Search Cheap Flights toSoutheast Missouri
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Southeast Missouri Flights as Low as $140
Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.
Fri, Jun 20 - Sun, Jun 22
DTW
Detroit Metropolitan Wayne County
STL
Lambert-St. Louis Intl.
$140 Roundtrip, found 1 day ago
$140
Roundtrip
found 1 day ago
Thu, Jul 17 - Sun, Jul 20
DTW
Detroit Metropolitan Wayne County
STL
Lambert-St. Louis Intl.
$170 Roundtrip, found 6 days ago
$170
Roundtrip
found 6 days ago
Thu, Jul 17 - Sun, Jul 20
DTW
Detroit Metropolitan Wayne County
STL
Lambert-St. Louis Intl.
$189 Roundtrip, found 6 days ago
$189
Roundtrip
found 6 days ago
Tue, Jun 17 - Thu, Jun 19
DTW
Detroit Metropolitan Wayne County
STL
Lambert-St. Louis Intl.
$193 Roundtrip, found 6 days ago
$193
Roundtrip
found 6 days ago
Thu, Jul 17 - Sun, Jul 20
DTW
Detroit Metropolitan Wayne County
STL
Lambert-St. Louis Intl.
$194 Roundtrip, found 6 days ago
$194
Roundtrip
found 6 days ago
Tue, Jun 17 - Wed, Jun 18
DTW
Detroit Metropolitan Wayne County
STL
Lambert-St. Louis Intl.
$199 Roundtrip, found 4 days ago
$199
Roundtrip
found 4 days ago
Fri, Jun 20 - Sun, Jun 22
DTW
Detroit Metropolitan Wayne County
STL
Lambert-St. Louis Intl.
$201 Roundtrip, found 1 day ago
$201
Roundtrip
found 1 day ago
Tue, Jun 17 - Wed, Jun 18
DTW
Detroit Metropolitan Wayne County
STL
Lambert-St. Louis Intl.
$202 Roundtrip, found 4 days ago
$202
Roundtrip
found 4 days ago
Thu, Jul 17 - Sun, Jul 20
DTW
Detroit Metropolitan Wayne County
STL
Lambert-St. Louis Intl.
$205 Roundtrip, found 6 days ago
$205
Roundtrip
found 6 days ago
Fri, Jun 20 - Sun, Jun 22
DTW
Detroit Metropolitan Wayne County
STL
Lambert-St. Louis Intl.
$206 Roundtrip, found 1 day ago
$206
Roundtrip
found 1 day ago
Sat, Jun 14 - Sun, Jun 15
DTW
Detroit Metropolitan Wayne County
STL
Lambert-St. Louis Intl.
$209 Roundtrip, found 4 days ago
$209
Roundtrip
found 4 days ago
Fri, Jun 20 - Fri, Jun 20
DTW
Detroit Metropolitan Wayne County
STL
Lambert-St. Louis Intl.
$209 Roundtrip, found 2 days ago
$209
Roundtrip
found 2 days ago
Tue, Jun 17 - Wed, Jun 18
DTW
Detroit Metropolitan Wayne County
STL
Lambert-St. Louis Intl.
$237 Roundtrip, found 4 days ago
$237
Roundtrip
found 4 days ago
Thu, May 1 - Sat, May 3
DTW
Detroit Metropolitan Wayne County
STL
Lambert-St. Louis Intl.
$240 Roundtrip, found 17 hours ago
$240
Roundtrip
found 17 hours ago
Sat, May 3 - Mon, May 12
DTW
Detroit Metropolitan Wayne County
MWA
Williamson County Regional
$422 Roundtrip, found 17 hours ago
$422
Roundtrip
found 17 hours ago
Fri, May 2 - Mon, May 12
DTW
Detroit Metropolitan Wayne County
CGI
Cape Girardeau Municipal
$422 Roundtrip, found 17 hours ago
$422
Roundtrip
found 17 hours ago
Cheap Flights to Southeast Missouri
Fall in love at first flight with your vacation to Southeast Missouri by saving a ton of cash on your last-minute cheap flight. There’s no more scouring the internet for a good deal—book your flight to Southeast Missouri on Hotwire, and you’ll be up, up, and on a getaway in no time.
Because once the wheels are down in Southeast Missouri, the good times start rolling. So buckle up, you’re in for a fun ride.
Frequently Asked Questions About flights to Southeast Missouri
Don’t waste your time on endless searches for cheap airline tickets oneway or roundtrip. We’ll have you on your way to Southeast Missouri with a tiny bag of pretzels in your hand before you can say “tray tables in the upright position”—and for a ticket price that works for your vacay budget.
So all you have to worry about is where you’re headed after the STL airport.
What is the cheapest month to fly to Southeast Missouri?
Airline ticket prices fluctuate all the time, depending on the day of the week or the month of the year. The cheapest round trip flights to Southeast Missouri are in June, but when you book your flight on Hotwire, savings are always in season.
How many airlines fly to Southeast Missouri?
Variety is the spice of life, even when it comes to booking your next trip. Want options for airlines? You’ll find 16 to choose from for your flight to Southeast Missouri.
What airport is best to fly into Southeast Missouri?
When you’re planning your trip to Southeast Missouri, convenience is the name of the game. Luckily, Southeast Missouri Cape Girardeau Municipal Airport is nearby so you can deplane and get going on checking off everything on your Southeast Missouri must-do list.
How much are flights to Southeast Missouri?
Got very cheap flights on your vacation itinerary? When you book your airline tickets to Southeast Missouri on Hotwire, you may just get what’s on your getaway wish list. With tickets as low as $140, you’ll have leftover cash for at least a magazine and a bottle of water at the airport book store.
How to get cheap flights to Southeast Missouri?
The trick to saving a stack of cash on your flight to Southeast Missouri? Snatch up that Hotwire flight deal when you see a killer rate because it could be gone in a flash. And with flights as low as $140 right now, why wait?
Destination airport | Lambert-St. Louis Intl. |
Destination airport IATA code | STL |
Roundtrip price | $140 |
Last Minute Hotel Deals in Southeast Missouri
The Riverview
777 Main St, Cape Girardeau, MO
The price is $109 per night from Apr 20 to Apr 21
$109
includes taxes & fees
Apr 20 - Apr 21
Stay at this 3.5-star hotel in Cape Girardeau. Enjoy free WiFi, free parking, and 2 restaurants. Popular attractions Isle Casino Cape Girardeau and Riverfront ...
9.2/10 Wonderful! (226 reviews)
"A beautiful clean place to stay"
Reviewed on Apr 15, 2025
Baymont Inn and Suites by Wyndham Farmington, MO
1625 W Columbia St, Farmington, MO
The price is $63 per night from Apr 27 to Apr 28
$63
includes taxes & fees
Apr 27 - Apr 28
Book a stay at this business-friendly hotel in Farmington. Enjoy free breakfast, free parking, and an outdoor pool. Our guests praise the breakfast and the helpful ...
8/10 Very Good! (919 reviews)
"There was not a lot of places near by to eat at."
Reviewed on Apr 15, 2025
Drury Plaza Hotel Cape Girardeau Conference Center
3351 Percy Drive, Cape Girardeau, MO
The price is $112 per night from Apr 27 to Apr 28
$112
includes taxes & fees
Apr 27 - Apr 28
Stay at this 3-star business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.4/10 Exceptional! (1,014 reviews)
"Great place!!"
Reviewed on Apr 18, 2025
Motel 6 Poplar Bluff, MO
4101 Highway 67 N, Poplar Bluff, MO
The price is $83 per night from Apr 21 to Apr 22
$83
includes taxes & fees
Apr 21 - Apr 22
Stay at this motel in Poplar Bluff. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff and the clean rooms in our reviews. ...
7.8/10 Good! (1,004 reviews)
"Staff was very accommodating. Very nice place that is dog friendly."
Reviewed on Apr 16, 2025
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
3253 William Street, Cape Girardeau, MO
The price is $116 per night from May 4 to May 5
$116
includes taxes & fees
May 4 - May 5
Book a stay at this spa hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in ...
9.4/10 Exceptional! (1,003 reviews)
"Will definitely stay there again!!"
Reviewed on Apr 9, 2025
Pear Tree Inn Sikeston
2602 E Malone Avenue, Sikeston, MO
The price is $98 per night from Apr 23 to Apr 24
$98
includes taxes & fees
Apr 23 - Apr 24
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the helpful ...
9.2/10 Wonderful! (1,000 reviews)
Quiet area
"Quiet and comfortable enough to get a good days sleep before working a night shift"
Reviewed on Apr 14, 2025
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
3003 SOUTH OLD ORCHARD ROAD, Jackson, MO
The price is $90 per night from May 4 to May 5
$90
includes taxes & fees
May 4 - May 5
Book a stay at this business-friendly hotel in Jackson. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8.8/10 Excellent! (538 reviews)
LaQuinta inn
"Loved the healthy options for breakfast, also the spaciousness of the room and the big comfortale chair with the extra high foot rest"
Reviewed on Apr 15, 2025
The Farmstead Hotel
778 E 3rd St, Caruthersville, MO
The price is $101 per night from Apr 20 to Apr 21
$101
includes taxes & fees
Apr 20 - Apr 21
Stay at this hotel in Caruthersville. Enjoy free WiFi, free parking, and a casino. Our guests praise the helpful staff and the clean rooms in our reviews. Popular ...
8.6/10 Excellent! (331 reviews)
"This is a nicely remodeled and well-appointed property. The only problem I had is that the walls and floors seemed very thin. I heard people loudly thumping around above me during my entire stay, and I could clearly hear the television next door until after 2:30 a.m."
Reviewed on Apr 14, 2025
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Southeast Missouri Hotels
- Baymont Inn and Suites by Wyndham Farmington, MO
- Motel 6 Poplar Bluff, MO
- Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
- Fairfield Inn & Suites by Marriott Poplar Bluff
- Best Western Plus Sikeston
- Candlewood Suites Cape Girardeau by IHG
- La Quinta Inn & Suites by Wyndham Festus - St. Louis South