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Wytheville

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Wytheville Flights as Low as $210

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

Bargain Flight
Tue, Apr 28 - Tue, May 5
BUF
Buffalo Niagara Intl.
ROA
Roanoke Regional
$210 Roundtrip, found 17 hours ago
$210
Roundtrip
found 17 hours ago
Select Bargain Flight flight, departing Tue, Apr 28 from Buffalo Niagara Intl. to Roanoke Regional, returning Tue, May 5, priced at $210 found 17 hours ago
Bargain Flight
Tue, Apr 21 - Fri, May 1
SYR
Hancock Intl.
ROA
Roanoke Regional
$215 Roundtrip, found 14 hours ago
$215
Roundtrip
found 14 hours ago
Select Bargain Flight flight, departing Tue, Apr 21 from Hancock Intl. to Roanoke Regional, returning Fri, May 1, priced at $215 found 14 hours ago
Bargain Flight
Tue, Aug 4 - Sun, Aug 9
BNA
Nashville Intl.
ROA
Roanoke Regional
$231 Roundtrip, found 12 hours ago
$231
Roundtrip
found 12 hours ago
Select Bargain Flight flight, departing Tue, Aug 4 from Nashville Intl. to Roanoke Regional, returning Sun, Aug 9, priced at $231 found 12 hours ago
Bargain Flight
Tue, Apr 21 - Tue, Apr 28
BNA
Nashville Intl.
ROA
Roanoke Regional
$238 Roundtrip, found 15 hours ago
$238
Roundtrip
found 15 hours ago
Select Bargain Flight flight, departing Tue, Apr 21 from Nashville Intl. to Roanoke Regional, returning Tue, Apr 28, priced at $238 found 15 hours ago
Bargain Flight
Sat, May 16 - Wed, May 20
ATL
Hartsfield-Jackson Atlanta Intl.
ROA
Roanoke Regional
$258 Roundtrip, found 14 hours ago
$258
Roundtrip
found 14 hours ago
Select Bargain Flight flight, departing Sat, May 16 from Hartsfield-Jackson Atlanta Intl. to Roanoke Regional, returning Wed, May 20, priced at $258 found 14 hours ago
United
Sat, May 23 - Wed, May 27
ORD
O'Hare Intl.
ROA
Roanoke Regional
$269 Roundtrip, found 9 hours ago
$269
Roundtrip
found 9 hours ago
Select United flight, departing Sat, May 23 from O'Hare Intl. to Roanoke Regional, returning Wed, May 27, priced at $269 found 9 hours ago
American Airlines
Sat, May 23 - Wed, May 27
ORD
O'Hare Intl.
ROA
Roanoke Regional
$269 Roundtrip, found 9 hours ago
$269
Roundtrip
found 9 hours ago
Select American Airlines flight, departing Sat, May 23 from O'Hare Intl. to Roanoke Regional, returning Wed, May 27, priced at $269 found 9 hours ago
United
Wed, May 27 - Tue, Jun 2
ORD
O'Hare Intl.
ROA
Roanoke Regional
$274 Roundtrip, found 12 hours ago
$274
Roundtrip
found 12 hours ago
Select United flight, departing Wed, May 27 from O'Hare Intl. to Roanoke Regional, returning Tue, Jun 2, priced at $274 found 12 hours ago
United
Tue, Apr 28 - Tue, May 5
BUF
Buffalo Niagara Intl.
ROA
Roanoke Regional
$276 Roundtrip, found 17 hours ago
$276
Roundtrip
found 17 hours ago
Select United flight, departing Tue, Apr 28 from Buffalo Niagara Intl. to Roanoke Regional, returning Tue, May 5, priced at $276 found 17 hours ago
Delta
Tue, Apr 28 - Tue, May 5
BUF
Buffalo Niagara Intl.
ROA
Roanoke Regional
$276 Roundtrip, found 17 hours ago
$276
Roundtrip
found 17 hours ago
Select Delta flight, departing Tue, Apr 28 from Buffalo Niagara Intl. to Roanoke Regional, returning Tue, May 5, priced at $276 found 17 hours ago
Bargain Flight
Sat, May 16 - Tue, May 19
TPA
Tampa Intl.
ROA
Roanoke Regional
$278 Roundtrip, found 13 hours ago
$278
Roundtrip
found 13 hours ago
Select Bargain Flight flight, departing Sat, May 16 from Tampa Intl. to Roanoke Regional, returning Tue, May 19, priced at $278 found 13 hours ago
Delta
Sun, Jun 14 - Sun, Jun 21
LGA
LaGuardia
ROA
Roanoke Regional
$279 Roundtrip, found 13 hours ago
$279
Roundtrip
found 13 hours ago
Select Delta flight, departing Sun, Jun 14 from LaGuardia to Roanoke Regional, returning Sun, Jun 21, priced at $279 found 13 hours ago
Delta
Tue, May 5 - Wed, May 6
DEN
Denver Intl.
ROA
Roanoke Regional
$291 Roundtrip, found 15 hours ago
$291
Roundtrip
found 15 hours ago
Select Delta flight, departing Tue, May 5 from Denver Intl. to Roanoke Regional, returning Wed, May 6, priced at $291 found 15 hours ago
American Airlines
Wed, Sep 9 - Wed, Sep 16
TPA
Tampa Intl.
TRI
Tri-Cities Regional
$299 Roundtrip, found 1 hour ago
$299
Roundtrip
found 1 hour ago
Select American Airlines flight, departing Wed, Sep 9 from Tampa Intl. to Tri-Cities Regional, returning Wed, Sep 16, priced at $299 found 1 hour ago
Delta
Fri, Jul 31 - Tue, Aug 4
DTW
Detroit Metropolitan Wayne County
ROA
Roanoke Regional
$309 Roundtrip, found 13 hours ago
$309
Roundtrip
found 13 hours ago
Select Delta flight, departing Fri, Jul 31 from Detroit Metropolitan Wayne County to Roanoke Regional, returning Tue, Aug 4, priced at $309 found 13 hours ago
American Airlines
Wed, Apr 29 - Mon, May 4
DTW
Detroit Metropolitan Wayne County
TRI
Tri-Cities Regional
$314 Roundtrip, found 1 day ago
$314
Roundtrip
found 1 day ago
Select American Airlines flight, departing Wed, Apr 29 from Detroit Metropolitan Wayne County to Tri-Cities Regional, returning Mon, May 4, priced at $314 found 1 day ago

Cheap Flights to Wytheville

Fall in love at first flight with your vacation to Wytheville by saving a ton of cash on your last-minute cheap flight. There’s no more scouring the internet for a good deal—book your flight to Wytheville on Hotwire, and you’ll be up, up, and on a getaway in no time.

Because once the wheels are down in Wytheville, the good times start rolling. So buckle up, you’re in for a fun ride.

Frequently Asked Questions About flights to Wytheville

Don’t waste your time on endless searches for cheap airline tickets oneway or roundtrip. We’ll have you on your way to Wytheville with a tiny bag of pretzels in your hand before you can say “tray tables in the upright position”—and for a ticket price that works for your vacay budget.

So all you have to worry about is where you’re headed after the ROA airport.

What is the cheapest month to fly to Wytheville?

Airline ticket prices fluctuate all the time, depending on the day of the week or the month of the year. The cheapest round trip flights to Wytheville are in April, but when you book your flight on Hotwire, savings are always in season.

How many airlines fly to Wytheville?

Variety is the spice of life, even when it comes to booking your next trip. Want options for airlines? You’ll find 10 to choose from for your flight to Wytheville.

What airport is best to fly into Wytheville?

When you’re planning your trip to Wytheville, convenience is the name of the game. Luckily, Wytheville Virginia Highlands Airport is nearby so you can deplane and get going on checking off everything on your Wytheville must-do list.

How much are flights to Wytheville?

Got very cheap flights on your vacation itinerary? When you book your airline tickets to Wytheville on Hotwire, you may just get what’s on your getaway wish list. With tickets as low as $210, you’ll have leftover cash for at least a magazine and a bottle of water at the airport book store.

How to get cheap flights to Wytheville?

The trick to saving a stack of cash on your flight to Wytheville? Snatch up that Hotwire flight deal when you see a killer rate because it could be gone in a flash. And with flights as low as $210 right now, why wait?

Wytheville Flight Information
Destination airport
Tri-Cities Regional
Destination airport IATA code
TRI
Roundtrip price
$106

Last Minute Hotel Deals in Wytheville

Sleep Inn Wytheville I-77 and I-81

Sleep Inn Wytheville I-77 and I-81

2.5 out of 5
135 Nye Cir Wytheville VA
Stay at this hotel in Wytheville. Enjoy free breakfast, free parking, and a fitness center. Our guests praise the breakfast and the helpful staff in our reviews. ...
9.2/10 Wonderful! (1,919 reviews)
Didn’t see the pool

Reviewed on Apr 5, 2026

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Sleep Inn Wytheville I-77 and I-81
Red Roof Inn Wytheville

Red Roof Inn Wytheville

3 out of 5
220 Lithia Rd Wytheville VA
Stay at this motel in Wytheville. Enjoy free WiFi, free parking, and a 24-hour front desk. Popular attractions Wohlfahrt Haus Dinner Theatre and Mountainview ...
8.4/10 Very Good! (315 reviews)
Bed very comfortable

Reviewed on Apr 5, 2026

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Red Roof Inn Wytheville
Spark by Hilton Wytheville Holston Rd I 81

Spark by Hilton Wytheville Holston Rd I 81

2.5 out of 5
315 Holston Rd Wytheville VA
Stay at this hotel in Wytheville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions ...
8.6/10 Excellent! (173 reviews)
The issue I personally had with this hotel was the general floor plan of this hotel. Maybe it's just me but when you park your car where they tell you to park (in my case this was B)and you press the elevator for 1B you come out in a totally different area than your car is parked. Some instruction ...

Reviewed on Apr 5, 2026

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Spark by Hilton Wytheville Holston Rd I 81
Tru by Hilton Wytheville

Tru by Hilton Wytheville

2.5 out of 5
245 Boyd Ave Wytheville VA
Book a stay at this business-friendly hotel in Wytheville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9/10 Wonderful! (1,002 reviews)
Easy stop off 81. Super clean. Plenty of storage in room. Gym is nicer than many hotels. Breakfast is okay (I’m picky though) and don’t like most breakfast foods. Staff friendly and caters to guest. Only downside is the noise off 81, so maybe request the other side if a light sleeper. We didn’t bring ...

Reviewed on Apr 6, 2026

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Tru by Hilton Wytheville
Ramada by Wyndham Wytheville

Ramada by Wyndham Wytheville

2.5 out of 5
955 Peppers Ferry Rd Wytheville VA
Book a stay at this business-friendly hotel in Wytheville. Enjoy free breakfast, free WiFi, and an outdoor pool. Our guests praise the breakfast and the pool ...
8/10 Very Good! (1,520 reviews)
Okay for a quick stay I guess. Floor was so dirty had to wash the kids feet within 5 min of walking on it. Sheets seemed washed but stained. Fridge was barely cold. Ice maker didn’t work. Didn't see any bugs or anything like that. To be fair the front counter gentleman was very polite and likely ...

Reviewed on Apr 5, 2026

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Ramada by Wyndham Wytheville
The Bolling Wilson Hotel

The Bolling Wilson Hotel

3 out of 5
170 East Main Street Wytheville VA
Book a stay at this business-friendly hotel in Wytheville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the restaurant and the helpful ...
9.6/10 Exceptional! (831 reviews)
Enjoyed our stay, loved the location and historical aspect. Breakfast was ok…

Reviewed on Mar 31, 2026

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The Bolling Wilson Hotel
Country Inn & Suites by Radisson, Wytheville, VA

Country Inn & Suites by Radisson, Wytheville, VA

3 out of 5
697 Peppers Ferry Road Wytheville VA
Book a stay at this business-friendly hotel in Wytheville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
8.2/10 Very Good! (1,005 reviews)
The housekeepers made sure the room was clean. We had the same room that we had on 3/31 so bathtub still did not drain. Breakfast was not very well stocked, the person handling breakfast was also covering front desk (btw breakfast was 7-10:30 am and we were there at 9 am. When we went to check out ...

Reviewed on Apr 4, 2026

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Country Inn & Suites by Radisson, Wytheville, VA
Holiday Inn Express and Suites Wytheville by IHG

Holiday Inn Express and Suites Wytheville by IHG

2.5 out of 5
165 Malin Dr Wytheville VA
Book a stay at this business-friendly hotel in Wytheville. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the helpful ...
9.2/10 Wonderful! (1,004 reviews)
Staff were real nice and helpful. Room was large. Breakfast had a nice variety of hot and cold foods.

Reviewed on Apr 6, 2026

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Holiday Inn Express and Suites Wytheville by IHG
See all 392 properties in Wytheville
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.