Search for Cheap Deals on
Four Seasons in Historic Route 66

You choose what matters — star rating, location, amenities.

We pick the perfect hotel, packed with all your must-haves.

Your hotel is revealed right after booking!


Featured Historic Route 66 Four Seasons

Four Seasons Hotel Chicago
Four Seasons Hotel Chicago
5 out of 5
120 East Delaware Place, Chicago, IL
Fully refundableReserve now, pay when you stay
Stay at this 5-star luxury hotel in Chicago. Enjoy free WiFi, a full-service spa, and breakfast (surcharge). Our guests praise the helpful staff and the property ...
Four Seasons Hotel Chicago
Four Seasons Hotel St Louis
Four Seasons Hotel St Louis
5 out of 5
999 North Second Street, St. Louis, MO
Fully refundable
Stay at this 5-star luxury hotel in St. Louis. Enjoy free WiFi, a full-service spa, and a rooftop terrace. Our guests praise the helpful staff in our reviews. ...
Four Seasons Hotel St Louis
Four Seasons Resort Rancho Encantado Santa Fe
Four Seasons Resort Rancho Encantado Santa Fe
5 out of 5
198 State Road 592, Santa Fe, NM
Fully refundableReserve now, pay when you stay
Stay at this 5-star luxury resort in Santa Fe. Enjoy a full-service spa, breakfast (surcharge), and 24-hour room service. Our guests praise the room service ...
Four Seasons Resort Rancho Encantado Santa Fe
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Four Seasons hotels in Historic Route 66

You’ve already taken the guesswork out of your next vacation. You know you want a Four Seasons hotel in Historic Route 66. What can you say? You like their style, they’re in a good part of Historic Route 66, and they never let you down. New bar in town? You’re the first one to check it out. Spiciest item on the menu? You can take the heat. But even the best gamblers hedge their bets. No matter how crazy good your trip is, you want something familiar waiting for you at the end of the day.

All in a name

We all have favorites. There’s nothing wrong with knowing what you like. You like to stay at Four Seasons near , Historic Route 66 to do the tourist thing (because sometimes it is fun) and then hit up the places that aren’t on the map. And no matter what fun you get into, you have Four Seasons hotels with their comfy beds and thoughtful amenities waiting to tuck you in.

As you like it

Have a price you want to stick to, so you can paint the town red? Maybe, it’s all about the hotel features. Who couldn’t use a hot tub? Pick your pleasure by:

  • Hotwire Hot Rate: Grab the Four Seasons hotel in Historic Route 66 at an absolute steal. After you book it, we’ll tell you the hotel name. You might nab that 4-star hotel for a 2-star price.
  • Price: How low can we go? Quite low in fact. Check out our prices per night, starting at $438.
  • Amenities: Grab a cocktail at the lounge and maybe wander upstairs to the rooftop terrace—all the stuff that makes a great vacay.

You’ve already done the hard part—figuring out where you want to stay. Now it’s time to use the money you saved to let the real fun begin. Underground shows? Off-beat attractions? Rooftop escapes? The choice is yours. The only thing wonderfully predictable about this trip is the Four Seasons room you’ll be staying in.