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Southeast Missouri

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Southeast Missouri Flights as Low as $66

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

Frontier Airlines
Wed, Aug 12 - Tue, Aug 25
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$66 Roundtrip, found 2 hours ago
$66
Roundtrip
found 2 hours ago
Select Frontier Airlines flight, departing Wed, Aug 12 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Tue, Aug 25, priced at $66 found 2 hours ago
Frontier Airlines
Tue, Jul 14 - Tue, Jul 14
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$68 Roundtrip, found 4 hours ago
$68
Roundtrip
found 4 hours ago
Select Frontier Airlines flight, departing Tue, Jul 14 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Tue, Jul 14, priced at $68 found 4 hours ago
Frontier Airlines
Mon, Jul 6 - Wed, Jul 22
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$77 Roundtrip, found 7 hours ago
$77
Roundtrip
found 7 hours ago
Select Frontier Airlines flight, departing Mon, Jul 6 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Wed, Jul 22, priced at $77 found 7 hours ago
Frontier Airlines
Tue, Jun 23 - Wed, Jul 1
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$79 Roundtrip, found 1 hour ago
$79
Roundtrip
found 1 hour ago
Select Frontier Airlines flight, departing Tue, Jun 23 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Wed, Jul 1, priced at $79 found 1 hour ago
Frontier Airlines
Wed, Jun 24 - Wed, Jul 1
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$84 Roundtrip, found 4 hours ago
$84
Roundtrip
found 4 hours ago
Select Frontier Airlines flight, departing Wed, Jun 24 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Wed, Jul 1, priced at $84 found 4 hours ago
Frontier Airlines
Tue, Jun 23 - Tue, Jun 23
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$90 Roundtrip, found 17 hours ago
$90
Roundtrip
found 17 hours ago
Select Frontier Airlines flight, departing Tue, Jun 23 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Tue, Jun 23, priced at $90 found 17 hours ago
Frontier Airlines
Tue, Jun 23 - Mon, Jun 29
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$96 Roundtrip, found 2 days ago
$96
Roundtrip
found 2 days ago
Select Frontier Airlines flight, departing Tue, Jun 23 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Mon, Jun 29, priced at $96 found 2 days ago
Delta
Wed, Aug 12 - Tue, Aug 25
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$97 Roundtrip, found 2 hours ago
$97
Roundtrip
found 2 hours ago
Select Delta flight, departing Wed, Aug 12 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Tue, Aug 25, priced at $97 found 2 hours ago
Delta
Mon, Jul 6 - Wed, Jul 22
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$107 Roundtrip, found 7 hours ago
$107
Roundtrip
found 7 hours ago
Select Delta flight, departing Mon, Jul 6 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Wed, Jul 22, priced at $107 found 7 hours ago
Delta
Tue, Jul 14 - Tue, Jul 14
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$124 Roundtrip, found 4 hours ago
$124
Roundtrip
found 4 hours ago
Select Delta flight, departing Tue, Jul 14 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Tue, Jul 14, priced at $124 found 4 hours ago
American Airlines
Wed, Aug 12 - Tue, Aug 25
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$257 Roundtrip, found 2 hours ago
$257
Roundtrip
found 2 hours ago
Select American Airlines flight, departing Wed, Aug 12 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Tue, Aug 25, priced at $257 found 2 hours ago
Delta
Sat, Oct 17 - Tue, Oct 20
DAL
Love Field
STL
Lambert-St. Louis Intl.
$263 Roundtrip, found 4 hours ago
$263
Roundtrip
found 4 hours ago
Select Delta flight, departing Sat, Oct 17 from Love Field to Lambert-St. Louis Intl., returning Tue, Oct 20, priced at $263 found 4 hours ago
Bargain Flight
Sat, Jun 13 - Tue, Jun 16
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$263 Roundtrip, found 13 hours ago
$263
Roundtrip
found 13 hours ago
Select Bargain Flight flight, departing Sat, Jun 13 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Tue, Jun 16, priced at $263 found 13 hours ago
Bargain Flight
Tue, Jun 9 - Fri, Jun 19
DCA
Ronald Reagan Washington National
STL
Lambert-St. Louis Intl.
$272 Roundtrip, found 2 days ago
$272
Roundtrip
found 2 days ago
Select Bargain Flight flight, departing Tue, Jun 9 from Ronald Reagan Washington National to Lambert-St. Louis Intl., returning Fri, Jun 19, priced at $272 found 2 days ago
American Airlines
Tue, Sep 1 - Tue, Sep 15
AMA
Rick Husband Amarillo Intl.
STL
Lambert-St. Louis Intl.
$387 Roundtrip, found 4 hours ago
$387
Roundtrip
found 4 hours ago
Select American Airlines flight, departing Tue, Sep 1 from Rick Husband Amarillo Intl. to Lambert-St. Louis Intl., returning Tue, Sep 15, priced at $387 found 4 hours ago
United
Wed, Jun 10 - Thu, Jun 18
ATL
Hartsfield-Jackson Atlanta Intl.
PAH
Barkley Regional
$564 Roundtrip, found 1 day ago
$564
Roundtrip
found 1 day ago
Select United flight, departing Wed, Jun 10 from Hartsfield-Jackson Atlanta Intl. to Barkley Regional, returning Thu, Jun 18, priced at $564 found 1 day ago

Cheap Flights to Southeast Missouri

Fall in love at first flight with your vacation to Southeast Missouri by saving a ton of cash on your last-minute cheap flight. There’s no more scouring the internet for a good deal—book your flight to Southeast Missouri on Hotwire, and you’ll be up, up, and on a getaway in no time.

Because once the wheels are down in Southeast Missouri, the good times start rolling. So buckle up, you’re in for a fun ride.

Frequently Asked Questions About flights to Southeast Missouri

Don’t waste your time on endless searches for cheap airline tickets oneway or roundtrip. We’ll have you on your way to Southeast Missouri with a tiny bag of pretzels in your hand before you can say “tray tables in the upright position”—and for a ticket price that works for your vacay budget.

So all you have to worry about is where you’re headed after the STL airport.

What is the cheapest month to fly to Southeast Missouri?

Airline ticket prices fluctuate all the time, depending on the day of the week or the month of the year. The cheapest round trip flights to Southeast Missouri are in August, but when you book your flight on Hotwire, savings are always in season.

How many airlines fly to Southeast Missouri?

Variety is the spice of life, even when it comes to booking your next trip. Want options for airlines? You’ll find 14 to choose from for your flight to Southeast Missouri.

What airport is best to fly into Southeast Missouri?

When you’re planning your trip to Southeast Missouri, convenience is the name of the game. Luckily, Southeast Missouri Cape Girardeau Municipal Airport is nearby so you can deplane and get going on checking off everything on your Southeast Missouri must-do list.

How much are flights to Southeast Missouri?

Got very cheap flights on your vacation itinerary? When you book your airline tickets to Southeast Missouri on Hotwire, you may just get what’s on your getaway wish list. With tickets as low as $66, you’ll have leftover cash for at least a magazine and a bottle of water at the airport book store.

How to get cheap flights to Southeast Missouri?

The trick to saving a stack of cash on your flight to Southeast Missouri? Snatch up that Hotwire flight deal when you see a killer rate because it could be gone in a flash. And with flights as low as $66 right now, why wait?

Southeast Missouri Flight Information
Destination airport
Lambert-St. Louis Intl.
Destination airport IATA code
STL
Roundtrip price
$66

Last Minute Hotel Deals in Southeast Missouri

Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center

3 out of 5
3351 Percy Drive Cape Girardeau MO
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.6/10 Exceptional! (1,005 reviews)
"Very clean, helpful staff"

Reviewed on Jun 2, 2026

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Drury Plaza Hotel Cape Girardeau Conference Center
Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

3 out of 5
2608 East Malone Ave, Miner Sikeston MO
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9.6/10 Exceptional! (1,006 reviews)
"Clean rooms and was ready when we arrived. We did not use the pool but other guests were enjoying it. Breakfast and Kick back were both great meals."

Reviewed on Jun 4, 2026

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Drury Inn & Suites Sikeston, MO
Baymont Inn and Suites by Wyndham Farmington, MO

Baymont Inn and Suites by Wyndham Farmington, MO

2.5 out of 5
1625 W Columbia St Farmington MO
Book a stay at this business-friendly hotel in Farmington. Enjoy free breakfast, free parking, and an outdoor pool. Our guests praise the helpful staff and the ...
8/10 Very Good! (1,002 reviews)
"Staff was courteous. However in hallway was a pungent odor. The room had same odor and we had to get some air freshener and turn on AC unit to circulate air."

Reviewed on Jun 1, 2026

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Baymont Inn and Suites by Wyndham Farmington, MO
Candlewood Suites Cape Girardeau by IHG

Candlewood Suites Cape Girardeau by IHG

2.5 out of 5
485 S Mount Auburn Rd Cape Girardeau MO
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free WiFi, free parking, and a fitness center. Our guests praise the helpful staff and the ...
8/10 Very Good! (956 reviews)
"on check-in, staff did not tell us there was not breakfast provided. Room clean, well-organized. Had plenty of towels without having to ask for any extra. Had we known no kitchen we might have brought in food for breakfast. the bag of popcorn provided was tasty and welcome. Main negative was the ..."

Reviewed on Jun 6, 2026

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Candlewood Suites Cape Girardeau by IHG
The Riverview

The Riverview

4 out of 5
777 Main St Cape Girardeau MO
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free WiFi, free parking, and 2 restaurants. Popular attractions Century Casino & Hotel Cape ...
9.4/10 Exceptional! (591 reviews)
"Out room wasn't ready (we arrived a little after 3, check-in time). We had to wait for the room to be cleaned. Other than that, it was clean and comfortable. I wish they had a better breakfast option and an earlier time."

Reviewed on Jun 1, 2026

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The Riverview
Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

2 out of 5
7555 State Hwy Y French Village MO
Stay at this cabin in French Village. Enjoy free parking, patios, and climate control.
9.8/10 Exceptional! (75 reviews)
"The best accomodation I have had for years. The staff is easy to answer any request as long the request is reasonable. I also highly recommend the place for its superb cleanliness and cozy."

Reviewed on May 31, 2026

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Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy
Drury Inn & Suites Hayti Caruthersville

Drury Inn & Suites Hayti Caruthersville

3 out of 5
1317 E Highway 84 Hayti MO
Book a stay at this business-friendly hotel in Hayti. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9.4/10 Exceptional! (1,006 reviews)
"Clean & quiet are it priorities. All the other perks offered here were very pleasant extras"

Reviewed on Jun 6, 2026

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Drury Inn & Suites Hayti Caruthersville
Hampton Inn Poplar Bluff

Hampton Inn Poplar Bluff

2.5 out of 5
2420 Crestwood Dr Poplar Bluff MO
Stay at this hotel in Poplar Bluff. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. ...
9.4/10 Exceptional! (865 reviews)
"This was the best check in experience we've had. Rooms were ready and keys made when we checked in. Took 3 min. They also had all the rooms side by side we had 6 total. Will be using g Hilton owned from here on out."

Reviewed on Jun 6, 2026

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Hampton Inn Poplar Bluff
See all 663 properties in Southeast Missouri
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.