Search Cheap Flights to
Kirksville

Search 400 airlines and 321,000 hotels worldwide.

Stop Planning & Start Exploring

FREE 24 hour cancellation on most flights

Kirksville Flights as Low as $285

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

American Airlines
Tue, Jul 14 - Tue, Jul 28
DEN
Denver Intl.
COU
Columbia Regional
$285 Roundtrip, found 14 hours ago
$285
Roundtrip
found 14 hours ago
Select American Airlines flight, departing Tue, Jul 14 from Denver Intl. to Columbia Regional, returning Tue, Jul 28, priced at $285 found 14 hours ago
United
Wed, Jun 24 - Mon, Jun 29
MSY
Louis Armstrong New Orleans Intl.
COU
Columbia Regional
$323 Roundtrip, found 11 hours ago
$323
Roundtrip
found 11 hours ago
Select United flight, departing Wed, Jun 24 from Louis Armstrong New Orleans Intl. to Columbia Regional, returning Mon, Jun 29, priced at $323 found 11 hours ago
United
Wed, Jun 24 - Sat, Jun 27
MSY
Louis Armstrong New Orleans Intl.
COU
Columbia Regional
$338 Roundtrip, found 11 hours ago
$338
Roundtrip
found 11 hours ago
Select United flight, departing Wed, Jun 24 from Louis Armstrong New Orleans Intl. to Columbia Regional, returning Sat, Jun 27, priced at $338 found 11 hours ago
United
Tue, Aug 4 - Sun, Aug 16
DEN
Denver Intl.
COU
Columbia Regional
$339 Roundtrip, found 5 days ago
$339
Roundtrip
found 5 days ago
Select United flight, departing Tue, Aug 4 from Denver Intl. to Columbia Regional, returning Sun, Aug 16, priced at $339 found 5 days ago
American Airlines
Tue, Jul 14 - Tue, Jul 28
DEN
Denver Intl.
COU
Columbia Regional
$341 Roundtrip, found 14 hours ago
$341
Roundtrip
found 14 hours ago
Select American Airlines flight, departing Tue, Jul 14 from Denver Intl. to Columbia Regional, returning Tue, Jul 28, priced at $341 found 14 hours ago
United
Wed, Jul 8 - Sat, Jul 25
DEN
Denver Intl.
COU
Columbia Regional
$346 Roundtrip, found 5 days ago
$346
Roundtrip
found 5 days ago
Select United flight, departing Wed, Jul 8 from Denver Intl. to Columbia Regional, returning Sat, Jul 25, priced at $346 found 5 days ago
American Airlines
Wed, Jun 24 - Tue, Jun 30
EWR
Newark Liberty Intl. Airport
COU
Columbia Regional
$350 Roundtrip, found 8 hours ago
$350
Roundtrip
found 8 hours ago
Select American Airlines flight, departing Wed, Jun 24 from Newark Liberty Intl. Airport to Columbia Regional, returning Tue, Jun 30, priced at $350 found 8 hours ago
United
Wed, Jun 24 - Mon, Jun 29
MSY
Louis Armstrong New Orleans Intl.
COU
Columbia Regional
$352 Roundtrip, found 11 hours ago
$352
Roundtrip
found 11 hours ago
Select United flight, departing Wed, Jun 24 from Louis Armstrong New Orleans Intl. to Columbia Regional, returning Mon, Jun 29, priced at $352 found 11 hours ago
American Airlines
Tue, Jul 7 - Sat, Jul 18
DEN
Denver Intl.
COU
Columbia Regional
$358 Roundtrip, found 5 days ago
$358
Roundtrip
found 5 days ago
Select American Airlines flight, departing Tue, Jul 7 from Denver Intl. to Columbia Regional, returning Sat, Jul 18, priced at $358 found 5 days ago
United
Tue, Jul 14 - Tue, Jul 28
DEN
Denver Intl.
COU
Columbia Regional
$361 Roundtrip, found 14 hours ago
$361
Roundtrip
found 14 hours ago
Select United flight, departing Tue, Jul 14 from Denver Intl. to Columbia Regional, returning Tue, Jul 28, priced at $361 found 14 hours ago
American Airlines
Tue, Jul 14 - Tue, Jul 28
DEN
Denver Intl.
COU
Columbia Regional
$367 Roundtrip, found 14 hours ago
$367
Roundtrip
found 14 hours ago
Select American Airlines flight, departing Tue, Jul 14 from Denver Intl. to Columbia Regional, returning Tue, Jul 28, priced at $367 found 14 hours ago
United
Wed, Jun 17 - Sat, Jul 4
DEN
Denver Intl.
COU
Columbia Regional
$367 Roundtrip, found 5 days ago
$367
Roundtrip
found 5 days ago
Select United flight, departing Wed, Jun 17 from Denver Intl. to Columbia Regional, returning Sat, Jul 4, priced at $367 found 5 days ago
American Airlines
Sat, Jun 20 - Mon, Jul 6
DEN
Denver Intl.
COU
Columbia Regional
$387 Roundtrip, found 5 days ago
$387
Roundtrip
found 5 days ago
Select American Airlines flight, departing Sat, Jun 20 from Denver Intl. to Columbia Regional, returning Mon, Jul 6, priced at $387 found 5 days ago
American Airlines
Wed, Jun 17 - Mon, Jul 6
DEN
Denver Intl.
COU
Columbia Regional
$387 Roundtrip, found 5 days ago
$387
Roundtrip
found 5 days ago
Select American Airlines flight, departing Wed, Jun 17 from Denver Intl. to Columbia Regional, returning Mon, Jul 6, priced at $387 found 5 days ago
United
Fri, Jul 3 - Tue, Jul 7
TPA
Tampa Intl.
COU
Columbia Regional
$459 Roundtrip, found 4 days ago
$459
Roundtrip
found 4 days ago
Select United flight, departing Fri, Jul 3 from Tampa Intl. to Columbia Regional, returning Tue, Jul 7, priced at $459 found 4 days ago
Bargain Flight
Sat, Jun 27 - Tue, Jun 30
DFW
Dallas-Fort Worth Intl.
COU
Columbia Regional
$470 Roundtrip, found 11 hours ago
$470
Roundtrip
found 11 hours ago
Select Bargain Flight flight, departing Sat, Jun 27 from Dallas-Fort Worth Intl. to Columbia Regional, returning Tue, Jun 30, priced at $470 found 11 hours ago

Cheap Flights to Kirksville

Fall in love at first flight with your vacation to Kirksville by saving a ton of cash on your last-minute cheap flight. There’s no more scouring the internet for a good deal—book your flight to Kirksville on Hotwire, and you’ll be up, up, and on a getaway in no time.

Because once the wheels are down in Kirksville, the good times start rolling. So buckle up, you’re in for a fun ride.

Frequently Asked Questions About flights to Kirksville

Don’t waste your time on endless searches for cheap airline tickets oneway or roundtrip. We’ll have you on your way to Kirksville with a tiny bag of pretzels in your hand before you can say “tray tables in the upright position”—and for a ticket price that works for your vacay budget.

So all you have to worry about is where you’re headed after the COU airport.

What is the cheapest month to fly to Kirksville?

Airline ticket prices fluctuate all the time, depending on the day of the week or the month of the year. The cheapest round trip flights to Kirksville are in July, but when you book your flight on Hotwire, savings are always in season.

How many airlines fly to Kirksville?

Variety is the spice of life, even when it comes to booking your next trip. Want options for airlines? You’ll find 15 to choose from for your flight to Kirksville.

What airport is best to fly into Kirksville?

When you’re planning your trip to Kirksville, convenience is the name of the game. Luckily, Kirksville Kirksville Municipal Airport is nearby so you can deplane and get going on checking off everything on your Kirksville must-do list.

How much are flights to Kirksville?

Got very cheap flights on your vacation itinerary? When you book your airline tickets to Kirksville on Hotwire, you may just get what’s on your getaway wish list. With tickets as low as $285, you’ll have leftover cash for at least a magazine and a bottle of water at the airport book store.

How to get cheap flights to Kirksville?

The trick to saving a stack of cash on your flight to Kirksville? Snatch up that Hotwire flight deal when you see a killer rate because it could be gone in a flash. And with flights as low as $285 right now, why wait?

Kirksville Flight Information
Destination airport
Columbia Regional
Destination airport IATA code
COU
Roundtrip price
$284

Last Minute Hotel Deals in Kirksville

Super 8 by Wyndham Kirksville-University Area

Super 8 by Wyndham Kirksville-University Area

2.5 out of 5
1101 Country Club Dr Kirksville MO
Book a stay at this golf hotel in Kirksville. Enjoy free breakfast, free WiFi, and free parking. Popular attraction Thousand Hills State Park is located ...
9/10 Wonderful! (220 reviews)
"Honestly this was a perfect choice for my daughter’s two day golf tournament. The hotel is not new but rooms have recently been updated. The only negative that I can say is that there wasn’t an iron in the room, other than that the stay was great and comfortable!"

Reviewed on Jun 7, 2026

Get rates
Super 8 by Wyndham Kirksville-University Area
Days Inn by Wyndham Kirksville

Days Inn by Wyndham Kirksville

2 out of 5
3805 S Baltimore St Kirksville MO
Book a stay at this business-friendly hotel in Kirksville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
6.6/10 (1,006 reviews)
"The only thing that was good about this hotel was the comfort of the beds. Amenities were not as advertised: the pool and hot tub were both not in working order; the bar was never open; and the breakfast consisted of only packaged bagels, donuts, pop tarts, coffee and juice. No milk, yogurt, waffles ..."

Reviewed on Jun 9, 2026

Get rates
Days Inn by Wyndham Kirksville
Baymont by Wyndham Kirksville University Area

Baymont by Wyndham Kirksville University Area

2.5 out of 5
2702 South Franklin Kirksville MO
Book a stay at this business-friendly hotel in Kirksville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7.6/10 Good! (918 reviews)
"This was OK for an overnight stay. It definitely needs some maintenance, but it was overall clean. The whirpool tub was nice for a soak, but we didn’t run the motor because it was unbelievably loud. Breakfast was a typical continental breakfast with some hot food items. The staff was quick with check-in ..."

Reviewed on Jun 7, 2026

Get rates
Baymont by Wyndham Kirksville University Area
Hampton Inn Kirksville

Hampton Inn Kirksville

2.5 out of 5
2604 N. Baltimore Street Kirksville MO
Book a stay at this business-friendly hotel in Kirksville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.2/10 Wonderful! (638 reviews)
"Was so nice and comfortable loved it"

Reviewed on Jun 8, 2026

Get rates
Hampton Inn Kirksville
Holiday Inn Express & Suites Kirksville - University Area by IHG

Holiday Inn Express & Suites Kirksville - University Area by IHG

2.5 out of 5
2523 South Franklin St. Kirksville MO
Book a stay at this business-friendly hotel in Kirksville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.2/10 Wonderful! (540 reviews)
"The Staff was not helpful at all. Tv was hard to navigate, no channels were displayed. Breakfast was not ready at 7 Prices were jacked up almost double"

Reviewed on Jun 5, 2026

Get rates
Holiday Inn Express & Suites Kirksville - University Area by IHG
Quality Inn Kirksville

Quality Inn Kirksville

2.5 out of 5
2209 N. Baltimore Street Kirksville MO
Book a stay at this business-friendly hotel in Kirksville. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff in our ...
7.6/10 Good! (404 reviews)
"Clean room convenient"

Reviewed on May 17, 2026

Get rates
Quality Inn Kirksville
Knights Inn Kirksville

Knights Inn Kirksville

1.5 out of 5
2521 South Franklin Street Kirksville MO
Stay at this motel in Kirksville. Enjoy free parking, a garden, and a picnic area. Popular attraction Thousand Hills State Park is located nearby.
7.2/10 Good! (264 reviews)
"The property is old. The room is huge but smells a little musty. there are 2 doors for the room. Park by the back door and across the room is another door leading to a huge courtyard. There are day/ road maintenance workers temporarily living there. But the place is pretty quiet. The towels and sheets ..."

Reviewed on Jun 5, 2026

Get rates
Knights Inn Kirksville
Budget Host Village Inn

Budget Host Village Inn

2 out of 5
1304 S Baltimore Kirksville MO
Book a stay at this business-friendly motel in Kirksville. Enjoy free WiFi, free parking, and room service. Popular attraction Thousand Hills State Park is located ...
6/10 (131 reviews)
"Mold in dresser, mold in shower and bathroom floor. Door has to be forced shut, manager approach my son and told him to do a Google and Expedia review and mark high (he didn't stay at hotel with me). Sorry will not stay there again. If could include pictures I would."

Reviewed on May 24, 2026

Get rates
Budget Host Village Inn
See all 52 properties in Kirksville
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top Hotels With Free Airport Shuttle

Days Inn by Wyndham Kirksville

Days Inn by Wyndham Kirksville

2 out of 5
3805 S Baltimore St Kirksville MO
Book a stay at this business-friendly hotel in Kirksville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
6.6/10 (1,006 reviews)
"The only thing that was good about this hotel was the comfort of the beds. Amenities were not as advertised: the pool and hot tub were both not in working order; the bar was never open; and the breakfast consisted of only packaged bagels, donuts, pop tarts, coffee and juice. No milk, yogurt, waffles ..."

Reviewed on Jun 9, 2026

Get rates
Days Inn by Wyndham Kirksville
See all 52 properties in Kirksville
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.