Search Cheap Flights to
Southeast Missouri

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Southeast Missouri Flights as Low as $515

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

American Airlines
Wed, Mar 26 - Fri, Apr 4
EWR
Newark Liberty Intl. Airport
PAH
Barkley Regional
$515 Roundtrip, found 1 day ago
$515
Roundtrip
found 1 day ago
Select American Airlines flight, departing Wed, Mar 26 from Newark Liberty Intl. Airport to Barkley Regional, returning Fri, Apr 4, priced at $515 found 1 day ago
American Airlines
Tue, Mar 25 - Fri, Apr 4
EWR
Newark Liberty Intl. Airport
PAH
Barkley Regional
$517 Roundtrip, found 1 day ago
$517
Roundtrip
found 1 day ago
Select American Airlines flight, departing Tue, Mar 25 from Newark Liberty Intl. Airport to Barkley Regional, returning Fri, Apr 4, priced at $517 found 1 day ago
American Airlines
Thu, Mar 27 - Fri, Apr 4
JFK
John F. Kennedy Intl.
PAH
Barkley Regional
$540 Roundtrip, found 1 day ago
$540
Roundtrip
found 1 day ago
Select American Airlines flight, departing Thu, Mar 27 from John F. Kennedy Intl. to Barkley Regional, returning Fri, Apr 4, priced at $540 found 1 day ago
American Airlines
Wed, Mar 26 - Thu, Mar 27
EWR
Newark Liberty Intl. Airport
PAH
Barkley Regional
$550 Roundtrip, found 1 day ago
$550
Roundtrip
found 1 day ago
Select American Airlines flight, departing Wed, Mar 26 from Newark Liberty Intl. Airport to Barkley Regional, returning Thu, Mar 27, priced at $550 found 1 day ago
American Airlines
Tue, Mar 25 - Thu, Mar 27
EWR
Newark Liberty Intl. Airport
PAH
Barkley Regional
$552 Roundtrip, found 1 day ago
$552
Roundtrip
found 1 day ago
Select American Airlines flight, departing Tue, Mar 25 from Newark Liberty Intl. Airport to Barkley Regional, returning Thu, Mar 27, priced at $552 found 1 day ago
American Airlines
Sat, Mar 29 - Fri, Apr 4
EWR
Newark Liberty Intl. Airport
PAH
Barkley Regional
$555 Roundtrip, found 1 day ago
$555
Roundtrip
found 1 day ago
Select American Airlines flight, departing Sat, Mar 29 from Newark Liberty Intl. Airport to Barkley Regional, returning Fri, Apr 4, priced at $555 found 1 day ago
American Airlines
Fri, Mar 28 - Fri, Apr 4
EWR
Newark Liberty Intl. Airport
PAH
Barkley Regional
$556 Roundtrip, found 1 day ago
$556
Roundtrip
found 1 day ago
Select American Airlines flight, departing Fri, Mar 28 from Newark Liberty Intl. Airport to Barkley Regional, returning Fri, Apr 4, priced at $556 found 1 day ago
American Airlines
Wed, Mar 26 - Thu, Apr 3
EWR
Newark Liberty Intl. Airport
PAH
Barkley Regional
$560 Roundtrip, found 1 day ago
$560
Roundtrip
found 1 day ago
Select American Airlines flight, departing Wed, Mar 26 from Newark Liberty Intl. Airport to Barkley Regional, returning Thu, Apr 3, priced at $560 found 1 day ago
American Airlines
Sun, Mar 30 - Fri, Apr 4
EWR
Newark Liberty Intl. Airport
PAH
Barkley Regional
$561 Roundtrip, found 1 day ago
$561
Roundtrip
found 1 day ago
Select American Airlines flight, departing Sun, Mar 30 from Newark Liberty Intl. Airport to Barkley Regional, returning Fri, Apr 4, priced at $561 found 1 day ago
American Airlines
Tue, Mar 25 - Thu, Apr 3
EWR
Newark Liberty Intl. Airport
PAH
Barkley Regional
$562 Roundtrip, found 1 day ago
$562
Roundtrip
found 1 day ago
Select American Airlines flight, departing Tue, Mar 25 from Newark Liberty Intl. Airport to Barkley Regional, returning Thu, Apr 3, priced at $562 found 1 day ago
American Airlines
Wed, Mar 26 - Thu, Mar 27
EWR
Newark Liberty Intl. Airport
PAH
Barkley Regional
$574 Roundtrip, found 1 day ago
$574
Roundtrip
found 1 day ago
Select American Airlines flight, departing Wed, Mar 26 from Newark Liberty Intl. Airport to Barkley Regional, returning Thu, Mar 27, priced at $574 found 1 day ago
American Airlines
Sat, Mar 29 - Fri, Apr 4
EWR
Newark Liberty Intl. Airport
PAH
Barkley Regional
$575 Roundtrip, found 1 day ago
$575
Roundtrip
found 1 day ago
Select American Airlines flight, departing Sat, Mar 29 from Newark Liberty Intl. Airport to Barkley Regional, returning Fri, Apr 4, priced at $575 found 1 day ago
American Airlines
Sat, Mar 29 - Sun, Apr 6
EWR
Newark Liberty Intl. Airport
PAH
Barkley Regional
$580 Roundtrip, found 1 day ago
$580
Roundtrip
found 1 day ago
Select American Airlines flight, departing Sat, Mar 29 from Newark Liberty Intl. Airport to Barkley Regional, returning Sun, Apr 6, priced at $580 found 1 day ago
American Airlines
Wed, Mar 26 - Thu, Mar 27
JFK
John F. Kennedy Intl.
PAH
Barkley Regional
$583 Roundtrip, found 1 day ago
$583
Roundtrip
found 1 day ago
Select American Airlines flight, departing Wed, Mar 26 from John F. Kennedy Intl. to Barkley Regional, returning Thu, Mar 27, priced at $583 found 1 day ago
American Airlines
Thu, Mar 27 - Thu, Apr 3
EWR
Newark Liberty Intl. Airport
PAH
Barkley Regional
$585 Roundtrip, found 1 day ago
$585
Roundtrip
found 1 day ago
Select American Airlines flight, departing Thu, Mar 27 from Newark Liberty Intl. Airport to Barkley Regional, returning Thu, Apr 3, priced at $585 found 1 day ago
American Airlines
Wed, Mar 26 - Fri, Mar 28
EWR
Newark Liberty Intl. Airport
PAH
Barkley Regional
$589 Roundtrip, found 1 day ago
$589
Roundtrip
found 1 day ago
Select American Airlines flight, departing Wed, Mar 26 from Newark Liberty Intl. Airport to Barkley Regional, returning Fri, Mar 28, priced at $589 found 1 day ago

Cheap Flights to Southeast Missouri

Fall in love at first flight with your vacation to Southeast Missouri by saving a ton of cash on your last-minute cheap flight. There’s no more scouring the internet for a good deal—book your flight to Southeast Missouri on Hotwire, and you’ll be up, up, and on a getaway in no time.

Because once the wheels are down in Southeast Missouri, the good times start rolling. So buckle up, you’re in for a fun ride.

Frequently Asked Questions About flights to Southeast Missouri

Don’t waste your time on endless searches for cheap airline tickets oneway or roundtrip. We’ll have you on your way to Southeast Missouri with a tiny bag of pretzels in your hand before you can say “tray tables in the upright position”—and for a ticket price that works for your vacay budget.

So all you have to worry about is where you’re headed after the STL airport.

What is the cheapest month to fly to Southeast Missouri?

Airline ticket prices fluctuate all the time, depending on the day of the week or the month of the year. The cheapest round trip flights to Southeast Missouri are in March, but when you book your flight on Hotwire, savings are always in season.

How many airlines fly to Southeast Missouri?

Variety is the spice of life, even when it comes to booking your next trip. Want options for airlines? You’ll find 16 to choose from for your flight to Southeast Missouri.

What airport is best to fly into Southeast Missouri?

When you’re planning your trip to Southeast Missouri, convenience is the name of the game. Luckily, Southeast Missouri Cape Girardeau Municipal Airport is nearby so you can deplane and get going on checking off everything on your Southeast Missouri must-do list.

How much are flights to Southeast Missouri?

Got very cheap flights on your vacation itinerary? When you book your airline tickets to Southeast Missouri on Hotwire, you may just get what’s on your getaway wish list. With tickets as low as $515, you’ll have leftover cash for at least a magazine and a bottle of water at the airport book store.

How to get cheap flights to Southeast Missouri?

The trick to saving a stack of cash on your flight to Southeast Missouri? Snatch up that Hotwire flight deal when you see a killer rate because it could be gone in a flash. And with flights as low as $515 right now, why wait?

Southeast Missouri Flight Information
Destination airport
Lambert-St. Louis Intl.
Destination airport IATA code
STL
Roundtrip price
$148

Last Minute Hotel Deals in Southeast Missouri

The Riverview
The Riverview
3.5 out of 5
777 Main St, Cape Girardeau, MO
The price is $106 per night from Mar 24 to Mar 25
$106
includes taxes & fees
Mar 24 - Mar 25
Stay at this 3.5-star hotel in Cape Girardeau. Enjoy free WiFi, free parking, and 2 restaurants. Popular attractions Isle Casino Cape Girardeau and Riverfront ...
9.2/10 Wonderful! (188 reviews)
"Unexpected gem!"

Reviewed on Mar 19, 2025

The Riverview
Drury Plaza Hotel Cape Girardeau Conference Center
Drury Plaza Hotel Cape Girardeau Conference Center
3 out of 5
3351 Percy Drive, Cape Girardeau, MO
The price is $107 per night from Mar 30 to Mar 31
$107
includes taxes & fees
Mar 30 - Mar 31
Stay at this 3-star business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.4/10 Exceptional! (1,005 reviews)
"Great location, great hotel"

Reviewed on Mar 21, 2025

Drury Plaza Hotel Cape Girardeau Conference Center
Baymont Inn and Suites by Wyndham Farmington, MO
Baymont Inn and Suites by Wyndham Farmington, MO
2.5 out of 5
1625 W Columbia St, Farmington, MO
The price is $59 per night from Apr 6 to Apr 7
$59
includes taxes & fees
Apr 6 - Apr 7
Book a stay at this business-friendly hotel in Farmington. Enjoy free breakfast, free parking, and an outdoor pool. Our guests praise the breakfast and the helpful ...
8/10 Very Good! (885 reviews)
"The door wouldn't lock, the chain was to sort and i didn't feel that sage with it like that it was room 134."

Reviewed on Mar 19, 2025

Baymont Inn and Suites by Wyndham Farmington, MO
Motel 6 Poplar Bluff, MO
Motel 6 Poplar Bluff, MO
2 out of 5
4101 Highway 67 N, Poplar Bluff, MO
The price is $71 per night from Mar 25 to Mar 26
$71
includes taxes & fees
Mar 25 - Mar 26
Stay at this motel in Poplar Bluff. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff and the clean rooms in our reviews. ...
7.8/10 Good! (1,002 reviews)
"Clean, friendly staff frim desk to house keeping, actually quiet in room even with construction crews being majority of guests ( sorry guys) , well lit parking, quick hwy access."

Reviewed on Mar 21, 2025

Motel 6 Poplar Bluff, MO
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
2.5 out of 5
3253 William Street, Cape Girardeau, MO
The price is $116 per night from Mar 30 to Mar 31
$116
includes taxes & fees
Mar 30 - Mar 31
Book a stay at this spa hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in ...
9.4/10 Exceptional! (1,000 reviews)
"it was very clean, comfortable, Rooma are super cool for the price. Just a great experience."

Reviewed on Mar 19, 2025

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Days Inn and Suites by Wyndham Sikeston
Days Inn and Suites by Wyndham Sikeston
2 out of 5
220 S Interstate Dr, Sikeston, MO
The price is $87 per night from Mar 25 to Mar 26
$87
includes taxes & fees
Mar 25 - Mar 26
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7.2/10 Good! (1,002 reviews)
"Having the suite, really makes it much more comfortable I would like to see them making the bed as regular as the towell check"

Reviewed on Mar 11, 2025

Days Inn and Suites by Wyndham Sikeston
The Farmstead Hotel
The Farmstead Hotel
2.5 out of 5
778 E 3rd St, Caruthersville, MO
The price is $101 per night from Mar 24 to Mar 25
$101
includes taxes & fees
Mar 24 - Mar 25
Stay at this hotel in Caruthersville. Enjoy free WiFi, free parking, and a casino. Our guests praise the helpful staff and the clean rooms in our reviews. Popular ...
8.6/10 Excellent! (310 reviews)
"Nothing else. Good value though."

Reviewed on Mar 21, 2025

The Farmstead Hotel
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
2.5 out of 5
3003 SOUTH OLD ORCHARD ROAD, Jackson, MO
The price is $88 per night from Mar 24 to Mar 25
$88
includes taxes & fees
Mar 24 - Mar 25
Book a stay at this business-friendly hotel in Jackson. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8.8/10 Excellent! (519 reviews)
A great place to stay
"We love this hotel. We stay here every time we visit our daughter at SEMO."

Reviewed on Mar 22, 2025

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
See all 552 properties in Southeast Missouri
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.