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Southeast Missouri

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Southeast Missouri Flights as Low as $277

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

Spirit Airlines
Tue, Jan 14 - Sat, Jan 18
PHL
Philadelphia Intl.
STL
Lambert-St. Louis Intl.
$277 Roundtrip, found 3 days ago
$277
Roundtrip
found 3 days ago
Select Spirit Airlines flight, departing Tue, Jan 14 from Philadelphia Intl. to Lambert-St. Louis Intl., returning Sat, Jan 18, priced at $277 found 3 days ago
Delta
Mon, Feb 3 - Sat, Feb 8
GTF
Great Falls Intl.
STL
Lambert-St. Louis Intl.
$303 Roundtrip, found 4 days ago
$303
Roundtrip
found 4 days ago
Select Delta flight, departing Mon, Feb 3 from Great Falls Intl. to Lambert-St. Louis Intl., returning Sat, Feb 8, priced at $303 found 4 days ago
Delta
Thu, Feb 6 - Fri, Feb 7
GTF
Great Falls Intl.
STL
Lambert-St. Louis Intl.
$316 Roundtrip, found 4 days ago
$316
Roundtrip
found 4 days ago
Select Delta flight, departing Thu, Feb 6 from Great Falls Intl. to Lambert-St. Louis Intl., returning Fri, Feb 7, priced at $316 found 4 days ago
Delta
Thu, Feb 6 - Sun, Feb 9
GTF
Great Falls Intl.
STL
Lambert-St. Louis Intl.
$318 Roundtrip, found 4 days ago
$318
Roundtrip
found 4 days ago
Select Delta flight, departing Thu, Feb 6 from Great Falls Intl. to Lambert-St. Louis Intl., returning Sun, Feb 9, priced at $318 found 4 days ago
Delta
Mon, Feb 3 - Fri, Feb 7
GTF
Great Falls Intl.
STL
Lambert-St. Louis Intl.
$323 Roundtrip, found 4 days ago
$323
Roundtrip
found 4 days ago
Select Delta flight, departing Mon, Feb 3 from Great Falls Intl. to Lambert-St. Louis Intl., returning Fri, Feb 7, priced at $323 found 4 days ago
American Airlines
Tue, Jan 14 - Sat, Jan 18
PHL
Philadelphia Intl.
STL
Lambert-St. Louis Intl.
$350 Roundtrip, found 3 days ago
$350
Roundtrip
found 3 days ago
Select American Airlines flight, departing Tue, Jan 14 from Philadelphia Intl. to Lambert-St. Louis Intl., returning Sat, Jan 18, priced at $350 found 3 days ago
Frontier Airlines
Tue, Jan 14 - Sat, Jan 18
PHL
Philadelphia Intl.
STL
Lambert-St. Louis Intl.
$353 Roundtrip, found 3 days ago
$353
Roundtrip
found 3 days ago
Select Frontier Airlines flight, departing Tue, Jan 14 from Philadelphia Intl. to Lambert-St. Louis Intl., returning Sat, Jan 18, priced at $353 found 3 days ago
American Airlines
Tue, Jan 14 - Sat, Jan 18
PHL
Philadelphia Intl.
STL
Lambert-St. Louis Intl.
$354 Roundtrip, found 3 days ago
$354
Roundtrip
found 3 days ago
Select American Airlines flight, departing Tue, Jan 14 from Philadelphia Intl. to Lambert-St. Louis Intl., returning Sat, Jan 18, priced at $354 found 3 days ago
American Airlines
Tue, Jan 14 - Sat, Jan 18
PHL
Philadelphia Intl.
STL
Lambert-St. Louis Intl.
$357 Roundtrip, found 3 days ago
$357
Roundtrip
found 3 days ago
Select American Airlines flight, departing Tue, Jan 14 from Philadelphia Intl. to Lambert-St. Louis Intl., returning Sat, Jan 18, priced at $357 found 3 days ago
United
Tue, Jan 14 - Sat, Jan 18
PHL
Philadelphia Intl.
STL
Lambert-St. Louis Intl.
$366 Roundtrip, found 3 days ago
$366
Roundtrip
found 3 days ago
Select United flight, departing Tue, Jan 14 from Philadelphia Intl. to Lambert-St. Louis Intl., returning Sat, Jan 18, priced at $366 found 3 days ago
Delta
Tue, Jan 14 - Sat, Jan 18
PHL
Philadelphia Intl.
STL
Lambert-St. Louis Intl.
$366 Roundtrip, found 3 days ago
$366
Roundtrip
found 3 days ago
Select Delta flight, departing Tue, Jan 14 from Philadelphia Intl. to Lambert-St. Louis Intl., returning Sat, Jan 18, priced at $366 found 3 days ago
Frontier Airlines
Fri, Dec 20 - Mon, Jan 13
TTN
Mercer
STL
Lambert-St. Louis Intl.
$368 Roundtrip, found 10 hours ago
$368
Roundtrip
found 10 hours ago
Select Frontier Airlines flight, departing Fri, Dec 20 from Mercer to Lambert-St. Louis Intl., returning Mon, Jan 13, priced at $368 found 10 hours ago
Frontier Airlines
Fri, Dec 20 - Sat, Jan 11
PHL
Philadelphia Intl.
STL
Lambert-St. Louis Intl.
$368 Roundtrip, found 10 hours ago
$368
Roundtrip
found 10 hours ago
Select Frontier Airlines flight, departing Fri, Dec 20 from Philadelphia Intl. to Lambert-St. Louis Intl., returning Sat, Jan 11, priced at $368 found 10 hours ago
Alaska Airlines
Tue, Feb 4 - Tue, Feb 11
GTF
Great Falls Intl.
STL
Lambert-St. Louis Intl.
$372 Roundtrip, found 11 hours ago
$372
Roundtrip
found 11 hours ago
Select Alaska Airlines flight, departing Tue, Feb 4 from Great Falls Intl. to Lambert-St. Louis Intl., returning Tue, Feb 11, priced at $372 found 11 hours ago
American Airlines
Tue, Jan 14 - Sat, Jan 18
PHL
Philadelphia Intl.
STL
Lambert-St. Louis Intl.
$377 Roundtrip, found 3 days ago
$377
Roundtrip
found 3 days ago
Select American Airlines flight, departing Tue, Jan 14 from Philadelphia Intl. to Lambert-St. Louis Intl., returning Sat, Jan 18, priced at $377 found 3 days ago
Frontier Airlines
Fri, Dec 20 - Fri, Jan 10
TTN
Mercer
STL
Lambert-St. Louis Intl.
$378 Roundtrip, found 10 hours ago
$378
Roundtrip
found 10 hours ago
Select Frontier Airlines flight, departing Fri, Dec 20 from Mercer to Lambert-St. Louis Intl., returning Fri, Jan 10, priced at $378 found 10 hours ago

Cheap Flights to Southeast Missouri

Fall in love at first flight with your vacation to Southeast Missouri by saving a ton of cash on your last-minute cheap flight. There’s no more scouring the internet for a good deal—book your flight to Southeast Missouri on Hotwire, and you’ll be up, up, and on a getaway in no time.

Because once the wheels are down in Southeast Missouri, the good times start rolling. So buckle up, you’re in for a fun ride.

Frequently Asked Questions About flights to Southeast Missouri

Don’t waste your time on endless searches for cheap airline tickets oneway or roundtrip. We’ll have you on your way to Southeast Missouri with a tiny bag of pretzels in your hand before you can say “tray tables in the upright position”—and for a ticket price that works for your vacay budget.

So all you have to worry about is where you’re headed after the STL airport.

What is the cheapest month to fly to Southeast Missouri?

Airline ticket prices fluctuate all the time, depending on the day of the week or the month of the year. The cheapest round trip flights to Southeast Missouri are in January, but when you book your flight on Hotwire, savings are always in season.

How many airlines fly to Southeast Missouri?

Variety is the spice of life, even when it comes to booking your next trip. Want options for airlines? You’ll find 16 to choose from for your flight to Southeast Missouri.

What airport is best to fly into Southeast Missouri?

When you’re planning your trip to Southeast Missouri, convenience is the name of the game. Luckily, Southeast Missouri Cape Girardeau Municipal Airport is nearby so you can deplane and get going on checking off everything on your Southeast Missouri must-do list.

How much are flights to Southeast Missouri?

Got very cheap flights on your vacation itinerary? When you book your airline tickets to Southeast Missouri on Hotwire, you may just get what’s on your getaway wish list. With tickets as low as $277, you’ll have leftover cash for at least a magazine and a bottle of water at the airport book store.

How to get cheap flights to Southeast Missouri?

The trick to saving a stack of cash on your flight to Southeast Missouri? Snatch up that Hotwire flight deal when you see a killer rate because it could be gone in a flash. And with flights as low as $277 right now, why wait?

Southeast Missouri Flight Information
Destination airport
Lambert-St. Louis Intl.
Destination airport IATA code
STL
Roundtrip price
$116

Last Minute Hotel Deals in Southeast Missouri

Motel 6 Poplar Bluff, MO
Motel 6 Poplar Bluff, MO
2 out of 5
4101 Highway 67 N, Poplar Bluff, MO
The price is $79 per night from Dec 22 to Dec 23
$79
includes taxes & fees
Dec 22 - Dec 23
Stay at this motel in Poplar Bluff. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff and the clean rooms in our reviews. ...
7.8/10 Good! (1,004 reviews)
"Everyone is so friendly and the rooms are always so cozy and clean!"

Reviewed on Dec 16, 2024

Motel 6 Poplar Bluff, MO
Baymont Inn and Suites by Wyndham Farmington, MO
Baymont Inn and Suites by Wyndham Farmington, MO
2.5 out of 5
1625 W Columbia St, Farmington, MO
The price is $59 per night from Dec 25 to Dec 26
$59
includes taxes & fees
Dec 25 - Dec 26
Book a stay at this business-friendly hotel in Farmington. Enjoy free breakfast, free parking, and an outdoor pool. Our guests praise the breakfast and the helpful ...
7.8/10 Good! (815 reviews)
"I don't really like being right next to people but it's a hotel and i love the poolside rooms only, i just wish i could stay more working for AI to get work done on secure location"

Reviewed on Dec 12, 2024

Baymont Inn and Suites by Wyndham Farmington, MO
Holiday Inn Express Hotel & Suites Cape Girardeau I-55, an IHG Hotel
Holiday Inn Express Hotel & Suites Cape Girardeau I-55, an IHG Hotel
2.5 out of 5
3253 William Street, Cape Girardeau, MO
The price is $103 per night from Jan 12 to Jan 13
$103
includes taxes & fees
Jan 12 - Jan 13, 2025
Book a stay at this spa hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in ...
9.4/10 Exceptional! (999 reviews)
Overnight stay
"I stayed over with 6 of my volleyball players for a tournament. Staff was friendly and helpful. Room was clean."

Reviewed on Dec 16, 2024

Holiday Inn Express Hotel & Suites Cape Girardeau I-55, an IHG Hotel
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
2.5 out of 5
3003 SOUTH OLD ORCHARD ROAD, Jackson, MO
The price is $84 per night from Dec 22 to Dec 23
$84
includes taxes & fees
Dec 22 - Dec 23
Book a stay at this business-friendly hotel in Jackson. Enjoy free WiFi, free parking, and room service. Our guests praise the helpful staff and the clean rooms ...
8.8/10 Excellent! (479 reviews)
"Breakfast"

Reviewed on Dec 14, 2024

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
Drury Inn & Suites Cape Girardeau
Drury Inn & Suites Cape Girardeau
3 out of 5
3303 Campster Drive, Cape Girardeau, MO
The price is $102 per night from Jan 10 to Jan 11
$102
includes taxes & fees
Jan 10 - Jan 11, 2025
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the ...
9.2/10 Wonderful! (838 reviews)
"Spacious rooms and super friendly and pleasant staff."

Reviewed on Dec 16, 2024

Drury Inn & Suites Cape Girardeau
Pear Tree Inn Cape Girardeau West
Pear Tree Inn Cape Girardeau West
2.5 out of 5
103 Cape West Pkwy, Cape Girardeau, MO
The price is $71 per night from Dec 24 to Dec 25
$71
includes taxes & fees
Dec 24 - Dec 25
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the ...
9/10 Wonderful! (1,000 reviews)
"Always a great place to stay."

Reviewed on Nov 29, 2024

Pear Tree Inn Cape Girardeau West
Pear Tree Inn Cape Girardeau Near the Medical Center
Pear Tree Inn Cape Girardeau Near the Medical Center
2.5 out of 5
3248 William St, Cape Girardeau, MO
The price is $66 per night from Dec 24 to Dec 25
$66
includes taxes & fees
Dec 24 - Dec 25
Stay at this hotel in Cape Girardeau. Enjoy free WiFi, an outdoor pool, and a 24-hour front desk. Our guests praise the helpful staff and the clean rooms in ...
8.8/10 Excellent! (1,000 reviews)
"clean room. barking dog"

Reviewed on Dec 9, 2024

Pear Tree Inn Cape Girardeau Near the Medical Center
Pear Tree Inn Sikeston
Pear Tree Inn Sikeston
2.5 out of 5
2602 E Malone Avenue, Sikeston, MO
The price is $88 per night from Jan 10 to Jan 11
$88
includes taxes & fees
Jan 10 - Jan 11, 2025
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the helpful ...
9.2/10 Wonderful! (1,003 reviews)
"Estuvo bonito todo"

Reviewed on Dec 9, 2024

Pear Tree Inn Sikeston
See all 531 properties in Southeast Missouri
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.