Search Cheap Flights to
Wytheville

Photo by Meng Fan

Search 400 airlines and 321,000 hotels worldwide.

Stop Planning & Start Exploring

FREE 24 hour cancellation on most flights

Wytheville Flights as Low as $181

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

Bargain Flight
Wed, Aug 20 - Sun, Aug 31
BUF
Buffalo Niagara Intl.
ROA
Roanoke Regional
$181 Roundtrip, found 8 hours ago
$181
Roundtrip
found 8 hours ago
Select Bargain Flight flight, departing Wed, Aug 20 from Buffalo Niagara Intl. to Roanoke Regional, returning Sun, Aug 31, priced at $181 found 8 hours ago
Bargain Flight
Tue, Sep 16 - Tue, Sep 23
LGA
LaGuardia
ROA
Roanoke Regional
$186 Roundtrip, found 11 hours ago
$186
Roundtrip
found 11 hours ago
Select Bargain Flight flight, departing Tue, Sep 16 from LaGuardia to Roanoke Regional, returning Tue, Sep 23, priced at $186 found 11 hours ago
Delta
Wed, Aug 20 - Sun, Aug 31
BUF
Buffalo Niagara Intl.
ROA
Roanoke Regional
$217 Roundtrip, found 8 hours ago
$217
Roundtrip
found 8 hours ago
Select Delta flight, departing Wed, Aug 20 from Buffalo Niagara Intl. to Roanoke Regional, returning Sun, Aug 31, priced at $217 found 8 hours ago
American Airlines
Wed, Sep 10 - Sat, Sep 13
ALB
Albany Intl.
ROA
Roanoke Regional
$229 Roundtrip, found 2 hours ago
$229
Roundtrip
found 2 hours ago
Select American Airlines flight, departing Wed, Sep 10 from Albany Intl. to Roanoke Regional, returning Sat, Sep 13, priced at $229 found 2 hours ago
Delta
Tue, Aug 5 - Tue, Aug 12
GRR
Gerald R. Ford Intl.
ROA
Roanoke Regional
$233 Roundtrip, found 10 hours ago
$233
Roundtrip
found 10 hours ago
Select Delta flight, departing Tue, Aug 5 from Gerald R. Ford Intl. to Roanoke Regional, returning Tue, Aug 12, priced at $233 found 10 hours ago
Delta
Tue, Sep 16 - Tue, Sep 23
LGA
LaGuardia
ROA
Roanoke Regional
$239 Roundtrip, found 11 hours ago
$239
Roundtrip
found 11 hours ago
Select Delta flight, departing Tue, Sep 16 from LaGuardia to Roanoke Regional, returning Tue, Sep 23, priced at $239 found 11 hours ago
American Airlines
Tue, Aug 19 - Wed, Aug 20
BOS
Logan Intl.
ROA
Roanoke Regional
$249 Roundtrip, found 15 hours ago
$249
Roundtrip
found 15 hours ago
Select American Airlines flight, departing Tue, Aug 19 from Logan Intl. to Roanoke Regional, returning Wed, Aug 20, priced at $249 found 15 hours ago
American Airlines
Sat, Aug 16 - Wed, Aug 20
MSY
Louis Armstrong New Orleans Intl.
ROA
Roanoke Regional
$249 Roundtrip, found 6 hours ago
$249
Roundtrip
found 6 hours ago
Select American Airlines flight, departing Sat, Aug 16 from Louis Armstrong New Orleans Intl. to Roanoke Regional, returning Wed, Aug 20, priced at $249 found 6 hours ago
Delta
Sat, Nov 15 - Tue, Nov 25
FLL
Fort Lauderdale - Hollywood Intl.
ROA
Roanoke Regional
$249 Roundtrip, found 8 hours ago
$249
Roundtrip
found 8 hours ago
Select Delta flight, departing Sat, Nov 15 from Fort Lauderdale - Hollywood Intl. to Roanoke Regional, returning Tue, Nov 25, priced at $249 found 8 hours ago
Delta
Mon, Jul 28 - Wed, Aug 6
ATL
Hartsfield-Jackson Atlanta Intl.
TRI
Tri-Cities Regional
$254 Roundtrip, found 1 hour ago
$254
Roundtrip
found 1 hour ago
Select Delta flight, departing Mon, Jul 28 from Hartsfield-Jackson Atlanta Intl. to Tri-Cities Regional, returning Wed, Aug 6, priced at $254 found 1 hour ago
American Airlines
Tue, Aug 12 - Sat, Aug 16
IAH
George Bush Intercontinental
ROA
Roanoke Regional
$263 Roundtrip, found 9 hours ago
$263
Roundtrip
found 9 hours ago
Select American Airlines flight, departing Tue, Aug 12 from George Bush Intercontinental to Roanoke Regional, returning Sat, Aug 16, priced at $263 found 9 hours ago
American Airlines
Tue, Sep 9 - Tue, Sep 16
BUF
Buffalo Niagara Intl.
TRI
Tri-Cities Regional
$287 Roundtrip, found 10 hours ago
$287
Roundtrip
found 10 hours ago
Select American Airlines flight, departing Tue, Sep 9 from Buffalo Niagara Intl. to Tri-Cities Regional, returning Tue, Sep 16, priced at $287 found 10 hours ago
American Airlines
Tue, Jul 29 - Tue, Aug 5
IAH
George Bush Intercontinental
TRI
Tri-Cities Regional
$294 Roundtrip, found 3 hours ago
$294
Roundtrip
found 3 hours ago
Select American Airlines flight, departing Tue, Jul 29 from George Bush Intercontinental to Tri-Cities Regional, returning Tue, Aug 5, priced at $294 found 3 hours ago
Bargain Flight
Thu, Aug 14 - Tue, Aug 19
ATL
Hartsfield-Jackson Atlanta Intl.
ROA
Roanoke Regional
$298 Roundtrip, found 9 hours ago
$298
Roundtrip
found 9 hours ago
Select Bargain Flight flight, departing Thu, Aug 14 from Hartsfield-Jackson Atlanta Intl. to Roanoke Regional, returning Tue, Aug 19, priced at $298 found 9 hours ago
Delta
Tue, Oct 14 - Tue, Oct 21
LGA
LaGuardia
TRI
Tri-Cities Regional
$345 Roundtrip, found 2 hours ago
$345
Roundtrip
found 2 hours ago
Select Delta flight, departing Tue, Oct 14 from LaGuardia to Tri-Cities Regional, returning Tue, Oct 21, priced at $345 found 2 hours ago
United
Wed, Jul 16 - Fri, Jul 18
YOW
Macdonald-Cartier Intl.
ROA
Roanoke Regional
$582 Roundtrip, found 7 hours ago
$582
Roundtrip
found 7 hours ago
Select United flight, departing Wed, Jul 16 from Macdonald-Cartier Intl. to Roanoke Regional, returning Fri, Jul 18, priced at $582 found 7 hours ago

Cheap Flights to Wytheville

Fall in love at first flight with your vacation to Wytheville by saving a ton of cash on your last-minute cheap flight. There’s no more scouring the internet for a good deal—book your flight to Wytheville on Hotwire, and you’ll be up, up, and on a getaway in no time.

Because once the wheels are down in Wytheville, the good times start rolling. So buckle up, you’re in for a fun ride.

Frequently Asked Questions About flights to Wytheville

Don’t waste your time on endless searches for cheap airline tickets oneway or roundtrip. We’ll have you on your way to Wytheville with a tiny bag of pretzels in your hand before you can say “tray tables in the upright position”—and for a ticket price that works for your vacay budget.

So all you have to worry about is where you’re headed after the ROA airport.

What is the cheapest month to fly to Wytheville?

Airline ticket prices fluctuate all the time, depending on the day of the week or the month of the year. The cheapest round trip flights to Wytheville are in August, but when you book your flight on Hotwire, savings are always in season.

How many airlines fly to Wytheville?

Variety is the spice of life, even when it comes to booking your next trip. Want options for airlines? You’ll find 13 to choose from for your flight to Wytheville.

What airport is best to fly into Wytheville?

When you’re planning your trip to Wytheville, convenience is the name of the game. Luckily, Wytheville Virginia Highlands Airport is nearby so you can deplane and get going on checking off everything on your Wytheville must-do list.

How much are flights to Wytheville?

Got very cheap flights on your vacation itinerary? When you book your airline tickets to Wytheville on Hotwire, you may just get what’s on your getaway wish list. With tickets as low as $181, you’ll have leftover cash for at least a magazine and a bottle of water at the airport book store.

How to get cheap flights to Wytheville?

The trick to saving a stack of cash on your flight to Wytheville? Snatch up that Hotwire flight deal when you see a killer rate because it could be gone in a flash. And with flights as low as $181 right now, why wait?

Wytheville Flight Information
Destination airport
Roanoke Regional
Destination airport IATA code
ROA
Roundtrip price
$185

Last Minute Hotel Deals in Wytheville

Ramada by Wyndham Wytheville
Ramada by Wyndham Wytheville
2.5 out of 5
955 Peppers Ferry Rd, Wytheville, VA
Book a stay at this business-friendly hotel in Wytheville. Enjoy free breakfast, free WiFi, and an outdoor pool. Our guests praise the breakfast and the pool ...
8.2/10 Very Good! (1,286 reviews)
"Nice place for the price and great hospitality"

Reviewed on Jul 6, 2025

Get rates
Ramada by Wyndham Wytheville
Sleep Inn Wytheville I-77 and I-81
Sleep Inn Wytheville I-77 and I-81
2.5 out of 5
135 Nye Cir, Wytheville, VA
Stay at this hotel in Wytheville. Enjoy free breakfast, free parking, and a fitness center. Our guests praise the breakfast and the helpful staff in our reviews. ...
9.2/10 Wonderful! (1,594 reviews)
"Good value for the money."

Reviewed on Jul 5, 2025

Get rates
Sleep Inn Wytheville I-77 and I-81
Travelodge by Wyndham Wytheville
Travelodge by Wyndham Wytheville
2 out of 5
140 Lithia Rd, Wytheville, VA
Book a stay at this business-friendly motel in Wytheville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
8.2/10 Very Good! (1,333 reviews)
"The staff is very kind and hard-working."

Reviewed on Jul 6, 2025

Get rates
Travelodge by Wyndham Wytheville
Days Inn by Wyndham Wytheville
Days Inn by Wyndham Wytheville
2 out of 5
150 Malin Dr, I-81 and I-77 Exit 73, Wytheville, VA
Book a stay at this business-friendly hotel in Wytheville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7.8/10 Good! (1,006 reviews)
"Very, very nice place to stay. We come back every time we are in the area - its the only place we stay. There is obviously real pride of place; the rooms are immaculate, the lobby is welcoming, staff is kind and friendly, the dining room is peaceful and breakfast is....actually breakfast. Almost ..."

Reviewed on Jul 2, 2025

Get rates
Days Inn by Wyndham Wytheville
Country Inn & Suites by Radisson, Wytheville, VA
Country Inn & Suites by Radisson, Wytheville, VA
3 out of 5
697 Peppers Ferry Road, Wytheville, VA
Stay at this 3-star business-friendly hotel in Wytheville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
8.2/10 Very Good! (1,013 reviews)
"Very clean"

Reviewed on Jul 6, 2025

Get rates
Country Inn & Suites by Radisson, Wytheville, VA
La Quinta Inn & Suites by Wyndham Wytheville
La Quinta Inn & Suites by Wyndham Wytheville
3 out of 5
1800 East Main Street, Wytheville, VA
Stay at this 3-star business-friendly hotel in Wytheville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7.6/10 Good! (1,003 reviews)
"Great place to stop when traveling"

Reviewed on Jul 2, 2025

Get rates
La Quinta Inn & Suites by Wyndham Wytheville
Comfort Suites Wytheville
Comfort Suites Wytheville
2.5 out of 5
695 Peppers Ferry Rd, Wytheville, VA
Book a stay at this business-friendly hotel in Wytheville. Enjoy free breakfast, free parking, and a fitness center. Our guests praise the breakfast and the ...
8.6/10 Excellent! (1,007 reviews)
Just stayed one night
"Excellent spot with good coffee options."

Reviewed on Jul 7, 2025

Get rates
Comfort Suites Wytheville
Super 8 by Wyndham Wytheville
Super 8 by Wyndham Wytheville
2 out of 5
130 Nye Circle, I-77 exit 41, Wytheville, VA
Book a stay at this business-friendly hotel in Wytheville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
8/10 Very Good! (1,002 reviews)
"Very friendly staff"

Reviewed on Jul 4, 2025

Get rates
Super 8 by Wyndham Wytheville
See all 368 properties in Wytheville
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.