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Southeast Illinois

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Southeast Illinois Flights as Low as $355

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

American Airlines
Wed, Aug 20 - Wed, Aug 27
DFW
Dallas-Fort Worth Intl.
PAH
Barkley Regional
$355 Roundtrip, found 2 days ago
$355
Roundtrip
found 2 days ago
Select American Airlines flight, departing Wed, Aug 20 from Dallas-Fort Worth Intl. to Barkley Regional, returning Wed, Aug 27, priced at $355 found 2 days ago
American Airlines
Thu, Aug 21 - Mon, Aug 25
DEN
Denver Intl.
PAH
Barkley Regional
$359 Roundtrip, found 1 day ago
$359
Roundtrip
found 1 day ago
Select American Airlines flight, departing Thu, Aug 21 from Denver Intl. to Barkley Regional, returning Mon, Aug 25, priced at $359 found 1 day ago
American Airlines
Wed, Aug 20 - Wed, Aug 27
DFW
Dallas-Fort Worth Intl.
PAH
Barkley Regional
$363 Roundtrip, found 1 day ago
$363
Roundtrip
found 1 day ago
Select American Airlines flight, departing Wed, Aug 20 from Dallas-Fort Worth Intl. to Barkley Regional, returning Wed, Aug 27, priced at $363 found 1 day ago
American Airlines
Wed, Aug 20 - Wed, Aug 27
DFW
Dallas-Fort Worth Intl.
PAH
Barkley Regional
$365 Roundtrip, found 2 days ago
$365
Roundtrip
found 2 days ago
Select American Airlines flight, departing Wed, Aug 20 from Dallas-Fort Worth Intl. to Barkley Regional, returning Wed, Aug 27, priced at $365 found 2 days ago
American Airlines
Tue, Aug 19 - Wed, Aug 20
DEN
Denver Intl.
PAH
Barkley Regional
$369 Roundtrip, found 2 days ago
$369
Roundtrip
found 2 days ago
Select American Airlines flight, departing Tue, Aug 19 from Denver Intl. to Barkley Regional, returning Wed, Aug 20, priced at $369 found 2 days ago
American Airlines
Wed, Aug 20 - Wed, Aug 27
DFW
Dallas-Fort Worth Intl.
PAH
Barkley Regional
$371 Roundtrip, found 5 days ago
$371
Roundtrip
found 5 days ago
Select American Airlines flight, departing Wed, Aug 20 from Dallas-Fort Worth Intl. to Barkley Regional, returning Wed, Aug 27, priced at $371 found 5 days ago
American Airlines
Wed, Aug 20 - Wed, Aug 27
DFW
Dallas-Fort Worth Intl.
PAH
Barkley Regional
$372 Roundtrip, found 5 days ago
$372
Roundtrip
found 5 days ago
Select American Airlines flight, departing Wed, Aug 20 from Dallas-Fort Worth Intl. to Barkley Regional, returning Wed, Aug 27, priced at $372 found 5 days ago
American Airlines
Wed, Aug 20 - Wed, Aug 27
DFW
Dallas-Fort Worth Intl.
PAH
Barkley Regional
$373 Roundtrip, found 5 days ago
$373
Roundtrip
found 5 days ago
Select American Airlines flight, departing Wed, Aug 20 from Dallas-Fort Worth Intl. to Barkley Regional, returning Wed, Aug 27, priced at $373 found 5 days ago
American Airlines
Wed, Aug 20 - Wed, Aug 27
DFW
Dallas-Fort Worth Intl.
PAH
Barkley Regional
$375 Roundtrip, found 1 day ago
$375
Roundtrip
found 1 day ago
Select American Airlines flight, departing Wed, Aug 20 from Dallas-Fort Worth Intl. to Barkley Regional, returning Wed, Aug 27, priced at $375 found 1 day ago
American Airlines
Tue, Aug 19 - Fri, Aug 22
DEN
Denver Intl.
PAH
Barkley Regional
$379 Roundtrip, found 20 hours ago
$379
Roundtrip
found 20 hours ago
Select American Airlines flight, departing Tue, Aug 19 from Denver Intl. to Barkley Regional, returning Fri, Aug 22, priced at $379 found 20 hours ago
American Airlines
Fri, Aug 22 - Mon, Aug 25
DEN
Denver Intl.
PAH
Barkley Regional
$385 Roundtrip, found 2 days ago
$385
Roundtrip
found 2 days ago
Select American Airlines flight, departing Fri, Aug 22 from Denver Intl. to Barkley Regional, returning Mon, Aug 25, priced at $385 found 2 days ago
American Airlines
Fri, Aug 22 - Sun, Aug 24
DEN
Denver Intl.
PAH
Barkley Regional
$386 Roundtrip, found 2 days ago
$386
Roundtrip
found 2 days ago
Select American Airlines flight, departing Fri, Aug 22 from Denver Intl. to Barkley Regional, returning Sun, Aug 24, priced at $386 found 2 days ago
American Airlines
Mon, Aug 18 - Wed, Aug 27
DFW
Dallas-Fort Worth Intl.
PAH
Barkley Regional
$389 Roundtrip, found 5 days ago
$389
Roundtrip
found 5 days ago
Select American Airlines flight, departing Mon, Aug 18 from Dallas-Fort Worth Intl. to Barkley Regional, returning Wed, Aug 27, priced at $389 found 5 days ago
American Airlines
Sat, Aug 23 - Tue, Aug 26
PHX
Sky Harbor Intl.
EVV
Evansville Regional
$432 Roundtrip, found 3 days ago
$432
Roundtrip
found 3 days ago
Select American Airlines flight, departing Sat, Aug 23 from Sky Harbor Intl. to Evansville Regional, returning Tue, Aug 26, priced at $432 found 3 days ago
Delta
Sat, Aug 23 - Tue, Aug 26
PHX
Sky Harbor Intl.
EVV
Evansville Regional
$432 Roundtrip, found 3 days ago
$432
Roundtrip
found 3 days ago
Select Delta flight, departing Sat, Aug 23 from Sky Harbor Intl. to Evansville Regional, returning Tue, Aug 26, priced at $432 found 3 days ago
American Airlines
Wed, Sep 24 - Tue, Sep 30
PHX
Sky Harbor Intl.
PAH
Barkley Regional
$502 Roundtrip, found 1 day ago
$502
Roundtrip
found 1 day ago
Select American Airlines flight, departing Wed, Sep 24 from Sky Harbor Intl. to Barkley Regional, returning Tue, Sep 30, priced at $502 found 1 day ago

Cheap Flights to Southeast Illinois

Fall in love at first flight with your vacation to Southeast Illinois by saving a ton of cash on your last-minute cheap flight. There’s no more scouring the internet for a good deal—book your flight to Southeast Illinois on Hotwire, and you’ll be up, up, and on a getaway in no time.

Because once the wheels are down in Southeast Illinois, the good times start rolling. So buckle up, you’re in for a fun ride.

Frequently Asked Questions About flights to Southeast Illinois

Don’t waste your time on endless searches for cheap airline tickets oneway or roundtrip. We’ll have you on your way to Southeast Illinois with a tiny bag of pretzels in your hand before you can say “tray tables in the upright position”—and for a ticket price that works for your vacay budget.

So all you have to worry about is where you’re headed after the MDH airport.

What is the cheapest month to fly to Southeast Illinois?

Airline ticket prices fluctuate all the time, depending on the day of the week or the month of the year. The cheapest round trip flights to Southeast Illinois are in August, but when you book your flight on Hotwire, savings are always in season.

How many airlines fly to Southeast Illinois?

Variety is the spice of life, even when it comes to booking your next trip. Want options for airlines? You’ll find 16 to choose from for your flight to Southeast Illinois.

What airport is best to fly into Southeast Illinois?

When you’re planning your trip to Southeast Illinois, convenience is the name of the game. Luckily, Southeast Illinois Evansville Regional Airport is nearby so you can deplane and get going on checking off everything on your Southeast Illinois must-do list.

How much are flights to Southeast Illinois?

Got very cheap flights on your vacation itinerary? When you book your airline tickets to Southeast Illinois on Hotwire, you may just get what’s on your getaway wish list. With tickets as low as $355, you’ll have leftover cash for at least a magazine and a bottle of water at the airport book store.

How to get cheap flights to Southeast Illinois?

The trick to saving a stack of cash on your flight to Southeast Illinois? Snatch up that Hotwire flight deal when you see a killer rate because it could be gone in a flash. And with flights as low as $355 right now, why wait?

Southeast Illinois Flight Information
Destination airport
Evansville Regional
Destination airport IATA code
EVV
Roundtrip price
$101

Last Minute Hotel Deals in Southeast Illinois

Country Inn & Suites by Radisson, Effingham, IL

Country Inn & Suites by Radisson, Effingham, IL

2.5 out of 5
1200 N Raney, Effingham, IL
Book a stay at this business-friendly hotel in Effingham. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8.6/10 Excellent! (1,007 reviews)
"Needs renovation."

Reviewed on Jul 21, 2025

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Country Inn & Suites by Radisson, Effingham, IL
La Quinta Inn & Suites by Wyndham Effingham

La Quinta Inn & Suites by Wyndham Effingham

3 out of 5
1103 Avenue Of Mid America, Effingham, IL
Stay at this 3-star business-friendly hotel in Effingham. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9/10 Wonderful! (1,005 reviews)
"Loved the size of the room very comfy and cozy."

Reviewed on Jul 13, 2025

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La Quinta Inn & Suites by Wyndham Effingham
Days Inn & Suites by Wyndham Casey

Days Inn & Suites by Wyndham Casey

2 out of 5
933 N Route 49, Casey, IL
Book a stay at this business-friendly hotel in Casey. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
7.4/10 Good! (749 reviews)
"Great location and a quite place to stay and relax"

Reviewed on Jul 13, 2025

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Days Inn & Suites by Wyndham Casey
Baymont by Wyndham Effingham

Baymont by Wyndham Effingham

2.5 out of 5
1811 W Fayette Avenue, I-57 & 70 Exit 159, Effingham, IL
Book a stay at this business-friendly hotel in Effingham. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7.8/10 Good! (925 reviews)
"The staff was very courteous and helpfully, going above and beyond to make sure that our stay went well."

Reviewed on Jul 21, 2025

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Baymont by Wyndham Effingham
Best Western Delta Inn

Best Western Delta Inn

2.5 out of 5
1509 Hampton Dr, Located right off of I-57/70, Effingham, IL
Book a stay at this business-friendly hotel in Effingham. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
9/10 Wonderful! (1,004 reviews)
"very helpful staff"

Reviewed on Jul 20, 2025

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Best Western Delta Inn
Holiday Inn Express Metropolis by IHG

Holiday Inn Express Metropolis by IHG

2.5 out of 5
2179 East 5th Street, Metropolis, IL
Book a stay at this business-friendly hotel in Metropolis. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
8.2/10 Very Good! (1,000 reviews)
"Spacious and clean"

Reviewed on Jul 13, 2025

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Holiday Inn Express Metropolis by IHG
Holiday Inn Effingham by IHG

Holiday Inn Effingham by IHG

3.5 out of 5
1301 Avenue Of Mid America, Effingham, IL
Stay at this 3.5-star business-friendly hotel in Effingham. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff and ...
9/10 Wonderful! (624 reviews)
"Superb service and assistance from the entire team during the threat of an imminent tornado! The staff was fabulous in checking in guests who were seeking shelter during the threat of a tornado as well as meeting their needs. They remained calm, collected, kind and caring throughout the evening! ..."

Reviewed on Jul 22, 2025

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Holiday Inn Effingham by IHG
Suite Dreams Hotel

Suite Dreams Hotel

2.5 out of 5
300 Broadway Avenue East, Mattoon, IL
Book a stay at this business-friendly hotel in Mattoon. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7.2/10 Good! (488 reviews)
"Perfect location to walk to Bagelfest"

Reviewed on Jul 20, 2025

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Suite Dreams Hotel
See all 952 properties in Southeast Illinois
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.