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Southeast Missouri

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Southeast Missouri Flights as Low as $193

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

Bargain Flight
Sat, May 17 - Mon, May 19
CVG
Cincinnati - Northern Kentucky Intl.
STL
Lambert-St. Louis Intl.
$193 Roundtrip, found 1 day ago
$193
Roundtrip
found 1 day ago
Select Bargain Flight flight, departing Sat, May 17 from Cincinnati - Northern Kentucky Intl. to Lambert-St. Louis Intl., returning Mon, May 19, priced at $193 found 1 day ago
Delta
Wed, May 28 - Thu, May 29
HSV
Huntsville Intl.
STL
Lambert-St. Louis Intl.
$202 Roundtrip, found 14 hours ago
$202
Roundtrip
found 14 hours ago
Select Delta flight, departing Wed, May 28 from Huntsville Intl. to Lambert-St. Louis Intl., returning Thu, May 29, priced at $202 found 14 hours ago
Bargain Flight
Thu, May 15 - Sun, May 18
CVG
Cincinnati - Northern Kentucky Intl.
STL
Lambert-St. Louis Intl.
$205 Roundtrip, found 2 hours ago
$205
Roundtrip
found 2 hours ago
Select Bargain Flight flight, departing Thu, May 15 from Cincinnati - Northern Kentucky Intl. to Lambert-St. Louis Intl., returning Sun, May 18, priced at $205 found 2 hours ago
Bargain Flight
Thu, May 15 - Mon, May 19
CVG
Cincinnati - Northern Kentucky Intl.
STL
Lambert-St. Louis Intl.
$213 Roundtrip, found 15 hours ago
$213
Roundtrip
found 15 hours ago
Select Bargain Flight flight, departing Thu, May 15 from Cincinnati - Northern Kentucky Intl. to Lambert-St. Louis Intl., returning Mon, May 19, priced at $213 found 15 hours ago
Delta
Sat, May 31 - Tue, Jun 10
HSV
Huntsville Intl.
STL
Lambert-St. Louis Intl.
$218 Roundtrip, found 16 hours ago
$218
Roundtrip
found 16 hours ago
Select Delta flight, departing Sat, May 31 from Huntsville Intl. to Lambert-St. Louis Intl., returning Tue, Jun 10, priced at $218 found 16 hours ago
Frontier Airlines
Tue, May 20 - Thu, May 29
BWI
Baltimore Washington Intl. Thurgood Marshall
STL
Lambert-St. Louis Intl.
$223 Roundtrip, found 15 hours ago
$223
Roundtrip
found 15 hours ago
Select Frontier Airlines flight, departing Tue, May 20 from Baltimore Washington Intl. Thurgood Marshall to Lambert-St. Louis Intl., returning Thu, May 29, priced at $223 found 15 hours ago
American Airlines
Wed, Jun 4 - Sun, Jun 8
HSV
Huntsville Intl.
STL
Lambert-St. Louis Intl.
$233 Roundtrip, found 16 hours ago
$233
Roundtrip
found 16 hours ago
Select American Airlines flight, departing Wed, Jun 4 from Huntsville Intl. to Lambert-St. Louis Intl., returning Sun, Jun 8, priced at $233 found 16 hours ago
Delta
Sat, May 24 - Wed, May 28
HSV
Huntsville Intl.
STL
Lambert-St. Louis Intl.
$236 Roundtrip, found 14 hours ago
$236
Roundtrip
found 14 hours ago
Select Delta flight, departing Sat, May 24 from Huntsville Intl. to Lambert-St. Louis Intl., returning Wed, May 28, priced at $236 found 14 hours ago
Delta
Sun, Jun 1 - Tue, Jun 10
HSV
Huntsville Intl.
STL
Lambert-St. Louis Intl.
$238 Roundtrip, found 16 hours ago
$238
Roundtrip
found 16 hours ago
Select Delta flight, departing Sun, Jun 1 from Huntsville Intl. to Lambert-St. Louis Intl., returning Tue, Jun 10, priced at $238 found 16 hours ago
Frontier Airlines
Sat, May 17 - Mon, May 19
CVG
Cincinnati - Northern Kentucky Intl.
STL
Lambert-St. Louis Intl.
$242 Roundtrip, found 1 day ago
$242
Roundtrip
found 1 day ago
Select Frontier Airlines flight, departing Sat, May 17 from Cincinnati - Northern Kentucky Intl. to Lambert-St. Louis Intl., returning Mon, May 19, priced at $242 found 1 day ago
Frontier Airlines
Tue, May 20 - Wed, May 28
BWI
Baltimore Washington Intl. Thurgood Marshall
STL
Lambert-St. Louis Intl.
$242 Roundtrip, found 15 hours ago
$242
Roundtrip
found 15 hours ago
Select Frontier Airlines flight, departing Tue, May 20 from Baltimore Washington Intl. Thurgood Marshall to Lambert-St. Louis Intl., returning Wed, May 28, priced at $242 found 15 hours ago
Frontier Airlines
Sun, May 18 - Mon, May 19
SFO
San Francisco Intl.
STL
Lambert-St. Louis Intl.
$304 Roundtrip, found 14 hours ago
$304
Roundtrip
found 14 hours ago
Select Frontier Airlines flight, departing Sun, May 18 from San Francisco Intl. to Lambert-St. Louis Intl., returning Mon, May 19, priced at $304 found 14 hours ago
United
Mon, Jul 14 - Sat, Jul 19
SFO
San Francisco Intl.
STL
Lambert-St. Louis Intl.
$449 Roundtrip, found 1 hour ago
$449
Roundtrip
found 1 hour ago
Select United flight, departing Mon, Jul 14 from San Francisco Intl. to Lambert-St. Louis Intl., returning Sat, Jul 19, priced at $449 found 1 hour ago
Spirit Airlines
Sat, May 17 - Thu, May 29
BWI
Baltimore Washington Intl. Thurgood Marshall
STL
Lambert-St. Louis Intl.
$460 Roundtrip, found 15 hours ago
$460
Roundtrip
found 15 hours ago
Select Spirit Airlines flight, departing Sat, May 17 from Baltimore Washington Intl. Thurgood Marshall to Lambert-St. Louis Intl., returning Thu, May 29, priced at $460 found 15 hours ago
Hawaiian Airlines
Sun, May 18 - Tue, May 20
SFO
San Francisco Intl.
STL
Lambert-St. Louis Intl.
$816 Roundtrip, found 14 hours ago
$816
Roundtrip
found 14 hours ago
Select Hawaiian Airlines flight, departing Sun, May 18 from San Francisco Intl. to Lambert-St. Louis Intl., returning Tue, May 20, priced at $816 found 14 hours ago
Alaska Airlines
Thu, May 15 - Sun, May 18
SFO
San Francisco Intl.
STL
Lambert-St. Louis Intl.
$952 Roundtrip, found 14 hours ago
$952
Roundtrip
found 14 hours ago
Select Alaska Airlines flight, departing Thu, May 15 from San Francisco Intl. to Lambert-St. Louis Intl., returning Sun, May 18, priced at $952 found 14 hours ago

Cheap Flights to Southeast Missouri

Fall in love at first flight with your vacation to Southeast Missouri by saving a ton of cash on your last-minute cheap flight. There’s no more scouring the internet for a good deal—book your flight to Southeast Missouri on Hotwire, and you’ll be up, up, and on a getaway in no time.

Because once the wheels are down in Southeast Missouri, the good times start rolling. So buckle up, you’re in for a fun ride.

Frequently Asked Questions About flights to Southeast Missouri

Don’t waste your time on endless searches for cheap airline tickets oneway or roundtrip. We’ll have you on your way to Southeast Missouri with a tiny bag of pretzels in your hand before you can say “tray tables in the upright position”—and for a ticket price that works for your vacay budget.

So all you have to worry about is where you’re headed after the STL airport.

What is the cheapest month to fly to Southeast Missouri?

Airline ticket prices fluctuate all the time, depending on the day of the week or the month of the year. The cheapest round trip flights to Southeast Missouri are in May, but when you book your flight on Hotwire, savings are always in season.

How many airlines fly to Southeast Missouri?

Variety is the spice of life, even when it comes to booking your next trip. Want options for airlines? You’ll find 13 to choose from for your flight to Southeast Missouri.

What airport is best to fly into Southeast Missouri?

When you’re planning your trip to Southeast Missouri, convenience is the name of the game. Luckily, Southeast Missouri Cape Girardeau Municipal Airport is nearby so you can deplane and get going on checking off everything on your Southeast Missouri must-do list.

How much are flights to Southeast Missouri?

Got very cheap flights on your vacation itinerary? When you book your airline tickets to Southeast Missouri on Hotwire, you may just get what’s on your getaway wish list. With tickets as low as $193, you’ll have leftover cash for at least a magazine and a bottle of water at the airport book store.

How to get cheap flights to Southeast Missouri?

The trick to saving a stack of cash on your flight to Southeast Missouri? Snatch up that Hotwire flight deal when you see a killer rate because it could be gone in a flash. And with flights as low as $193 right now, why wait?

Southeast Missouri Flight Information
Destination airport
Lambert-St. Louis Intl.
Destination airport IATA code
STL
Roundtrip price
$327

Last Minute Hotel Deals in Southeast Missouri

The Riverview
The Riverview
3.5 out of 5
777 Main St, Cape Girardeau, MO
Stay at this 3.5-star hotel in Cape Girardeau. Enjoy free WiFi, free parking, and 2 restaurants. Popular attractions Isle Casino Cape Girardeau and Riverfront ...
9.2/10 Wonderful! (258 reviews)
Would stay again but bring my own towels
"Everything was great except for the towels. They were very very stiff and scratchy. It was not a nice experience after a shower"

Reviewed on May 11, 2025

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The Riverview
Baymont Inn and Suites by Wyndham Farmington, MO
Baymont Inn and Suites by Wyndham Farmington, MO
2.5 out of 5
1625 W Columbia St, Farmington, MO
Book a stay at this business-friendly hotel in Farmington. Enjoy free breakfast, free parking, and an outdoor pool. Our guests praise the breakfast and the helpful ...
8/10 Very Good! (938 reviews)
"Was really impressed with this place. Rooms were clean, staff was friendly and breakfast was really good. Scrambled eggs, sausage, gravy, bisquits, toast, yogurt, 3 different cereals and of course coffee."

Reviewed on May 8, 2025

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Baymont Inn and Suites by Wyndham Farmington, MO
Drury Plaza Hotel Cape Girardeau Conference Center
Drury Plaza Hotel Cape Girardeau Conference Center
3 out of 5
3351 Percy Drive, Cape Girardeau, MO
Stay at this 3-star business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.4/10 Exceptional! (1,007 reviews)
Comfy
"From the second we walked in the door we felt welcomed. The young lady at the desk was friendly and very accommodating. Each member of the staff was very kind. I highly recommend this hotel."

Reviewed on May 9, 2025

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Drury Plaza Hotel Cape Girardeau Conference Center
Motel 6 Poplar Bluff, MO
Motel 6 Poplar Bluff, MO
2 out of 5
4101 Highway 67 N, Poplar Bluff, MO
Stay at this motel in Poplar Bluff. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff and the clean rooms in our reviews. ...
7.8/10 Good! (1,007 reviews)
Barking dogs
"It was fine overall. Got woke up a few times by dogs barking. Dogs barking in a hotel!? I understand people bring pets on vaca but that’s nuts. Then the people in the room next to mine having “Whoopi” and not even attempting to be quiet 😂. I’ll be back!!!"

Reviewed on May 11, 2025

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Motel 6 Poplar Bluff, MO
Pear Tree Inn Sikeston
Pear Tree Inn Sikeston
2.5 out of 5
2602 E Malone Avenue, Sikeston, MO
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the helpful ...
9.2/10 Wonderful! (1,003 reviews)
"Possibly the best overnight stay we have experienced in our travels."

Reviewed on May 8, 2025

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Pear Tree Inn Sikeston
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
2.5 out of 5
3003 SOUTH OLD ORCHARD ROAD, Jackson, MO
Book a stay at this business-friendly hotel in Jackson. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8.8/10 Excellent! (550 reviews)
"Signing in was a breeze and I will be back."

Reviewed on May 7, 2025

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La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
2.5 out of 5
3253 William Street, Cape Girardeau, MO
Book a stay at this spa hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in ...
9.4/10 Exceptional! (1,001 reviews)
"Great room and good breakfast. Great place to stay with central location."

Reviewed on May 5, 2025

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Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Fairfield Inn & Suites by Marriott Poplar Bluff
Fairfield Inn & Suites by Marriott Poplar Bluff
2.5 out of 5
3109 Oak Grove, Poplar Bluff, MO
Book a stay at this business-friendly hotel in Poplar Bluff. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
9.2/10 Wonderful! (731 reviews)
"Overall property was great , only complaint was I had AC set in room at 63 and there was no way it was 63 in there and it was making a weird noise ."

Reviewed on May 9, 2025

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Fairfield Inn & Suites by Marriott Poplar Bluff
See all 572 properties in Southeast Missouri
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.