Hotels with smoking rooms in
Southeast Missouri


Featured Southeast Missouri Hotels with smoking rooms

Drury Inn & Suites Cape Girardeau
Drury Inn & Suites Cape Girardeau
3 out of 5
3303 Campster Drive, Cape Girardeau, MO
The price is $107 per night from Mar 23 to Mar 24
$107
includes taxes & fees
Mar 23 - Mar 24
Drury Inn & Suites Cape Girardeau
Eagle Inn Charleston
Eagle Inn Charleston
2 out of 5
2811 East Marshall Street, Charleston, MO
The price is $71 per night from Mar 16 to Mar 17
$71
includes taxes & fees
Mar 16 - Mar 17
Eagle Inn Charleston
Fort Davidson Hotel
Fort Davidson Hotel
2.5 out of 5
310 South McCune St, Pilot Knob, Ironton, MO
The price is $139 per night from Mar 14 to Mar 15
$139
includes taxes & fees
Mar 14 - Mar 15
Fort Davidson Hotel
Pear Tree Inn Sikeston
Pear Tree Inn Sikeston
2.5 out of 5
2602 E Malone Avenue, Sikeston, MO
The price is $88 per night from Mar 23 to Mar 24
$88
includes taxes & fees
Mar 23 - Mar 24
Pear Tree Inn Sikeston
Quality Inn Festus
Quality Inn Festus
3 out of 5
1200 W Gannon Dr, Festus, MO
The price is $90 per night from Apr 4 to Apr 5
$90
includes taxes & fees
Apr 4 - Apr 5
Quality Inn Festus
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels in Southeast Missouri

Missouri is a city that has a lot going on, but you have your sights set on Southeast Missouri. This part of town is perfect for what you want to be doing, and that is everything that is not on everyone’s radar. For all that Southeast Missouri has going on, you’ll still need a place to crash, eventually. But you don’t want any old shack, you need something that fits the trip. We have a slew of Southeast Missouri hotels that will do the trick.

A beautiful day in the neighborhood

As much as you like getting out there, it’s also good to know a part of Missouri so well you’ll be telling the tourists where to go. Make friends with the concierge or be bold and chat up a local. It’s your trip, so choose your own adventure. And when you get in at night, you’ll have a comfy room and plenty of amenities to help you settle in. Call a friend and spin tales from the Southeast Missouri underground. What’s a journey without a good story to go with it?

Beyond the block

We’re not talking about the Southeast Missouri city block. We’re talking about looking beyond that block of hotels you always focus on. We give you tons of ways to sort our stash of Southeast Missouri cheap hotels. And if you feel like living a little, but not killing your vacation vibes, choose the Hotwire Hot Rate deal. Filter by:

  • Hotwire Hot Rate: Snag some of the best hotels in Southeast Missouri at an almost too good to be true rate. After you book, we’ll reveal the name of the hotel. You can get a luxury hotel at a budget price.
  • Price: You have a price in mind, and we have solutions. Hotels start as low as $71
  • Amenities: Rooftop lounge, designer furniture, 24-7 room service, and everything else you look for to live it up large.

Find the Southeast Missouri hotel you want, book it, and never look back. Because your great escape is ahead of you.