Search for Cheap Deals onSpa Resort Hotels in Opelousas
Check Last Minute Opelousas Hotel Deals
You choose what matters — star rating, location, amenities.
We pick the perfect hotel, packed with all your must-haves.
Your hotel is revealed right after booking!
Featured Opelousas Resorts & Hotels with Spas

Holiday Inn Express & Suites Opelousas by IHG
5696 I-49 N Service Rd, Opelousas, LA
Fully refundable
Stay at this 3-star business-friendly hotel in Opelousas. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Hotels by Star Rating
More Hotel Options in Opelousas
- Hotels with a Pool in Opelousas
- Historic Hotels in Opelousas
- Hotels with Free Parking in Opelousas
- Family Hotels in Opelousas
- Pet-friendly Hotels in Opelousas
- Casinos in Opelousas
- Hotel Wedding Venues in Opelousas
- Hotels with smoking rooms in Opelousas
- Hotels with an Indoor Pool in Opelousas
- Hotels with Hot Tubs in Opelousas
Top Points of Interests in Opelousas
- Hotels near Evangeline Downs Racetrack & Casino
- Hotels near St. Landry Catholic Church
- Hotels near Louisiana Orphan Train Museum
- Hotels near University of Louisiana at Lafayette
- Hotels near Cajundome
- Hotels near Acadian Village
- Hotels near CIty Club at River Ranch
- Hotels near Cajun Field
- Hotels near Girard Park
- Hotels near Moore Park
- Hotels near Vermilionville Historic Village
Cities near Opelousas
- Lafayette Hotels (21.68 mi)
- Gulf Coast Hotels (146.43 mi)
- Breaux Bridge Hotels (20.98 mi)
- Scott Hotels (20.58 mi)
- Youngsville Hotels (30.41 mi)
- Broussard Hotels (27.63 mi)
- Eunice Hotels (20.18 mi)
- Crowley Hotels (28.13 mi)
- Rayne Hotels (23.43 mi)
- Oakdale Hotels (39.46 mi)
- St. Martinville Hotels (32.07 mi)
- Ville Platte Hotels (15.53 mi)
- Duson Hotels (23.45 mi)
- Carencro Hotels (15.07 mi)
- Bunkie Hotels (30.06 mi)
- Henderson Hotels (23.06 mi)
- Southern Louisiana Hotels (34.4 mi)
- Sunset Hotels (8.47 mi)
- Mamou Hotels (21.24 mi)
- Church Point Hotels (12.02 mi)