambert-St. Louis Intl.
$215 Roundtrip, found 4 days ago
$215
Roundtrip
found 4 days ago
Select Frontier Airlines flight, departing Sat, Apr 5 from Philadelphia Intl. to Lambert-St. Louis Intl., returning Sat, Apr 12, priced at $215 found 4 days ago
Frontier Airlines
Fri, Jan 24 - Sat, Jan 25
MDT
Harrisburg Intl.
STL
Lambert-St. Louis Intl.
$300 Roundtrip, found 21 hours ago
$300
Roundtrip
found 21 hours ago
Select Frontier Airlines flight, departing Fri, Jan 24 from Harrisburg Intl. to Lambert-St. Louis Intl., returning Sat, Jan 25, priced at $300 found 21 hours ago
Spirit Airlines
Tue, Apr 8 - Sun, Apr 13
PHL
Philadelphia Intl.
STL
Lambert-St. Louis Intl.
$309 Roundtrip, found 2 days ago
$309
Roundtrip
found 2 days ago
Select Spirit Airlines flight, departing Tue, Apr 8 from Philadelphia Intl. to Lambert-St. Louis Intl., returning Sun, Apr 13, priced at $309 found 2 days ago
American Airlines
Tue, Apr 8 - Wed, Apr 16
PHL
Philadelphia Intl.
STL
Lambert-St. Louis Intl.
$337 Roundtrip, found 4 days ago
$337
Roundtrip
found 4 days ago
Select American Airlines flight, departing Tue, Apr 8 from Philadelphia Intl. to Lambert-St. Louis Intl., returning Wed, Apr 16, priced at $337 found 4 days ago
United
Tue, Apr 8 - Wed, Apr 16
PHL
Philadelphia Intl.
STL
Lambert-St. Louis Intl.
$357 Roundtrip, found 4 days ago
$357
Roundtrip
found 4 days ago
Select United flight, departing Tue, Apr 8 from Philadelphia Intl. to Lambert-St. Louis Intl., returning Wed, Apr 16, priced at $357 found 4 days ago
Delta
Tue, Apr 8 - Wed, Apr 16
PHL
Philadelphia Intl.
STL
Lambert-St. Louis Intl.
$357 Roundtrip, found 4 days ago
$357
Roundtrip
found 4 days ago
Select Delta flight, departing Tue, Apr 8 from Philadelphia Intl. to Lambert-St. Louis Intl., returning Wed, Apr 16, priced at $357 found 4 days ago
American Airlines
Mon, Mar 3 - Mon, Mar 3
PHL
Philadelphia Intl.
MWA
Williamson County Regional
$421 Roundtrip, found 5 days ago
$421
Roundtrip
found 5 days ago
Select American Airlines flight, departing Mon, Mar 3 from Philadelphia Intl. to Williamson County Regional, returning Mon, Mar 3, priced at $421 found 5 days ago

Cheap Flights to Southeast Missouri

Fall in love at first flight with your vacation to Southeast Missouri by saving a ton of cash on your last-minute cheap flight. There’s no more scouring the internet for a good deal—book your flight to Southeast Missouri on Hotwire, and you’ll be up, up, and on a getaway in no time.

Because once the wheels are down in Southeast Missouri, the good times start rolling. So buckle up, you’re in for a fun ride.

Frequently Asked Questions About flights to Southeast Missouri

Don’t waste your time on endless searches for cheap airline tickets oneway or roundtrip. We’ll have you on your way to Southeast Missouri with a tiny bag of pretzels in your hand before you can say “tray tables in the upright position”—and for a ticket price that works for your vacay budget.

So all you have to worry about is where you’re headed after the STL airport.

What is the cheapest month to fly to Southeast Missouri?

Airline ticket prices fluctuate all the time, depending on the day of the week or the month of the year. The cheapest round trip flights to Southeast Missouri are in April, but when you book your flight on Hotwire, savings are always in season.

How many airlines fly to Southeast Missouri?

Variety is the spice of life, even when it comes to booking your next trip. Want options for airlines? You’ll find 16 to choose from for your flight to Southeast Missouri.

What airport is best to fly into Southeast Missouri?

When you’re planning your trip to Southeast Missouri, convenience is the name of the game. Luckily, Southeast Missouri Cape Girardeau Municipal Airport is nearby so you can deplane and get going on checking off everything on your Southeast Missouri must-do list.

How much are flights to Southeast Missouri?

Got very cheap flights on your vacation itinerary? When you book your airline tickets to Southeast Missouri on Hotwire, you may just get what’s on your getaway wish list. With tickets as low as $140, you’ll have leftover cash for at least a magazine and a bottle of water at the airport book store.

How to get cheap flights to Southeast Missouri?

The trick to saving a stack of cash on your flight to Southeast Missouri? Snatch up that Hotwire flight deal when you see a killer rate because it could be gone in a flash. And with flights as low as $140 right now, why wait?

Southeast Missouri Flight Information
Destination airport
Lambert-St. Louis Intl.
Destination airport IATA code
STL
Roundtrip price
$120

Last Minute Hotel Deals in Southeast Missouri

Days Inn and Suites by Wyndham Sikeston
Days Inn and Suites by Wyndham Sikeston
2 out of 5
220 S Interstate Dr, Sikeston, MO
The price is $72 per night from Jan 21 to Jan 22
$72
includes taxes & fees
Jan 21 - Jan 22
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7.2/10 Good! (1,000 reviews)
"Quick trip. Just needed a stopover. Comfy beds clean room"

Reviewed on Jan 13, 2025

Days Inn and Suites by Wyndham Sikeston
Baymont Inn and Suites by Wyndham Farmington, MO
Baymont Inn and Suites by Wyndham Farmington, MO
2.5 out of 5
1625 W Columbia St, Farmington, MO
The price is $59 per night from Jan 26 to Jan 27
$59
includes taxes & fees
Jan 26 - Jan 27
Book a stay at this business-friendly hotel in Farmington. Enjoy free breakfast, free parking, and an outdoor pool. Our guests praise the breakfast and the helpful ...
8/10 Very Good! (836 reviews)
"Its good"

Reviewed on Jan 9, 2025

Baymont Inn and Suites by Wyndham Farmington, MO
Motel 6 Poplar Bluff, MO
Motel 6 Poplar Bluff, MO
2 out of 5
4101 Highway 67 N, Poplar Bluff, MO
The price is $79 per night from Jan 20 to Jan 21
$79
includes taxes & fees
Jan 20 - Jan 21
Stay at this motel in Poplar Bluff. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff and the clean rooms in our reviews. ...
7.8/10 Good! (1,002 reviews)
"Clean room"

Reviewed on Jan 8, 2025

Motel 6 Poplar Bluff, MO
Drury Inn & Suites Cape Girardeau
Drury Inn & Suites Cape Girardeau
3 out of 5
3303 Campster Drive, Cape Girardeau, MO
The price is $107 per night from Jan 23 to Jan 24
$107
includes taxes & fees
Jan 23 - Jan 24
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the ...
9.2/10 Wonderful! (871 reviews)
"Amazing staff and hotel!"

Reviewed on Jan 15, 2025

Drury Inn & Suites Cape Girardeau
Holiday Inn Express Hotel & Suites Cape Girardeau I-55, an IHG Hotel
Holiday Inn Express Hotel & Suites Cape Girardeau I-55, an IHG Hotel
2.5 out of 5
3253 William Street, Cape Girardeau, MO
The price is $112 per night from Feb 3 to Feb 4
$112
includes taxes & fees
Feb 3 - Feb 4
Book a stay at this spa hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in ...
9.4/10 Exceptional! (999 reviews)
"very good, nice location"

Reviewed on Jan 9, 2025

Holiday Inn Express Hotel & Suites Cape Girardeau I-55, an IHG Hotel
Pear Tree Inn Cape Girardeau West
Pear Tree Inn Cape Girardeau West
2.5 out of 5
103 Cape West Pkwy, Cape Girardeau, MO
The price is $71 per night from Jan 23 to Jan 24
$71
includes taxes & fees
Jan 23 - Jan 24
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the ...
8.8/10 Excellent! (1,001 reviews)
"Wonderful Stay"

Reviewed on Jan 16, 2025

Pear Tree Inn Cape Girardeau West
Drury Plaza Hotel Cape Girardeau Conference Center
Drury Plaza Hotel Cape Girardeau Conference Center
3 out of 5
3351 Percy Drive, Cape Girardeau, MO
The price is $112 per night from Jan 23 to Jan 24
$112
includes taxes & fees
Jan 23 - Jan 24
Stay at this 3-star business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.4/10 Exceptional! (1,001 reviews)
"Clean and let us stay a little late because I was under the weather."

Reviewed on Jan 16, 2025

Drury Plaza Hotel Cape Girardeau Conference Center
The Riverview
The Riverview
3.5 out of 5
777 Main St, Cape Girardeau, MO
The price is $109 per night from Jan 26 to Jan 27
$109
includes taxes & fees
Jan 26 - Jan 27
Stay at this 3.5-star hotel in Cape Girardeau. Enjoy free WiFi, free parking, and 2 restaurants. Popular attractions Isle Casino Cape Girardeau and Riverfront ...
9.2/10 Wonderful! (123 reviews)
"Great property! Really enjoyed the wonderful location and the staff was very helpful."

Reviewed on Jan 3, 2025

The Riverview
See all 533 properties in Southeast Missouri
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.