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Hotels in Mainz City Center

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IntercityHotel Mainz

IntercityHotel Mainz

Binger Strasse 21 Mainz RP
  • 19 min walk from Mainz Cathedral
Book a stay at this business-friendly hotel in Mainz. Enjoy breakfast (surcharge), parking (surcharge), and a 24-hour front desk. Popular attractions Mainz Cathedral ...
8.4/10 Very Good! (1,000 reviews)
"All good very clean very friendly"

Reviewed on Jun 2, 2026

IntercityHotel Mainz
Leonardo Hotel Mainz

Leonardo Hotel Mainz

Augustusstrasse 6 Mainz RP
  • 15 min walk from Mainz Cathedral
Stay at this hotel in Mainz. Enjoy breakfast (surcharge), 24-hour room service, and a fitness center. Our guests praise the helpful staff in our reviews. Popular ...
8.4/10 Very Good! (890 reviews)
"Staff seemed put out by having to do their job of checking us in, the concept of hospitality was not in their vocabulary. Housekeeping left our soap contact empty, left dirty cups and upon asking for soap and clean towels, nothing happened until I asked again. A sauna and pool are adventure but the ..."

Reviewed on May 18, 2026

Leonardo Hotel Mainz
Hyatt Regency Mainz

Hyatt Regency Mainz

Templerstraße 6 Mainz
  • 11 min walk from Mainz Cathedral
Book a stay at this luxury hotel in Mainz. Enjoy free WiFi, a full-service spa, and breakfast (surcharge). Our guests praise the helpful staff in our reviews. ...
Hyatt Regency Mainz
Hilton Mainz

Hilton Mainz

Rheinstrasse 68 Mainz
  • 6 min walk from Mainz Cathedral
Book a stay at this luxury hotel in Mainz. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the helpful staff in our reviews. Popular ...
8.6/10 Excellent! (448 reviews)
"Amazing stay in Hilton. The hotel is excellent, great service, our room was upgraded to River View which was a pleasant suprise. Easy to get anywhere from the hotel, lovely bars along the bank of Rhein just at the door step."

Reviewed on May 31, 2026

Hilton Mainz
Me and All Hotel Mainz, by Hyatt

Me and All Hotel Mainz, by Hyatt

Binger Straße 23 Mainz RP
  • 20 min walk from Mainz Cathedral
Book a stay at this luxury hotel in Mainz. Enjoy free WiFi, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the helpful staff in our reviews. ...
9.4/10 Exceptional! (390 reviews)
"Excellent"

Reviewed on May 20, 2026

Me and All Hotel Mainz, by Hyatt
Brunfels Hotel, in the Unbound Collection by Hyatt

Brunfels Hotel, in the Unbound Collection by Hyatt

Muensterstrasse 11 Mainz
  • 10 min walk from Mainz Cathedral
Book a stay at this luxury hotel in Mainz. Enjoy free WiFi, breakfast (surcharge), and 24-hour room service. Popular attractions Fastnachtsbrunnen and Sanctuary ...
9.8/10 Exceptional! (133 reviews)
"Modern and comfortable excellent staff"

Reviewed on Jun 4, 2026

Brunfels Hotel, in the Unbound Collection by Hyatt
Mercure Hotel Mainz City Center

Mercure Hotel Mainz City Center

3.5 out of 5
Kaiserstraße 7 Mainz RP
  • 16 min walk from Mainz Cathedral
Stay at this hotel in Mainz. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the helpful staff and the property condition in our ...
8/10 Very Good! (492 reviews)
"The rooms were in good condition. The staff was inconsistent. We arrived with a decent sized group of kids and it felt like some of the staff did not want us there. They were ready for a problem and it showed."

Reviewed on Feb 8, 2026

Mercure Hotel Mainz City Center
Sheraton Frankfurt Airport Hotel & Conference Center

Sheraton Frankfurt Airport Hotel & Conference Center

Flughafen Terminal 1 Frankfurt HE
  • 49 min drive from Mainz Cathedral
Book a stay at this luxury hotel in Frankfurt. Enjoy free WiFi, 3 restaurants, and 2 bars/lounges. Our guests praise the helpful staff and the clean rooms in ...
8.8/10 Excellent! (3,009 reviews)
"Very nice and helpful welocme at the check in, nice rooms next to each other and a very good experience in the restaurant. Very helpful waiter. Everything was perfect."

Reviewed on Jun 5, 2026

Sheraton Frankfurt Airport Hotel & Conference Center
Hyatt Place Frankfurt Airport

Hyatt Place Frankfurt Airport

De-Saint-Exupéry-Straße 4 Frankfurt HE
  • 53 min drive from Mainz Cathedral
Book a stay at this luxury hotel in Frankfurt. Enjoy free WiFi, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the breakfast and the ...
9.2/10 Wonderful! (2,261 reviews)
"My stay was only for one night but, it was great. The room was clean, comfortable, and quiet. This was my second time staying here before my flight. The breakfast was second to none and excellent. The front desk attendents were very friendly. I will deffinitely recommend a stay here. It felt like ..."

Reviewed on Jun 6, 2026

Hyatt Place Frankfurt Airport
IntercityHotel Frankfurt Hauptbahnhof Süd

IntercityHotel Frankfurt Hauptbahnhof Süd

Mannheimer Str. 21 Frankfurt HE
  • 1 hour drive from Mainz Cathedral
Book a stay at this business-friendly hotel in Frankfurt. Enjoy free WiFi, breakfast (surcharge), and a 24-hour front desk. Our guests praise the helpful staff ...
8.8/10 Excellent! (1,477 reviews)
"It was right across from the train station, very convenient."

Reviewed on Jun 5, 2026

IntercityHotel Frankfurt Hauptbahnhof Süd
Hilton Garden Inn Frankfurt Airport

Hilton Garden Inn Frankfurt Airport

The Squaire Frankfurt
  • 49 min drive from Mainz Cathedral
Book a stay at this spa hotel in Frankfurt. Enjoy free WiFi, a full-service spa, and breakfast (surcharge). Our guests praise the breakfast and the helpful staff ...
8.8/10 Excellent! (2,783 reviews)
"Perfect location for catching annearly flight out of Europe"

Reviewed on Jun 5, 2026

Hilton Garden Inn Frankfurt Airport
Hampton by Hilton Frankfurt Airport

Hampton by Hilton Frankfurt Airport

Thea-Rasche, 6 Frankfurt
  • 52 min drive from Mainz Cathedral
Book a stay at this business-friendly hotel in Frankfurt. Enjoy free breakfast, free WiFi, and room service. Our guests praise the breakfast and the helpful ...
9/10 Wonderful! (1,466 reviews)
"Very nice and clean hotel, breakfast was very good."

Reviewed on Jun 5, 2026

Hampton by Hilton Frankfurt Airport
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find cheap hotels in Mainz City Center

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For you, intrepid voyager, Hotwire has a large selection of the best hotels in Mainz City Center.

Choosing the right hotel in Rhineland-Palatinate has everything to do with the way you want your trip to go. If you’ve scribbled a few obscure destinations on your itinerary, you probably already have a good sense of how your getaway is taking shape. Lean into that by booking one of Mainz City Center’s 1,266 hotels. Choose the one that best catches your trip’s tourist drift.

If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $78. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get great Mainz City Center hotel deals at the last minute.

While traveling, where you stay plays a major role in your overall vacation enjoyment. Choosing the right hotel is just as important as making sure you book the right flight and car rental. If you’re traveling with family or friends, you may need to book a hotel with connecting rooms. If you enjoy an elegant and relaxing hotel ambiance, opt for one of Hotwire’s luxury hotels in Mainz City Center. No matter your reason for visiting Mainz City Center, with Hotwire’s large selection of hotels in the area, you’re sure to book a hotel that meets all your accommodation needs.

Frequently Asked Questions About Mainz City Center hotels

Where can I find the best last-minute travel deals?

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How many hotels are there in Mainz City Center?

With over 1,266 hotels in Mainz City Center, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $78.

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Finding a cheap car rental deal in Mainz City Center is as easy as scoring cheap hotels in Mainz City Center. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can unlock great car rental deals if you book a Hotwire Hot Rate at the last minute.