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Southeast Missouri

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Southeast Missouri Flights as Low as $271

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

Bargain Flight
Sun, Jun 15 - Thu, Jun 19
OKC
Will Rogers World
STL
Lambert-St. Louis Intl.
$271 Roundtrip, found 4 days ago
$271
Roundtrip
found 4 days ago
Select Bargain Flight flight, departing Sun, Jun 15 from Will Rogers World to Lambert-St. Louis Intl., returning Thu, Jun 19, priced at $271 found 4 days ago
Bargain Flight
Tue, Jun 10 - Wed, Jun 18
OKC
Will Rogers World
STL
Lambert-St. Louis Intl.
$289 Roundtrip, found 4 days ago
$289
Roundtrip
found 4 days ago
Select Bargain Flight flight, departing Tue, Jun 10 from Will Rogers World to Lambert-St. Louis Intl., returning Wed, Jun 18, priced at $289 found 4 days ago
American Airlines
Sun, Jun 15 - Thu, Jun 19
OKC
Will Rogers World
STL
Lambert-St. Louis Intl.
$432 Roundtrip, found 4 days ago
$432
Roundtrip
found 4 days ago
Select American Airlines flight, departing Sun, Jun 15 from Will Rogers World to Lambert-St. Louis Intl., returning Thu, Jun 19, priced at $432 found 4 days ago
American Airlines
Sun, Jun 15 - Thu, Jun 19
OKC
Will Rogers World
STL
Lambert-St. Louis Intl.
$433 Roundtrip, found 4 days ago
$433
Roundtrip
found 4 days ago
Select American Airlines flight, departing Sun, Jun 15 from Will Rogers World to Lambert-St. Louis Intl., returning Thu, Jun 19, priced at $433 found 4 days ago
American Airlines
Sun, Jun 15 - Thu, Jun 19
OKC
Will Rogers World
STL
Lambert-St. Louis Intl.
$446 Roundtrip, found 4 days ago
$446
Roundtrip
found 4 days ago
Select American Airlines flight, departing Sun, Jun 15 from Will Rogers World to Lambert-St. Louis Intl., returning Thu, Jun 19, priced at $446 found 4 days ago
American Airlines
Sun, Jun 15 - Thu, Jun 19
OKC
Will Rogers World
STL
Lambert-St. Louis Intl.
$461 Roundtrip, found 4 days ago
$461
Roundtrip
found 4 days ago
Select American Airlines flight, departing Sun, Jun 15 from Will Rogers World to Lambert-St. Louis Intl., returning Thu, Jun 19, priced at $461 found 4 days ago
United
Sun, Jun 15 - Thu, Jun 19
OKC
Will Rogers World
STL
Lambert-St. Louis Intl.
$462 Roundtrip, found 4 days ago
$462
Roundtrip
found 4 days ago
Select United flight, departing Sun, Jun 15 from Will Rogers World to Lambert-St. Louis Intl., returning Thu, Jun 19, priced at $462 found 4 days ago
Delta
Sun, Jun 15 - Thu, Jun 19
OKC
Will Rogers World
STL
Lambert-St. Louis Intl.
$470 Roundtrip, found 4 days ago
$470
Roundtrip
found 4 days ago
Select Delta flight, departing Sun, Jun 15 from Will Rogers World to Lambert-St. Louis Intl., returning Thu, Jun 19, priced at $470 found 4 days ago
American Airlines
Sun, Jun 15 - Thu, Jun 19
OKC
Will Rogers World
STL
Lambert-St. Louis Intl.
$479 Roundtrip, found 4 days ago
$479
Roundtrip
found 4 days ago
Select American Airlines flight, departing Sun, Jun 15 from Will Rogers World to Lambert-St. Louis Intl., returning Thu, Jun 19, priced at $479 found 4 days ago
Delta
Sun, Jun 15 - Thu, Jun 19
OKC
Will Rogers World
STL
Lambert-St. Louis Intl.
$493 Roundtrip, found 4 days ago
$493
Roundtrip
found 4 days ago
Select Delta flight, departing Sun, Jun 15 from Will Rogers World to Lambert-St. Louis Intl., returning Thu, Jun 19, priced at $493 found 4 days ago
United
Sun, Jun 15 - Thu, Jun 19
OKC
Will Rogers World
STL
Lambert-St. Louis Intl.
$494 Roundtrip, found 4 days ago
$494
Roundtrip
found 4 days ago
Select United flight, departing Sun, Jun 15 from Will Rogers World to Lambert-St. Louis Intl., returning Thu, Jun 19, priced at $494 found 4 days ago
American Airlines
Sun, Jun 15 - Thu, Jun 19
OKC
Will Rogers World
STL
Lambert-St. Louis Intl.
$497 Roundtrip, found 4 days ago
$497
Roundtrip
found 4 days ago
Select American Airlines flight, departing Sun, Jun 15 from Will Rogers World to Lambert-St. Louis Intl., returning Thu, Jun 19, priced at $497 found 4 days ago
United
Thu, Jun 12 - Mon, Jun 16
OKC
Will Rogers World
STL
Lambert-St. Louis Intl.
$500 Roundtrip, found 2 days ago
$500
Roundtrip
found 2 days ago
Select United flight, departing Thu, Jun 12 from Will Rogers World to Lambert-St. Louis Intl., returning Mon, Jun 16, priced at $500 found 2 days ago
United
Sun, Jun 15 - Thu, Jun 19
OKC
Will Rogers World
STL
Lambert-St. Louis Intl.
$503 Roundtrip, found 4 days ago
$503
Roundtrip
found 4 days ago
Select United flight, departing Sun, Jun 15 from Will Rogers World to Lambert-St. Louis Intl., returning Thu, Jun 19, priced at $503 found 4 days ago
American Airlines
Sat, Jul 5 - Thu, Jul 10
OKC
Will Rogers World
CGI
Cape Girardeau Municipal
$527 Roundtrip, found 1 day ago
$527
Roundtrip
found 1 day ago
Select American Airlines flight, departing Sat, Jul 5 from Will Rogers World to Cape Girardeau Municipal, returning Thu, Jul 10, priced at $527 found 1 day ago
Delta
Wed, Jun 11 - Wed, Jun 18
OKC
Will Rogers World
STL
Lambert-St. Louis Intl.
$572 Roundtrip, found 3 days ago
$572
Roundtrip
found 3 days ago
Select Delta flight, departing Wed, Jun 11 from Will Rogers World to Lambert-St. Louis Intl., returning Wed, Jun 18, priced at $572 found 3 days ago

Cheap Flights to Southeast Missouri

Fall in love at first flight with your vacation to Southeast Missouri by saving a ton of cash on your last-minute cheap flight. There’s no more scouring the internet for a good deal—book your flight to Southeast Missouri on Hotwire, and you’ll be up, up, and on a getaway in no time.

Because once the wheels are down in Southeast Missouri, the good times start rolling. So buckle up, you’re in for a fun ride.

Frequently Asked Questions About flights to Southeast Missouri

Don’t waste your time on endless searches for cheap airline tickets oneway or roundtrip. We’ll have you on your way to Southeast Missouri with a tiny bag of pretzels in your hand before you can say “tray tables in the upright position”—and for a ticket price that works for your vacay budget.

So all you have to worry about is where you’re headed after the STL airport.

What is the cheapest month to fly to Southeast Missouri?

Airline ticket prices fluctuate all the time, depending on the day of the week or the month of the year. The cheapest round trip flights to Southeast Missouri are in June, but when you book your flight on Hotwire, savings are always in season.

How many airlines fly to Southeast Missouri?

Variety is the spice of life, even when it comes to booking your next trip. Want options for airlines? You’ll find 14 to choose from for your flight to Southeast Missouri.

What airport is best to fly into Southeast Missouri?

When you’re planning your trip to Southeast Missouri, convenience is the name of the game. Luckily, Southeast Missouri Cape Girardeau Municipal Airport is nearby so you can deplane and get going on checking off everything on your Southeast Missouri must-do list.

How much are flights to Southeast Missouri?

Got very cheap flights on your vacation itinerary? When you book your airline tickets to Southeast Missouri on Hotwire, you may just get what’s on your getaway wish list. With tickets as low as $271, you’ll have leftover cash for at least a magazine and a bottle of water at the airport book store.

How to get cheap flights to Southeast Missouri?

The trick to saving a stack of cash on your flight to Southeast Missouri? Snatch up that Hotwire flight deal when you see a killer rate because it could be gone in a flash. And with flights as low as $271 right now, why wait?

Southeast Missouri Flight Information
Destination airport
Lambert-St. Louis Intl.
Destination airport IATA code
STL
Roundtrip price
$115

Last Minute Hotel Deals in Southeast Missouri

Drury Plaza Hotel Cape Girardeau Conference Center
Drury Plaza Hotel Cape Girardeau Conference Center
3 out of 5
3351 Percy Drive, Cape Girardeau, MO
Stay at this 3-star business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.4/10 Exceptional! (1,000 reviews)
"The room, kick back, breakfast, everything was absolutely awesome!!! This is the first time we have ever booked a hotel better than motel 6 so it was a new experience for us. Absolutely everything was perfect, HOWEVER we did have a few rough phone calls when calling down for basic information. Both ..."

Reviewed on Jun 2, 2025

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Drury Plaza Hotel Cape Girardeau Conference Center
Baymont Inn and Suites by Wyndham Farmington, MO
Baymont Inn and Suites by Wyndham Farmington, MO
2.5 out of 5
1625 W Columbia St, Farmington, MO
Book a stay at this business-friendly hotel in Farmington. Enjoy free breakfast, free parking, and an outdoor pool. Our guests praise the breakfast and the helpful ...
8/10 Very Good! (962 reviews)
"It was a very comfortable room. The bed was great and it was good sized. Staff was excellent. There was some confusion on the duration of our stay even though I had messaged property in advance. They corrected it and thankfully had rooms available."

Reviewed on Jun 1, 2025

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Baymont Inn and Suites by Wyndham Farmington, MO
The Riverview
The Riverview
2 out of 5
777 Main St, Cape Girardeau, MO
Stay at this hotel in Cape Girardeau. Enjoy free WiFi, free parking, and 2 restaurants. Popular attractions Isle Casino Cape Girardeau and Riverfront Park are ...
9.2/10 Wonderful! (284 reviews)
"It was great!"

Reviewed on Jun 4, 2025

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The Riverview
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
3 out of 5
3003 SOUTH OLD ORCHARD ROAD, Jackson, MO
Stay at this 3-star business-friendly hotel in Jackson. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8.8/10 Excellent! (563 reviews)
"We did a weekend getaway to do some shopping. This hotel was close to the stores where we wanted to shop. It was nice and clean and we were able to do any early check in online."

Reviewed on Jun 1, 2025

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La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
Motel 6 Poplar Bluff, MO
Motel 6 Poplar Bluff, MO
2 out of 5
4101 Highway 67 N, Poplar Bluff, MO
Stay at this motel in Poplar Bluff. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff and the clean rooms in our reviews. ...
7.8/10 Good! (1,004 reviews)
"It was nice only problem was no ice machine was down"

Reviewed on Jun 3, 2025

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Motel 6 Poplar Bluff, MO
Pear Tree Inn Cape Girardeau Near the Medical Center
Pear Tree Inn Cape Girardeau Near the Medical Center
2.5 out of 5
3248 William St, Cape Girardeau, MO
Stay at this hotel in Cape Girardeau. Enjoy free WiFi, an outdoor pool, and a 24-hour front desk. Our guests praise the helpful staff and the clean rooms in ...
8.8/10 Excellent! (1,001 reviews)
"Good"

Reviewed on Jun 2, 2025

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Pear Tree Inn Cape Girardeau Near the Medical Center
Candlewood Suites Cape Girardeau by IHG
Candlewood Suites Cape Girardeau by IHG
2.5 out of 5
485 S Mount Auburn Rd, Cape Girardeau, MO
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free WiFi, free parking, and a fitness center. Our guests praise the helpful staff and the ...
8/10 Very Good! (798 reviews)
"Clean and friendly"

Reviewed on Jun 2, 2025

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Candlewood Suites Cape Girardeau by IHG
Fairfield Inn & Suites by Marriott Poplar Bluff
Fairfield Inn & Suites by Marriott Poplar Bluff
2.5 out of 5
3109 Oak Grove, Poplar Bluff, MO
Book a stay at this business-friendly hotel in Poplar Bluff. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
9.4/10 Exceptional! (753 reviews)
"very nice"

Reviewed on Jun 5, 2025

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Fairfield Inn & Suites by Marriott Poplar Bluff
See all 580 properties in Southeast Missouri
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.